Modified

modifiedgmopodcast
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Join me as we dig into a heaped serving of GMO crops through the lens of science, history, and culture. From the Victorian origins of plant genetics through to the genetically modified world we live in today. I’m Orlando de Lange and I’ll be your guide as we explore (true) stories that just might change how you think about the food on your plate, and the future of agriculture.

  1. 5 NGÀY TRƯỚC

    Bt Crops - GMOs go mainstream

    The NewLeaf potato was a failure, appearing and disappearing in under a decade. But it was the first of a new wave of GMO crops that have endured to the present day - Bt crops.    Key references Insect Resistance in Crops: A Case Study of Bacillus thuringiensis (Bt) and its Transfer to Developing Countries. 1997.   The chronicle of the ups and downs that made Bacillus thuringiensis a natural insecticide by Ninfa Rosas-Garcia, 2023.    https://dfg-vk-darmstadt.de/Lexikon_Auflage_2/BerlinerErnst.htm Biographical details about Ernst Berliner.  https://www.ers.usda.gov/topics/farm-practices-management/biotechnology → 2025 USDA data on Bt crops   https://farmingfirst.org/2025/12/how-africa-can-benefit-from-south-africa-success-with-gm-crops/ ⇒ GMO crops in South Africa.    https://farmingfirst.org/2025/12/how-africa-can-benefit-from-south-africa-success-with-gm-crops/ ⇒ GMO crops in Kenya Rise and fall of the New Leaf Potato - https://krautnah.de/wp-content/uploads/2020/06/15_7_2_Thornton.pdf.  https://time.com/archive/6925559/why-mcdonalds-pulled-frankenfries-from-menu/TIME article about lack of commercial interest in NewLeaf potato.  Resources on Bt and milkweed https://news.cornell.edu/stories/1999/04/toxic-pollen-bt-corn-can-kill-monarch-butterflies https://academic.oup.com/jee/article/116/2/297/6968925 → 2023 review paper on Bt crops and resistance https://www.monarchscience.org/single-post/2020/09/02/a-look-back-at-the-time-when-the-entire-world-thought-bt-corn-was-killing-monarchs → Blog post summarizing the incident https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001415 → Bt crops and bees https://www.pnas.org/doi/abs/10.1073/pnas.241503398 → read this and see if its useful

    40 phút

  2. 7 THG 2

    First ever GMO: The FlavrSavr tomato

    How one tomato changed the world? Or was it two? And what is a GMO tomato anyway. Slice into the story of the FlavrSavr tomato.    Key references Grierson D. Identifying and silencing tomato ripening genes with antisense genes. Plant Biotechnol J. 2016 Mar;14(3):835-8. doi: 10.1111/pbi.12463. Epub 2015 Sep 15. PMID: 26369550; PMCID: PMC11389017.     https://www.supermarketnews.com/grocery-operations/altered-stakes https://www.spokesman.com/stories/1995/jun/14/hot-tomatoes-genetically-altered-tomatoes-are/ → Articles about the sales of the Flavr Savr. Commercialization_of_a_tomato_with_an_antisense_po.pdf - 1994, Euphytica The Flavr Savr Tomato, an Early Example of RNAi Technology.pdf - 2008, HortScience

    31 phút

  3. 24 THG 1

    How to Make a GMO Plant

    From hacking bacteria to blasting your way into the heart of the cell, in this episode we explore the ways to get a transgene into a plant cell and go from there to a whole genetically engineered plant.    Key references Herrera-Estrella L. My journey into the birth of plant transgenesis and its impact on modern plant biology. Plant Biotechnol J. 2020   Chimeric Genes as Dominant Selectable Markers in Plant Cells. Herrera-Estrella et al., 1983, the EMBO Journal. - First publication of delivering a recombinant T-DNA plasmid into plant cells.   History of Plant Tissue Culture. Trevor A Thorpe. University of Calgary   Current Advancement and Future Prospects in Simplified Transformation Based Plant Genome Editing. Han et al., Plants (Basel). 2025 - Review of plant transformation techniques.    Deep Dive into Plant Transformation: Protoplast Mediated, Biolistic, Agrobacterium Mediated Gene Transfer. Dr Adriana Gallego. GoldBio.  - Article about different plant transformation methods.

    32 phút

  4. 10 THG 1

    The Early Days of Genetic Engineering

    How did a few labs in the San Francisco area transform our relationship to life itself?   Guidelines for Hybrid DNA Molecules - Maxine Singer and Dieter Soll - Science, 1973 Potential Biohazards of Recombinant DNA Molecules - Berg et al., Science, 1974 Electron Micrograph of plasmid DNA, 1967 Valentine remembered for visionary thinking that transformed agriculture - Trina Kleist, 2023

    27 phút

  5. 27/12/2025

    How Science Took Over Plant Breeding

    What actually is plant breeding and how did it become so deeply intertwined with genetics?

    39 phút

  6. 13/12/2025

    What makes a plant a crop?

    Learn what sushi and sugar beets can teach us about how to turn a plant into a crop and how this connects to GMOs.

    29 phút

  7. 15/11/2025

    Your Questions Answered

    Ant plants, Chameleon plants, and skinny-peel mangoes. Let's dive into your questions and I'll do my best to answer them.    References Leaf Mimicry in a Climbing Plant Protects Against Herbivory - Gianoli & Carrasco-Urra - Current Biology, 2014 Boquila trifoliata Mimics Leaves of an Artificial Plastic Host Plant - White & Yamashita - Plant Signaling & Behavior, 2021 Endophytic Bacterial Communities are Associated with Leaf Mimicry in the Vine Boquila trifoliata - Gianoli et al. - Scientific Reports, 2021 How the Tulip Breaking Virus Created Striped Tulips - Wong, Carrero & Hillen - Communications Biology, 2025 Start of the Art of Dahlia Breeding - A dissertation by Karen Renae Bender - Iowa State University, 2022 The Genome Evolution and Domestication of Tropical Fruit Mango - Wang et al. - Genome Biology, 2020

    57 phút

  8. 02/11/2025

    How Genes Keep Plants Alive

    How do plants defend themselves, fighting a war of attrition cell by cell? And how did a scientist in Minnesota in the 1950s reshape how we understand plant immune systems and the genetics at their heart. And of course, how does this all connect to GMOs? Let's find out.    References H. H. FLOR: PIONEER IN PHYTOPATHOLOGY Jin L, Chen M, Xiang M, Guo Z. RNAi-Based Antiviral Innate Immunity in Plants. Viruses. 2022 Feb 20;14(2):432.  FAO. 2022. FAO’s Plant Production and Protection Division. Rome. PAPAYA RINGSPOT VIRUS (PRY): A SERIOUS DISEASE OF PAPAYA   2024 STATE AGRICULTURE OVERVIEW - Hawaii

    26 phút
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Giới Thiệu

Join me as we dig into a heaped serving of GMO crops through the lens of science, history, and culture. From the Victorian origins of plant genetics through to the genetically modified world we live in today. I’m Orlando de Lange and I’ll be your guide as we explore (true) stories that just might change how you think about the food on your plate, and the future of agriculture.

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    modifiedgmopodcast
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