Invest in Progress

Scottish Mortgage

Invest in Progress is a podcast brought to you by the Scottish Mortgage Team. It offers a backstage pass to the conversations that occur between our managers and visionary leaders solving some of the world’s most complex problems. This podcast is for all UK investors, existing shareholders of Scottish Mortgage and professional investors in Australia, Germany, Switzerland, Belgium, The Netherlands, Luxembourg, Hong Kong and Singapore. The views expressed are those of the contributors and should not be considered as advice or a recommendation to buy, sell or hold a particular investment. The content of this podcast was accurate to the best of our knowledge at the time of publication. Scottish Mortgage Investment Trust PLC (Scottish Mortgage) is listed on the London Stock Exchange and is not authorised or regulated by the FCA. Hosted on Acast. See acast.com/privacy for more information. For further details please see our legal information at www.scottishmortgage.com Hosted on Acast. See acast.com/privacy for more information.

  1. 10-MINUTE TAKE: Enveda

    APR 29

    10-MINUTE TAKE: Enveda

    Summary: This is a compressed version of Scottish Mortgage’s interview with the biotech’s founder Viswa Colluru, for those of you wanting just the highlights. Listen to the full episode here. The biotech company Enveda has developed a new approach to explore and ‘decode’ nature’s chemistry. Its goal is to discover molecules that could underpin a new generation of blockbuster drugs. In this podcast, the firm’s founder and chief executive, Viswa Colluru, explains why Enveda has the potential to become a trillion-dollar business, and Scottish Mortgage Investment Trust manager Tom Slater considers the risks and opportunities the portfolio company faces.   Background: Scottish Mortgage first invested in Enveda in November 2024. The US-headquartered company uses a proprietary artificial intelligence (AI) large language model to discover and develop new medicines from natural sources. At the time of writing, it has a pipeline of 12 drug candidates in various stages of development that could form the basis of new therapies to treat dermatitis, obesity, inflammation and chronic pain. Enveda’s founder, Viswa Colluru, has reimagined the drug discovery process from first principles based on his insight that natural molecular compounds should have a better safety profile than engineered ones. “Healthcare is the biggest industry in the world, and if you can increase the odds of success in drug discovery, there are so many unmet needs that its opportunity is effectively unbounded,” says Scottish Mortgage manager, Tom Slater.   Timecodes: 00:00    Introduction 01:00    Interview starts 01:10    “Things that work in the lab [often] don’t work in people” 02:30    A mission grounded in a family death 04:25    Investing his life savings 08:45    Partnering with Microsoft and Sanofi   Glossary (in order of mention): Chronic myeloid leukaemia: A type of blood cancer that affects white blood cells. Mass spectrometer: A lab instrument that measures the mass of molecules to help identify them. SaaS: Software as a service – software accessed online via a subscription. Cost of capital: How expensive it is for a company to raise money from investors or lenders. Hosted on Acast. See acast.com/privacy for more information.

