45 episodes

This podcast is all about the Pharmacist leveraging the power of Pharmacogenomics. PGX for Pharmacists is a member of the Pharmacy Podcast Network. Pharmacogenomics is the study of the role of the genome in drug response. Its name (pharmaco- + genomics) reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects his/her response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with pharmacokinetics (drug absorption, distribution, metabolism, and elimination) and pharmacodynamics (effects mediated through a drug's biological targets).

PGX for Pharmacists Pharmacy Podcast Network

    • Business
    • 4.5 • 8 Ratings

This podcast is all about the Pharmacist leveraging the power of Pharmacogenomics. PGX for Pharmacists is a member of the Pharmacy Podcast Network. Pharmacogenomics is the study of the role of the genome in drug response. Its name (pharmaco- + genomics) reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects his/her response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with pharmacokinetics (drug absorption, distribution, metabolism, and elimination) and pharmacodynamics (effects mediated through a drug's biological targets).

    Camille Schrier - Miss America's Mental Health Journey | PGX For Pharmacsts

    Camille Schrier - Miss America's Mental Health Journey | PGX For Pharmacsts

    Camille Schrier, Miss America 2020 is currently pursuing her Pharmacy degree at Virginia Commonwealth University in Richmond. She completed a dual Bachelor of Science degrees in Biochemistry and systems biology. Camille blew up the onstage talent competition with a highly engaging and entertaining version of the “catalytic decomposition of hydrogen peroxide,” Ok let me repeat that. catalytic decomposition of hydrogen peroxide, and that won her Miss Virginia in June of 2019 and then Miss America in December 2019 live on NBC. While competing for the job, Camille wanted it known that “Miss America can be a scientist and a scientist can be Miss America.”
    She is not only the first woman to win the title using science as a talent, but also as the only Miss America to speak in the General Assembly of the UN, to become grounded by a global pandemic, and be asked to serve for two full years as a direct result of COVID-19.
    Since then Camille has focused on advocating for her social initiative which is called “Mind Your Meds: Drug Safety and Abuse Prevention from Pediatrics to Geriatrics” with a major focus on the opioid epidemic, as well as for exciting youth in the areas of STEM. Just last year, Camille launched her own science educational brand called “Her Royal Scientist”, which furthers her goal to inspire and educate youth and normalize females in science roles. She also works to raise awareness of the genetic condition that impacts her life, Ehlers Danlos Syndrome
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    • 44 min
    National Adverse Drug Event Awareness Day Featuring The Right Drug Dose Act | PGX For Pharmacists

    National Adverse Drug Event Awareness Day Featuring The Right Drug Dose Act | PGX For Pharmacists

    In recognition of National Adverse Drug Event Awareness Day, March 24, 2022, Dr. Becky Winslow, CEO of inGENEious RX Precision Medicine Consultants, and Dr. Behnaz Sarrami, PGx Medical Science Liaison of Missouri Pharmacogenomics Consulting, teamed up to cohost a special live episode of the PGx for Pharmacists Podcast.

    In this episode, Dr. Winslow and Dr. Sarrami interview Ms. Kristine Ashcraft, STRIPE Steering Committee member; former CEO and founder of YouScript; director of medical affairs at Invitae; a BIS Research recognized top 25 leading voice in precision medicine; and author of multiple publications on both the clinical and economic benefits of PGx testing, and Ms. Rachel Brummert, Special Government Employee (SGE) at the U.S. Food and Drug Administration; contributor at Drugwatch and Medshadow Foundation; and nationally recognized patient safety advocate who has turned the pain she suffered from an adverse drug event into her purpose.

    Topics discussed in this episode include:

    The financial and clinical costs resulting from adverse drug events' (ADEs) morbidity and mortality.

    Pharmacogenomic testing as a tool to mitigate ADEs.

