Live Longer World Aastha Jain

This is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity.

Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer.

Episode Show Notes: https://livelongerworld.com/p/rnuccitelli

Find me: https://twitter.com/aasthajs

BACKGROUND:
In 2022, I interviewed Dr. Michael Levin on his work on bioelectricity in cells and how that has the potential to solve cancer and aging. Since then, Mike has also appeared on Lex Fridman and many other podcasts talking about his revolutionary work.

Amongst all the podcasts I did, Mike’s work struck me as profound yet underappreciated. The field of biology has focused on the DNA and the relevance of the electric currents in our cells is not appreciated. Yes, the electrical energy powering our cells is what keeps us alive!

Earlier this year, I decided to dive deeper into bioelectricity. I’m starting by exploring the history of the field in conjunction with Michael Levin. We’re doing a series of interviews talking to scientists in the field to understand the origins of the field, bottlenecks, progress so far, and what the future could look like.

Today's interview is the first in the series with Dr. Richard Nuccitelli.

TIMESTAMPS:
0:00 Intro to History of Bioelectricity Series
1:09 How Rich got interested in bioelectricity
4:34 Bioelectrics didn't make it to biology literature
7:55 Vibrating probe use cases
10:20 Bioelectrics in 1970s
13:37 Why is bioelectrics underrated?
22:50 Field progression
29:02 Ultra high voltage in treating cancer
39:00 Understanding significance of bioelectrics from 1900s
44:40 Working with Lionel Jaffe
50:27 How Mike entered bioelectrics
54:02 Criticism received by bioelectrics?
57:04 Missing technology to advance bioelectrics
1:00:52 Electrical patterns in cells with age
1:03:12 Image of electrics in organisms

AASTHA, LIVE LONGER WORLD:
Twitter: https://twitter.com/aasthajs
Newsletter: https://livelongerworld.com/
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Airchat: https://www.getairchat.com/aasthajs

Michael Levin: https://twitter.com/drmichaellevin
Richard Nuccitelli: https://www.linkedin.com/in/nuccitelli/

Episode Show Notes: https://livelongerworld.com/p/rnuccitelli


Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm

Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin.

We discuss:
- The history of the FDA,
- The trial of Avastin which got FDA approval in 2008 and revoked in 2011
- FDA's funding mechanisms
- FDA ties to big pharma
- What can be improved about the FDA and the criticisms it receives


Episode Show Notes: https://livelongerworld.com/p/msekeres

TIMESTAMPS:
0:00 Surprising finding about the FDA
2:38 Why did the FDA get established in 1938?
11:48 1962 turning point in the FDA & Thalidomide
19:57 Kennedy’s efficacy act on drugs approval
25:40 FDA’s accelerated approval; HIV & AIDS
33:23 Avastin breast cancer drug controversy
41:13 Why was Avastin trial contentious?
45:23 Genentech’s argument
50:00 Media reaction
53:21 FDA funded by big pharma
56:39 FDA vs. patient activist groups
59:50 Opioid crisis
1:03:30 Does the FDA go against advisory committee?


CONNECT WITH AASTHA, LIVE LONGER WORLD:
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Newsletter: https://livelongerworld.com/
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DR. MIKKAEL SEKERES LINKS:
Website: https://www.mikkaelsekeres.com/
Twitter: https://twitter.com/MikkaelSekeres

Book: https://www.amazon.com/Drugs-FDA-Safety-Efficacy-Publics/dp/0262047314

If you enjoyed the episode, please share it and leave a rating. Best, Aastha.

Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer.


Episode Show Notes: https://livelongerworld.com/p/jgarrison


Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.com/

Find me (Aastha) on Twitter: https://twitter.com/aasthajs


DR. JENNIFER GARRISON LINKS:
Lab: http://garrisonlab.com/ Donate to her research: https://gcrle.org/

CONNECT WITH AASTHA, LIVE LONGER WORLD:
Twitter: https://twitter.com/aasthajs
Newsletter: https://livelongerworld.com/
Instagram: https://www.instagram.com/aasthajs/
Airchat: https://www.getairchat.com/aasthajs


TIMESTAMPS:
00:00 Intro
1:38 Jennifer Garrison Intro
2:32 Ovarian aging & health risks
5:23 Progression of Ovarian aging
8:49 Menopause and negative health effects
10:34 Hypothalamus & Mind body communication
14:40 Reproductive & Equality Initiatives
18:21 Biological Clock for Reproductive aging
20:20 Tweaking hormonal cues
22:07 Number of eggs vs. Quality of eggs
25:00 Genetics in ovarian aging
26:21 Understanding family history
27:39 Evolutionary benefit to Menopause?
32:33 Hormone Replacement Therapy (HRT) & its benefits
38:28 Narrow window for HRT
40:08 Perimenopause
42:56 Women’s health funding
45:14 Average age girls start menstruating is declining
49:10 PCOS
52:42 Athletes and irregular cycles
56:36 Individualized menopause symptoms
1:00:38 Exercise and ovarian aging
1:02:00 Support Jennifer's work


Episode Show Notes: https://livelongerworld.com/p/jgarrison

POPULAR EPSIODES:
- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA
- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg
- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8
- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8
- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo


Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.


Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.

Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity.

Episode Show Notes: https://livelongerworld.substack.com/p/gwest
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/

Find me (Aastha) on Twitter: https://twitter.com/aasthajs

DR. GEOFFREY WEST LINKS:
Profile: https://www.santafe.edu/people/profile/geoffrey-west
Book: https://amzn.to/3Xtl7wU
CONNECT WITH AASTHA, LIVE LONGER WORLD:

Newsletter: https://livelongerworld.substack.com/

Twitter: ⁠https://twitter.com/aasthajs

Instagram: https://www.instagram.com/aasthajs/

Airchat: https://www.getairchat.com/aasthajs

TIMESTAMPS:
1:35 Context on Dr. West's book Scale
9:00 Networks in biology & cities
22:50 Scaling laws in longevity

32:33 Upper limit to human age?

39:08 Quantifying Caloric restriction

41:52 Metabolism & Body temperature

49:05 Scaling laws in age-related damage

56:35 Scaling body sizes across species

1:01:38 Scaling laws in drug dosage (LSD & Elephants)

1:11:06 Drug dosage in children (Tylenol & babies)

1:13:44 Vaccine dosage scaling laws

1:17:51 Sleep & Aging in different organisms

1:31:22 Early stimulation for child development

1:36:35 Fasting, meal frequency & digestive time

1:39:10 Sleep demands with work & physical activity

1:43:40: Scaling laws in cities, companies & universities

2:02:00 Outro

POPULAR EPSIODES:

Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA

Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg

Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8

Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8

Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.

Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.

All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad 

Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions!   

There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad’s work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that don’t age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics.   

Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ 

Find me (Aastha) on Twitter: https://twitter.com/aasthajz 

DR. STEVEN AUSTAD LINKS: 

Website: https://www.stevenaustad.com/

Twitter: https://twitter.com/StevenAustad

Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad 

CONNECT WITH AASTHA, LIVE LONGER WORLD: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/aasthajz

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/aasthajz/ 

TIMESTAMPS: 

0:00 Training lions 

7:15 Learning from Long-lived species 

9:55 Bowhead whales live 200 years 

12:55 House sparrows & longevity 

14:40 Study "successful" animals 

18:10 Naked Mole Rats 

20:45 What do bowhead whales die from? 

26:05 Why do ocean animals live longest? 

31:05 Beyond Caloric Restriction 

36:00 Intermittent Fasting & Circadian Rhythm 

42:40 Caloric Restriction for Healthy people? 

46:24 Will coffee shorten your life? 

49:43 The Blue Zone Myth 

55:50 Young Blood, I can't get you of out my Mind 

1:00:26 Hormones & Health (Growth Hormones for longevity?) 

1:05:18 Sex differences in longevity 

Episode Show Notes: https://livelongerworld.substack.com/p/saustad 

POPULAR EPSIODES: 

- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA

- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg

- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8

- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8

- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo 

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.  Aging is universal. Let's unite in this fight. Stay in good health - Aastha.  

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2

Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.  

This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the ketogenic diet for exercise performance, keto for women & children, Dom's diet & supplement routine + more! Hope you enjoy the episode!

Part 1 with Dom on Ketogenic diets for Brain Health and Longevity: https://livelongerworld.substack.com/p/dom1

Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/

Find me (Aastha) on Twitter: https://twitter.com/aasthajz

SUPPORT LIVE LONGER WORLD:

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld

DOM D'AGOSTINO LINKS:

KetoNutrition: https://ketonutrition.org/

Website: https://linktr.ee/Domdagostino

Twitter: https://twitter.com/DominicDAgosti2

CONNECT WITH AASTHA, LIVE LONGER WORLD:

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/aasthajz

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/aasthajz/

TIMESTAMPS:

0:00 Ketogenic diet for muscle performance 

0:50 Dom’s supplements & modified keto diet 

3:20 Keto, NAD+, NMN 7:12 Biomarkers tracked by Dom 

9:30 LDL, Triglycerides, Fatty Foods & Keto diet 

14:15 Dom’s routine & supplements 

18:09 Melatonin benefits for anti-cancer & antioxidant 

22:37 Ketogenic diet for women 

30:55 Ketogenic diet for children 

32:48 Genetic aspect to keto diet? 

38:32 Metformin for suppressing cancer 

46:30 Ketogenic diet & Alzheimer’s  

54:40 Exercise for mental health 

55:53 Keto for exercise performance & bodybuilding 

59:32 Endogenous metabolite & psychedelics 

1:09:05 Connect with me (Aastha)

Episode Show Notes: https://livelongerworld.substack.com/p/dom2

Thanks for watching & if you enjoy the episode, let's spread the message on longevity. If you like the podcast, please leave a review on Apple podcasts.

Aging is universal. Let's unite in this fight. Stay in good health - Aastha.