Everything Epigenetics

Hannah Went

Don’t understand epigenetics? Don’t worry. There was a time when genetic analysis was hardly known or understood. Now, genetic analysis is performed by thousands of companies and your full genome can be decoded for less than $100. Epigenetics is how your behaviors change your outcome. Epigenetics gives us knowledge on how to change your life, and the ability to read biology to understand your current health status. You ARE in control. Your host, Hannah Went, is here to discuss the insights which can improve your life and health. She is here to bring you Everything Epigenetics, simplified. 

  1. ١٢ فبراير

    Men vs. Women: Who Really Ages Faster?

    Aging is a complex process, but have you ever wondered how it differs between men and women? In this week’s episode of the Everything Epigenetics podcast, Sara Hägg, an Associate Professor at Karolinska Institutet, and I discuss the fascinating differences in biological aging between sexes. We explore how genetics, hormones, and lifestyle choices contribute to aging disparities and what that means for longevity, disease risk, and overall health. You'll learn about: - How Sara Hägg became interested in aging research and what led her to study sex-specific differences - The major ways men and women age differently at the genetic, molecular, and epigenetic levels - The role of hormones like estrogen and testosterone in shaping the aging process - Why women typically live longer than men and what factors influence this disparity - How stress, diet, and environmental exposures impact aging uniquely for men and women - The latest epigenetic research uncovering biological sex differences in aging - How precision medicine may help tailor aging interventions based on sex-specific needs - Biomarkers of aging and how they reveal crucial insights into longevity and healthspan Chapters: 00:00 – Introduction to Everything Epigenetics Podcast 00:05 – Meet Sara Hägg: Her Background and Research Focus 02:30 – What Inspired Her to Study Aging and Sex Differences 06:30 – How Do Men and Women Age Differently? 10:00 – The Role of Hormones: Estrogen, Testosterone, and Aging 14:00 – Why Do Women Live Longer Than Men? 19:30 – Cellular and Epigenetic Differences in Male vs. Female Aging 24:00 – The Impact of Stress, Diet, and Environment on Aging 29:00 – Age-Related Diseases: Which Are More Common in Men vs. Women? 33:00 – How Biomarkers Help Predict Aging and Disease Risk 37:00 – The Future of Precision Medicine in Aging 40:00 – Surprising Findings from Sara Hägg’s Research & Closing Thoughts Support the show Where to Find Us: Instagram Twitter Facebook Follow us on: Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

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  2. ٢٩ يناير

    Breaking Down Epigenetics: Sperm, Seminal Plasma, and Generational Impact

    Epigenetics offers fascinating insights into how our genes are influenced by lifestyle and environmental factors. In this week’s episode of the Everything Epigenetics podcast, Dr. Raffaele Teperino and I delve into groundbreaking research on epigenetic inheritance and how reproductive fitness impacts long-term health. From the transfer of epigenetic material during conception to the role of paternal health in childhood obesity and diabetes risk, we discuss how these factors shape generational health outcomes. You'll learn about: • The role of epigenetics in reproductive fitness and how it goes beyond reproductive capacity. • How sperm and eggs transfer more than just DNA, influencing offspring development through epigenetic material. • The surprising impact of paternal health at conception on childhood obesity and metabolic disorders. • The importance of lifestyle changes before conception to improve offspring health. • Practical insights into integrating epigenetics into preventive medicine and public health. Chapters: 00:00 Welcome & Introduction 01:09 Dr. Teperino’s journey into epigenetics and its link to complex diseases. 03:56 Understanding reproductive fitness and its connection to epigenetics. 08:33 The transfer of epigenetic material from sperm to oocyte. 17:01 The role of paternal health in shaping offspring health risks. 24:07 Longitudinal studies on early-life risks of obesity and diabetes. 37:44 The overlooked role of seminal plasma in reproductive health. 42:00 The future of epigenetics: Neurodevelopmental disorders and preventive health. 45:32 Closing thoughts and where to connect with Dr. Teperino. Support the show Where to Find Us: Instagram Twitter Facebook Follow us on: Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