    The Right Drug Dose Now Act which was recently introduced by Representatives Swalwell and Emmer and whose intent is to update the Department of Health and Human Services’ National Action Plan for Adverse Drug Event Prevention to include funding for pharmacogenomics testing advocacy.
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    • 42 min
    Clinical Decision Support Software: A Key Tool for Optimizing Population Health Level Pharmacogenomics Programs | PGx For Pharmacist

    Clinical Decision Support Software: A Key Tool for Optimizing Population Health Level Pharmacogenomics Programs | PGx For Pharmacist

    Episode Description:
    On this episode, Dr. Jeffrey Shaman, Chief Science Officer at Coriell Life Sciences, and I discuss the importance of population health level pharmacogenomics versus one time pharmacogenomics tests and how clinical decision support software that integrates pharmacogenomics data into patients’ medication therapy management is a key tool to optimize population health level pharmacogenomics programs.
    References:
    1. Real-World Impact of a Pharmacogenomics-Enriched Comprehensive Medication Management Program https://www.mdpi.com/2075-4426/12/3/421
    2. Idiopathic Symptoms Resolved by Pharmacogenomics-Enriched Comprehensive Medication Management: A Case Report https://www.cureus.com/articles/81096-idiopathic-symptoms-resolved-by-pharmacogenomics-enriched-comprehensive-medication-management-a-case-report
    3. Consequences of CYP2D6 Copy-Number Variation for Pharmacogenomics in Psychiatry https://www.coriell.com/resources/consequences-of-cyp2d6-copy-number-variation-for-pharmacogenomics-in-psychiatry/
    4. The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978656/
    5. ASP Establishes March 24th as National Adverse Drug Event Awareness Day https://www.stopadr.org/blog/asp-establishes-march-24-as-national-adverse-drug-event-awareness-day-launches-awareness-campaign
    Guest’s Bio:
    Jeffrey A. Shaman, PhD, MS, is the Chief Science Officer at Coriell Life Sciences (CLS), an international leader in precision medicine. Leveraging extensive experience in genetics and pharmacology, he is a leading expert in the rapidly evolving field of pharmacogenomics (PGx), the study of how an individual’s DNA impacts his or her response to medication. Most importantly, Dr. Shaman plays a critical role in bridging the gap between genetic science and clinical application. This includes translating decades of cutting-edge genetic research into actionable insights on the safest and most effective medications for individuals based on their unique DNA and dozens of other factors.
    Driven to advance public health, Dr. Shaman is focused on enabling the delivery of personalized medicine at scale and empowering the most precise medical care worldwide. He consults with large employers, public and private payer organizations, healthcare systems, academic institutions, and laboratories around the globe, advising them on how to eliminate trial-and-error prescribing, improve population health, and control rising healthcare costs
    Dr. Shaman is dedicated to setting the industry standard for PGx and pioneering new advancements in the field. Along with his team, he actively researches and presents findings in top peer-reviewed journals and at leading industry events. He is an active member of the Clinical Pharmacogenetics Implementation Consortium (CPIC), Standardizing Laboratory Practices in Pharmacogenomics (STRIPE) Collaborative Community, Personalized Medicine Coalition (PMC), Pharmacogenomics Global Research Network (PGRN), and other organizations.
    Dr. Shaman holds a doctoral degree from The Johns Hopkins University School of Medicine in Pharmacology and Molecular Sciences, where his research centered on DNA, epigenetics, and nuclear structure and function. He earned his Master of Science degree from The University of Medicine and Dentistry of New Jersey in Cell & Developmental Biology. Dr. Shaman held a faculty position at the University of Hawai‘i Institute of Biogenesis Research before serving a fellowship at Harvard Medical School and implementing a translational research program at Beth Israel Deaconess Medical Center and the Bedford Stem Cell Research Foundation.
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    • 32 min
    Pharmacogenomics Changed My Life: A Patient's Story, Kristen Ruth Davis | PGX For Pharmacists

    Pharmacogenomics Changed My Life: A Patient's Story, Kristen Ruth Davis | PGX For Pharmacists

    Thanks for joining us today as our host, Dr. Jamie Wilkey talks with a patient, Kristen, who strongly feels that PGx testing saved her life. 

    Join us for a patient’s side of the story today!

    You may reach Kristen at her website: https://www.imnotcrazyproject.org/ her Facebook page: https://www.facebook.com/imnotcrazyproject or on LinkedIn: https://www.linkedin.com/in/kristen-ruth-davis-5540142a/

    You may reach Jamie at her website: drjamiewilkey.com or on her LinkedIn page: https://www.linkedin.com/in/dr-jamie-wilkey/


    *This episode discusses mental health and suicidal ideation. While it is not discussed in great detail, if you are having thoughts of ending your own life we strongly encourage you to push pause and call the National Suicide Prevention Hotline right away at 800-273-8255*

    References:

    IQVIA Institute for Human Data Science. Medicine Use and Spending in the U.S. https://www.iqvia.com/insights/the-iqvia-institute/reports/medicine-use-and-spending-in-the-us-a-review-of-2018-and-outlook-to-2023 Published May 2019. Accessed June 10, 2020.

