Morgellons Discussion

Jeremy Murphree

Jeremy Murphree discusses the latest research of Morgellons disease.

  1. New Morgellons Research? Say Whaaaaaaat! with Crystal Clear 🤯

    Apr 24

    New Morgellons Research? Say Whaaaaaaat! with Crystal Clear 🤯

    In this powerful crossover episode of Morgellons Discussion, host Jeremy Murphree sits down with Crystal Clear from the More Morgellons Podcast (moremorgellons.com) to break down the brand-new preprint study that’s sending shockwaves through the Morgellons community: “Metagenomics reveals a phylogenetically informed microbial signature associated with Morgellons disease” by Lambert and Kindschuh (bioRxiv, April 15, 2026). For years, patients have been told Morgellons is “all in their head.” This study says otherwise—loudly and with data. Using deep metagenomic sequencing on skin lesions from a family cohort, the researchers uncovered a distinct “shadow biome”: massive amounts of previously unclassified microbial DNA (61.4% unclassified non-human sequences in lesions vs. just 34% in healthy skin), a complete ecological takeover by Pseudomonadota and Bacteroidota, and a phylogenetically informed microbial signature tied directly to symptom severity. Even the infamous fibers? Confirmed as human keratin and collagen—not lint, not delusion. Jeremy and Crystal Clear unpack the methods, the groundbreaking findings, what the “Symptomatic Subtree” means for patients with fatigue and cognitive issues, and why this research finally gives the scientific community hard evidence that Morgellons is a real, biologically driven condition—not “delusional parasitosis.” If you’ve been fighting for answers, this episode is validation, hope, and the next chapter in the fight to be taken seriously. Listen now and share with anyone who still thinks Morgellons is “just mental.” Study breakdown: https://www.morgellons.io/new-research/new-metagenomic-evidence/ Correction from last night’s episode with Crystal Clear! 🎙️🧬 I wanted to clarify a detail regarding the paper I discussed: "Reframing delusional infestation: perspectives on unresolved puzzles." During the show, I mentioned it was published in the journal General Psychiatry (which previously held a high Impact Factor of 11.9, presently at 7). It was actually published in Psychology Research and Behavior Management. The "11.9" was on my mind because the authors (Lai, Xu, and Hu) are world-class researchers whose work often appears in General Psychiatry. I associated their high-caliber output with that specific journal’s impact factor. While the publication venue is different, the paper’s significance remains: it’s a major call for the medical community to stop dismissing patients and start looking at the "unresolved puzzles" of these symptoms through a more comprehensive, clinical lens. Accuracy is key when we're talking about real research. Thanks for tuning in! 🎧 Reframing delusional infestation: perspectives on unresolved puzzles - PMC#Morgellons #MedicalResearch #MorgellonsDisease #GeneralPsychiatry #ClinicalUpdate #FactCheck #CrystalClear You can reach Crystal Clear at her website More MorgellonsListen to Crystal Clear's podcast More Morgellons

    58 min
  2. Silenced by Similarity: How the Syphilis Comparison Shut Down Morgellons Research

    Apr 3

    Silenced by Similarity: How the Syphilis Comparison Shut Down Morgellons Research

    In February 2020, a groundbreaking peer-reviewed paper titled “Classification and Staging of Morgellons Disease: Lessons from Syphilis” dropped a bombshell. Researchers showed that Morgellons lesions mirror secondary syphilis in their wildly variable appearance, spirochetal burden (Borrelia in skin cells), and histopathological patterns. They even proposed a new staging system modeled directly on syphilis. Then… the information flow about Morgellons virtually stopped. No major new studies. Minimal mainstream coverage. Dermatology guidelines still call it delusional infestation. Even within the patient community, the full spirochetal picture — especially the syphilis parallels and visible fibers/sores — gets sidelined or ignored. In this episode, I break down the 2020 paper’s key findings, the suspicious silence that followed, and why almost nobody outside a small research circle wants to engage with this science. I also call out the gaps: the Charles E. Holman Foundation runs conferences and the Morgellons Lived Experience Project, but isn’t pushing the syphilis staging research hard enough through aggressive outreach. Meanwhile, some Lyme doctors like Daniel Cameron acknowledge crawling and biting sensations as neurologic Lyme symptoms, yet downplay the dermopathy, fibers, and full Morgellons picture. If Morgellons is another spirochetal infection like syphilis or chronic Lyme, patients deserve real testing, treatment discussions, and answers — not silence. Listen as we examine how the moment the science got too real, the conversation went quiet. Read the 2020 paper yourself (link below), demand better outreach from patient organizations, and help force this discussion back into the light. 2020 Paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC7012249/ Charles E. Holman Foundation: thecehf.org (support them… but push them for more outreach!) Daniel Cameron article on crawling sensations: danielcameronmd.com (example of narrowed view) Sources: Middelveen et al. 2020, CDC 2012 contrast, recent patient registry updates

