Dr. John Campbell

Campbellteaching

Hello Everyone, My name is John Campbell and I am a retired Nurse Teacher and former clinical nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally. LinkedIn profile, https://www.linkedin.com/in/dr-john-campbell-5256223b/ Twitter, https://twitter.com/Johnincarlisle Disclaimer; These media including videos, book, e book, articles, podcasts are not peer-reviewed. They should never replace individual clinical judgement from your own health care provider. No media-based material on this channel is suitable for using as professional medical advice. All comments are also for educational purposed only and must never replace advice from your own health care provider

  1. 2 giờ trước

    Zinc nutrition as we enter endemic phase

    Zinc and immune function: the biological basis of altered resistance to infection https://pubmed.ncbi.nlm.nih.gov/9701160/ Zinc is known to play a central role in the immune system and zinc-deficient persons experience increased susceptibility to a variety of pathogens It is clear that zinc affects multiple aspects of the immune system Zinc is crucial for normal development and function of cells mediating nonspecific immunity such as neutrophils and natural killer cells Zinc deficiency also affects development of acquired immunity, activation of T lymphocytes and B lymphocyte help B lymphocyte development and antibody production, particularly immunoglobulin G, is compromised The macrophage, is adversely affected by zinc deficiency Zinc is needed by these key immunologic mediators Basic cellular functions such as DNA replication RNA transcription, cell division, and cell activation https://www.frontiersin.org/articles/10.3389/fimmu.2020.01712/full Zinc deficiency results in altered numbers and dysfunction of all immune cells Suboptimal zinc states have an increased risk for infectious diseases, autoimmune disorders, and cancer Risk groups for zinc deficiency Malnutrition Elderly and patients with various inflammatory and autoimmune diseases Mild zinc deficiency is largely sub-clinical, it is unnoticed in most people World Health Organization Assumes that at least one third of the world population is affected by zinc deficiency Zinc deficiency is responsible for 16% of all deep respiratory infections world-wide Supplementation, for which minimal to no side effects are known. Europe 10 to 20% zinc deficiency https://translate.google.com/translate?hl=en&sl=es&u=https://www.phmk.es/i-d/suplementar-con-zinc-podria-reducir-la-mortalidad-en-el-paciente-de-covid-19&prev=search&pto=aue Zinc Protects the Human Body From Entering of the Virus Essential for tissue barriers equipped with cilia and mucus, anti-microbial peptides like lysozymes and interferons The expression of tight junction proteins was found to be zinc-dependent Mucociliar clearance of viruses is affected by zinc Physiological concentrations of zinc increase ciliary beat frequency Zinc-dependent alterations in gene expression by pneumocytes Associations with interferons Zinc Directly Inhibits Viral Replication Direct antiviral effects of zinc have been demonstrated E.g. coronaviridae, picornavirus, papilloma virus, metapneumovirus, rhinovirus, herpes simplex virus, varicella-zoster virus, respiratory syncytial virus, human immunodeficiency virus (HIV), and the hepatitis C virus It was suggested that zinc can prevent fusion with the host membrane Decreases the viral polymerase function Blocks viral particle release Destabilizes the viral envelope Zinc Balances the Immune Response During Infectious Diseases Hyper-inflammation, immune products including pro-inflammatory cytokines Movement and over activation of immune cells to the lungs Acute respiratory distress syndrome (ARDS) Need of zinc for lymphocyte development and function and that zinc supplementation can reverse lymphopenia Zinc is indispensable in the signal cascade of the T cell receptor and as a second messenger Zinc is required for B cell maturation and function Zinc Supplementation in Respiratory Infections A row of successful supplementation studies focusing on respiratory tract infection In most cases, prophylactic zinc supplementation was more effective than therapeutic proceedings Studies showed reduced symptom severity, reduced frequency, and duration of the common cold after zinc administration Zinc supplementation of children in developing countries Reduced pneumonia-specific morality by 15% and 19% of pneumonia morbidity by 19% Risk Groups and Symptoms of COVID-19 and Zinc Deficiency Reveal a Large Overlap Low serum zinc levels are regularly observe Learn more about your ad choices. Visit megaphone.fm/adchoices

  2. 3 giờ trước

    Covid optimism

    Right now there is no obvious replacement for the BA.5 variant, that is causing the current wave. This leaves open the real possibility that this could be the last significant wave this year, (or hopefully much longer). https://covid.cdc.gov/covid-data-tracker/#variant-proportions BA.5 85.5% BA.4 7.7% BA.4.6 4.1 BA2.12.1 2.6% BA.2 0.1% BA.1s 0% BA. 2.75 not US listed US hospitalizations Down 3.8% on the week Known daily case counts, test positivity, hospitalizations slow downward trend US deaths https://covid.cdc.gov/covid-data-tracker/#trends_dailydeaths_select_00 Last 7 days rolling average, 393 per day Dr. Fauci (81), Re. BA.5 https://www.washingtonpost.com/health/2022/08/05/fauci-vaccine-covid-trouble/?utm_campaign=wp_to_your_health&utm_medium=email&utm_source=newsletter&wpisrc=nl_tyh If they don’t get vaccinated or they don’t get boosted, they’re going to get into trouble Wants to increase vaccination and booster rates, so the virus does not have, ample opportunity to freely circulate It is about you as an individual, but it’s also about the communal responsibility to get this outbreak under control (POTUS, fully vaccinated and double boosted) Weekly national Influenza and COVID-19 surveillance report https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1096288/Weekly_Flu_and_COVID-19_report_w31.pdf COVID-19 activity decreased Highest number of respiratory incidents, (mostly SARS-CoV-2) in care homes Influenza positivity, 0.5% RSV positivity up to 6.5% overall RSV positivity in under 5s, 22.2% Rhinovirus positivity, down to 8.4% Symptom tracker data https://health-study.joinzoe.com/data New cases per day, 145,740 Current prevalence, 2,858,159 UK official data https://coronavirus.data.gov.uk ONS latest https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19/latestinsights 3.86% in England (1 in 25 people) 3.58% in Wales (1 in 30 people) 5.98% in Northern Ireland (1 in 17) 4.95% in Scotland (1 in 20) Long covid, as of 2 July 2022 1.8 million people, (2.8% of the population) Of those, 81% experiencing long COVID symptoms at least 12 weeks 43% at least one year Antibodies 179ng/ml level and the 800ng/ml theshold Learn more about your ad choices. Visit megaphone.fm/adchoices

Giới Thiệu

Hello Everyone, My name is John Campbell and I am a retired Nurse Teacher and former clinical nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally. LinkedIn profile, https://www.linkedin.com/in/dr-john-campbell-5256223b/ Twitter, https://twitter.com/Johnincarlisle Disclaimer; These media including videos, book, e book, articles, podcasts are not peer-reviewed. They should never replace individual clinical judgement from your own health care provider. No media-based material on this channel is suitable for using as professional medical advice. All comments are also for educational purposed only and must never replace advice from your own health care provider

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