Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf

Kent Holtorf, MD

Join Dr. Kent Holtorf as he explore groundbreaking science, innovative therapies, and the future of health and aging. In each episode, he dives deep into the world of peptides—potent molecules that regulate immune function, boost cellular regeneration and optimize metabolism. Through conversations with leading experts, Dr. Holtorf explains how peptides differ from traditional hormones, their role in reversing chronic illness, and their potential to enhance sleep, brain function, and overall vitality. https://holtorfmed.com/ https://integrativepeptides.com/

  1. قبل ٨ ساعات

    Making the Connection - Looking at Unconventional Patterns to Solve Autoimmune Disorders

    Reversing autoimmunity isn’t about chasing perfect lab numbers. It’s about teaching your immune system how to find balance again. In this episode of Peptides and Longevity, Elizabeth Tringali joins us to reveal how small, strategic steps like the right peptides, detox support, and food choices can quiet flares, rebuild energy, and help you feel like yourself again. ---- Elizabeth Tringali is a Board-Certified Physician Assistant and a Diplomate of the American Academy of Anti-Aging Medicine. A graduate of the University of Florida, she began her career in nutrition science and research with the Women’s Health Initiative, an experience that shaped her lifelong passion for holistic, patient-centered care. Blending her roots in nutrition with advanced training in anti-aging and regenerative medicine, she has spent more than two decades helping patients uncover the root causes of fatigue, hormone imbalance, and autoimmune conditions. Known for combining natural therapies with cutting-edge medical innovations, she creates personalized healing plans that restore energy, balance, and long-term wellness. ---- Elizabeth Tringali, PA-C Website: tringali-health.com Instagram: instagram.com/etringali Facebook: facebook.com/elizabeth.tringali.2025/ LinkedIn: linkedin.com/in/elizabeth-tringali-pa-c-0010a523 ---- Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠ ---- Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

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  2. ٢٢ أكتوبر

    The Underpinnings of Aging and What to Do About It

    The secret to living better for longer starts with removing the cells that make you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver pulls back the curtain on senolytics, showing how to clear senescent cells and build you back up with mitochondria, hormones, and targeted peptides. Want to age in reverse? Start by clearing out the cells making you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver reframes longevity around one simple idea, which is that you remove what ages you and then rebuild what keeps you young. He explains how senescent cells accumulate, why they become inflammatory factories, and how fasting and senolytics can clear the backlog. He then shows how to protect and upgrade mitochondria, why telomeres work as a useful marker rather than a destiny, and where peptides belong. The result is a stepwise, precision plan that starts with clearance, moves into cellular energy, and finishes with targeted repair for brain, skin, hair, and whole-body performance. Watch the full episode now and learn how to start clearing the cells that make you old. Dr. Joseph Cleaver is a board-certified internist and fellow in anti-aging and metabolic medicine who blends preventive lifestyle medicine, regenerative therapeutics, and peptide science. He teaches clinicians nationwide and sees patients through the Paradigm Wellness Medical Group. He also hosts small-group masterminds on longevity and regenerative medicine at his winery in Sonoma. Dr. Joseph Cleaver Website: www.pwmgmed.com Integrative Peptides Website: ⁠⁠⁠⁠⁠⁠https://integrativepeptides.com/⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠⁠⁠⁠⁠ ---- Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠ ---- Produced by DrTalks ⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

