Listen, Learn, Adapt

Anthony Novello
  • 5.0 (1)
  • HEALTH & FITNESS

Evidence over everything. Health and wellness is full of noise. We provide the signal. We break down the latest in physical medicine, rehab, and pain science—one research article at a time. ​No opinions. No "hacks." Just clear, actionable evidence for athletes, clinicians, and the health-conscious human. Understand the science. Master your movement. Dr. Anthony Novello, PT, DPT @anthonynovello.dpt

  1. 2D AGO

    116: Aerobic Exercise and Stress-Related Biomarkers in Midlife Adults

    This episode dissects a research article that investigates how long-term aerobic exercise influences various biological markers associated with cardiovascular disease (CVD) risk and psychological stress. Researchers conducted a year-long clinical trial with middle-aged adults, comparing a 150-minute weekly exercise regimen against a control group receiving only health information. The study measured diverse outcomes, including inflammation biomarkers, heart rate variability, and brain activity during stress-related tasks. Gianaros PJ, Wan L, DeCataldo MK, et al. Effects of a year-long aerobic exercise intervention on neuroendocrine, autonomic, and neural correlates of stress, emotion, and cardiovascular disease risk in midlife adults. J Sport Health Sci. 2026;101135. doi:10.1016/j.jshs.2026.101135 Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

    52 min

  2. 4D AGO

    115: Preventing Vestibular Migraine: A Systematic Review and Meta-analysis

    This episode dissects a systematic review and meta-analysis evaluating various preventative treatments for vestibular migraine (VM), a condition characterized by episodic vertigo and headaches. By analyzing 13 clinical studies, the authors examined the efficacy of pharmacologic agents—such as beta-blockers, calcium channel blockers, and antidepressants—alongside vestibular rehabilitation and dietary changes. Byun YJ, Levy DA, Nguyen SA, Brennan E, Rizk HG. Treatment of Vestibular Migraine: A Systematic Review and Meta-analysis. Laryngoscope. 2021;131(1):186-194. doi:10.1002/lary.28546 Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

    45 min

  3. APR 28

    114: Lived Experiences of People with Lower Limb Tendinopathy

    This episode does a deep dive into a systematic review that synthesizes qualitative research to explore the lived experiences of individuals suffering from lower limb tendinopathy. The researchers identified ten core themes. Hopes M, Stubbs P, Grimaldi A, Nasser A. Lived experiences of people with lower limb tendinopathy – a systematic review with qualitative evidence synthesis. J Orthop Sports Phys Ther. Published online 2026. doi:10.2519/jospt.2026.13666 Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

    50 min

  4. APR 24

    113: PFAS Exposure and Adolescent Bone Mineral Density Susceptibility Periods

    This episode dissects a clinical research article that investigates the impact of per- and polyfluoroalkyl substances (PFAS) on the bone mineral density of children as they enter adolescence. By tracking 218 participants from birth to age 12, researchers evaluated how exposure to these "forever chemicals" at different developmental stages correlates with skeletal health. Buckley JP, Marquess KM, Braun JM, et al. Per- and polyfluoroalkyl substances and adolescent bone mineral density: assessing periods of susceptibility. J Endocr Soc. 2026;10(4):bvag039. doi:10.1210/jendso/bvag039. Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

    44 min

  5. APR 21

    112: Low-Load Blood Flow Restriction Training Following ACL Reconstruction

    This episode dissects a clinical study that evaluates the efficacy of low-load blood flow restriction training (LL-BFRT) compared to traditional heavy-load resistance training (HLRT) during the initial recovery phase following ACL reconstruction. Researchers conducted a randomized controlled trial on patients with patellar tendon grafts to determine if lighter weights paired with blood flow occlusion could effectively restore muscle strength without aggravating the joint. Koc BB, Schotanus MGM, Ehlen T, Truyens A, de Bie R, Jansen EJP. Low-load blood flow restriction training as an alternative to heavy-load resistance training in early-stage rehabilitation following bone–patellar tendon–bone anterior cruciate ligament reconstruction: a randomized controlled trial. JOSPT Open. 2026;4(2):166-173. doi:10.2519/josptopen.2026.0185 Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

    23 min

  6. APR 19

    111: Genetic Predictors of GLP1 Receptor Agonist Efficacy and Side Effects

    This episode does a deep dive into an article that investigates the genetic factors that influence how different individuals respond to GLP1 receptor agonists like semaglutide and tirzepatide. Su QJ, Ashenhurst JR, Xu W, et al. Genetic predictors of GLP1 receptor agonist weight loss and side effects. Nature. Published online April 8, 2026. doi:10.1038/s41586-026-10330-z Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

    20 min

  7. APR 15

    110: The Impact of Exercise on Intervertebral Disc Health

    This episode does a deep dive into a systematic review and meta-analysis that investigates how physical activity and exercise training influence the structural health of intervertebral discs (IVDs) in the human spine. By evaluating data from 39 studies, researchers compared MRI-based measurements of disc integrity between active individuals and less active controls. Samanna CL, Owen PJ, Mitchell UH, et al. The impact of exercise on intervertebral disc health: a systematic review and meta-analysis. Sports Med. Published online March 16, 2026. doi:10.1007/s40279-025-02336-w. Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

    20 min

  8. APR 14

    109: Robotic Gait Training for Spinal Cord Injury Neuropathic Pain

    This episode dissects a systematic review and meta-analysis published in The Journal of Spinal Cord Medicine that investigates whether robotic-assisted gait training (RAGT) can alleviate neuropathic pain in patients with spinal cord injuries. Researchers analyzed 32 studies involving 567 participants to determine if using robotic exoskeletons or end-effector devices improved pain intensity, pain interference, and health-related quality of life. White C, Klus S, Ho WH, Barrett L, Doherty O, Lennon O. Robotic-assisted gait training for spinal cord injury neuropathic pain: A systematic review. J Spinal Cord Med. Published online June 6, 2025. doi:10.1080/10790268.2025.2503049 Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

    25 min
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Ratings & Reviews

About

Evidence over everything. Health and wellness is full of noise. We provide the signal. We break down the latest in physical medicine, rehab, and pain science—one research article at a time. ​No opinions. No "hacks." Just clear, actionable evidence for athletes, clinicians, and the health-conscious human. Understand the science. Master your movement. Dr. Anthony Novello, PT, DPT @anthonynovello.dpt

Information

  • Creator
    Anthony Novello
  • Years Active
    2025 - 2026
  • Episodes
    116
  • Rating
    Clean
  • Copyright
    © Anthony Novello
  • Show Website
    Listen, Learn, Adapt

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