Personal Genomics Zone

Manuel Corpas
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AI agents, genomic equity, and the future of bioinformatics. Dr. Manuel Corpas explores agentic genomics, autonomous pipelines, health equity metrics, and building inclusive research infrastructure for precision medicine worldwide. Listen on Spotify: https://open.spotify.com/show/7ybzmeQKx5xfwsGjDsiQZe or on Apple Podcasts: https://podcasts.apple.com/us/podcast/personal-genomics-zone/id1252419814

  1. 6d ago

    Validated skills are necessary but not sufficient for trustworthy agentic genomics

    Manuel Corpas's Crick AI Club talk, recorded on Zoom on 14 September 2026. Science after pipelines: what changes when scientists direct agents through objectives rather than manually connecting computational tools? This talk introduces ClawBio's inspectable scientific skills, the separation between reasoning, specification and execution, and the evidence needed to trust an agent's work. Two figures from the pharmacogenomics study show the central result and its boundary: validated rules improve recommendations in a controlled task, while interpretation of genetic inputs still needs separate validation. The talk closes with composable scientific capabilities, executable methods and practical ways to get involved. This is Manuel's recorded presentation, including the opening and closing remarks. It does not include a question-and-answer session or a live software demonstration. The pharmacogenomics evidence concerns tested components, not clinical validation of an end-to-end autonomous system. Slides (PDF and PowerPoint): https://docs.clawbio.ai/presentations/crick-science-after-pipelines-2026/ YouTube: https://www.youtube.com/watch?v=k-oJZjFLWuU Documentation: https://docs.clawbio.ai/ Events calendar: https://luma.com/clawbio ClawBio Slack: https://app.slack.com/client/T0BP97N69KM/C0BP1FSGTHV Event: https://luma.com/clawbio-7ibq Benchmark data: https://doi.org/10.5281/zenodo.22141182

    Validated skills are necessary but not sufficient for trustworthy agentic genomics

  2. Sep 7

    Agentic Genomics: Your Science, Made Executable

    What changes when a scientist can direct an AI agent using scientific context rather than programming syntax? In this lecture from the INFLAMomx Training School in Salerno, Manuel Corpas demonstrates real RNA-seq and single-cell workflows, an invalid control that stops safely, and the role of skills, evals and equity in clinical-grade agentic genomics. PDF slides: https://docs.clawbio.ai/presentations/salerno-agentic-genomics-2026/Salerno-Agentic-Genomics-Slides.pdf

  3. Sep 4

    Corpas Core + GBrain: five prompts for your first working AI memory system

    A practical starter for scientists and knowledge workers: requirements, five agentic prompts, a freshness test and a downloadable kit. Written by Manuel Corpas. Narrated with OpenAI Cedar, an AI-generated voice. Starter kit: https://manuelcorpas.github.io/podcast/resources/corpas-core-gbrain-starter.zip

  4. Jul 22

    Agentic Genomics: "My Agent Is Not a Servant, My Agent Is a Colleague" (Tomorrow's Medicine Ep. 16)

    I joined Arseniy Arsentyev on episode 16 of the Tomorrow's Medicine podcast to talk about agentic genomics: what it is, why I coined the term, and why the hard part is not intelligence but trust. We cover the road from a bioinformatics MSc in Manchester in 2000, to building DECIPHER at the Sanger Institute, to sequencing my own exome in 2010 and publishing my family's genomes. Then the last twelve months: Claude Code as the inflection point, ClawBio winning the Imperial College agentic AI hackathon, 43 contributors and around 5,000 clones a week, and why AI amplifies health inequity rather than solving it. Original show: https://www.youtube.com/@tommedpod

  5. Jul 14

    The Future of Transcriptomics in an Agentic World: Crick RNA Ideathon

    Manuel Corpas's opening talk for the Londonomics RNA Ideathon at the Francis Crick Institute, recorded 14 July 2026. The argument: the future of transcriptomics is not a smarter model, it is a trusted operating layer. Skills that carry a versioned context contract, fail safely, and keep a chain of custody, so an analysis is reproducible whichever model runs it. The talk reproduces the published Klim and Melamed TDP-43 knockdown result (STMN2 collapse) through the ClawBio rnaseq-de skill, then shows a nine-model, five-provider grid where skill execution collapses model-to-model variation. Slides: https://docs.clawbio.ai/presentations/crick-rna-ideathon-2026/

  6. Jul 9

    ClawBench: Building a Nature Methods Benchmark for Trustworthy Agentic Genomics

    A ~22 minute deep dive on ClawBench, our second-generation benchmark for trustworthy agentic genomics. What has been done and why, how the fail-closed contract, deterministic ACMG combiner and per-variant layer attribution actually work, the honest walk-backs behind each finding, and exactly what remains to make it Nature Methods level.

  7. Jun 24

    Agentic Genomics in Practice: ClawBio and Genomic Intelligence (Live Webinar)

    A live webinar where AI agents do real genomics work end to end. After a short framing on why trust is the new bottleneck in agentic genomics, Veniamin Fishman and the Genomic Intelligence team run live: reading promoters, splicing, expression and enhancers straight from DNA, blind gene-finding on the human genome, interpreting a disease-causing promoter deletion, and designing a glioblastoma-specific promoter, all inside ClawBio. Hosted by Manuel Corpas.

  8. May 6

    Qatar Genome Programme: From Six Thousand to Fourteen Thousand Genomes

    Inside the Qatar Genome Programme. The 2022 Phase One Mbarek paper that found 88 million variants in 6,047 Qataris, with 24 million novel. The 2024 Elfatih follow-up showing 3.5% of Qataris carry ACMG-actionable variants. The Q-Chip and the new pan-Arab array. And how the 96 percent Qatar share of Arab GWAS connects to the global equity question.

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About

AI agents, genomic equity, and the future of bioinformatics. Dr. Manuel Corpas explores agentic genomics, autonomous pipelines, health equity metrics, and building inclusive research infrastructure for precision medicine worldwide. Listen on Spotify: https://open.spotify.com/show/7ybzmeQKx5xfwsGjDsiQZe or on Apple Podcasts: https://podcasts.apple.com/us/podcast/personal-genomics-zone/id1252419814

Information

  • Creator
    Manuel Corpas
  • Years Active
    2017 - 2026
  • Episodes
    52
  • Rating
    Clean
  • Copyright
    © (CC-BY-3.0)
  • Show Website
    Personal Genomics Zone