Lab to Startup

Naresh Sunkara PhD
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Lab to Startup

Hundreds of thousands of researchers around the world are working to improve life and address imminent threats to humanity. Often, the research ends up in the “Scientific valley of death” in the form of publications and patents that never see the light of the day. Welcome to “Lab to Startup” a podcast aimed at showcasing the effort needed to translate lab research to startups. The show has two main goals:  1. Sharing the stories of those scientists and engineers who have successfully founded startups based on the research at university and national labs.  2. Highlighting the resources and tools needed to help those aspiring to launch startups in the deeptech space. We also want this show to be a way to communicate those technology development stories to the general public (taxpayers funding the research) in the hope that they will continue to support such research and startups. About the host Naresh Sunkara, Ph.D. is a chemical biologist, entrepreneur and the founder and Executive Director of the Berkeley Postdoc Entrepreneurship Program at the University of California, Berkeley. He has been running this program for the past ten years that has helped graduate students and postdocs at UC Berkeley and Lawrence Berkeley National Laboratory, and at several other universities in the US. He was previously a postdoc at UC Berkeley developing lipid nanoparticles for delivery of mRNA based drugs targeting viruses and cancers.

  1. Partnering to accelerate therapeutics: A primer on forming alliances and their management

    12/10/2024

    Partnering to accelerate therapeutics: A primer on forming alliances and their management

    Monica Rosoff, the founder and CEO of LBBAL™ Alianza. Prior to launching Alianza, Monica was a partnering executive with roles of increasing seniority at Genentech, Gilead, Kite and Exelixis. Over the course of over two decades, she had the opportunity to lead and participate in a wide diversity of deals, negotiations, diligence exercises, alliances, technology transfers, M&A integrations, dispute resolution negotiations, amendments and terminations–at all stages of the drug development and commercialization lifecycle and in multiple therapeutic areas. Dr. Rosoff earned a doctorate in Pharmacology from the University of Washington and conducted her postdoctoral work at Stanford. We talked about lessons learned from her experiences in alliance management, especially for early stage startups.  Shownotes Monica Rosoff https://lbbalalianza.com/ Monica’s entry into alliance management Principles that guide a good partnership: What’s best for the patient? Find synergies, timing and motivations Who to approach at a big pharma when identifying a partner? Evaluating motivations of a big pharma: Get specific Building trust Performing due diligence-How? Power dynamics: How to deal with a big partner when you have a power imbalance? Role of lawyers Communicating failures Have a list of “To-dont’s” as opposed to “To-do” list Conflicts might be important Repeating problems: Lessons learned How to prepare for unexpected changes at big companies? Conflict resolution: What to pick fights on? Allocating resources

    51 min
  2. From Pitches to Stories: Transforming Complex Ideas into Engaging Narratives

    09/10/2024

    From Pitches to Stories: Transforming Complex Ideas into Engaging Narratives

    Zack Shildhorn is an investing Partner at venture firm Lux Capital. He played multiple key roles that helped the firm scale from less than $100M to more than $4B in assets under management. After witnessing thousands of pitches, he saw that even the most disruptive startups often struggled to develop effective narratives. Having worked closely with leading technology companies as an investor and Board member, he brings a unique ability to connect with key stakeholders and distill complex ideas into engaging and relatable presentations. In order to help founders beyond Lux, He launched a firm called Series Z, to help a select group of tech companies and funds bring their vision to life. Zack also recently partnered with Khosla ventures to help founders there as well.  Zack kindly agreed to share some of the lessons from his experience teaching the art of storytelling to founders and VCs. I think you will benefit tremendously from this episode.  Show Notes: Series Z: https://www.series-z.co/ Zack Schildhorn: https://x.com/zacktrak Most founders are in a challenged position Repetition, iteration, feedback Founders have the disadvantage of not knowing an investor’s mindset Selling vision: Why should investors care? Framing your pitch: Ways to capture investor’s attention How to appeal to the emotions of an investor? Fear and greed Starting a presentation with words and not slides Presenting technical idea: How not to inundate listeners with too much data Reframing problems: Addressing known apprehensions How to not get offended by a question or being defensive? Media links: Power of Narrative for Entrepreneurs: https://www.youtube.com/watch?v=-llii7frwco Framing your pitch: https://www.youtube.com/watch?v=U4V89rywlR0 Pitching investors: https://www.youtube.com/watch?v=RYkOoRJGuvk

    54 min
  3. Turning great science into impactful medicine: Lessons from Corey Goodman, Pioneer in Science and Venture Capital

    07/16/2024

    Turning great science into impactful medicine: Lessons from Corey Goodman, Pioneer in Science and Venture Capital

