Peptides Explained

John Garrett

Peptides Explained breaks down the most talked-about peptides and GLP-1 medications in health, fitness, and longevity — including semaglutide, tirzepatide, BPC-157, TB-500, and more. Hosted by Registered Nurse John Garrett, this podcast explains how these compounds work, why they're popular, what the research shows, and the real risks and side effects — all in plain language. No bro science. No hype. Just clear, foundational education. For informational purposes only. Not medical advice. For Research Peptides; Offlinepeptides.com/ref/johngarrett/ https://www.skool.com/peptides-explained-15

  1. 14h ago

    Follistatin Explained: Can You Really Remove the Muscle-Growth Brake?

    Follistatin can bind myostatin—one of the body's major restraints on skeletal-muscle growth. Animal studies are dramatic, and small human gene-therapy studies have produced encouraging signals in serious muscle disease. But is a vial labeled "Follistatin-344" equivalent to the therapy used in those trials? John Garrett explains FST288, FST315, and FST344; the myostatin/activin pathway; the difference between gene therapy and recombinant protein; the evidence for muscle size versus function; and the key safety and product-identity questions. Follistatin is not an FDA-approved muscle-building medication. Educational content only; not medical advice. Explore the free Peptides Explained app: https://app.peptidesexplained.info

  2. 14h ago ·  Bonus

    You Might Enjoy: On Purpose with Jay Shetty

    Introducing SYLVESTER STALLONE: “I Wasn’t Stupid. I Was Just Misunderstood.” from On Purpose with Jay Shetty. Follow the show: On Purpose with Jay Shetty Jay sits down with Sylvester Stallone to trace the extraordinary journey from a painful, unwanted childhood to the creation of Rocky, and the $360,000 offer he turned down rather than compromise his self-respect. Stallone reflects on the decades of rejection, health struggles, and career setbacks that shaped the man behind the legend. He opens up about his mother’s emotional distance, his father’s advice on his deathbed, and the life philosophy he discovered only after letting go of the need to constantly fight. With Love and Gratitude, Jay Shetty Mazda crafts cars for people who do more than simply move. Visit Mazdausa.com to learn more. Consumer reports does not endorse products or services. JAY'S DAILY WISDOM DELIVERED STRAIGHT TO YOUR INBOX Join 900,000+ readers discovering how small daily shifts create big life change with my free newsletter. Subscribe here: https://news.jayshetty.me/subscribe Check out our Apple subscription to unlock bonus content of On Purpose! https://lnk.to/JayShettyPodcast What We Discuss: 00:00 Introduction 01:09 The Steps 01:48 The Fortune Teller Who Predicted His Future 03:39 The Power of Writing Your Thoughts Down 05:10 The Regret of Not Meeting Elvis Presley 05:55 Overcoming His Fear of Public Speaking 08:30 Birth Complications & Childhood Hardships 10:00 Queens Boarding House 11:40 Cinema As Sanctuary 13:23 The Words That Left Internal Scars 14:54 Making Peace With Rejection & "Mirror Therapy" 19:15 Writing About Edgar Allan Poe & Creating Rocky 20:27 Using Cruel Labels As Motivation 24:25 The Hells Angels Story 27:59 Turning Down $360,000 To Sell Rocky 31:35 Imposter Syndrome & Stepping Into Rocky's Shoes 33:29 Channeling Real-Life Pain In Acting 38:00 Rocky As A Love Story 41:26 The Painful Relationship With His Mother 49:45 Parents' Final Days 53:47 Learning To Let Go of Anger 56:12 An 8-Year Career Slump & The Return Of Rocky 59:06 Health Battles, Borrowed Time & Aging Gracefully 01:02:20 What Makes A Good Friend? 01:03:25 The Key To 29 Years of Marriage 01:07:30 Life Before Vs. After 40 01:13:20 The Power Of Dreams & Concrete Vision 01:16:38 Finally Getting His Father's Apology 01:19:35 Sylvester Stallone On Final 5 Episode Resources: The Steps | https://www.barnesandnoble.com/w/the-steps-sylvester-stallone Website | https://sylvesterstallone.com/ Instagram | https://www.instagram.com/officialslystallone Facebook  | https://www.facebook.com/share/1FMjtjkWJA/?mibextid=wwXIfr Learn more about your ad choices. Visit podcastchoices.com/adchoices DISCLAIMER: Please note, this is an independent podcast episode not affiliated with, endorsed by, or produced in conjunction with the host podcast feed or any of its media entities. The views and opinions expressed in this episode are solely those of the creators and guests. For any concerns, please reach out to team@podroll.fm.

    You Might Enjoy: On Purpose with Jay Shetty

  3. 2d ago

    Glutathione: The "Master Antioxidant" — or Master Marketing?