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  3. ١٥ يناير

    Methylation Screening Array: A Revolutionary Tool in Epigenetics

    DNA methylation, a cornerstone of epigenetic research, is vital for understanding gene regulation and its implications in health and disease. In this week’s episode of the Everything Epigenetics podcast, I speak with David Goldberg and Nicole Renke about the latest advancements in DNA methylation tools, including Illumina's groundbreaking Methylation Screening Array (MSA). We explore the history and evolution of methylation microarrays, why they remain the gold standard for Epigenome-Wide Association Studies (EWAS), and the design process behind the MSA array. David and Nicole provide insight into the practical applications of these tools for research in aging, neurodegenerative disorders, and environmental exposures. You'll learn about: •⁠  ⁠What methylation microarrays are and why they’re essential for EWAS •⁠  ⁠The market need and vision for Illumina's new MSA array •⁠  ⁠Key features and benefits of the MSA array for researchers •⁠  ⁠The role of cell-specific methylation in advancing epigenetic studies •⁠  ⁠Insights into the technical and biological validation of the MSA array Chapters: 00:00 Welcome and Introduction 02:30 History of Methylation Microarrays 10:45 Applications of EWAS in Research 20:15 Unveiling the MSA Array: Vision and Design 35:00 Technical Validation and Biological Insights 45:30 Future Directions in DNA Methylation Research 50:00 Closing Remarks Support the show Where to Find Us: Instagram Twitter Facebook Follow us on: Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

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  4. ١ يناير

    Heart Health and the Future of Epigenetics with Dr. Meesha Dogan

    How can epigenetics revolutionize heart disease prevention? In this week’s episode of the Everything Epigenetics podcast, Dr. Meesha Dogan and I discuss the groundbreaking role of AI-driven epigenetics in cardiovascular medicine. Dr. Dogan shares her journey into the field, the life-changing potential of precision diagnostics, and the critical connection between lifestyle and heart health. You'll learn about: •⁠  ⁠How epigenetics determines heart disease risk beyond genetics. •⁠  ⁠The role of AI in identifying biomarkers and enabling earlier interventions. •⁠  ⁠Real-world applications of personalized treatment plans informed by epigenetic testing. •⁠  ⁠Why behavior changes, guided by dynamic DNA data, are key to long-term heart health. •⁠  ⁠The future of epigenetics in drug development and preventative medicine. Chapters: 00:00 Introduction 03:00 Dr. Meesha Dogan’s journey into epigenetics and personalized health 10:00 How epigenetics informs heart disease risk and prevention 18:00 AI’s transformative role in cardiovascular diagnostics 26:00 Real-world applications: Precision CHD tests and success stories 35:00 Lifestyle interventions and the power of behavioral insights 45:00 The future of epigenetic research: Drug development and dynamic testing Support the show Where to Find Us: Instagram Twitter Facebook Follow us on: Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

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    Unlocking Fertility: How Epigenetics Can Predict and Enhance Reproductive Health with Katherine Zagone, ND

    Reproductive longevity and fertility are topics that impact women disproportionately across the globe. In this week’s episode of the Everything Epigenetics podcast, Dr. Katherine Zagone and I discuss how epigenetics can unlock key insights into fertility, biological age, and reproductive health. Dr. Zagone shares her journey into the fertility world, her pioneering work at Clockwize, and how biological age plays a crucial role in fertility outcomes. You'll learn about: How Dr. Zagone founded Clockwize and what inspired her focus on fertility.The importance of biological age over chronological age in predicting fertility outcomes.Clockwize’s "Fertility Wise Test" and how it measures biological aging and exposure to fertility toxins.Common fertility toxins, including phthalates, BPA, and parabens, and how to reduce exposure.The FAST framework (Food, Fitness, Associated conditions, Sleep, Stress, Trauma, and Toxins) to optimize fertility and rewind biological age.Future innovations in epigenetic fertility predictions and outcomes.Chapters: 00:00 Introduction 02:00 State of Reproductive Longevity and Its Disproportionate Impact on Women 05:00 Dr. Katherine Zagone’s Journey into Fertility and Founding Clockwize 10:30 Biological Age vs. Chronological Age in Fertility 15:00 How Epigenetics Can Predict Fertility and Health Outcomes 20:00 The FAST Framework: Rewinding Your Biological Clock 25:00 Identifying and Reducing Exposure to Fertility Toxins 30:00 Innovations and Future Directions in Fertility Epigenetics 40:00 Success Stories and Real-World Impacts 50:00 How to Connect with Dr. Zagone and Learn More About Clockwize Support the show Where to Find Us: Instagram Twitter Facebook Follow us on: Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

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    Unlocking the Secrets of Healthy Aging with Dr. Jamie Justice

