No Priors: Artificial Intelligence | Technology | Startups

Conviction
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No Priors: Artificial Intelligence | Technology | Startups

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.

  1. HÁ 5 DIAS

    Building the Platform for Scientific Breakthrough, with Noubar Afeyan of Moderna and Flagship Pioneering

    This week on No Priors, Sarah sits down with Noubar Afeyan, Co-founder and CEO of Flagship Pioneering, the biotech firm behind groundbreaking companies like Moderna. They explore how Flagship creates the conditions for scientific breakthroughs, tackles regulatory uncertainty, and pushes the boundaries of discovery. Noubar shares insights on AI’s role in healthcare, the challenges of bringing new therapies to market, and lessons learned from past pandemics. He also discusses Flagship’s platform approach to biotech innovation and introduces the idea of polyintelligence. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @NoubarAfeyan Show Notes:  0:00 Introduction 0:48 Founding Flagship  5:51 Fostering environments for emergence 11:17 Expanding into new frontiers 14:26 Developing technology amid regulatory uncertainty and risk 19:12 How Flagship has evolved 22:47 AI applications in healthcare 27:30 Bottlenecks in bringing new therapies to market 32:20 Lessons for the next pandemic 34:11 Building a platform 38:10 Polyintelligence

    41min

  2. 25 DE FEV.

    Virtual Cell Models, Tahoe-100 and Data for AI-in-Bio with Vevo Therapeutics and the Arc Institute

    On this week’s episode of No Priors, Sarah Guo is joined by leading members of the teams at Vevo Therapeutics and the Arc Institute – Nima Alidoust, CEO/Co-Founder at Vevo Therapeutics; Johnny Yu, CSO/Co-Founder at Vevo Therapeutics; Patrick Hsu, CEO/Co-Founder at Arc Institute; Dave Burke, CTO at Arc Institute; and Hani Goodarzi, Core Investigator at Arc Institute. Predicting protein structure (AlphaFold 3, Chai-1, Evo 2) was a big AI/biology breakthrough. The next big leap is modeling entire human cells—how they behave in disease, or how they respond to new therapeutics. The same way LLMs needed enormous text corpora to become truly powerful, Virtual Cell Models need massive, high-quality cellular datasets to train on. In this episode, the teams discuss the groundbreaking release of the Tahoe-100M single cell dataset, Arc Atlas, and how these advancements could transform drug discovery. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @Nalidoust | @IAmJohnnyYu | @PDHsh | @Davey_Burke | @Genophoria Download the Tahoe Dataset Show Notes: 0:00 Introduction 1:40 Significance of Tahoe-100M dataset 4:22 Where we are with virtual cell models and protein language models 10:26 Significance of perturbational data 17:39 Challenges and innovations in data collection 24:42 Open sourcing and community collaboration 33:51 Predictive ability and importance of virtual cell models 35:27 Drug discovery and virtual cell models 44:27 Platform vs. single hypothesis companies 46:05 Rise of Chinese biotechs 51:36 AI in drug discovery

    58min

  3. 20 DE FEV.

    Building Hard Tech in Hard Markets: Kyle Vogt on Cruise, Twitch, and The Bot Company

    Kyle Vogt joins Sarah and Elad on this week’s episode of No Priors. A serial entrepreneur, Kyle co-founded Twitch, transforming live streaming, and later Cruise, the autonomous vehicle company acquired by GM for $1 billion. Now he’s taking on AI-powered home robotics with The Bot Company. In this episode, Kyle shares his journey building transformative tech companies, the challenges of scaling autonomous systems, and why he believes home robots are the next frontier. They also discuss the parallels between AVs and robotics, overcoming consumer skepticism, US vs. China manufacturing, and the policies needed to foster a competitive robotics industry. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @KVogt Show Notes:  0:00 Introduction 0:29 Founding Cruise  3:12 Tesla vs. Waymo approach 4:44 Scaling autonomous vehicles 10:03 The Bot Company  16:35 Deploying  robots in the home 17:56 Parallels between robots and AV markets 20:51 Personifying robots and overcoming consumer skepticism 25:00 Timeline on consumer robots 26:47 Chinese vs. US manufacturing  29:15 Fostering a competitive domestic robotics industry 34:00 Lessons from Cruise & personal philosophies

    38min

  4. 14 DE FEV.

    How Harvey AI is Changing the Legal Industry with Winston Weinberg

    This week on No Priors, Sarah sits down with Harvey cofounder and CEO Winston Weinberg. Harvey is one of the leading application layer AI companies, building domain-specific AI for law firms, professional service providers, and the Fortune 500. They are already working with companies like Bridgewater, KKR, PWC, and O’Melveny with over $500M in funding from OpenAI, Sequoia, Kleiner, GV and Elad and Sarah. In this episode, Sarah and Winston cover AI product strategy, the future of professional services, company values, keeping up with research, and the law industry of the future.  Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @WinstonWeinberg Show Notes:  0:00 Introduction 2:39 Harvey’s founding story  3:46 Capability improvement 6:39 Building teams around AI capabilities 9:17 End to end task completion 12:37 Beginning with large industry leaders 17:21 Working with users skeptical of automation 20:40 Being a lawyer today and in the future 26:02 Adapting product for other domains 26:58 Hiring philosophy at Harvey 30:39 Lessons and mistakes as a founder 32:53 Personal drive 40:21 Advice to other founders 44:35 Prediction for next ChatGPT moment

    50min

  5. 7 DE FEV.

