Dr. M's Women and Children First Podcast

  1. 3d ago

    Dr. M’s SPA Newsletter Volume 16 Issue 26 – Story We Cannot See

    The Story We Cannot See For those that have not read Theo of Golden, do so. Quite an incredible read. There is a moment in Theo of Golden when Allen Levi introduces us more deeply to Ellen, a woman whose circumstances make it easy for the world to place her into a category. Homeless. Poor. Troubled. Someone living at the margins. But then we learn her story. And suddenly that category becomes inadequate. Worse, inappropriate. That is one of the quiet gifts of a beautifully told story. It forces us to remain with another human being long enough for our first judgment to become uncomfortable. For it to turn against us. For us to recoil against our prejudices. I have experienced versions of this countless times in the newborn nursery. A baby is born, and somewhere in the medical record is the story we have constructed about the mother. No permanent address. Limited prenatal care. Substance use. Domestic instability. Unemployed. Teenager. Medicaid. Social work involved. These things matter. As physicians, we need to know them. They may tell us something important about the risks facing a newborn. But they tell us remarkably little about love. Or lack there of. I have walked into rooms where a mother's life outside the hospital was extraordinarily difficult, yet there she sat holding her newborn with the same wonder I have seen in mothers surrounded by every imaginable advantage. She studies the baby's face. Counts the fingers. Asks whether the baby is eating enough. Worries about a rash. Pulls the blanket a little higher. And sometimes, sitting beside that bassinet, the distinction between the woman with everything and the woman with almost nothing disappears..... and a literature review. Dr. M

  2. Sep 27

    Dr. M’s Women and Children First Podcast #118: Nicholas Kelly, RD – Hope, CF and an RD

    My guest today is Nicholas Kelly, a registered dietitian, speaker, and someone who has spent essentially his entire life navigating medicine from the other side of the exam table. Nicholas was diagnosed with cystic fibrosis in infancy. That diagnosis meant growing up with a chronic disease that required constant attention: medications, treatments, nutrition, hospitalizations, and an intimate relationship with a healthcare system that most children never experience. But what makes Nicholas’s story so compelling is what he has done with that experience, a story that has inspired me. He ultimately became a healthcare professional himself, giving him the unusual perspective of being both clinician and lifelong patient. And through his TEDx talk, Healing Through the Human Experience, and his broader work, he has challenged clinicians to think more deeply about something that can easily get lost in modern medicine: What does healthcare actually feel like to the person receiving it? Our conversation moves well beyond cystic fibrosis. We talk about resilience, identity, nutrition, the evolution of CF treatment, the patient-clinician relationship, and the moments when healthcare gets that relationship right and when it gets it very wrong. We also explore what happens when a child who has spent his life being defined, at least partly, by a serious disease grows into an adult and begins to decide for himself what that disease will, and will not, mean for his life. Nicholas’s story is ultimately about much more than living with cystic fibrosis. There is an amazing story within the story about his mother. Listen and find out what she did for him. Beautiful. It is about living fully in the presence of uncertainty, finding purpose through adversity, and reminding those of us who practice medicine that treating disease and caring for a human being are not always the same thing. This is my conversation with Nicholas Kelly.   Enjoy, Dr. M

