Outperform Cancer

Marybeth Gilliam

Actionable, anti-cancer strategies found in peer-reviewed, scientific research to improve cancer outcomes.

  1. The Cancer Test Too Many Patients Still Aren't Getting

    APR 16

    The Cancer Test Too Many Patients Still Aren't Getting

    In this episode, Marybeth speaks with Dr. Nathan Fowler, Chief Medical Officer of BostonGene and former Professor of Medicine at MD Anderson Cancer Center, about why biomarker testing is helping turn personalized medicine from an idea into a reality. They discuss what biomarker testing, tumor sequencing, liquid biopsy, and ctDNA actually mean, why this information can be critical to choosing the right treatment, and why too many patients still are not being tested. Dr. Fowler explains why he believes biomarker testing should happen as early as possible, how patients can advocate for themselves, how tumor testing differs from inherited genetic testing, and when repeat testing may be needed. He also shares a remarkable story of a patient with advanced lymphoma whose biomarker matched an experimental therapy and led to a complete remission that has lasted more than a decade. Topics discussed: What biomarker-driven care actually means Why tumor sequencing can change treatment decisions The difference between tumor testing and genetic testing When liquid biopsy and ctDNA may be useful How biomarker testing can open clinical trial options Why testing should happen earlier in cancer care How BostonGene is using AI to improve precision oncology If you found this valuable, LIKE, SUBSCRIBE, and SHARE to help others access life-saving information! Facebook: https://www.facebook.com/outperformcancer/ LinkedIn: https://www.linkedin.com/company/outperform-cancer/ Instagram: https://www.instagram.com/marybethgilliam/ Threads: https://www.threads.com/@marybethgilliam

    54 min
  2. Dr. Abby Overacre's Warning for Cancer Patients: Sucralose May Block Immunotherapy

    11/07/2025

    Dr. Abby Overacre's Warning for Cancer Patients: Sucralose May Block Immunotherapy

    What if something as small as the sweetener in your coffee could decide whether your cancer treatment works? In this episode, Dr. Abby Overacre, a microbiome and immunology researcher at the University of Pittsburgh Medical Center, discusses her team’s new findings published in Cancer Discovery: the common artificial sweetener sucralose can undermine immunotherapy effectiveness by disrupting the gut microbiome and depleting immune-fueling amino acids like arginine. Even modest use—about three packets of Splenda per day—was associated with faster tumor growth and poorer progression-free survival in both preclinical models and cancer patients. Dr. Overacre explains how the microbiome links diet to immune response, why natural sweeteners such as stevia and monk fruit appear safer, and how fiber-rich and fermented foods can support gut and immune health during treatment. She also shares emerging research into arginine and citrulline supplementation, fecal microbiota transplants (FMT), and how restoring microbial balance could improve outcomes across cancer types, including melanoma, lung, and liver metastases. Key takeaways: —Sucralose consumption can blunt immunotherapy response. —Gut microbiome diversity plays a pivotal role in cancer outcomes. —Fiber and fermented foods strengthen immune-microbiome synergy. —Arginine and citrulline may help restore immune cell metabolism. Patients can take concrete steps to protect their microbiome during therapy. “Just three packets of sucralose a day were enough to completely blunt immunotherapy response. Patients deserve to know this.” — Dr. Abby Overacre 🎧 Listen now and learn what every cancer patient on immunotherapy should know about artificial sweeteners. If you found this valuable, LIKE, SUBSCRIBE, and SHARE to help others access life-saving information! Facebook: https://www.facebook.com/outperformcancer/ LinkedIn: https://www.linkedin.com/company/outperform-cancer/ Instagram: https://www.instagram.com/marybethgilliam/ Threads: https://www.threads.com/@marybethgilliam Bluesky: https://bsky.app/profile/outperformcancer.bsky.social

    1h 9m
  3. Double Survival in Pancreatic Cancer: High-Dose IV Vitamin C Breakthrough in New Randomized Trial

    11/20/2024

    Double Survival in Pancreatic Cancer: High-Dose IV Vitamin C Breakthrough in New Randomized Trial

    NEW RESULTS. Dr. Joseph Cullen’s latest randomized clinical trial reveals double progression-free survival and double overall survival for pancreatic cancer patients when receiving high-dose vitamin C with standard chemotherapy. Additional clinical trial work by Dr. Cullen indicates this approach also improves survival in for glioblastoma. We reconnect with Dr. Joseph Cullen, a distinguished Professor of Surgery at the University of Iowa Carver College of Medicine, to discuss his seminal research newly published in Redox Biology. This important study not only confirms the promise shown in previous trials but significantly strengthens the evidence supporting IVC's role as a game-changing adjunctive treatment in cancer care. Dr. Cullen, who has led extensive clinical investigations including trials on glioblastoma, non-small cell lung cancer, and colorectal cancer, has observed consistent life-extending benefits across cancer types with the integration of IVC. These consistent outcomes underscore the transformative potential of high-dose vitamin C in enhancing the efficacy of conventional cancer therapies. With over 162 peer-reviewed papers and 32 book chapters to his name, Dr. Cullen's expertise continues to shape the future of oncology. His ongoing research at the University of Iowa Carver College of Medicine is advancing the understanding of how pharmacological ascorbate manipulates redox metabolism, paving the way for innovative and more effective cancer treatments. Tune in to learn how this groundbreaking trial is reshaping the narrative around cancer treatment and why Dr. Cullen's work holds profound implications for patients and the medical community alike.

    28 min

Ratings & Reviews

5
out of 5
8 Ratings

About

Actionable, anti-cancer strategies found in peer-reviewed, scientific research to improve cancer outcomes.

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