    DeepSeek, Deep Research, and 2025 Predictions with Sarah and Elad

    This week on No Priors, Sarah and Elad celebrate the 100th episode! They dive into the biggest AI stories of 2025, breaking down DeepSeek—truth vs. hype, the rapid consumer adoption, and the real cost of training the models. They debate model commoditization and the value of being a frontier model provider vs. building on existing work. Plus, they unpack OpenAI’s new Deep Research release and the latest on Stargate. Finally, they share bold predictions for 2025, covering robots, autonomous vehicles, local AI models, emerging data-generation strategies, and reasoning breakthroughs. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil  Show Notes:  0:00 Introduction 0:19 DeepSeek  5:38 Are models commoditizing? 8:33 DeepSeek’s consumer adoption 9:16 OpenAI’s Deep Research release 13:30 Stargate 15:04 Elad & Sarah’s Predictions for 2025

    23min

  6. 30 DE JAN.

    Rick Caruso on LA’s Wildfires, Policy Failures, and the Path Forward

    This week on No Priors, Elad sits down with Rick Caruso, LA real estate developer and runner-up in the 2022 mayoral race. With experience serving under three LA mayors, as well as on the police commission and the board of water and power, Rick offers a unique perspective on the systemic failures that contributed to the devastation of the January 2025 wildfires in communities like the Palisades and Altadena. He discusses the steps he took to build more resilient infrastructure in his properties and how California can rebuild smarter to better prepare for future disasters. They also explore the state’s water management, rising crime, and how to leverage California’s vast natural resources and budget to create a better future for all residents. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @RickCarusoLA Show Notes 0:00 Introduction 0:56 Caruso’s history in business and public service 3:36 Failures in fire prevention and response 5:58 How Caruso’s properties survived  8:26 Water shortages and infrastructure failures  9:47 Arson, looting, and crime in LA 15:03 Rebuilding  20:50 Allocating California’s resources effectively 26:15 Caruso’s future plans

    27min

  7. 23 DE JAN.

    What Can We Do About Wildfires? With Convective Capital’s Bill Clerico

    This week on No Priors, Sarah and Elad sit down with Bill Clerico, founder of Convective Capital, an early stage venture fund focused on technology-driven solutions for wildfire mitigation and climate resilience. The wildfires in Los Angeles have caused unprecedented property damage and immense hardship for countless individuals and families. This episode is devoted to diving into understanding what happened and what we can do in the future. Bill shares his insights into the increasing severity of wildfires, the role of policy, and how infrastructure issues, like outdated building codes and underfunded utilities, are contributing to the crisis. They discuss the latest innovations in fire-fighting technology, from advanced detection to drones, and how these tools can help mitigate future damage. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @BillClerico Show Notes:  0:00 Introduction 1:02 Why are wildfires getting worse? 5:37 Policies and regulatory decisions 10:47 Housing: building codes and permitting 13:19 Key factors in response 16:20 Improving water supply and city infrastructure  19:10 Preventing wildfires 21:26 Underinvestment in California’s utilities 26:53  Innovative fire fighting technology 29:35 Accelerating Los Angeles’ recovery 34:29 Actions homeowners, insurance companies, and governments can take

    38min

  8. 16 DE JAN.

    How AI Agents Are Transforming Customer Support, with Decagon’s Jesse Zhang

    Today on No Priors, co-founder and CEO of Decagon, Jesse Zhang, joins Elad to discuss the future of agentic customer support. Decagon provides AI-powered customer interactions for companies like Rippling, Notion, Duolingo, Classpass, Substack, Vanta, Eventbrite, and more. Jesse shares the thesis behind starting Decagon, why he sees customer support as the ideal entry point for agentic technology, and what areas of AI excite him most. They also discuss voice-based interfaces, issues with latency in current capabilities, and the connection between young math olympiad communities and today’s AI startups. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @TheJesseZhang Show Notes:  0:00 Introduction  0:30 Starting Decagon  3:15 Business impact of adopting agents for customer support and customer ops 8:00 AI infrastructure and models for customer success agents 12:05 Voice-based capabilities and text-to-speech engines  15:00 Combatting latency  16:25 Crossover of math and AI communities 21:12 Exciting areas of AI  25:29 Strengths and weaknesses of agents

    30min
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At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.

Informações

  • Criado por
    Conviction
  • Anos de atividade
    2023 - 2025
  • Episódios
    105
  • Classificação
    Livre
  • Copyright
    © Copyright 2023 Conviction. All Rights Reserved.

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