Manifold

Steve Hsu
  • 4.6(102개의 평가)
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Steve Hsu is Professor of Theoretical Physics and Computational Mathematics, Science, and Engineering at Michigan State University. Join him for wide-ranging conversations with leading writers, scientists, technologists, academics, entrepreneurs, investors, and more.

  1. Beff Jezos and Effective Accelerationism: Machine God of Loving Grace

    1일 전

    Beff Jezos and Effective Accelerationism: Machine God of Loving Grace

    Beff Jezos (Guillaume Verdon) is a Canadian physicist, quantum computing researcher, and tech entrepreneur. He is best known as the founder of the Effective Accelerationism (e/acc) movement. This interview was recorded in collaboration with John Greer and Lei Huang for the documentary film Machine God. John Greer: https://www.johncgreer.com/ Chapter Markers: (00:00) - Meet Beff Jezos (01:56) - Hyperstition vs AI Doom (21:29) - Accelerate or Die (37:51) - Scaling Intelligence Upside (40:26) - Doomers Power Centralization (47:17) - EAC Physics Framework (01:10:10) - Debating Doom Narratives (01:16:13) - Beff Jezos Origin Story (01:28:06) - Pause Debate and Rapid Fire – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

    1시간 41분
  2. Razib Khan at Manifest 2026: Genetic Discoveries, AI, and Academia – #114

    6월 18일

    Razib Khan at Manifest 2026: Genetic Discoveries, AI, and Academia – #114

    This episode was recorded live at Manifest 2026. Razib Khan is a prominent writer, population geneticist, and podcaster. He is best known for his extensive deep-dives into human evolutionary history, consumer genomics, culture, and ancient DNA.  https://x.com/razibkhan https://x.com/razibkhan?lang=en Chapter Markers: (00:00) - Razib Khan at Manifest 2026: Genetic Discoveries, AI, and Academia (01:18) - Manifest Q&A Kickoff (02:43) - Yamnaya: Ancient DNA Mysteries (15:01) - Yamnaya: Y Chromosome Conquests (22:10) - Embryo Screening and AI (42:15) - Conformity and Tenure (46:34) - Academia: Reforms (53:55) - Academia: Ideological Capture and Funding (58:19) - Controversies and Closing Q&A – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

    1시간 21분
  3. Letter from Beijing 2: Tsinghua University – #113

    6월 4일

    Letter from Beijing 2: Tsinghua University – #113

    This special episode was recorded at Tsinghua University in Beijing, generally regarded as the top university in China. Our guests are 3 Americans studying and working at Tsinghua: Gabriel (undergrad), Justin (PhD student in AI), and Alex (Professor in AI research). Topics discussed include: Tsinghua University and elite human capital, AI in China, US-China competition, and the flow of human capital between the US and China Han Feizi, columnist at Asia Times and the guest from the previous "Letter from Beijing" episode, is also in the room. Letter from Beijing with Han Feizi: https://www.manifold1.com/episodes/letter-from-beijing-with-han-feizi-72 Chapter Markers: (00:00) - Welcome to Tsinghua University (02:47) - Gabriel’s Undergrad Journey (12:35) - Justin’s PhD (25:10) - Professor Alex on AI and Rankings (42:51) - Second Chances and Status Signals (46:48) - China’s Exam Ladder Explained (50:20) - Infrastructure and Tech Competition (01:17:18) - Semiconductors, EUV, and Wrap Up – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

    1시간 21분
  4. AI Billionaire on Existential Risk: Jaan Tallinn

    5월 21일

    AI Billionaire on Existential Risk: Jaan Tallinn

    Jaan Tallinn is a tech billionaire and founding engineer of Skype who leverages his wealth to mitigate existential risks from artificial general intelligence (AGI). He co-founded the Future of Life Institute and the Centre for the Study of Existential Risk, while making early foundational investments in frontier AI labs like DeepMind andAnthropic. Chapter Markers: 00:00 Assessing Current AI Risk Levels03:28 Inside Self-Sustaining AI Scenarios09:10 The Global AI Race Dynamics42:25 Explaining the Techno-Capital Flywheel45:34 Insider Origins of AI Safety56:06 Race Politics and Public Fear01:23:12 Pop Culture, Movies, and Fame01:30:15 Big Questions for Humanity's Future – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

