Minding Memory

Michigan Medicine Podcast Network

Welcome to Minding Memory. In this podcast we discuss topics related to dementia research. This is an all-hands-on-deck moment for dementia research, and we have topics for both those new to the space as well as old pros. We start with some basics, like: What exactly is dementia? What are the different types of dementia? What is the TICS, if not a swarm of blood-sucking insects?  But we also invite researchers on to discuss their interesting work to give you a glimpse at the questions, data, and methods moving the field forward.    Minding Memory is co-hosted by Matthew Davis and Lauren Gerlach. Matt and Lauren are health services researchers and professors at the University of Michigan. Matt’s PhD is in Data Science and Lauren is a geriatric psychiatrist. The Minding Memory podcast is part of the Center to Accelerate Population Research in Alzheimer’s (CAPRA) at the University of Michigan, supported by the National Institute on Aging at the National Institutes of Health. Additional support also comes from the Institute for Healthcare Policy and Innovation. The content of this podcast does not represent the views of the National Institutes of Health or the University of Michigan. Please consider subscribing to this podcast and make sure to check out our website. On our website you’ll also find links to the center’s seminar series and data products created specifically for dementia research.  You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.

  1. 3d ago

    Antipsychotic Use in Nursing Homes: Balancing Medication Safety, Policy, and Dementia Care

    In this episode, Lauren Gerlach and Matt Davis speak with Theresa Shireman, PhD, Director of the Center for Gerontology and Healthcare Research and a Professor of Health Services, Policy and Practice, and Epidemiology at the Brown University School of Public Health. Dr. Shireman’s research focuses on pharmaceutical policy, pharmacoepidemiology, health services research, and medication use among vulnerable populations. Dr. Shireman discusses her recent study, “The Impact of Federal Antipsychotic Use Policy in Nursing Homes on New Diagnoses for Approved Indications in Dementia Residents,” published in the Journal of the American Geriatrics Society. The study examines whether federal policies designed to reduce antipsychotic use in nursing homes were associated with increases in new diagnoses of conditions, such as schizophrenia, that exclude residents from publicly reported antipsychotic quality measures. Using an interrupted time-series design, the researchers examined changes following the 2012 National Partnership to Improve Dementia Care and the 2015 addition of antipsychotic use to the nursing home Five-Star Quality Rating System. They found that neither policy was associated with an increase in new exclusionary diagnoses, challenging concerns that nursing homes were increasingly assigning these diagnoses to circumvent restrictions on antipsychotic use. The conversation also explores the benefits and risks of antipsychotic medications for people living with dementia, including the potential for serious adverse effects such as sedation, falls, stroke, and increased mortality. Dr. Shireman discusses how public reporting and financial incentives can influence prescribing practices, the limitations of using a single quality measure to evaluate nursing home care, and the importance of balancing medication safety with residents’ individual needs. The discussion highlights the need for shared decision-making among clinicians, nursing home staff, residents, and families, as well as greater investment in staffing, resources, and nonpharmacological approaches to improve quality of life for people living with dementia. The transcript for this episode can be found here. Article Discussed in the Episode: Shireman TI, Coulibaly N, Zhang T, et al. Impact of federal antipsychotic use policy in nursing homes on new diagnoses for approved indications in dementia residents. J Am Geriatr Soc. 2024; 72(12): 3742-3752. doi:10.1111/jgs.19129 You can listen on the Michigan Medicine podcasting network and other podcasting platforms such as Apple Podcasts and Spotify. This episode is also available on our CAPRA website. Hosted on Acast. See acast.com/privacy for more information.

    Antipsychotic Use in Nursing Homes: Balancing Medication Safety, Policy, and Dementia Care
  2. Oct 12

    Can Your Voice Reveal Early Signs of Alzheimer’s?

    In this episode, Lauren & Matt speak with Neguine Rezaii, MD, an Assistant Professor of Neurology at Harvard Medical School and a Board-Certified Neuropsychiatrist at Mass General Hospital. Dr. Rezaii’s research focuses on using natural language processing and artificial intelligence to improve the detection and classification of neurodegenerative disorders. Dr. Rezaii talks about her recent study, “Voiceprints of Cognitive Impairment: Analyzing Digital Voice for Early Detection of Alzheimer’s and Related Dementias,” which explores how artificial intelligence can analyze short speech samples to identify subtle signs of cognitive impairment. The study used speech recordings from 120 individuals and found that features such as pauses, word choice and the specificity of language can help distinguish cognitive impairment and Alzheimer’s disease. The conversation also explores how a simple 30-second speech test could potentially be used in clinical settings to support earlier detection and monitoring of cognitive impairment, as well as the challenges and ethical considerations that come with using AI to analyze something as personal as a person’s voice. The transcript for this episode can be found here. Article Discussed in the Episode: Rezaii, N., Wong, B., Aisen, P. et al. Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias. npj Dement. 1, 35 (2025). https://doi.org/10.1038/s44400-025-00040-0 DOI; npj Dementia volume 1, Article number: 35 (2025) You can listen on the Michigan Medicine podcasting network and other podcasting platforms such as Apple Podcasts and Spotify. This episode is also available on our CAPRA website. Hosted on Acast. See acast.com/privacy for more information.