    12 min
  2. Enveda: Finding Hidden Medicines in Nature

    APR 27

    Enveda: Finding Hidden Medicines in Nature

    The biotech company Enveda has developed a new approach to explore and ‘decode’ nature’s chemistry. Its goal is to discover molecules that could underpin a new generation of blockbuster drugs. In this podcast, the firm’s founder and chief executive, Viswa Colluru, explains how Enveda could become a trillion-dollar business, and Scottish Mortgage Investment Trust manager Tom Slater considers the risks and opportunities the company faces.   Background: Scottish Mortgage first invested in Enveda in November 2024. The US-headquartered company uses a proprietary artificial intelligence (AI) large language model to discover and develop new medicines from natural sources. At the time of writing, it has a pipeline of 12 drug candidates in various stages of development that could form the basis of new therapies to treat dermatitis, obesity, inflammation and chronic pain. Enveda’s founder, Viswa Colluru, has reimagined the drug discovery process from first principles based on his insight that natural molecular compounds should have a better safety profile than engineered ones.“Healthcare is the biggest industry in the world, and if you can increase the odds of success in drug discovery, there are so many unmet needs that its opportunity is effectively unbounded,” says Scottish Mortgage manager, Tom Slater.   Timecodes: 00:03    Coming up… 00:50    Introduction 02:49    Viswa Colluru interview begins 03:08    “Things that work in the lab [often] don’t work in people” 04:35    A mission grounded in a family death 08:50    Invested life savings 11:24    Picking up from where evolution left off 15:16    Using AI to make sense of nature 21:32    A chemistry-first approach 25:16    Historic points of failure 27:32    Reimagining drug discovery from first principles 29:19    Splitting work between US and India 32:19    A growing drug candidate pipeline 35:07    Partnering with Microsoft and Sanofi 38:19    The relationship with Recursion Pharmaceuticals 41:02    “Incredible people looking in unexpected places” 43:00    A globally loved pharma company 43:38    Tom Slater on the investment case 52:42    Podcast lookahead Please see our glossary of terms. Check the podcast description to ensure this content is suitable for you. Your capital is at risk.  Presenter: Claire Shaw Executive Producer: Leo Kelion Line producer: Jessica Rooney Broadcast Technician: Samual O’Hare Editors: Kerry Ingram Hosted on Acast. See acast.com/privacy for more information.

    54 min
  3. Horizon Robotics: Driving the Autonomous Revolution

    05/06/2025

    Horizon Robotics: Driving the Autonomous Revolution

    How the founder of a Horizon Robotics plans to become the Microsoft for robots.     Join the Scottish Mortgage Team as we sit down with Dr. Kai Yu, founder of Horizon Robotics, a pioneer in autonomous driving technology. Discover how this ambitious company is transforming vehicles into "computers on wheels" and revolutionising the robotics industry. Episode highlights: Founder's Commitment to Machine Learning: Dr. Kai Yu, a leading AI scientist, has dedicated over 30 years to advancing machine learning. His passion for developing self-learning machines has been a driving force behind Horizon Robotics' innovative solutions.Founding Mission of Horizon Robotics: Horizon Robotics aims to transform vehicles into "computers on wheels" by mastering both hardware and software development. Their AI chips and computing platforms are pivotal in achieving various levels of autonomous driving, making them a key player in the autonomous driving revolution.Global Partnerships with OEMs: Horizon's "Journey Together" mantra has fostered strong relationships with automakers worldwide, including a significant $2bn investment from Volkswagen. These collaborations showcase Horizon's ability to build trust and embrace global partnerships.Embracing Innovation: The competitive and crowded EV market in China serves as an ideal testing ground for Horizon's technology. With over 50% market share, Horizon has successfully taken on Western Advanced Driver Assistance System providers, proving their scalable solutions' effectiveness.Vision for the Future: Horizon Robotics envisions becoming the "Microsoft for robots," applying their technology across various industries. This ambition highlights their potential to revolutionise not just autonomous driving but the entire robotics landscape.Whether you're an investor, tech enthusiast, or simply curious about the future of technology, this episode offers valuable insights into a company poised to become a leader in the robotics industry.   Check the podcast description to ensure this content is suitable for you. Your capital is at risk.  Presenter: Claire Shaw Executive Producer: Niamh Kidd Line producer: Jessica Rooney Broadcast Technician: Samual O’Hare Editors: Rhona Taylor-Craig, An Phan     Hosted on Acast. See acast.com/privacy for more information.