  3. Sep 15

    Dr. M’s SPA Newsletter Volume 16 Issue 24 – Story and Mom

    The Story Your Brain Decides to Tell Two people walk into the same room. One has been told that she is there to make new friends. The other has been told that she is there to determine whether the people in the room can be trusted. Same room. Same people. Same conversations. But perhaps not the same experience. That is the fascinating implication of emerging neuroscience exploring how the brain constructs the story of our lives. We tend to imagine that our senses work something like cameras. Light enters the eyes. Sound enters the ears. Information travels to the brain. Reality comes in, and we experience it. Except that isn't really what happens. The brain is constantly deciding what matters. Our goals, expectations, memories and beliefs create a frame through which incoming information is interpreted. This month's Scientific American article by Ingrid Wickelgren describes research suggesting that when people approach the same experience with different goals, their brains organize that experience differently. Their neural activity begins to reflect the narrative they are constructing. In other words, we don't simply experience reality. We edit it. This is even more complex because we all show up with epigenetic fingerprints of past experiences. Think about walking through an airport. If you are hungry, you suddenly notice restaurants. If you are late, you notice clocks. If you are angry, you notice people's energy and anger. If have a history of trauma, you notice similarities of past experience. If you have lost your child for thirty terrifying seconds, you notice every small person wearing a similar shirt. The airport hasn't changed. Your brain's response and perception has. Your orientation and current frame/goal determines which pieces of an impossibly complicated environment rise into conscious awareness. Neuroscientists have been circling this concept for decades. Marvin Minsky described mental "frames" as structures we bring to new situations. Rather than building our understanding of the world from scratch every second, the brain pulls up a model based upon previous experience and asks, essentially: What kind of situation is this? What should I expect? What matters here?..... And a section on maternal story and the default mode network. Dr. M

  4. Sep 12

    Dr. M’s Women and Children First Podcast #117: Kari Stubbs, PhD – Technology and Children

    Today’s conversation sits right at the intersection of childhood development, technology, and a question that is becoming harder for parents to ignore: What might our children need to develop before we hand them a screen? My guest today is Dr. Kari Stubbs, who holds a PhD in education and has spent her career in K–12 education technology. And that makes her current work particularly interesting. She isn’t approaching this conversation as someone who is anti-technology. Quite the opposite. She understands technology, has worked within it for years, and sees very clearly where the world is headed. But she also spends her weeks talking with early-childhood leaders and school-district directors, hearing firsthand that children are showing up at school differently than they did a generation ago. Kari raised her own two children using what she describes as a brain-based approach to movement and development, during a time when screens still largely stayed attached to walls and desks. Today, she argues for something that sounds almost countercultural coming from an education technologist: protecting significant screen-free time during the first five years of life. Her argument isn’t that technology is bad. It’s that timing matters. Those first five years are when children are building many of the foundational human capacities they will carry into school, relationships, and eventually the workplace—things like curiosity, adaptability, creativity, self-regulation, and collaboration. And ironically, as artificial intelligence becomes increasingly capable, these deeply human aptitudes may become more valuable, not less. Kari writes about these ideas in her Substack, The First Five: Before Screens, and today we’re going to explore what the developing brain actually needs from movement, play, relationships, and the physical world—and what may be lost when screens arrive too early or occupy too much of childhood. Enjoy, Dr. M

  5. Sep 9

    Dr. M’s SPA Newsletter Volume 16 Issue 23 – Back To School

    Back To School Thoughts As summer winds down and the school year starts, our attention naturally turns to backpacks, school supplies, new clothes, sports schedules, and carpools. But getting ready for school is about much more than checking items off a list. It is about helping our children return to the classroom with the physical, mental, and emotional foundation they need to thrive. A few simple changes now can make the transition much easier. 1) Start With Sleep Summer has a way of pushing bedtimes later and later. Often 1 to 3 hours beyond when a school child should wind down. Begin moving bedtime and wake-up time toward the school schedule a week or two before the first day. Sleep is not simply downtime. It is when the brain consolidates learning, regulates emotions, restores energy, and prepares for the next day. Deep sleep is critical for cleaning the brain of disruptive chemicals. Younger school-aged children generally need 9–12 hours of sleep, while teenagers need 8–10 hours. A consistent bedtime routine and getting phones and other screens out of the bedroom can make an enormous difference. 2) Feed The Brain Children cannot consistently perform their best when they are running on highly processed foods, sugar, and caffeine. Build meals around real food: vegetables and fruits, whole grains, beans, nuts and seeds, healthy fats, and quality proteins such as fish, poultry, and meat. Breakfast does not need to be elaborate, but including protein, fiber, and healthy fat can provide much steadier energy than starting the day with a sugary cereal or pastry. And remember the simplest nutrient of all: water. Send children to school well hydrated and encourage them to carry a water bottle when possible..... and back to school recipes. Dr. M

  6. Aug 10

    Dr. M’s Women and Children First Podcast #116: Russell Greenfield, MD – The Art of Listening

