A Chemist's Paradise

Rohith Krishna

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العلوم

I'm here to talk about all things Chemistry, toxicology and forensic science. Make sure to put on some personal protective equipments because the reaction's about to begin.

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Multimodal MSI for Drug Analysis on Fingerprints

My Second PhD Paper Although drug facilitated sexual assault (DFSA) is an old issue, current statistics on the frequency of this crime have led to growing concerns. As these drugs are metabolised very quickly, toxicological evidence from biological fluids, corroborating the victim's statement, is challenging to recover, especially with late reports. We are proposing an additional method involving the analysis of the victim's fingermarks recovered at the scene(s) of the crime, which may contain the parent drug and its metabolite. As a case study, a multi-modal mass spectrometry-based approach has been developed and explored to detect and image both risperidone and its pharmacologically active metabolite, paliperidone, after contamination of a fingertip at very low concentrations and deposition of a fingerprint on a surface. In particular Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Imaging (MALDI MSI), Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI MSI) and Soft Ionisation by Chemical Reaction In Transfer, (SICRIT®) have been used in different combinations to both detect the drugs and reconstruct the fingerprint ridge pattern; this approach enables the simultaneous provision of both chemical information (circumstances surrounding the crime) and biometric information. A forensic operational scenario has also been simulated whereby the contaminated fingerprint is deposited on paper and enhanced with a routine fingerprint enhancement technique prior to analysis via mass spectrometry imaging. Overall, our investigation indicates that this additional approach is feasible and is worth exploring further.Check the paper out: https://doi.org/10.1039/D5AN00328H

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Fingerprints and Mass spectrometry

Matrix-AssistedLaser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) has become acritical tool for biometric and lifestyle analysis through fingermarks,significantly aiding police investigations. Pioneered by Sheffield HallamUniversity and the Francese group, this technique revolutionizes chemicalfingerprint analysis by providing detailed molecular information and visualisingmultiple fingermark images. Our researchexplores the applications of MALDI-MSI using the state-of-the-art SELECT SERIESMALDI-MRT (Multi-Reflecting Time-of-Flight) mass spectrometer, which featuresexceptional mass measurement accuracy (sub-ppm) and spatial resolution (15 µm)in detecting and visualising various antipsychotics, date rape drugs, and otherforensic markers within latent fingermarks. The complexity of this state-of-the art mass spectrometerand it being the ever first installed instrument of this type in the UK,required very careful and non-trivial setting optimisation to maximise thesystem’s performance. Podcast created using Google NotebookLMResearch paper: https://doi.org/10.1016/j.aca.2025.343998

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The Brain on Drugs

This episode talks about how the personality of an individual is affected by drugs and different concepts in psychology and chemistry!

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Mental Health in Science

Hello fellow humans, In this episode, I talk about mental health in the scientific community and if you should publish or perish!

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Good Science Vs Bad Science ?

Hello fellow human beings, This is an episode for those who want to know what science is and what makes good science and also some tips to improve your scientific life. CREDIT: DENNIS KUNKEL MICROSCOPY, INC for the Episode Art!

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Let There Be Light !

Hello, people ! On this episode of A Chemist's Paradise I will be talking about light and some analytical techniques that uses light to do some awesome Chemistry ! Enjoy

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Let's Separate Some Chemicals !

Hello people ! I will be talking about an analytical technique which is often associated with coloured bands. listen to my podcast to learn more about this technique. *Enjoy!*

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PINK ? That's so Basic

Hello humans, On today's episode of A Chemist's Paradise I am going to talk about an interesting substance. ENJOY!

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Initiating a New Reaction !

This is the first episode to my podcast series and i'll be giving you a brief introduction to what my podcasts are going to revolve around. You are free to give me suggestions on the upcoming episodes. ENJOY !

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٩ حلقة

I'm here to talk about all things Chemistry, toxicology and forensic science. Make sure to put on some personal protective equipments because the reaction's about to begin.

صناع العمل

Rohith Krishna
سنوات النشاط

٢٠١٩ - ٢٠٢٥
الحلقات

٩
التقييم

ملائم
حقوق النشر

© Rohith Krishna
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A Chemist's Paradise