Inflammatory Content

Kellen Cavagnero, Ph.D.

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العلوم

Inflammatory Content is a podcast about immunology and biomedical sciences more broadly. UC San Diego immunologist Dr. Kellen Cavagnero PhD reviews the latest high-impact original articles and discusses all things science with leading researchers in the field. Inflammatory Content has been featured in Nature and received sponsorship from the NIH.

٤ يناير

#28: Hidradenitis Suppurativa

In this episode of Inflammatory Content, Dr. Kellen Cavagnero explores the debilitating skin disease hidradenitis suppurativa (HS) and takes a deep dive into a recent Immunity paper that comprehensively examines the role of tertiary lymphoid structures in HS pathogenesis. HS has long defied simple classification, with prevailing disease models emphasizing hair follicle dysfunction, aberrant wound healing, or chronic inflammation. This work adds a new dimension by implicating autoimmunity as a central contributor to HS pathogenesis, further underscoring the complexity of the disease. Relevant Links: • Paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC12404358/ • Commentary: https://pmc.ncbi.nlm.nih.gov/articles/PMC11790253/ If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast! You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero. I’d love to hear from you! Feel free to reach out with questions, feedback, or topic suggestions via email at kcavagnero@gmail.com, on X @KellenCavagnero, or connect with me on LinkedIn. Stay curious and keep exploring at www.inflammatorycontent.com

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#27: A Surprising New Role for Neutrophils in Wound Healing

In this episode of Inflammatory Content, Dr. Kellen Cavagnero breaks down a new Nature paper showing that a subset of skin neutrophils doesn’t just fight bacteria—they also build extracellular matrix (ECM). After injury, these neutrophils rapidly assemble rings of ECM around the wound that strengthen the barrier and limit bacterial entry. This program depends on TGF-β signaling within neutrophils; when that pathway is disabled, the rings fail to form and bacteria penetrate more easily. Relevant Links: • Paper: https://pubmed.ncbi.nlm.nih.gov/40108463/ • Commentary: https://www.nature.com/articles/s41577-025-01170-5 If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast! You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero. I’d love to hear from you! Feel free to reach out with questions, feedback, or topic suggestions via email at kcavagnero@gmail.com, on X @KellenCavagnero, or connect with me on LinkedIn. Stay curious and keep exploring at www.inflammatorycontent.com

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#26: Spatial Proteomics Uncovers a Lifesaving Treatment for Severe Skin Drug Reactions

In this episode of Inflammatory Content, Dr. Kellen Cavagnero dives into a landmark 2024 Nature study by Thierry Nordman and colleagues, titled “Spatial proteomics identifies JAKi as treatment for a lethal skin disease.” This cutting-edge research changes the game for patients suffering from toxic epidermal necrolysis (TEN)—a devastating cutaneous adverse drug reaction with limited treatment options. Using a powerful approach including spatial proteomics and mouse models of TEN, the authors identify interferon signaling as a key inflammatory pathway driving TEN. Most remarkably, they repurpose an FDA-approved JAK inhibitor to safely and effectively treat patients with TEN in a small clinical trial. This episode is a must-listen for anyone interested in how ‘omics technologies can rapidly unlock therapies for even the rarest and most lethal diseases. Relevant Links: • Paper: https://pubmed.ncbi.nlm.nih.gov/39415009/ • Commentary: https://pubmed.ncbi.nlm.nih.gov/39501097/ If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast! You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero. I’d love to hear from you! Feel free to reach out with questions, feedback, or topic suggestions via email at kcavagnero@gmail.com, on X @KellenCavagnero, or connect with me on LinkedIn. Stay curious and keep exploring at www.inflammatorycontent.com.

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#25: Immuno-endocrinology with Dr. Dequina Nicholas, Ph.D.

In this episode, Dr. Kellen Cavagnero is joined by Dr. Dequina Nicholas. Dr. Nicholas is an Assistant Professor at the University of California Irvine in the Department of Molecular Biology and Biochemistry. Her laboratory studies endocrine diseases, including type 2 diabetes and polycystic ovary syndrome. Specifically, her group investigates the intersection of the nutrient environment, the immune system, and metabolic disease using a combination of molecular and cellular biology, transgenic mouse models, cytokine profiling, and flow cytometry. Dr. Nicholas is the recipient of numerous awards including the NIH Director’s New Innovator Award. In their conversation, Kellen and Dequina discuss type 2 diabetes, polycystic ovary syndrome, lipid antigen presentation, transitioning to independence, DEI, and more. Relevant Links: • Nicholas Lab Website: https://nicholaslab.bio.uci.edu/ • Transitioning to Independence: https://pubmed.ncbi.nlm.nih.gov/35644775/ • TikTok: @NicholasLab • X: @QuinaScience • Bluesky: @quinascience.bsky.social If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast! You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero. I’d love to hear from you! Feel free to reach out with questions, feedback, or topic suggestions via email at kcavagnero@gmail.com, on X @KellenCavagnero, or connect with me on LinkedIn. Stay curious and keep exploring at www.inflammatorycontent.com.