    Welcome back to Dr. M's Women and Children First. One of the recurring themes on this podcast is that the future of medicine won't be discovered through faster-paced healthcare alone. It will be discovered by slowing down, listening more carefully, and embracing a patient-centered approach that seeks to understand the whole person—not just the disease. Ultimately, the future of medicine begins with a better question: How do we truly hear a patient's story so that we can better serve the person sitting in front of us? Today's guest has spent his entire career helping answer that question. Our conversation today centers on one of the most overlooked aspects of healing: why so many people struggle to begin the healing process in the first place—and more importantly, how we, as clinicians, parents, and patients, can help that process finally move forward. Dr. Russell Greenfield is a board-certified emergency medicine physician and a Diplomate of the American College of Lifestyle Medicine whose career has been dedicated to transforming healthcare from a disease-centered model into one focused on whole-person health. He has served as Medical Director of Integrative Medicine for major health systems, including Novant Health and the Weisiger Cancer Institute, held national leadership positions within the Veterans Health Administration's Whole Health Initiative, and continues to advise organizations across the country that are reimagining what healthcare can become. What makes Dr. Greenfield's journey especially unique is that he was one of the select physicians chosen to complete a residential fellowship under the mentorship of Dr. Andrew Weil at the University of Arizona—the birthplace of academic integrative medicine. At a time when very few physicians were willing to challenge the traditional boundaries of healthcare, Dr. Greenfield immersed himself in a model that recognized nutrition, movement, sleep, stress, relationships, purpose, and environment as fundamental pillars of health, while embracing the remarkable advances of modern medical science. For me, this conversation is especially meaningful because many of us in medicine are asking the same question: How do we move upstream? How do we stop waiting for chronic disease to develop and instead create the conditions where health can flourish? Today we'll explore the art of becoming an experienced listener in service of the patient before us. We'll discuss why curiosity often matters more than certainty, why healing frequently begins long before the prescription pad comes out, and how understanding a person's story can unlock opportunities that laboratory tests and imaging studies alone may never reveal. Whether you're a clinician, a parent, or simply someone searching for a deeper understanding of health, I think you'll come away from this conversation with a renewed appreciation for one of medicine's most powerful tools: listening. Enjoy, Dr. M

  7. Aug 4

    Dr. M’s SPA Newsletter Volume 16 Issue 20 – Healthcare Policy

    Failing Them Why Are We? We are failing our children, the next generation. I have been spending an inordinate amount of time studying cellular biology and mitochondrial function in order to understand worsening disease trends. Thus, I want to revisit a landmark study that is one of the most comprehensive assessments of pediatric health ever conducted in the United States. Rather than examining a single disease or health outcome, Dr. Forrest and colleagues integrated data from multiple nationally representative surveys, mortality databases, and electronic health records encompassing millions of children to evaluate whether the health of American children has changed over the past 17 years. The answer was strikingly consistent: across virtually every major health domain, children in the United States are becoming less healthy. The investigators examined mortality, chronic physical and mental health conditions, obesity, functional status, sleep, puberty, physical symptoms, and emotional well-being between 2007 and 2023. Nearly every indicator worsened over time. "From 2007 to 2022, infants (1 year old) were 1.78 and 1- to 19-year-old individuals were 1.80 times more likely to die in the US than in the OECD18. The 2 causes of death with the largest net difference between the US and OECD18 were prematurity and sudden unexpected infant death for infants 12 months or younger, and firearm-related incidents and motor vehicle crashes for 1- to 19-year-old individuals. From 2011 to 2023, the prevalence of 3- to 17-year-old individuals with a chronic condition rose from 39.9% to 45.7% within PEDSnet, and from 25.8% to 31.0% within the general population. Rates of obesity, early onset of menstruation, trouble sleeping, limitations in activity, physical symptoms, depressive symptoms, and loneliness all increased during the study period." (Forrest et. al. 2025)... and literature review. Enjoy, Dr. M