    Corey Goodman, Ph.D., is the managing partner of venBio, a venture capital firm he cofounded in 2011. venBio already has 7 FDA approved drugs on the market, saving and improving lives. Corey spent 25 years as Professor of Biology at Stanford University and Evan Rauch Chair of Neurobiology at U.C. Berkeley, where he was a HHMI Investigator, Head of the Neurobiology Division, and co-founder and Director of the Wills Neuroscience Institute. Corey co-founded seven biotechnology companies, and led one of them (Renovis) as President and CEO from a private to public company until its acquisition by Evotec. Two of the companies he co-founded have been acquired and three have done IPOs to date.  He then moved to Pfizer, where he was President of the Biotherapeutics and Bioinnovation Center and a member of the executive leadership team. We talk about transformation of UC Berkeley as a startup powerhouse;  his entrepreneurial journey starting with the founding of Exelixis while being a faculty at UC Berkeley; role played by mentors and co-founders; lessons learned from founding startups that founders today could benefit from; changing careers at various stages of his life as he turned 50 and 60 (he recently turned 73); lessons from big pharma; experiences and lessons from partnerships and acquisitions by big pharma; and his experiences investing. Show Notes: Corey Goodman, Ph.D. Corey Goodman’s autobiography: https://www.sfn.org/-/media/SfN/Documents/NEW-SfN/About/History-of-Neuroscience/20220914_HON_volume12_goodman.pdf Turn around story of UC Berkeley entrepreneurship: remarkable 10 years People and leadership matter Carol Christ Exelixis: Corey’s first startup, co-founded with Gerry Rubin. George Scangos joined the company as CEO in 1996;  Learning from genetic modeling organisms Find a big brother/sister who can help you: Role played by Stelios Papadopoulos and Ed Penhoet Donald Kennedy: Corey’s mentor Taking risks at various stages of life: Turning 50, 60, and now 73 Life as an executive at Pfizer and lessons learned in that space Big pharma companies are unbelievably inefficient in early stage drug discovery James Allison: Immune checkpoint inhibitors Importance of academia and startup ecosystem in drug discovery Lessons from big pharma acquiring biotechs: What, when, how and what not to do Lessons learned from biotech partnering with big pharma: Don’t partner on everything- keep some to yourself Operator VCs: Investors/board members who went through building companies are more valuable than those who come from consulting backgrounds Building teams Transition to Pfizer and out: “Come change the world” Launching VenBio: Everybody’s voice matters Investment thesis

    1h 21m
  4. Pushing Boundaries: Abhishek Tripathi’s Experience with NASA, SpaceX, UC Berkeley and Startups

    06/25/2024

    Pushing Boundaries: Abhishek Tripathi’s Experience with NASA, SpaceX, UC Berkeley and Startups

    Abhishek Tripathi, is the Director of Mission operations of the Space Sciences Laboratory at the University of California, Berkeley. Abhi is also the Chair of the Air and Space track startups at Skydeck, which is UC Berkeley's startup accelerator program. For over two decades, Abhi has been at the forefront of human and robotic space exploration. At SpaceX, he spearheaded the certification of both the cargo and crew Dragon programs, a pivotal achievement in commercial spaceflight. His expertise was further showcased as Dragon Mission Director, where he orchestrated a dozen critical cargo resupply missions to the International Space Station. Abhi's technical acumen reached new heights when he assumed the role of Dragon Chief Engineer for Flight Reliability on the groundbreaking Crew Demo 1 and Demo 2 missions. Prior to his transformative work at SpaceX, Abhi honed his skills during a decade-long tenure as an Aerospace Systems engineer at NASA, laying the foundation for his remarkable career in space technology.  We talked about the lessons learned from Abhi’s journey at NASA, SpaceX and his work at the University of California, Berkeley, where he continues to lead several space missions. He shared some of the lessons learned from working at a highly demanding job at SpaceX; and also translated his experiences into lessons for startups and life in general. And Yes, he did share some of his experiences working with Elon Musk. Show Notes: Abhishek Tripathi https://www.ssl.berkeley.edu/ Setting overarching goals that ties with the vision for a company Building factories to vow consumers and the larger population (new age moats) Journey at NASA Try to work at a cutting edge company before launching a startup, (except if you are a deeply involved in a research area during postdoc or similar compelling situation) Picking advisors: Pick tactical advisors instead of strategic ones End all instances of gatekeeping (one of the rules set by Musk) Leading the Dragon mission to deliver cargo to ISS Regulations: Working with NASA/government for approvals ‘Bring me a rock exercise” Experiences working on Falcon 9 mission Transition to academia https://www.ssl.berkeley.edu/ “Other than the brutal pace of Space X, we have many of the elements of Space X at Space Sciences Laboratory at the University of California, Berkeley.” Space track https://skydeck.berkeley.edu/ What startups in the space track should possess Timing, funding, technology readiness SSL LEADERSHIP AND ADMINISTRATIVE CONTACTS https://www.ssl.berkeley.edu/administrative-contacts/ https://x.com/SpaceAbhi