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#24: AI Generated Podcast on Immune-Acting Fibroblasts

Today we’re going to do a journal club, but it will not be your run of the mill journal club. Everyone who knows me knows I am always searching for the latest technology that can increase my efficiency. Lately, I have been especially attuned to the newest developments in artificial intelligence.Well, I recently discovered a new AI tool by Google called NotebookLM that creates audio overviews of documents. What this means is that it will--within minutes--create a journal club podcast if you upload a research article. It is BANANAS! There are a few minor instances where the speech is buggy and words are mis-pronounced, but, overall, I am super impressed with how well it communicates research findings—very accessible and high fidelity. So today I bring to you an experimental AI generated journal club on my 2 latest research articles. The first article was published in the Journal of Experimental Medicine in early 2024 and the second was published as a preprint (meaning not yet peer reviewed) on bioRxiv in late 2024. Relevant Links: • Paper 1: https://pubmed.ncbi.nlm.nih.gov/38393304/ • Paper 2: https://pubmed.ncbi.nlm.nih.gov/38979312/ If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast. You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero I’d love to hear from you. Feel free to reach out with questions, feedback, or topic suggestions via email at kcavagnero@gmail.com, on X (formerly Twitter) @KellenCavagnero, or connect with me on LinkedIn.

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#23: The PhD Fellowship Application Survival Guide

One of the most common questions I get from undergraduate and graduate students is: How do I get a Ph.D. fellowship? During my Ph.D., I was fortunate to be awarded two fellowships, and I’ve received two more as a postdoc. In this solo episode, I provide an overview of the who, what, where, when, why, and how of Ph.D. fellowship applications, with the goal of helping you secure a fellowship to support your research. Please reach out to me if you would like the PowerPoint version of The Ph.D. Fellowship Application Survival Guide. Relevant Links: • NOFO Database: https://research.jhu.edu/rdt/funding-opportunities/graduate/ • NIH Grant Writing Course: https://bouviergrant.com/ If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast. You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero. I’d love to hear from you. Feel free to reach out with questions, feedback, or topic suggestions via email at kcavagnero@gmail.com, on X (formerly Twitter) @KellenCavagnero, or connect with me on LinkedIn. Stay curious and keep exploring at www.inflammatorycontent.com.

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#22: Mpox (formerly monkeypox) with Dr. Aaron Oom, Ph.D.

In this episode, Kellen is joined by Dr. Aaron Oom, a Postdoctoral Scholar in the lab of Dr. Mark Mulligan at NYU Langone Health. Aaron is an expert in virology and immunology. He completed his Ph.D. in the lab of Dr. John Guatelli’s at UC San Diego. Aaron has made significant contributions to our understanding of viruses including HIV, Zika, and Dengue. Now, as a Postdoctoral Scholar in the Mulligan lab, he’s focused on Mpox (formerly known as monkeypox), which has recently re-emerged as a major global health threat. In this conversation, Kellen and Aaron discuss Aaron’s recent mpox publication, the challenges of transitioning to independence, the tough decisions around “killing” projects that aren’t working, and much more. Relevant Links: • Mulligan Lab Website: https://med.nyu.edu/research/mulligan-lab/ • Aaron’s MedRxiv preprint: https://www.medrxiv.org/content/10.1101/2024.01.28.24301893v1 • Mpox review: https://www.nature.com/articles/s41577-022-00775-4 If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast! You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero. I’d love to hear from you! Feel free to reach out with questions, feedback, or topic suggestions via email at kcavagnero@gmail.com, on X (formerly Twitter) @KellenCavagnero, or connect with me on LinkedIn. Stay curious and keep exploring at www.inflammatorycontent.com.

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#21: Functional genomics identifies a novel therapeutic target for inflammatory bowel disease

Genome-wide association studies (GWAS) have identified thousands of disease-associated genetic variants. Many of these variants lie in non-coding regions of the genome, making interpretation of GWAS difficult and leading to poor translation into therapeutics. In this episode, Kellen reviews an exciting original article published in Nature in June 2024 titled, “A disease-associated gene desert directs macrophage inflammation through ETS2”. Here, Stankey et al. use a cutting-edge functional genomic strategy to identify a novel therapeutic target for the treatment of inflammatory bowel disease. Paper: https://pubmed.ncbi.nlm.nih.gov/38839969/ To help us spread science, please consider writing a review, sharing this episode with your friends and colleagues, or donating to support our work (Venmo @Kellen-Cavagnero). Please reach out to us via email (kcavagnero@gmail.com) or X (@KellenCavagnero) with any questions, comments, topic suggestions, etc.

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‫١١ من التقييمات‬

Inflammatory Content is a podcast about immunology and biomedical sciences more broadly. UC San Diego immunologist Dr. Kellen Cavagnero PhD reviews the latest high-impact original articles and discusses all things science with leading researchers in the field. Inflammatory Content has been featured in Nature and received sponsorship from the NIH.

صناع العمل

Kellen Cavagnero, Ph.D.
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© Kellen Cavagnero, Ph.D.
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Inflammatory Content