  8. Jul 31

    Dr. M’s SPA Newsletter Volume 16 Issue 19 – Pain

    Pain Do we listen to its signal? Pain: Your Body's Built-In Warning System Pain is one of the body's oldest and most important protective mechanisms. It isn't your enemy. It is a messenger. Imagine walking barefoot across your living room and accidentally kicking the corner of the coffee table. The sharp pain that shoots through your toe isn't there to punish you, it is there to protect you. Within fractions of a second, nerves carry a signal to your brain, telling you that cells and tissue have been injured. Your body immediately encourages you to stop what you're doing. Protect the area and allow it to heal. This is acute pain, and it serves an essential purpose for both protection and survival. The problem arises when we stop thinking of pain as information and begin viewing it as something that simply needs to be eliminated. Over the past several decades, this mindset has increasingly influenced modern medicine. Around the turn of the century, pain was widely promoted as the "fifth vital sign," emphasizing the importance of recognizing and treating it. While this movement helped address the undertreatment of pain, it also contributed, in some settings, to an emphasis on suppressing pain rather than understanding why it existed in the first place. From an evolutionary perspective, pain is not a design flaw, it is a sophisticated communication system. It evolved to capture our attention, protect us from further injury, and encourage behaviors that promote healing. When we focus solely on silencing the signal without investigating its source, we risk missing the very message our bodies are trying to deliver, and deliver it will. Pain is information Every pain signal is your body's way of saying, "Something isn't quite right." Sometimes the cause is obvious like a sprained ankle, a cut, a burn, or a broken bone. Other times the message is much more subtle. .... Dr. M

  9. Jul 26

    Dr. M’s Women and Children First Podcast #115: Michelle Chalfant – The Adult Chair

    Welcome back to Dr. M's Women and Children First Podcast, where we explore the science, stories, and strategies that help children thrive and families flourish. Today, we're diving into something that affects every parent, every marriage, every friendship, and really every human being: our emotional triggers. Why do seemingly small moments sometimes provoke such big reactions? Why do we repeat the same patterns even when we know better? And perhaps most importantly, how do we become the kind of adults who respond with wisdom instead of reacting from old wounds? To help us answer those questions, I'm thrilled to welcome Michelle Chalfant. Michelle is a licensed therapist, holistic life coach, creator of The Adult Chair® model, and author of the bestselling book The Adult Chair. Her work has helped hundreds of thousands of people understand how childhood experiences shape adult relationships and how emotional healing doesn't require becoming someone new—it requires reconnecting with the healthiest version of ourselves. As a pediatrician, I spend my days thinking about children's physical health, but I've become increasingly convinced that emotional health deserves equal attention. The way parents regulate their own emotions becomes the blueprint for how their children learn to navigate disappointment, conflict, fear, and joy. In many ways, raising emotionally healthy children begins with becoming emotionally healthy adults. Whether you're a parent trying to break generational patterns, someone hoping to improve your relationships, or simply curious about why certain situations seem to push your buttons, I think you're going to find today's conversation both practical and deeply hopeful. Dr. M

  10. Jul 19

    Dr. M’s SPA Newsletter Volume 16 Issue 18 – Autism and Microbiomes

    Autism and Diagnosis Metabolites and Phenotypes In a brand new paper entitled. “Elevated Microbially-Derived Metabolites in Autism: A Possible Diagnostic Screening Test for a Distinct ASD Phenotype,” Dr. Flynn and colleagues investigated whether specific urinary metabolites produced by intestinal microbes could serve as predictive biomarkers for autism spectrum disorder. The study proposes that a large subset of children with autism may represent a biologically distinct phenotype characterized by markedly elevated microbial metabolites, which the authors term ASD-MDM (Autism Spectrum Disorder associated with Microbially-Derived Metabolites). The investigators analyzed urine samples from 52 children with ASD and 47 typically developing (TD) controls, ages 2–11 years. They measured microbial metabolites derived primarily from phenylalanine metabolism, tryptophan metabolism, and yeast metabolism. These were chosen because decades of autism, microbiome, and metabolic research have repeatedly implicated abnormalities in microbial metabolism of aromatic amino acids, especially phenylalanine and tryptophan, along with evidence of elevated fungal/yeast metabolites in subsets of children with ASD. The findings were striking. Children with ASD demonstrated significantly higher concentrations of many microbial metabolites than controls. Some metabolites were elevated by hundreds to thousands of percent, and in certain children concentrations were reported to be 100–1000 times higher than the highest levels observed in any control participant. Twenty-three of twenty-four measured microbial metabolites were higher in ASD participants. Ninety percent of the ASD participants (45 of 50) had one or more extremely elevated MDMs. Particularly notable were elevations in compounds related to p-cresol, p-cresol sulfate, phenylacetylglutamine, indole derivatives, and arabinitol, suggesting abnormalities in microbial metabolism involving aromatic amino acids and yeast overgrowth.... Also, Inflammation and Allergy. Enjoy, Dr. M