    1h 1m
  5. Lessons from Evolution of Innovation and Entrepreneurship Ecosystem at UC Berkeley

    04/30/2024

    Lessons from Evolution of Innovation and Entrepreneurship Ecosystem at UC Berkeley

    Richard Lyons, Ph.D., is the Associate Vice Chancellor and Chief Innovation & Entrepreneurship Officer, at the University of California, Berkeley. Rich is an economist and the former dean of the business school. Rich will become the next chancellor of the University of California, Berkeley.  We talk about a wide variety of topics around the Evolution of innovation and entrepreneurship ecosystem at Berkeley. We covered topics like paradigm shifts, cultural transformations, overcoming inertia; global impact and many others.  I hope you get some insights from this story, and walk away with appreciation and potentially actionable steps if you are trying to build startup ecosystems on your campuses. Show Notes: https://vcresearch.berkeley.edu/faculty/rich-lyons Report on entrepreneurship at UC Berkeley from the Faculty Entrepreneurship Committee: https://vcresearch.berkeley.edu/sites/default/files/2018-08/Entrepreneurship_at_Berkeley.pdf  UC Regents taskforce report: From Discovery to Societal Impact: A Roadmap to Unleashing UC Innovation and Entrepreneurship: https://regents.universityofcalifornia.edu/regmeet/may21/g1attach.pdf Cultural transformation at UC Berkeley: https://newsroom.haas.berkeley.edu/berkeley-named-top-university-for-number-of-venture-backed-companies-founded/#:~:text=PitchBook%20has%20ranked%20Berkeley%20%231,public%20university%20for%20startup%20founders. Bakar fellows program: https://bakarfellows.berkeley.edu/ Cultural transformation to embrace entrepreneurship Mission of academic institutions is impact Overcoming inertia at academic institutions Ecosystem dynamics & talent pipeline Start with “Yes, if” framework to address difficult questions Pilot programs Berkeley RIC  I&E Council Inclusivity: Dual degree program  Berkeley Changemaker program Failures and hurdles Ethical considerations Parts of the ecosystem that could be replicated and hard to do so by other universities Sutardja Center for Entrepreneurship and Technology (SCET)

    58 min
  6. Civilization Ventures: Lessons learned from founding, exiting and applying them to support founders as an investor

    04/09/2024

    Civilization Ventures: Lessons learned from founding, exiting and applying them to support founders as an investor

    Shahram Seyedin-Noor is the founder and managing partner at Civilization Ventures. Shahram received a JD from Harvard and worked at Wilson Solsinis and Cooley before going into investment banking at firms like Goldman Sachs and Bank of America. He then entered the startup world co-founding several startups. He eventually ended up Angel investing and in 2017, launched Civilization Ventures, focused on supporting cutting-edge innovations in health tech and biology. Shahram has over a dozen exits under his belt, which is a phenomenal achievement. Here are some of his investments: Rewrite (acq. by Intellia), Replace (acq. by Tome), Lemonaid (acq. by 23andme), Singular Bio (acq. by Invitae), Rocket Pharma (listed on Nasdaq), Palamedrix (acq. by SomaLogic), Foresight Diagnostics, BillionToOne, Omada and others. Shahram takes an active role in company building. Prior to founding CV, Shahram was the founding CEO/Chairman of Inspirna, an oncology therapeutics company currently in Phase 2 human trials, and the CFO and VP of Corporate Development at NextBio, a genomics software pioneer acquired by Illumina. Shownotes: https://www.civilizationventures.com/ Success has a thousand fathers but failure is an orphan Accountability: Few people blame themselves for failure and give credit for success to others Evolution of mindset: Don’t let others dictate what you can or supposed to do in life EQ is more/equally important than IQ Transition from law school to startups Advice for recruiting a non-scientific co-founder Rewrite therapeutics acquired by Intellia Investment thesis at Civilization Ventures: Drive to do things differently Lessons learned from exits Contact email: shahram@civilizationventures.com

    55 min
  7. Humba Ventures: Investing in Deep Tech Startups with Engineering Focus