    1시간 41분
  5. Embryo Selection and Frontier Genomics with Dr. Alex Young – #111

    5월 7일

    Embryo Selection and Frontier Genomics with Dr. Alex Young – #111

    Dr. Alex Young, a statistical geneticist and assistant professor in the Human Genetics department at UCLA, joins Steve Hsu to discuss the cutting edge of genomic prediction. They cover his research on polygenic embryo screening in IVF (including the ImputePGTA method), family-based DNA analysis, missing heritability, and the implications of polygenic scores for traits like education and disease. Alex also discusses his recent battles with cancer. https://x.com/AlexTISYoung Chapter Markers: (00:00) - Alex Young Bio (06:36) - Biobank Era Genetics (10:49) - Missing Heritability Debate (27:18) - Embryo Selection Controversy (50:32) - Embryo Selection Backlash (53:42) - Mexico City Admixture Study (01:00:13) - Censorship Via Data Access Control (01:05:02) - Battle With Cancer and Circulating Tumor DNA (ctDNA) – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

    1시간 31분
  6. Iran War is the First Missile War (crossover with Seeking Truth From Facts podcast) – #110

    4월 23일

    Iran War is the First Missile War (crossover with Seeking Truth From Facts podcast) – #110

    Steve and Alf discuss the Iran War, emphasizing what it reveals about modern missile and anti-missile technology, drones, and the implications for a US-China conflict in the Western Pacific. Links:https://seekingtruthfromfacts.substack.com/ Chapter Markers: (00:00) - Missile War Reality Check (01:49) - How the War Started (04:46) - Iran Outperforms Expectations (06:22) - Why Missile Defense Fails (14:25) - Ceasefire and Hormuz Brinkmanship (19:52) - Nukes and the JCPOA Fallout (33:44) - US Politics and Israel Lobby Aftershocks – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

    49분
  7. Dreamers and Doomers: Our AI future, with Richard Ngo – #109

    4월 9일

    Dreamers and Doomers: Our AI future, with Richard Ngo – #109

    Richard Ngo is an independent AI researcher and philosopher known for his work on AGI safety and alignment. He recently resigned from OpenAI, where he was a member of the Governance team focused on forecasting the capabilities and risks of advanced AI systems. His debut fiction collection is titled "The Gentle Romance: Stories of AI and Humanity", published in December 2025. The book features 22 science fiction stories that explore the psychological and sociological impacts of advanced artificial intelligence. On X: @RichardMCNgo (00:00) - Richard Ngo Origins (03:48) - DeepMind vs LLMs (09:24) - OpenAI Futurist and AGI Risk (39:17) - Machine God Tail Risk (45:20) - Weird Futures and Normies (51:28) - Alignment Research and Academia (01:16:25) - Doomers vs Skeptics (01:23:57) - Labs Governance Futures (01:39:37) - Doom Scenarios Society – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

    1시간 52분
  8. China, Acceleration, and Nick Land - with Matt Southey – #108

    3월 26일

    China, Acceleration, and Nick Land - with Matt Southey – #108

    Matt Southey is an editor for an AI safety organization. He wrote his PhD dissertation on the philosophy of Nick Land. Matt's "A Brief History of Accelerationism" can be found here, and he recommends the second chapter of Crypto-Current as a good introduction to Land's usage of Kant. He and Steve discuss Accelerationism, AI, and Steve's recent meeting with Land in Shanghai. Chapter Markers: (00:00) - Introduction (02:07) - China Trip: Shenzhen, Beijing, Shanghai (03:16) - Tsinghua University: Talent (09:02) - Robotics and AI research (24:01) - Shanghai and Nick Land (35:46) - Land’s Esotericism (37:19) - Accelerationism and Orthogonality (43:01) - Simulation Metaphysics and Physics (54:36) - Dark Enlightenment and Inevitable Complexity – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models.  Mechanize is hiring!  https://mechanize.work/b/hsu  Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists.  For example:  Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary  Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary  Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

    1시간 4분
모두 보기(166개)

4.6
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102개의 평가

소개

Steve Hsu is Professor of Theoretical Physics and Computational Mathematics, Science, and Engineering at Michigan State University. Join him for wide-ranging conversations with leading writers, scientists, technologists, academics, entrepreneurs, investors, and more.

정보

  • 제작진
    Steve Hsu
  • 방송 연도
    2019년 - 2026년
  • 에피소드
    166
  • 등급
    무삭제판
  • 저작권
    © Steve Hsu - All Rights Reserved
  • 웹사이트 보기
    Manifold

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