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  3. ٨ أكتوبر

    Secrets to Fatigue, Brain Fog, Mood Disorders, Chronic Pain

    This protocol helps even the most sensitive patients move forward. In this episode of Peptides and Longevity, Dr. Christopher Wakely joins us to lay out a roadmap for complex chronic illness that involves opening detox pathways, restoring immune tolerance, and tackling infections and toxins. Watch now to get practical tips on reading basic tests and knowing when to add peptides, neural therapy, ozone, hypercoagulation support, and even strategies for kids with PANS/PANDAS. ----- Still stuck? This doctor’s roadmap skips the guesswork. In this episode of Peptides and Longevity, Dr. Christopher Wakely joins us to share a clear plan for tackling complex chronic illness. He explains why treatment must start by ‘opening the drains’ or helping the liver, gut, kidneys, and brain move toxins out. He also shows how simple labs and natural killer cell testing can guide what to treat first, saving time and money. Dr. Wakely also dives into restoring immune balance, using binders safely, and choosing the right tools at the right time. You will hear about drainage remedies, herbs, neural therapy, peptides, ozone, and other strategies designed to help patients heal without big flares. If you’ve felt stuck or flared with every new protocol, this episode is for you. ----- Dr. Christopher Wakely is a naturopathic physician and the owner of Aster Integrative Medicine in Edmonds, Washington. Known for helping patients who have seen countless doctors without answers, he specializes in complex chronic illness, including tick-borne diseases, mycotoxin illness, chemical sensitivity, and autoimmune conditions. Dr. Wakely blends the best of conventional and naturopathic care. His approach includes targeted detox and drainage, immune system retraining, herbal and homeopathic therapies, peptides, nutritional support, and, when needed, pharmaceuticals—always to help patients heal safely and sustainably. When he’s not in the clinic, he enjoys life in Seattle with his wife and two daughters, hiking, weightlifting, reading, and cheering on the Boston Red Sox. ----- Christopher Wakely, ND Website: https://www.drwakely.com/ LinkedIn: https://www.linkedin.com/in/christopher-wakely-8a906369/ ----- Integrative Peptides Website: ⁠⁠⁠https://integrativepeptides.com/⁠⁠⁠ Facebook: ⁠⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠⁠ Instagram: ⁠⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠⁠ ---- Holtorf Medical Group Website: ⁠⁠⁠https://holtorfmed.com/⁠⁠⁠ Facebook: ⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠ Instagram: ⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠ ---- Produced by DrTalks ⁠⁠⁠https://drtalks.com/podcast-service/

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  4. ١ أكتوبر

    The Metabolic Code®: A Roadmap to Real Results

    If your protocol isn’t working, you might be starting in the wrong place. In this episode of Peptides and Longevity, Dr. Kelly Halderman joins us to explain how the Metabolic Code® helps decode your unique biochemistry into simple TRIADS™, revealing where to focus first so protocols don’t stall. She shares her personal recovery story and the often-missed detox step that opens up healing and turns scattered data into an actionable plan. ---- If your detox isn’t working, it might be your bile. Here’s how to fix it. In this episode of Peptides and Longevity, Dr. Kelly Halderman shows how the Metabolic Code® combines symptom questionnaires with key tests to map five interconnected TRIADS™ in the body. This map gives patients and clinicians a clear starting point, helps target the right nutraceuticals and peptides, and provides measurable feedback so progress doesn’t feel like guesswork. Dr. Halderman also shares her own journey from being bedridden and misdiagnosed to reclaiming her health through nutrition, detox, and root-cause thinking. One of her biggest breakthroughs is fixing bile flow to reopen the body’s toxin highways and reduce systemic inflammation. With better detox and precise personalization, patients can stop spinning their wheels, and practitioners can finally deliver the results they’ve been chasing. ---- Dr. Kelly Halderman is a physician and clinical nutritionist with a uniquely broad background in medicine, research, and nutraceutical innovation. She currently serves as Chief Health Officer at Weo. Her career includes academic roles such as adjunct professor at North Central University and instructor for the American Heart Association, as well as advanced training in functional neurology, plant-based nutrition, and neurofeedback. Dr. Halderman earned her MD from SABA University School of Medicine, completed family practice training at the University of Minnesota, and holds a Doctorate in Clinical Nutrition. Passionate about translating complex science into actionable care, she is known for making precision health accessible and helping both patients and practitioners move beyond guesswork toward measurable, personalized results. ---- Kelly Halderman, DCN Website: https://drkellyhalderman.com/ Instagram: https://www.instagram.com/nutraceuticalformulators/ LinkedIn: https://www.linkedin.com/in/dr-kelly-halderman-b8253346/ ----- Integrative Peptides Website: ⁠⁠https://integrativepeptides.com/⁠⁠ Facebook: ⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠ Instagram: ⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠ ---- Holtorf Medical Group Website: ⁠⁠https://holtorfmed.com/⁠⁠ Facebook: ⁠⁠https://www.facebook.com/holtorfmed/⁠⁠ Instagram: ⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠ ---- Produced by DrTalks ⁠⁠https://drtalks.com/podcast-service/