    02/27/2024

    Humba Ventures: Investing in Deep Tech Startups with Engineering Focus

    Leo Polovets is the Co-founder and General Partner at Susa Ventures. Leo focuses on enterprise software and technical products at Susa. About two years ago, He also started Humba Ventures, a fund that invests in deep tech and critical national sectors like energy and defense at Humba.   Leo led Susa's investments in Mashgin, People Data Labs, Scalyr, and Treasury Prime. Having been a software engineer for 10+ years, Leo approaches challenges with an engineering mindset and supports portfolio companies in vetting and hiring technical talent. Prior to Susa, Leo was the second engineering hire at Linkedin, where he worked on the first versions of products like LinkedIn Jobs and LinkedIn Groups. Leo then worked on payment fraud detection algorithms at Google, and was also an early engineer at Factual, where he built data processing software. Leo received a bachelor's degree in Engineering and Applied Science (Computer Science) from Caltech. We talk about lessons that translate from investing in traditional startups; explore lessons learned about market sizing, pricing, team dynamics, managing burn, scaling, valuation and many other topics in the deep tech space.   Shownotes: https://humbaventures.com/ Leo’s presentation on “Exploring Startup Ideas” https://docs.google.com/presentation/d/1C-JFkqsY40tidqPD1OZbV3-OXPAyrsPIV5Q_00PkToQ/edit#slide=id.g221d008c440_0_35 Thinking about making money for scientific founders Thinking about market attributes for a potential startup Intro to Humba ventures Investing in deep tech Founder-market fit; Time to make money Investment thesis Communication: between team members, to investors and beyond Working with startup teams: Commercialization Pricing in deep tech: Think of value being created How to ask for money for your product? Aloha robot- https://www.youtube.com/watch?v=HaaZ8ss-HP4&t=5s Story telling Manage your burn! Scaling: Calibrating on talent; learning to delegate; firing Bs and B+s on the team Keeping up with new technologies Thoughts on valuation What Leo likes to hear while being pitched to

    53 min
  8. Berkeley Skydeck- Catalyzing the growth of deep tech startups at the world’s number one ranked public university.

    02/13/2024

    Berkeley Skydeck- Catalyzing the growth of deep tech startups at the world’s number one ranked public university.

    Caroline Winnett is the Executive Director of Berkeley Skydeck, a startup accelerator at the University of California, Berkeley. Skydeck started as a mentoring space in 2012 and soon translated into one of the leading startup accelerators in the world. SkyDeck was Formed as a partnership between UC Berkeley’s Haas School of Business, the College of Engineering, and the Office of the Vice Chancellor for Research. While it offers all the benefits of a traditional accelerator, what makes Skydeck special is the vast resources of the world’s number one ranked public university. The robust and vibrant ecosystem includes a deep network of advisors, industry partners, and attracts some of the best investors. I have seen its evolution first hand because of my own association since my postdocs days at UC Berkeley We discuss the evolution of the startup ecosystem at UC Berkeley and then dive into how Skydeck has been supporting deep tech startups, challenges and lessons learned.   Shownotes: Berkeley Skydeck: https://skydeck.berkeley.edu/ Startup resources at Berkeley: https://begin.berkeley.edu/ Berkeley named top university for number of venture-backed companies Evolution of startup ecosystem at UC Berkeley: Pre & post Skydeck Changing academia-industry relations Skydeck is just not for UC Berkeley community Support for deep tech startups at Skydeck Criteria for picking deep tech startups for accelerations Lessons learned from working with scientific and faculty founders Scalability and market potential of deep tech startups Partnerships with corporations: realistic expectations Picking advisors Commercializing deep tech startups Investing in deep tech: Evaluating founders Tips for applying to Berkeley Skydeck Apply here: https://skydeck.berkeley.edu/apply/

    52 min
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Trailer

About

Hundreds of thousands of researchers around the world are working to improve life and address imminent threats to humanity. Often, the research ends up in the “Scientific valley of death” in the form of publications and patents that never see the light of the day. Welcome to “Lab to Startup” a podcast aimed at showcasing the effort needed to translate lab research to startups. The show has two main goals:  1. Sharing the stories of those scientists and engineers who have successfully founded startups based on the research at university and national labs.  2. Highlighting the resources and tools needed to help those aspiring to launch startups in the deeptech space. We also want this show to be a way to communicate those technology development stories to the general public (taxpayers funding the research) in the hope that they will continue to support such research and startups. About the host Naresh Sunkara, Ph.D. is a chemical biologist, entrepreneur and the founder and Executive Director of the Berkeley Postdoc Entrepreneurship Program at the University of California, Berkeley. He has been running this program for the past ten years that has helped graduate students and postdocs at UC Berkeley and Lawrence Berkeley National Laboratory, and at several other universities in the US. He was previously a postdoc at UC Berkeley developing lipid nanoparticles for delivery of mRNA based drugs targeting viruses and cancers.

Information

  • Creator
    Naresh Sunkara PhD
  • Years Active
    2022 - 2024
  • Episodes
    59
  • Rating
    Clean
  • Copyright
    © Naresh Sunkara PhD
  • Show Website
    Lab to Startup

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