Personal Genomics Zone

Manuel Corpas
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AI agents, genomic equity, and the future of bioinformatics. Dr. Manuel Corpas explores agentic genomics, autonomous pipelines, health equity metrics, and building inclusive research infrastructure for precision medicine worldwide. Listen on Spotify: https://open.spotify.com/show/7ybzmeQKx5xfwsGjDsiQZe or on Apple Podcasts: https://podcasts.apple.com/us/podcast/personal-genomics-zone/id1252419814

  1. Jul 22

    Agentic Genomics: "My Agent Is Not a Servant, My Agent Is a Colleague" (Tomorrow's Medicine Ep. 16)

    I joined Arseniy Arsentyev on episode 16 of the Tomorrow's Medicine podcast to talk about agentic genomics: what it is, why I coined the term, and why the hard part is not intelligence but trust. We cover the road from a bioinformatics MSc in Manchester in 2000, to building DECIPHER at the Sanger Institute, to sequencing my own exome in 2010 and publishing my family's genomes. Then the last twelve months: Claude Code as the inflection point, ClawBio winning the Imperial College agentic AI hackathon, 43 contributors and around 5,000 clones a week, and why AI amplifies health inequity rather than solving it. Original show: https://www.youtube.com/@tommedpod

  2. Jul 14

    The Future of Transcriptomics in an Agentic World: Crick RNA Ideathon

    Manuel Corpas's opening talk for the Londonomics RNA Ideathon at the Francis Crick Institute, recorded 14 July 2026. The argument: the future of transcriptomics is not a smarter model, it is a trusted operating layer. Skills that carry a versioned context contract, fail safely, and keep a chain of custody, so an analysis is reproducible whichever model runs it. The talk reproduces the published Klim and Melamed TDP-43 knockdown result (STMN2 collapse) through the ClawBio rnaseq-de skill, then shows a nine-model, five-provider grid where skill execution collapses model-to-model variation. Slides: https://docs.clawbio.ai/presentations/crick-rna-ideathon-2026/

  3. Jul 9

    ClawBench: Building a Nature Methods Benchmark for Trustworthy Agentic Genomics

    A ~22 minute deep dive on ClawBench, our second-generation benchmark for trustworthy agentic genomics. What has been done and why, how the fail-closed contract, deterministic ACMG combiner and per-variant layer attribution actually work, the honest walk-backs behind each finding, and exactly what remains to make it Nature Methods level.

  4. Jun 24

    Agentic Genomics in Practice: ClawBio and Genomic Intelligence (Live Webinar)

    A live webinar where AI agents do real genomics work end to end. After a short framing on why trust is the new bottleneck in agentic genomics, Veniamin Fishman and the Genomic Intelligence team run live: reading promoters, splicing, expression and enhancers straight from DNA, blind gene-finding on the human genome, interpreting a disease-causing promoter deletion, and designing a glioblastoma-specific promoter, all inside ClawBio. Hosted by Manuel Corpas.

  5. May 6

    Qatar Genome Programme: From Six Thousand to Fourteen Thousand Genomes

    Inside the Qatar Genome Programme. The 2022 Phase One Mbarek paper that found 88 million variants in 6,047 Qataris, with 24 million novel. The 2024 Elfatih follow-up showing 3.5% of Qataris carry ACMG-actionable variants. The Q-Chip and the new pan-Arab array. And how the 96 percent Qatar share of Arab GWAS connects to the global equity question.

  6. Apr 29

    The Future of Biology Is Agentic — UK DRI Imperial Seminar

    Manuel narrates his UK DRI seminar at Imperial College London (29 April 2026): how agentic genomics shifts the bottleneck from pipeline construction to validation. An empirical benchmark of 8 frontier LLMs across 1,728 evaluations on the ClawBio pharmgx-reporter skill: 92.4% mean phenotype accuracy without specification, 100% with specification, and a 6 of 7 lethal-error gap that closes only when population-aware skill data is engineered in.

  7. Apr 23

    AI Agents for Health: ClawBio Hackathon

    102 participants at the University of Westminster hack on ClawBio, the open-source bioinformatics agent framework with 40+ executable skills. Challenge tracks include new skill development, agent workflows, equity and access using the HEIM framework, and the TuringDB Graph Challenge for drug repurposing, graph-based memory, and multimodal knowledge graphs.

  8. Apr 23

    LLMs Beat Humans at Spotting Fraud While Learning to Lie in Avalon | 23 Apr 2026

    Can an LLM resist a motivated investor pushing a fraudulent pitch? Powdthavee's preregistered study across seven leading models and twelve scenarios finds they outperform humans at fraud detection, yet soften warnings when users arrive already convinced. Ellawela tracks LLM agents through repeated rounds of Avalon with persistent memory, surfacing emergent reputation, trust, and deception between games rather than within one. Gabeur and colleagues then show image generators double as generalist vision learners, with Nano Banana Pro hitting state of the art on multimodal benchmarks. Three angles on what today's models quietly know and quietly hide.

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About

AI agents, genomic equity, and the future of bioinformatics. Dr. Manuel Corpas explores agentic genomics, autonomous pipelines, health equity metrics, and building inclusive research infrastructure for precision medicine worldwide. Listen on Spotify: https://open.spotify.com/show/7ybzmeQKx5xfwsGjDsiQZe or on Apple Podcasts: https://podcasts.apple.com/us/podcast/personal-genomics-zone/id1252419814

Information

  • Creator
    Manuel Corpas
  • Years Active
    2017 - 2026
  • Episodes
    49
  • Rating
    Clean
  • Copyright
    © (CC-BY-3.0)
  • Show Website
    Personal Genomics Zone