Personal Genomics Zone

Manuel Corpas
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  • TECHNOLOGY

Why does 81% of genomic research exclude most of humanity? Dr. Manuel Corpas examines how genomic diversity--or its absence--shapes the future of precision medicine. Exploring health equity metrics (HEIM), pharmacogenomics, and the global infrastructure needed to make genomic medicine work for everyone, not just a few. Featuring insights on building inclusive genomic research across Latin America, the Middle East, and beyond.

  1. 2D AGO

    Vibe Coding: How I Built AI Research Infrastructure Without Engineering Training

    How I built a complete AI research infrastructure -- from personal knowledge base to automated pipelines -- without software engineering training. Practical lessons on vibe coding, the six-layer RAG architecture, and leveraging domain expertise to build tools that matter.

    16 min

  2. 3D AGO

    How to Learn AI With AI: 7 Actionable Insights for Researchers

    Seven actionable insights for researchers on using AI as a learning partner: pair-programming with LLMs, handoff documents, project organisation, autonomous agents, voice interfaces, AI-to-AI orchestration, and context-first prompting.

    18 min

  3. 5D AGO

    10 Tips for Becoming a Top 1% AI User

    What separates casual AI users from the top 1%? Drawing on lessons from building a personal agentic AI system over six months and insights from Calvin French-Owen (co-founder of Segment, former OpenAI Codex team), this episode covers ten practical strategies: building persistent memory systems, mastering context management, test-driven AI workflows, moving from chatbots to agents, automating intelligence pipelines, clearing context aggressively, thinking like an engineering manager, keeping your workspace clean, shipping citable artifacts weekly, and building for sovereignty over your own AI.

    18 min

  4. 6D AGO

    Genetic Diseases in the Era of Precision Medicine

    A 71-minute lecture on how genomics is transforming medicine from trial-and-error to targeted, predictive care. Covers the paradigm shift from population averages to personalised treatment, variant interpretation using ACMG guidelines, the distinction between Mendelian and complex diseases, genome-wide association studies, and next-generation sequencing. Examines the critical equity gap: 86% of genomic research participants are of European ancestry yet Europeans represent only 16% of the global population. Introduces the HEIM framework for quantifying genomic data representativeness. Includes pharmacogenomics, liquid biopsy, direct-to-consumer testing, and ethics of genomic data. Delivered at the University of Westminster, 30 January 2026.

    1h 11m

  5. FEB 4

    Building an Agentic AI System: Lessons from Six Weeks in Production

    A practical walkthrough of building a personal agentic AI system that runs at production scale. Covering architecture (ChromaDB, Voyage AI, tiered Claude models), a nine-tool Telegram agent called RoboTerri, six automated daily jobs including ArXiv paper digests and podcast intelligence, cost engineering with three-tier model routing, and seven lessons learned from six weeks of autonomous operation.

    25 min

  6. JAN 25

    Why LLMs Can Hurt Your Academic Writing If You Trust Them Too Much

    I spend many hours working with LLMs to help me support my academic writing. This post summarises what I have learned. If you are using LLMs to help write academic papers, grant applications, or technical reports, these observations might save you from some painful mistakes.

    22 min

  7. JAN 18

    Quantitative Confidence: Navigating Uncertainty in Genomics and Precision Medicine

    A deep dive into quantitative confidence in genomics and precision medicine — exploring confidence intervals, p-values, Bayesian methods, calibration, and why honest uncertainty quantification is essential for good science and patient care.

    18 min

  8. 12/10/2025

    Missing Pieces: Why Genomic Diversity Is the Key to Better Science

    Presented at the UK-Indonesia Health Genomics Forum, London, 25 November 2025. When we speak about the future of precision medicine, it is easy to focus on the technology. Yet the real foundation of precision medicine is something much more fundamental.

    11 min
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About

Why does 81% of genomic research exclude most of humanity? Dr. Manuel Corpas examines how genomic diversity--or its absence--shapes the future of precision medicine. Exploring health equity metrics (HEIM), pharmacogenomics, and the global infrastructure needed to make genomic medicine work for everyone, not just a few. Featuring insights on building inclusive genomic research across Latin America, the Middle East, and beyond.

Information

  • Creator
    Manuel Corpas
  • Years Active
    2017 - 2026
  • Episodes
    18
  • Rating
    Clean
  • Copyright
    © (CC-BY-3.0)
  • Show Website
    Personal Genomics Zone