    Spear BB, Heath-Chiozzi M, Hu J. Clinical application of pharmacogenetics. Trends Mol. Med. 2001; 7, 201–204.

    Table of Pharmacogenomic Biomarkers in Drug Labeling. U.S. Food and Drug Administration website.: https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labelinghttps://www.fda.gov/Drugs/ScienceResearch/ucm572698.htm Accessed June 10, 2020.

    Preventable Adverse Drug Reactions: A Focus on Drug Interactions. U.S. Food and Drug Administration website. www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm110632.htm. Accessed June 10, 2020.

    Van Driest SL, Shi Y, Bowton EA, et al. Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing. Clin Pharmacol Ther. 2014; 95(4):423‐431.


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    • 41 min
    Patient Impact of Limited Provider PGX Knowledge | PGX For Pharmacists

    Patient Impact of Limited Provider PGX Knowledge | PGX For Pharmacists

    According to the American Academy of Family Physicians, there are more than 50 Cytochrome P450 enzymes but there are just 6 of them that metabolize about 90% of the drugs. One of the most significant ones is the CYP2D6. In an article on healio written by Dr. Jai Patel, he talks about CYP2D6 metabolizing many of the SSRIs, SNRIs and TCAs that are the treatment options for depression. The clearance of TCA’s for example is 50-67% lowered in CYP2D6 poor metabolizers compared to normal.
    www.aafp.org/afp/2007/0801/p391.html 
    Pharmacogenetic testing may improve outcomes for patients with depression (healio.com)
    Kristine Ashcraft is a molecular biologist by training and is the former CEO and founder of YouScript which was recently acquired by Invitae. She has worked in pharmacogenomics space since 2000 and was recently named one of the 25 leading voices in precision medicine. Kristine has authored multiple publications on both the clinical and economic benefits of PGx testing. She serves on the Steering Committee of STRIPE which is the FDA collaborative community for PGx. She has been interviewed by numerous media including the New York Times, the Wall Street Journal, and NBC Nightly News and has spoken at American Society of Human Genetics, and numerous precision medicine conferences and now speaking at one of the top 20 genomics podcast in the globe, PGx for Pharmacist Podcast.
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    • 42 min
    Pharmacists as Pharmacogenomic Counselors | PGX for Pharmacists

    Pharmacists as Pharmacogenomic Counselors | PGX for Pharmacists

    On this episode, Dr. Gillian Bell, a Doctor of Clinical Pharmacy, shares her path from pharmacy school to her non-traditional PharmD job as Pharmacogenomics Lead, Genome Medical. 
    On This Episode We Discuss: 

    • Gillian’s education (Brief) 

    • Gillian’s PharmD work experience prior to PGx (Brief) Residency 

    • Gillian’s PGx work experience prior to Genome Medical (Brief) Mission Hospital 

    • Brief description of Genome Medical, its mission, its services, its clients 

    • Gillian’s roles and responsibilities as the Pharmacogenomics Lead at Genome Medical 

    • What does a typical day at Genome Medical look like for its pharmacists? How do the pharmacists interact with the genetic counselors? 

    • “Genetic Counseling” or “PGx Inclusive Medication Therapy Management’ do the pharmacists provide one or the other or both? Neither? To whom are the services provided? Providers and/or to patients? 

    • Gillian’s advice to pharmacists who want to pursue a career in PGx 


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    • 32 min

Customer Reviews

4.5 out of 5
8 Ratings

8 Ratings

A Duzan ,

General evaluations

The webinars were really nice and touch the professionals as pharmacist issues nowadays. I would like to highlight point and hope you guys bring someone who can or he may can help with issue of pharmacy education and how schools now focus the generarte pharmacist as dispenser or clinical pharmacist ( with very limited knowledge & clinically ). I’m old pharmacy school system and pharmacy has a lot of area where the pharmacist must lead those such as function medicine, herb medicine, food medicine, Food drug interaction, genetic Side effects , medicinal chemistry of drugs, natural products, quality control pharmaceutical products- and so on.

cmaxx23 ,

Genomics ?

Change the title if you are not going to talk about genomics. Some pharmacists are looking for new career paths- certificates, training, opportunities ** not discussions about we what we already do

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