    10 min
  3. Morgellons Disease: Bacterial Truth vs. Psychiatric Myth

    Jan 24

    Morgellons Disease: Bacterial Truth vs. Psychiatric Myth

    Morgellons is not a mystery; it is microbiology. In this 15-minute clinical briefing, host Jeremy Murphree strips away the stigma of "unexplained dermopathy" and replaces it with a concrete bacterial framework. For years, patients have been trapped in the "Delusional Parasitosis" (DP) label—a diagnostic dead end that halts medical investigation. Today, we turn the tide. In this episode, we cover: The Diagnostic Barrier: Why the DP label is used to gaslight patients and how to bypass the "negative test trap." The Spirochetal Link: Exploring the connection between Borrelia (Lyme Disease), Syphilis, and the cutaneous manifestations of infection. Biofilm Science: How mixed biofilms and proteins like β-amyloid protect pathogens from the immune system. The Middelveen Criteria: Breaking down the Stages A–C of infection and the truth about human biofilaments (keratin/collagen) vs. textile myths. Your Action Plan: How to find ILADS-trained doctors, demand "Direct Detection" (PCR/FISH) testing, and access financial aid. Stop fighting for belief and start fighting with biochemistry. Middelveen, M. J., et al. (2015). Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients. BMC Dermatology. Read the full study here. Key takeaway: Confirmed the presence of spirochetes in 24 out of 25 MD patients. Middelveen, M. J., et al. (2020). Classification and Staging of Morgellons Disease: Lessons from Syphilis. Clinical, Cosmetic and Investigational Dermatology. Read the full study here. Key takeaway: Establishes the Classes I-IV and Stages A-C framework used in the episode. Middelveen, M. J., & Stricker, R. B. (2016). Morgellons disease: a filamentous borrelial dermatitis. International Journal of General Medicine. Read the full study here. Key takeaway: Provides the histological proof that fibers are human biofilaments (keratin/collagen). Ekbom, K. A. (1938). Der prasenile Dermatozoenwahn. (The original study on "delusions" where subjects actually had syphilis). Vié, J. (1935). Les idées de possession et d'infestation parasitaires. (Early documentation of spirochetal links to parasitic delusions). The New Morgellons Movement - Free Morgellons Course The Charles E. Holman Morgellons Disease Foundation (CEHMDF): The leading source for MD research, patient education, and financial aid information. Visit thecehf.org. ILADS (International Lyme and Associated Diseases Society): For finding clinicians who specialize in complex tick-borne infections and intracellular-targeting protocols. Visit ilads.org. IU Indianapolis ScholarWorks: For accessing the latest posters and data on the diagnostic overlaps between DP and MD. Search the Repository. Tick-Borne Disease Working Group (TBDWG): 2020 Report to Congress. This report acknowledges the gaps in diagnosis and the need for better validation of Lyme-related conditions. Download the 2020 Report.

    10 min
  4. Utah State Morgellons Response

    04/20/2025

    Utah State Morgellons Response

    Brian Kirk’s video (https://www.youtube.com/watch?v=_SWGH_qr1rE&list=PL3nII97JiwYt359ydCh_z7c2qxk2_3u6l&index=16) about his college project to raise #Morgellons awareness is awesome—he’s giving a voice to folks dealing with something super tough. Morgellons brings weird fibers in skin sores, crawling or stinging feelings, plus exhaustion and achy joints, and it’s often dismissed as “all in your head.” Brian’s work shines a light on these struggles, showing how real they are for patients who feel ignored. But he missed mentioning #LymeDisease, and that’s a big deal because research ties it closely to Morgellons, offering clues to what’s really going on.Studies are flipping the old story that Morgellons is just psychological. A 2015 study found #Borrelia burgdorferi, the Lyme bacteria from tick bites, in 24 out of 25 Morgellons patients, using tests like PCR to spot it in skin or blood. Those fibers? Not clothes—they’re keratin and collagen, made by your body, likely reacting to the infection. Another study in 2018 saw 6% of 1000 Lyme patients with Morgellons symptoms, all testing positive for Borrelia, often with extra bugs like Babesia. This link suggests Morgellons isn’t random—it’s tied to Lyme for many, giving patients a starting point to seek help.Why This Changes EverythingKnowing Morgellons and Lyme are connected is a game-changer for people stuck in limbo. Patients often get told their sores and crawling sensations are imaginary, which is crushing when you’re living it. Finding Borrelia in most Morgellons cases proves there’s a real infection, not a delusion, giving folks hope and a reason to push for doctors who’ll dig deeper. It’s like finally having proof you’re not making it up, which can be a huge relief after being dismissed.This connection also points to better testing and treatment. Lyme’s hard to catch with standard blood tests, especially in chronic cases, but sensitive ones like PCR can find Borrelia in Morgellons patients, as that 2015 study showed. Antibiotics like doxycycline have helped some, like a woman in a 2021 case whose lesions cleared up fast. Plus, many Morgellons folks have other infections like Bartonella, so checking for those helps too. Brian’s project gets people talking, and adding the Lyme angle means more patients might get the right tests and meds, not just shrugs.Morgellons or Not?Figuring out if someone’s got Morgellons takes careful work, but doctors can do it by listening and checking the right things. Start with the patient’s story: Are there fibers in sores? Crawling sensations? Tiredness or aches? Ask about tick bites or time in Lyme-heavy areas, though lots of folks don’t recall a bite. Then check the skin—Morgellons fibers show up under a magnifying glass, stuck in lesions, made of body stuff like keratin, not random threads. A dermatologist can biopsy if needed to be sure.Next, test for Lyme with sensitive tools like PCR, since regular tests often miss chronic cases—that 2015 study nailed Borrelia in nearly every patient this way. Check for other tick bugs like Babesia too. If fibers aren’t there or tests are negative, consider scabies, allergies, or, only after ruling out infections, something psychological like delusional parasitosis. Don’t rush to that, though—Lyme can cause anxiety, and chronic symptoms stress anyone out. Brian’s video pushes for understanding, and getting the diagnosis right, with help from non-profits like the Charles E. Holman Morgellons Disease Foundation, means patients get answers, whether it’s Morgellons or something else.Middelveen MJ, et al. Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients. BMC Dermatology. 2015;15:1.https://bmcdermatol.biomedcentral.com/articles/10.1186/s12895-015-0023-0

    7 min

Ratings & Reviews

4.8
out of 5
5 Ratings

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Jeremy Murphree discusses the latest research of Morgellons disease.