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  5. ٢٤ سبتمبر

    The Brain and Gut Connection

    Leaky gut isn’t just about digestion—it’s also messing with your brain. In this episode of Peptides and Longevity, Kiran Krishnan, a research microbiologist, breaks down the gut–brain connection and why a leaky gut can fuel inflammation, brain fog, and mood issues. He also reveals groundbreaking research on spore-based probiotics—how they repair the gut lining, calm inflammation, and may even help reprogram metabolism for better energy and body composition. ----- A mass extinction is happening inside your gut—and it’s fueling everything from brain fog to autoimmunity. In this episode of Peptides and Longevity, Kiran Krishnan explains why the microbiome is not just trillions of organisms, but a vast genetic toolkit that powers most of our body’s chemistry. He warns that modern living is driving a ‘mass extinction’ of gut species, weakening immune training, fueling leaky gut, and setting the stage for allergies, autoimmunity, and chronic illness. Krishnan then connects the dots to the brain, showing how toxins from a leaky gut trigger inflammation, brain fog, mood issues, and even neurodegeneration. He shares evidence on how spore-based probiotics restore gut diversity, strengthen keystone species, repair the gut barrier, and lower inflammatory markers—sometimes in as little as a month. Krishnan also highlights a pilot study where spores and prebiotics reduced visceral fat and improved insulin health without diet changes, pointing to true ‘metabolic reprogramming.’ He wraps up with a reality check on overhyped probiotics and testing, urging a smarter, science-based approach to gut health. ----- Kiran Krishnan is a research microbiologist with over two decades of experience in the field of nutrition and supplements. Trained in molecular medicine and microbiology at the University of Iowa, he went on to hold leadership roles in global product development before becoming General Manager of Novozymes One Health America, Microbiome Labs. A sought-after speaker at medical and nutrition conferences, he is known for making complex science on the human microbiome practical and accessible. He is actively involved in more than a dozen human clinical trials, serves on multiple scientific advisory boards, and holds peer-reviewed publications and global patents in probiotic and microbiome research. ----- Kiran Krishnan Website: https://microbiomelabs.com/home/ Instagram: https://www.instagram.com/kiranbiome/ Facebook: https://www.facebook.com/kiran.krishnan.9279 LinkedIn: https://www.linkedin.com/in/kiran-k-b302147/ ----- Integrative Peptides Website: ⁠https://integrativepeptides.com/⁠ Facebook: ⁠https://www.facebook.com/integrativepeptidesofficial/⁠ Instagram: ⁠https://www.instagram.com/integrativepeptides/⁠ ---- Holtorf Medical Group Website: ⁠https://holtorfmed.com/⁠ Facebook: ⁠https://www.facebook.com/holtorfmed/⁠ Instagram: ⁠https://www.instagram.com/holtorfmedicalgroup/⁠ ---- Kent Holtorf, MD YouTube: ⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠ ---- Produced by DrTalks ⁠https://drtalks.com/podcast-service/

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  6. ١٧ سبتمبر

    Solutions to Orthopedic and Musculoskeletal Conditions

    Want to heal injuries faster, bounce back from surgery stronger, or even slow aging with your body’s own healing signals? In this episode of Peptides & Longevity, Dr. R. David Calvo reveals how he uses peptides and regenerative therapies to supercharge recovery, protect joints, and help patients feel decades younger. ---- Dr. R. David Calvo spent decades as a high-volume orthopedic surgeon before realizing that surgery alone wasn’t enough. So he began exploring regenerative medicine, using platelet-rich plasma, bone marrow, fat-derived stem cell products, and later peptides, to improve not just surgical outcomes, but overall vitality. What he discovered transformed both his patients’ results and his own health: by optimizing the “terrain” of the body, recovery accelerates and performance rebounds. In this episode of Peptides & Longevity, Dr. Calvo joins us to explain how he now uses targeted peptides alongside regenerative procedures to help patients heal faster, sleep better, and stay strong as they age. He also shares real-world cases of athletes bouncing back from injuries in record time, surgical wounds closing faster, and patients regaining energy and focus by supporting their mitochondria and hormones. His message is simple yet powerful: you don’t have to accept decline—if you give your body the right signals, it can repair itself. ---- Dr. R. David Calvo is a board-certified orthopedic surgeon and sports medicine expert with over three decades of experience caring for athletes from high school to professional levels. After decades in surgical practice, he shifted his focus to preventative, regenerative, and anti-aging medicine—founding Texas Center Wellness in Austin, Texas. Trained through the American Academy of Anti-Aging Medicine and the Age Management Medicine Group, Dr. Calvo now helps patients worldwide through telemedicine, using cutting-edge therapies like peptides, stem cells, exosomes, platelet-rich plasma, and bioidentical hormones to accelerate healing, enhance longevity, and optimize human performance. ---- R. David Calvo, MD Website: https://texascenterwellness.com/ LinkedIn: https://www.linkedin.com/in/dr-david-calvo-698b541a/ ---- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