    Glutathione gets called the "master antioxidant," and the underlying biology really is important. But does that mean oral supplements, liposomal products or glutathione IVs deliver the sweeping detox, energy, immune and anti-aging benefits often attached to them? John breaks down glutathione biology, the GSH/GSSG cycle, oral human data, NAC, skin-related research and the gap between changing a biomarker and changing a meaningful health outcome. The episode also covers the 2026 FDA warning and recalls involving compounded injectable glutathione and elevated endotoxin levels. The key question: where does established biology end and wellness marketing begin? Educational only. Not medical advice.

  4. Sep 23

    GLP-1 Split Dosing: This Is NOT Microdosing

    For more information on Research Peptides go to PeptidesExplained.info/OfflinePeptides Is taking smaller GLP-1 doses multiple times per week actually "microdosing"? Not necessarily. This episode separates split dosing from true dose reduction and explains the pharmacokinetic logic using semaglutide, tirzepatide, and retatrutide. John breaks down half-life, peaks, troughs, total exposure, and why changing the schedule does not automatically mean using less drug. We also examine the major evidence gap: once-weekly dosing has a strong clinical foundation for semaglutide and tirzepatide, while retatrutide remains investigational — and direct randomized evidence showing routine split dosing is superior is not established. Educational only. No individualized dosing protocols are provided.

  5. Sep 21

    Icotyde: The Oral Peptide That Could Change Medicine

    Download The Peptide App at ThePeptide.App/Explained For more information on research peptides check out PeptidesExplained.info/OfflinePeptides A peptide…in a pill? Icotyde, or icotrokinra, is an FDA-approved oral peptide designed to block the IL-23 receptor in moderate-to-severe plaque psoriasis. In Phase 3 trials, it produced substantial skin clearance and outperformed an established oral comparator on several key endpoints. But the biggest story may be the delivery platform itself. Peptides usually struggle to survive the digestive tract and reach circulation. Icotyde shows what can happen when medicinal chemistry, structural engineering and extreme receptor potency come together. This episode breaks down what worked, what the safety data show, and what this does—and does not—mean for the future of oral peptides. Educational only. Not medical advice.

  6. Sep 16

    Why Your Favorite Peptides May Never Get a Big Human Trial

    If BPC-157, TB-500, KPV, MOTS-C and similar peptides are so interesting, why don't we have giant randomized human trials? This episode looks at the less dramatic—and more important—answer: clinical trials require a sponsor, regulatory strategy, manufacturing package, defined indication, safety program, and a very large amount of money. For old, easily copied, poorly protected, or commercially fragmented compounds, the incentive to fund definitive trials may be weak. John also explains why that does not excuse the evidence gap. "No Phase 3 trial" is not proof that a peptide works. It simply means confidence should remain limited until better evidence exists. Educational only. Not medical advice.

  7. Sep 14

    The Hollywood Trinity Stack: What Happened When I Tried It

    Download The Peptide App @ ThePeptide.App/Explained For more info on research peptides visit PeptidesExplained.info/OfflinePeptides John Garrett shares his N=1 experience with the so-called "Trinity Stack"—established TRT, retatrutide, and tesamorelin—combined with resistance training, Zone 2 cardio, high protein intake, creatine, sauna, and cold plunging. The transformation was dramatic. But what likely came from appetite control? What helped preserve muscle? What might the GH/IGF-1 axis have added? And how much credit belongs to the boring fundamentals? This is a candid personal testimony and accessible science breakdown—not a deep dive, a dosing guide, or a warning lecture. John also explains what happened during an eight-week break and why he recently restarted with a goal of reaching 10% body fat. Educational only. Retatrutide remains investigational and is not FDA-approved.

  8. Sep 9

    SNAP-8: Is "Botox in a Bottle" Real?

    SNAP-8 is a synthetic cosmetic octapeptide marketed for expression lines and frequently called "Botox in a bottle." John Garrett, RN, breaks down the SNAP-25 and SNARE-complex mechanism, the difference between topical SNAP-8 and injected botulinum toxin, the skin-penetration problem, the Argireline evidence, a small 2024 microneedle combination study, safety, and the limits of the current human data. The mechanism is plausible. The evidence is not strong enough to call it a needle-free Botox equivalent. Educational content only; not medical advice.

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4.5
out of 5
30 Ratings

About

Peptides Explained breaks down the most talked-about peptides and GLP-1 medications in health, fitness, and longevity — including semaglutide, tirzepatide, BPC-157, TB-500, and more. Hosted by Registered Nurse John Garrett, this podcast explains how these compounds work, why they're popular, what the research shows, and the real risks and side effects — all in plain language. No bro science. No hype. Just clear, foundational education. For informational purposes only. Not medical advice. For Research Peptides; Offlinepeptides.com/ref/johngarrett/ https://www.skool.com/peptides-explained-15

Information

  • Creator
    John Garrett
  • Years Active
    2026
  • Episodes
    56
  • Rating
    Explicit
  • Copyright
    © 2026
  • Show Website
    Peptides Explained

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