    What does it take to live not just longer but healthier lives? In this week’s episode of the Everything Epigenetics podcast, Dr. Jamie Justice and I explore the groundbreaking research and initiatives shaping the future of healthy aging. From bridging the gap between lifespan and healthspan to revolutionary breakthroughs like the XPRIZE Healthspan prize, we dive deep into the science and innovations driving progress in geroscience. You'll learn about: What “healthy aging” truly means and why it’s vital for everyone.How the gap between lifespan and healthspan impacts society and what can be done to close it.The critical factors influencing long-term healthspan and actionable steps individuals can take.The goals and potential of the XPRIZE Healthspan initiative and the exciting innovations emerging from it.How targeted initiatives like the SOLVE FSHD Bonus Prize could shape the future of disease-specific health research.A look ahead: breakthroughs and milestones expected in the next 5-10 years in aging research.Chapters: 00:00 Welcome and Introduction 02:30 What “healthy aging” means to Dr. Jamie Justice 07:15 Lifespan vs. Healthspan: Bridging the gap 15:40 Key factors influencing long-term healthspan 22:10 Overview of the XPRIZE Healthspan Prize 28:45 Promising innovations from XPRIZE participants 35:20 The SOLVE FSHD Bonus Prize and its impact 42:10 Future breakthroughs in geroscience and aging research 49:30 Where to connect with Dr. Jamie Justice Support the show Where to Find Us: Instagram Twitter Facebook Follow us on: Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

    ٥٢ من الدقائق
  7. ٢٠‏/١١‏/٢٠٢٤

    Epigenetics and Canine Longevity: Unlocking Healthier, Longer Lives for Dogs

    In this week’s episode of the Everything Epigenetics podcast, Dr. Christopher Minteer, Nicholas Minteer, and I dive into the fascinating intersection of canine health, longevity, and epigenetics. We explore how their company, Woofgenix, is revolutionizing the field through cutting-edge research and innovative products that aim to extend the lifespan and healthspan of our beloved pets. From understanding the unique epigenetic processes in dogs to uncovering the secrets behind varying breed lifespans, this episode offers insights into how science is shaping a better future for our furry friends. You'll learn about: How Woofgenix uses epigenetic testing to enhance canine longevity.The surprising ways epigenetic processes in dogs differ from humans.Exciting breakthroughs in canine aging research, including the role of rapamycin.Woofgenix's innovative products like WoofAge, WoofSpan, and Woof Wellness.How dog lovers can get involved in longevity research through citizen science initiatives.Chapters:  00:00 Introduction 03:00 Meet Dr. Christopher and Nicholas Minteer 09:00 Canine Epigenetics: Comparing Dogs and Humans 16:00 The Science Behind Longevity: Breed and Size Insights 24:00 Woofgenix: Research and Products Revolutionizing Dog Care 36:00 How to Support Canine Aging Research Support the show Where to Find Us: Instagram Twitter Facebook Follow us on: Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

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    Epigenetic Hacks for Longevity: Strategies to Thrive at 62

    In this episode of Everything Epigenetics, host Hannah Went sits down with Dave Pascoe, a retired network security architect who’s redefining the way we think about aging. Despite being 62, Dave has been able to have a lower "biological age" and slow pace of aging, a testament to his dedication to health optimization, epigenetics, and biological tuning. Known for ranking among the top contenders in the Rejuvenation Olympics leaderboard, Dave’s journey offers invaluable insights into affordable and effective longevity practices. You'll learn about: Dave’s routines and habits for maintaining youthful epigenetic markersThe Rejuvenation Olympics: what it is and how Dave has made his markHow personalized routines and lifestyle changes can slow down agingChapters: 00:00 – Introduction to Everything Epigenetics and Dave Pascoe 00:16 – Dave’s early experiences and what sparked his interest in health and wellness 02:01 – Rejuvenation Olympics and its goals 05:14 – Dave’s evening and morning routines supporting epigenetic health 08:50 – Dave’s “AHA” moment and lifestyle changes 12:33 – Biohacking techniques and tools for longevity 15:50 – Practical steps for longevity accessible to a broad audience 18:40 – Reflections on balancing stress, mindset, and communityJoin us as we explore practical longevity strategies and learn how you, too, can take control of your health journey! Support the show Where to Find Us: Instagram Twitter Facebook Follow us on: Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

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Don’t understand epigenetics? Don’t worry. There was a time when genetic analysis was hardly known or understood. Now, genetic analysis is performed by thousands of companies and your full genome can be decoded for less than $100. Epigenetics is how your behaviors change your outcome. Epigenetics gives us knowledge on how to change your life, and the ability to read biology to understand your current health status. You ARE in control. Your host, Hannah Went, is here to discuss the insights which can improve your life and health. She is here to bring you Everything Epigenetics, simplified. 

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