    Can Your Voice Reveal Early Signs of Alzheimer’s?
  3. Apr 20

    The Impact of Social Isolation and Loneliness on Cognitive Health

    In this episode we're going to discuss a topic that's increasingly recognized as central to cognitive health and social connection. We'll define what it is and what happens when it's missing. Social isolation and loneliness are now widely discussed as public health concerns, and evidence has really mounted that social disconnection has profound effects on health, including cognitive decline and dementia risk. To help us think through this, we're joined by Dr. Ashwin Kotwal, a geriatrician and health services researcher at UCSF and the director of the Social Connections and Aging Lab. His work examines how social relationships shape aging related outcomes, including cognitive health, disability, and mortality.  The transcript for this episode can be found here. Additional Links:    Ashwin Kotwal Faculty Profile  Social Connections & Aging Lab @ UCSF    Relevant Articles:   Kotwal AA, Cenzer IS, Yaffe K, Perissinotto C, Smith AK. End-of-life health care use among socially isolated and cognitively impaired older adults. J Am Geriatr Soc. 2023 Mar;71(3):880-887. doi: 10.1111/jgs.18131. Epub 2022 Nov 23. PMID: 36420540; PMCID: PMC10023302.    Kotwal AA, Allison TA, Halim M, Garrett SB, Perissinotto CM, Ritchie CS, Smith AK, Harrison KL. "Relationships, Very Quickly, Turn to Nothing": Loneliness, Social Isolation, and Adaptation to Changing Social Lives Among Persons Living With Dementia and Care Partners. Gerontologist. 2024 Apr 1;64(4):gnae014. doi: 10.1093/geront/gnae014. PMID: 38499400; PMCID: PMC10948338.    Kotwal AA, Cenzer I, Hunt LJ, Ankuda C, Torres JM, Smith AK, Aldridge M, Harrison KL. Psychosocial distress among spouses of persons with dementia before and after their partner's death. J Am Geriatric Soc. 2024 Aug;72(8):2336-2346. doi: 10.1111/jgs.19030. Epub 2024 Jun 1. PMID: 38822746; PMCID: PMC11323186.  You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.

    The Impact of Social Isolation and Loneliness on Cognitive Health
  4. Mar 23

    Neighborhood Income and Cognitive Health

    Welcome back to Minding Memory! In today’s episode, Lauren & Matt speak with Dr. Laura Zahodne – a professor of psychology at the University of Michigan and an affiliate of the Institute for Social Research. She's a clinical neuropsychologist by training and studies how psychosocial experiences shape late life, cognitive health, and risk of neurodegenerative disease.  Also, a new member of our CAPRA leadership team!      In this episode, we’ll get to know Laura a little better and talk with her about one of her research studies, the Neighborhood Racial Income Inequality in Cognitive Health, which looks at the association between racial income differences and a variety of cognitive measures.  The transcript for this episode can be found here.   Links of Interest:   Laura Zahodne Faculty Profile   Introduction to the Michigan Cognitive Aging Project    Articles Referenced in Podcast:  Zahodne LB, Sol K, Scambray K, Lee JH, Palms JD, Morris EP, Taylor L, Ku V, Lesniak M, Melendez R, Elliott MR, Clarke PJ. Neighborhood racial income inequality and cognitive health. Alzheimers Dement. 2024 Aug;20(8):5338-5346. doi: 10.1002/alz.13911. Epub 2024 Jun 27. PMID: 38934219; PMCID: PMC11350017.    Hu Y, Elliott MR, Meier HCS, Chen L, Walters ME, Sol K, Zahodne LB. The impact of census-tract level mortgage discrimination on cognitive function: accounting for measurement instability in small-area data via joint modeling. Am J Epidemiol. 2025 Nov 4;194(11):3258-3266. doi: 10.1093/aje/kwaf131. PMID: 40522478; PMCID: PMC12634109.   You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.

    Neighborhood Income and Cognitive Health

Ratings & Reviews

4.4
out of 5
7 Ratings

About

Welcome to Minding Memory. In this podcast we discuss topics related to dementia research. This is an all-hands-on-deck moment for dementia research, and we have topics for both those new to the space as well as old pros. We start with some basics, like: What exactly is dementia? What are the different types of dementia? What is the TICS, if not a swarm of blood-sucking insects?  But we also invite researchers on to discuss their interesting work to give you a glimpse at the questions, data, and methods moving the field forward.    Minding Memory is co-hosted by Matthew Davis and Lauren Gerlach. Matt and Lauren are health services researchers and professors at the University of Michigan. Matt’s PhD is in Data Science and Lauren is a geriatric psychiatrist. The Minding Memory podcast is part of the Center to Accelerate Population Research in Alzheimer’s (CAPRA) at the University of Michigan, supported by the National Institute on Aging at the National Institutes of Health. Additional support also comes from the Institute for Healthcare Policy and Innovation. The content of this podcast does not represent the views of the National Institutes of Health or the University of Michigan. Please consider subscribing to this podcast and make sure to check out our website. On our website you’ll also find links to the center’s seminar series and data products created specifically for dementia research.  You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.

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