  11. Jul 5

    Dr. M’s Women and Children First Podcast #114: Aimie Apigian, MD – Biology of Trauma

    Today's podcast guest is Dr. Aimie Apigian, a physician who has become one of the leading voices in helping us understand the biology of trauma. Dr. Aimie is double board-certified in Preventive Medicine and Addiction Medicine, with advanced training in biochemistry, public health, and functional medicine. She earned her medical degree from Loma Linda University, where her education also included behavioral health, child psychiatric therapy, play therapy, and addiction family counseling. Before medical school, she studied Cell and Molecular Biology at the University of Washington, where she worked in the laboratory of renowned cancer researcher Dr. Larry Loeb. She is the national bestselling author of The Biology of Trauma, featuring a foreword by Dr. Gabor Maté. The book has appeared on the USA TODAY Best-Selling Book List and has received multiple national book awards. What makes Dr. Aimie's work unique is her ability to bridge neuroscience, functional medicine, attachment science, and trauma therapy into a practical framework that explains how our bodies store survival patterns after stress and adversity. Rather than viewing trauma as simply a psychological experience, she teaches that it is a biological state—one that can be identified, measured, and, importantly, healed. She is the creator of the Biology of Trauma® framework, which integrates somatic therapies, parts work, nervous system regulation, and targeted biological interventions into a structured sequence designed to restore the body's innate capacity for healing. She is also the founder of Trauma Healing Accelerated™ and the host of the popular Biology of Trauma® Podcast, where she has educated thousands of clinicians and individuals around the world. Today, we're going to explore what trauma actually is from a biological perspective, how it influences immune function, metabolism, chronic disease, and childhood development, and perhaps most importantly, what it truly takes to move from surviving to thriving. Dr. M

  12. Jun 29

    Dr. M’s SPA Newsletter Volume 16 Issue 16 – Fake it Till You Make it

    Fake It Till You Make It? One of the most misunderstood pieces of advice in our culture is the phrase "fake it until you make it." At face value, it sounds dishonest. It sounds like pretending to be something you are not. It sounds like confidence without competence. But after nearly three decades in medicine, I have come to believe there is a deeper truth hiding inside that phrase. Most success in life is not built on pretending. It is built on being willing to step into situations where you are not yet fully prepared, knowing that growth happens only when you are slightly or deeply beyond your comfort zone. If I am being honest, much of my professional life has felt this way, and the depth vacillated based on the context. When I finished my pediatric residency at the University of Virginia, I was 29 years old and knew just enough to realize how much I did not know. Medical school and residency provide an enormous foundation, but they also expose you to the staggering volume of knowledge that exists in the world. And that volume has only skyrocketed in the past 30 years. The farther I traveled in medicine, the more I realized the horizon kept moving, often unattainable. One experience from those early years remains crystal clear, almost like a scar from a wound. I had been asked to give a lecture to the pediatric residents at UVA on electrolyte solutions and exercise physiology. I spent time preparing and thought I knew the material reasonably well. I walked into the room feeling confident. Then the questions started..... and a literature review. Enjoy, Dr. M

  13. Jun 14

    Dr. M’s Women and Children First Podcast #113: Navaz Habib, DC – Vagal Action and Health

