Jess Mah has one of the wildest founder journeys in Silicon Valley. She taught herself to code at 10. Launched her first company at 11. Got into Berkeley at 16. Joined Y Combinator at 19. Landed magazine covers. Raised money. Built a company people said would “change everything.” And then it all collapsed. Jess ran out of money. Laid off her entire team. Fell into a long, brutal burnout that forced her to confront who she was when the hype disappeared. Most founders never talk about these moments. Jess does. Openly, fearlessly, and with a level of honesty you rarely hear from anyone who’s been placed on a pedestal that young. And that’s what makes this conversation special. This episode is raw, honest, energizing, and full of the kind of clarity that only comes from someone who’s lived through hype, collapse, reinvention, and purpose-driven building. Jess is one of the most multidimensional entrepreneurs I know, and I’m excited for you to hear this one. ⏱️ Timestamps 00:00 – The 996 debate and the myth of “hustle harder” 03:00 – How burnout really shows up 05:00 – Presence vs. productivity 06:00 – Meaning, fulfillment, and what we want at the end of life 08:00 – Why in-person connection still matters 09:00 – Vibes, energy, and choosing the right people 10:00 – Negativity, insecurity, and online projection 12:00 – Are we living through a once-in-a-generation moment 13:30 – Biotech, BCI, and the future of being human 15:00 – Emotional health, identity, and finding love 17:00 – Hobbies, flow states, and building a life outside work 19:00 – How Jess avoided being typecast as a founder 22:00 – Why mentorship is a lifelong process 24:00 – Meeting your heroes and learning from people “five levels up” 27:00 – Tough businesses and why biotech is brutal 29:00 – Reinvention and multi-industry curiosity 31:00 – Fertility, health, and the next wave of physical-world innovation 33:00 – Rare diseases, orphan drugs, and what Jess is building next 35:00 – Cancer research and “normalizing” tumors 38:00 – Longevity, clean living, microplastics 41:00 – Can humans live to 500 43:00 – China’s edge in AI and energy 45:00 – Aviation, rockets, and supersonic dreams 47:00 – Identity, judgment, and founder pressure 51:00 – Personal growth and generational trauma 54:00 – Parenting, boundaries, and becoming a better CEO 58:00 – The founder’s true journey: becoming a different version of yourself 1:02:00 – The future of education and AI tutors 1:06:00 – Nonprofits, AI leverage, and impact at scale 1:10:00 – The weirdest topics we nerd out on 1:14:00 – Consciousness, reincarnation, quantum intuition 1:17:00 – What Jess would tell her 19-year-old self If this episode resonated with you, share it with a founder who needs it. And if you want more conversations like this, subscribe and follow Not Another Podcast.