    44 min
  4. Nubank: The Missionaries of Modern Banking

    03/18/2025

    Nubank: The Missionaries of Modern Banking

    How the co-founder of a Latin American challenger bank plans to transform the future of finance.   Join us for the latest episode of Invest in Progress, featuring David Vélez, co-founder and CEO of Nubank – the largest challenger outside China. Vélez shares with Lawrence Burns how he's revolutionising banking across Latin America and saving users tens of billions in the process. Episode Highlights: Breaking the Banking Monopoly: When five banks controlled Brazil's financial sector, making services expensive and inaccessible, Vélez spotted an opportunity to disrupt the status quo with simplified processes and reduced costs. Unlikely Disruptor: Despite having no retail banking experience, technology background, or Portuguese language skills, Vélez envisioned a technology-driven banking transformation focused on consumer needs and digital-first solutions. Economic Impact: Nubank has returned approximately $20 billion to customers – money that would have otherwise gone to traditional banks as fees – demonstrating their commitment to affordability and customer value. Scale and Reach: Now serving over 114 million customers across Brazil, Colombia, and Mexico, Nubank has grown into the largest challenger bank outside China by delivering a seamless digital banking experience. Customer Love: With one of the highest Net Promoter Scores worldwide, Nubank's customer-centric approach has built extraordinary brand loyalty rarely seen in financial services. AI-Powered Future: Vélez discusses how AI integration could evolve banking from merely "having a bank in your pocket" to enjoying a personalised experience akin to having a banker in your pocket too. Worldwide Ambitions: With a methodical approach to global expansion, Nubank aims to become the world's largest retail bank by addressing inefficiencies in banking models worldwide.   Check the podcast description to ensure this content is suitable for you. Your capital is at risk.  Presenter: Claire Shaw Executive Producer: Niamh Kidd Line producer: Jessica Rooney Broadcast Technician: Samual O’Hare Editors: Rhona Taylor-Craig, An Phan Hosted on Acast. See acast.com/privacy for more information.

    1h 8m
  5. Tempus AI: Pioneering AI-Enabled Healthcare

    02/25/2025

    Tempus AI: Pioneering AI-Enabled Healthcare

    Hear from the founder on a mission to make his company the Amazon of the healthcare industry.    Join us for the latest episode of Invest in Progress, in which Eric Lefkofsky, Founder and CEO of Tempus AI, tells Scottish Mortgage manager Tom Slater about transforming the healthcare landscape with artificial intelligence and big data. Episode Highlights: Personalized Healthcare Revolution: Discover how Tempus AI is revolutionising cancer diagnosis and treatment by leveraging one of the largest libraries of oncology data. Eric shares the personal journey that led to the creation of Tempus AI, driven by a desire to improve his wife's cancer treatment. Technological Edge: Learn about Tempus AI's unique technological advantage, akin to Tesla's in the EV market. Eric explains how Tempus integrates AI with diagnostics to provide intelligent, personalised insights that empower physicians and improve patient outcomes. Data-Driven Insights: Explore how Tempus AI's vast data resources are being utilised to accelerate drug discovery and enhance clinical trials, in partnership with major pharmaceutical companies like GSK and AstraZeneca. AI's Transformative Potential: Eric discusses the future of AI in healthcare, envisioning a world where AI diagnostics become the norm, saving the global healthcare industry trillions of dollars and significantly extending human life expectancy. A Visionary Leader: Gain insights into Eric's entrepreneurial spirit and his ability to articulate a compelling vision for Tempus AI, drawing parallels with industry giants like Amazon and Google. This episode is a must-listen for anyone interested in the intersection of technology and healthcare, offering a glimpse into a future where AI not only saves lives but also transforms the efficiency of healthcare systems worldwide. Don't miss this opportunity to hear from a leader who is not just imagining the future but actively building it.   Check the podcast description to ensure this content is suitable for you. Your capital is at risk.  Presenter: Claire Shaw Executive Producer: Niamh Kidd Line producer: Jessica Rooney Broadcast Technician: Samual O’Hare Editors: Rhona Taylor-Craig, An Phan Hosted on Acast. See acast.com/privacy for more information.

    1h 4m

Trailers

About

Invest in Progress is a podcast brought to you by the Scottish Mortgage Team. It offers a backstage pass to the conversations that occur between our managers and visionary leaders solving some of the world’s most complex problems. This podcast is for all UK investors, existing shareholders of Scottish Mortgage and professional investors in Australia, Germany, Switzerland, Belgium, The Netherlands, Luxembourg, Hong Kong and Singapore. The views expressed are those of the contributors and should not be considered as advice or a recommendation to buy, sell or hold a particular investment. The content of this podcast was accurate to the best of our knowledge at the time of publication. Scottish Mortgage Investment Trust PLC (Scottish Mortgage) is listed on the London Stock Exchange and is not authorised or regulated by the FCA. Hosted on Acast. See acast.com/privacy for more information. For further details please see our legal information at www.scottishmortgage.com Hosted on Acast. See acast.com/privacy for more information.

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