    Welcome back to Dr. M’s Women and Children First. Today, we are joined by one of the leading voices in the world of vagus nerve health, functional medicine, and autonomic nervous system regulation, Dr. Navaz Habib. Dr. Habib is a chiropractor, educator, international speaker, and author of the bestselling books *Activate Your Vagus Nerve* and *Upgrade Your Vagus Nerve*. His work has helped bring the science of the vagus nerve from the research world into practical clinical medicine, helping providers and patients better understand the powerful connection between the brain, immune system, gut, metabolism, and overall health. On today's episode, we take a pediatric lens to this fascinating topic. We explore how vagal tone influences inflammation, stress resilience, digestion, sleep, emotional regulation, and neurodevelopment. We discuss what happens when the autonomic nervous system becomes dysregulated, how chronic stress can shape a child's physiology, and why the vagus nerve may be one of the most important communication highways in the body. We'll also dive into practical strategies that families and clinicians can use to support vagal function, including breathing techniques, movement, nutrition, social connection, sleep, and other evidence-informed interventions that can help children build greater resilience in an increasingly stressful world. If you've ever wondered how the nervous system intersects with immune health, behavior, gut function, and chronic disease risk, this conversation is for you. Please join me in welcoming Dr. Navaz Habib. Dr. M

  14. Jun 7

    Dr. M’s SPA Newsletter Volume 16 Issue 14 – The Adult Chair

    The Adult Chair, the Adolescent Chair and the Child's Chair The Adult Chair by Michelle Chalfant is a practical framework for emotional maturity, self-awareness, and healing old patterns that unconsciously drive adult behavior. The central premise is that most people move through life reacting not from their grounded adult self, but from unresolved emotional states formed during childhood and adolescence. She organizes this idea into what she calls the “three chairs”: the Child Chair, the Adolescent Chair, and the Adult Chair. The Child Chair represents the emotional self formed in early childhood. This is the place of vulnerability, fear, shame, abandonment, loneliness, and unmet needs. When people react from this chair, they often feel helpless, emotionally flooded, overly dependent on validation, or afraid of rejection. Many adult relationship conflicts, according to Chalfant, are actually wounded children (in adult bodies) interacting with each other while wearing grown-up clothing and carrying iPhones. Same child like nervous system. Better accessories. Think of the statement: lipstick on a pig, you cannot dress up dysfunction and make it disappear. The Adolescent Chair reflects the defensive coping strategies people develop to protect the wounded child. This includes control, perfectionism, blame, avoidance, rebellion, people-pleasing, passive aggression, and emotional shutdown. The adolescent self seeks power and protection but often creates disconnection and conflict. Chalfant argues that many high-achieving adults unknowingly operate from this chair, appearing successful externally while internally driven by fear, insecurity, or the need for approval. The Adult Chair is the goal.... Enjoy, Dr. M

  15. May 22

    Dr. M’s Women and Children First Podcast #112: Mona Delahooke, PhD – Beyond Behaviors

    Today on Dr. M’s Women and Children First, we welcome one of the most important voices in modern child development and behavioral science, Mona Delahooke. Dr. Delahooke is a licensed clinical psychologist, internationally recognized speaker, and the author of groundbreaking books including Beyond Behaviors and Brain-Body Parenting. Her work challenges one of the deepest assumptions in modern parenting and education: that difficult behaviors are simply choices to be corrected. Instead, she invites us to ask a radically different question, what is the nervous system trying to communicate? This conversation sits right at the crossroads of neuroscience, attachment theory, polyvagal theory, developmental psychology, and the lived experience of parenting. In many ways, Mona’s work gives language to something clinicians and parents often feel intuitively but struggle to articulate: behavior is not merely compliance or defiance, behavior is biology expressed through the body. We explore how stress physiology, early attachment, sensory processing, trauma, neurodivergence, and autonomic nervous system states shape the way children interact with the world around them. We discuss why punishment-based models often fail vulnerable children, how “bad behavior” may actually represent adaptive survival responses, and why safety and connection are foundational to learning, resilience, and emotional regulation. For me personally, this conversation resonates deeply with the broader themes we often discuss on this podcast, the interaction between environment, physiology, immune health, metabolism, and neurodevelopment. Mona helps bridge the gap between cellular stress and relational stress, between body and mind, between physiology and behavior. If you’ve ever cared for a child with anxiety, ADHD, autism, sensory challenges, explosive behavior, school struggles, or chronic dysregulation, this episode offers both compassion and a fundamentally different framework. One that moves away from blame and toward curiosity. Away from control and toward connection. This is a conversation about seeing children more clearly. And perhaps, seeing ourselves more clearly too. Please enjoy this conversation with Dr. Mona Delahooke. Dr. M