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  7. ١٠ سبتمبر

    Combatting Environmental Toxins With Peptides

    What if your lingering fatigue, brain fog, or pain isn’t ‘just in your head’ but the result of hidden biotoxins disrupting your immune system and energy production? In this episode of Peptides & Longevity, Dr. Cory Tichauer unpacks the complex world of biotoxin illness—from mold and heavy metals to chronic infections—and shares how accurate testing, binder strategies, and targeted peptides can restore balance, repair mitochondria, and help you reclaim lasting health. It’s not just mold—it’s mold plus metals, infections, and a body stuck in survival mode. In this episode of Peptides & Longevity, Dr. Cory Tichauer joins us to explain that biotoxin illness is rarely just about mold—it’s the combined effect of environmental toxins like pesticides, heavy metals, and solvents, along with hidden infections such as Lyme. For some people, genetic patterns make it harder to clear these toxins, trapping them in a cycle of chronic inflammation that disrupts hormones, damages mitochondria, and fuels symptoms like fatigue, brain fog, pain, and sleep issues. He connects this to the ‘cell danger response,’ where overwhelmed cells shut down energy production and repair in an attempt to protect themselves—leaving patients stuck in survival mode. Dr. Tichauer’s treatment approach follows a seven-step roadmap: remove exposures, stop toxins from recirculating with binders and bile support, and then restore balance step by step. Peptides play a key role in calming inflammation, repairing tissue, and helping the immune and hormonal systems reset—offering patients a path to true recovery when standard medicine falls short. Watch the episode now to learn how to break free from the cycle of toxins and reclaim your health. Dr. Cory Tichauer is a naturopathic physician and founder of Bear Creek Naturopathic Clinic in Medford, Oregon. With a background in neurobiology and medical training focused on integrative and functional care, he has spent almost two decades treating complex chronic conditions. His clinical expertise spans tick-borne infections, mold and biotoxin illness, autoimmune disorders, and neurodegeneration.  A member of both the International Lyme and Associated Diseases Society and the International Society for Environmentally Acquired Illness, Dr. Tichauer is recognized for his systems-based approach, which combines thorough diagnostic workups with targeted therapies to restore immune regulation, mitochondrial health, and neuroendocrine balance. Today, he is recognized for integrating peptides into biotoxin and chronic illness protocols to help patients recover when standard treatments have failed. Dr. Cory Tichauer Website: https://www.bearcreekclinic.com/ Instagram: https://www.instagram.com/bearcreekclinic/ Facebook: https://www.facebook.com/bearcreekclinic Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

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  8. ٣ سبتمبر

    How Hydrogen Gas Affects Peptides

    Can drinking hydrogen water really restore your gut, boost your mitochondria, and slow aging? In this episode of Peptides & Longevity, Dr. Paul Barattiero joins us to explain the history of hydrogen water, its medical applications, and current research. We discuss how molecular hydrogen functions as a selective antioxidant and impacts pathways, telomerase, and mitochondria.  Dr. Barattiero emphasizes the importance of gut terrain: after antibiotics and environmental chemicals, restoring the gut’s electrical potential and microbial balance is essential, and dissolved hydrogen may support this process. He suggests mimicking natural gut fermentation by drinking hydrogen water several times per day. He also touches on spacing hydrogen from ozone therapy, field experiences ranging from energy and sleep to vision and reflux anecdotes, and briefly outlines his team’s electromagnetic field solution that depolarizes radiation and lowers signal strength in a defined area. Dr. Paul Barattiero is a leading voice in the field of molecular hydrogen and the founder of Echo Water. His journey began nearly two decades ago when his wife’s chronic illnesses weren’t improving with conventional medicine. After discovering the power of dissolved hydrogen in water, he dove deep into the research and witnessed firsthand the profound impact it had on her health. Inspired by her transformation, he dedicated his career to advancing hydrogen technology and making it accessible for both patients and practitioners. Today, he develops innovative solutions that support gut health, reduce oxidative stress, and even protect against electromagnetic fields. ----- Dr. Paul Barattiero Website: https://echowater.com/ Instagram: https://www.instagram.com/echohydrogen/?hl=en LinkedIn: https://www.linkedin.com/company/echohydrogen/ Facebook: https://www.facebook.com/echohydrogen ----- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

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Join Dr. Kent Holtorf as he explore groundbreaking science, innovative therapies, and the future of health and aging. In each episode, he dives deep into the world of peptides—potent molecules that regulate immune function, boost cellular regeneration and optimize metabolism. Through conversations with leading experts, Dr. Holtorf explains how peptides differ from traditional hormones, their role in reversing chronic illness, and their potential to enhance sleep, brain function, and overall vitality. https://holtorfmed.com/ https://integrativepeptides.com/

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