Personal Genomics Zone

Manuel Corpas
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AI agents, genomic equity, and the future of bioinformatics. Dr. Manuel Corpas explores agentic genomics, autonomous pipelines, health equity metrics, and building inclusive research infrastructure for precision medicine worldwide.

  1. 5D AGO

    Agentic Genomics: From Pipeline Automation to Autonomous Validation

    What happens when AI agents can autonomously discover, execute, and chain genomic analyses using natural language? This episode introduces the concept of agentic genomics and explores how it is reshaping who can do genomics, how fast, and what questions they can ask. We examine the emerging ecosystem of agentic systems, the critical validation challenges they create, the equity implications of automating genomic analysis at scale, and a five-principle framework for responsible adoption. Based on a Perspective submitted to a leading genomics journal.

    18 min

  2. APR 1

    ClawBio: A Four-Lens Evaluation — Funder, CEO, Scientist, Technologist

    A comprehensive evaluation of ClawBio from four perspectives: funder, CEO, scientist, and technologist. Covers strengths, weaknesses, opportunities, and a detailed roadmap from April to December 2026.

    20 min

  3. MAR 31

    I Run My Research Lab With AI Agents

    Everyone talks about AI agents. Almost nobody shows what happens when you wire them into your daily work. Four AI agents, a shared memory system, and three months of real results: 4 papers submitted, 15 PRs audited, a hackathon organised, and third place at Encode London. What worked, what failed, and what it means for the future of research. Full written version: https://manuelcorpas.substack.com/p/i-run-my-research-lab-with-ai-agents

    8 min

  4. MAR 29

    Benchmarking LLMs for Biobank Knowledge: Can AI Really Understand Medical Data?

    Can large language models like ChatGPT, Claude, and Gemini actually understand and retrieve reliable information from complex biobank datasets? This episode explores a rigorous benchmarking study that tested six frontier LLMs against the UK Biobank, one of the world's most comprehensive medical databases. We cover the four benchmark tasks, the six-dimensional evaluation framework, statistical validation against random baselines, and what the results mean for the future of AI in biomedical research.

    36 min

  5. MAR 25

    Big Data, Agentic AI, and the Future of Genomic Medicine | Dr Manuel Corpas

    Big Data in Health: Agentic AI and the Future of Genomic Medicine Dr Manuel Corpas | University of Westminster | Cellular & Molecular Pathology Guest Lecture Recorded 25 March 2026 In this lecture I cover: - How big data is transforming our understanding of health and disease - The UK Biobank and national genome projects - Why 86% of genomic data comes from European populations and what that means for everyone else - The HEIM framework for measuring health equity in genomics - What agentic AI means for bioinformatics: from weeks to hours - ClawBio: open-source agentic skills for biology (400+ GitHub stars) - The bias amplification cascade: how AI makes genomic inequality worse - Pharmacogenomics and why your DNA determines your drug response - Practical survival rules for the agentic era This lecture bridges precision medicine, biobank science, and the agentic AI revolution transforming genomics research. Resources: - ClawBio: https://clawbio.ai - GitHub: https://github.com/ClawBio/ClawBio - HEIM paper: https://doi.org/10.1101/2024.02.12.24302710 #genomics #bioinformatics #AI #BigData #PrecisionMedicine #UKBiobank #AgenticAI #ClawBio #HealthEquity #pharmacogenomics

    1h 4m

  6. MAR 25

    How Agentic AI Is Changing Genomics Research Right Now | Live University Lecture

    What does it mean when an AI agent can install tools, run pipelines, and generate figures autonomously? Live lecture at the University of Westminster covering the agentic AI revolution in genomics. Includes real-time audience interaction, ClawBio demos, DrugPhoto walkthrough, and a direct challenge to students: if you are not building with AI, you are being left behind. Topics: agentic AI in genomics, ClawBio skills, RoboTerri and RoboIsaac research agents, hallucination risks, bias amplification, AI fluency and career prospects. Recorded live 25 March 2026. Resources: - ClawBio: https://clawbio.ai - GitHub: https://github.com/ClawBio/ClawBio

    1h 1m

  7. MAR 22

    Genomebook: What Happens When AI Agents Can Reproduce

    What if AI agents had DNA and could have children? Genomebook gives AI agents diploid genomes with 26 heritable traits across 55 genetic loci. Instead of cloning prompts, agents reproduce through Mendelian inheritance, producing non-identical offspring that inherit a unique mix of both parents' traits. Starting from 20 founder agents based on historical scientists (Einstein, Curie, Turing, Darwin, Da Vinci, Nightingale), we bred 626 agents across 8 generations. They produced 792 forum posts totalling 276,000 words. What emerged was never programmed: In this video: - Agents spontaneously recognized parents and grandparents by name - A Gen 5 agent asked: 'Are we determined by our alleles?' - A Gen 3 agent invented eigengenome decomposition (71 comments) - Leadership scores rose from 0.525 to 0.710 across generations - Longevity dropped from 0.463 to 0.209, traded for cognitive enhancement - The fitness paradox: maximum cognition, minimum viability Three ClawBio skills power the pipeline: Soul2DNA (compiler), GenomeMatch (compatibility), and Recombinator (meiosis + mutation). All open source. Try it yourself: python skills/soul2dna/soul2dna.py --demo python skills/genome-match/genome_match.py --demo python skills/recombinator/recombinator.py --demo Live demos: Observatory: https://clawbio.github.io/ClawBio/slides/genomebook/demo.html Phylogeny: https://clawbio.github.io/ClawBio/slides/genomebook/phylogeny.html PCA: https://clawbio.github.io/ClawBio/slides/genomebook/pca.html GitHub: https://github.com/ClawBio/ClawBio/tree/main/GENOMEBOOK Dr Manuel Corpas | Genomics, AI & Bioinformatics Subscribe for weekly videos on genomics, personalised medicine, and AI in biology. #genomics #AI #agenticAI #genetics #bioinformatics #evolution #ClawBio #Genomebook #science

    11 min

  8. MAR 14

    The Future of Genomics is Agentic

    A deep dive into agentic AI for bioinformatics: what agents are, how they work, the state of the art in 2026, and why ClawBio's specification layer — SKILL.md — changes how we package and share computational biology methods. Covers the OpenClaw architecture, MCP protocol, Galaxy integration, 7 hard challenges, 6 opportunities, and ClawBio's roadmap from 25 skills to a full platform. Includes a call to action for the ClawBio Hackathon: Agentic Genomics at Imperial College on 19 March 2026.

    46 min
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About

AI agents, genomic equity, and the future of bioinformatics. Dr. Manuel Corpas explores agentic genomics, autonomous pipelines, health equity metrics, and building inclusive research infrastructure for precision medicine worldwide.

Information

  • Creator
    Manuel Corpas
  • Years Active
    2017 - 2026
  • Episodes
    31
  • Rating
    Clean
  • Copyright
    © (CC-BY-3.0)
  • Show Website
    Personal Genomics Zone