  16. May 17

    Dr. M’s SPA Newsletter Volume 16 Issue 12 – Creatine and Microbiomes

    Creatine and Microbiomes A new 2026 Cell Metabolism study explores a compelling and increasingly central idea in modern biology: the gut/brain/immune/metabolism axis is not just associative, it is mechanistic. Specifically, Dr. Lu and colleagues investigate how the gut microbiota can directly influence depressive behavior by reshaping systemic and neural metabolism. This is another in a long running list of papers describing the amazing work that bacterial commensal microbes do for us. In this case, our minds and moods. "Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic profiling to reveal elevated fecal creatine alongside reduced plasma and cerebrospinal fluid creatine in both patients with depression and mouse depression models. Exogenous creatine produced antidepressant-like effects mediated by gut microbiota. Bifidobacterium pseudolongum was identified as a significantly reduced gut bacterial species in depression, correlating with impaired creatine absorption. Subsequent supplementation with Bifidobacterium enhanced the antidepressant effects of creatine. Mechanistically, B. pseudolongum-derived acetate promoted the creatine transporter (Slc6a8) expression in intestinal epithelial cells via histone acetylation. The Slc6a8 mediated the antidepressant-like effects of creatine. Neuronal creatine deficiency influenced energetic metabolism and neurophysiological function. In patients with depression taking antidepressants, co-administration of creatine and Bifidobacterium increased plasma creatine levels and reduced depression scores. These findings identify the Bifidobacterium-creatine combination as a promising antidepressant strategy and highlight the critical role of gut-brain energy metabolism in depression." "The brain, as an energy-intensive organ, relies on precise metabolic regulation to maintain synaptic plasticity, neurotransmitter synthesis, and stress response systems. Accumulating evidence implicates energy metabolism dysregulation as a hallmark of depression. Neuroimaging studies using positron emission tomography (PET) have identified marked glucose hypometabolism in the medial prefrontal cortex (mPFC) of patients with depression. Cerebral mitochondrial dysfunction and ATP imbalance have been mechanistically linked to depression progression. Notably, emerging studies emphasize the bidirectional interplay between peripheral metabolic signals and central energy regulation, which is fundamental to neural metabolism. Clinical observations such as fatigue, appetite dysregulation, and unexplained weight fluctuations in patients with depression further suggest systemic metabolic disturbances spanning peripheral organs and the CNS.." (Lu et. al. 2026) This is next-level medicine. Mental health can no longer be framed as a disorder of genetics, experience, or circumstance alone. This work opens a clearer window, showing how the microbiome participates as an active partner, shaping brain function through the metabolites it helps produce and deliver. Compounds like creatine are no longer just peripheral players. They become signals, fuel, structure, and information, bridging gut and brain, metabolism and behavior.... and more Enjoy, Dr. M

  17. May 10

    Dr. M’s Women and Children First Podcast #111: Duey Freeman, MA – Attachment

    Welcome back to Dr. M’s Women and Children First. Today’s conversation moves into one of the deepest layers of human development: attachment, relationship, and the way early experiences shape the architecture of our emotional lives. My guest today is Duey Freeman, a licensed therapist, teacher, mentor, and internationally respected voice in attachment theory, human development, and relational psychology. Duey has spent decades teaching therapists, graduate students, and helping professionals around the world, developing a practical framework for understanding how connection, or the absence of it, shapes the nervous system, identity, and the capacity for intimacy. He has logged nearly 80,000 direct clinical hours and co-founded both the Gestalt Equine Institute and the Gestalt Institute of the Rockies. What makes Duey’s work unique, and it is unique, is that he does not approach attachment as a sterile academic theory. He approaches it as lived human experience. His work centers on a simple but profound truth: what is injured in relationship is often only healed in relationship. In this episode, we explore how attachment patterns emerge in childhood, how they quietly shape adult relationships, parenting, stress physiology, and even our sense of safety in the world. We discuss the roots of attachment theory through the work of John Bowlby and Mary Ainsworth, and we move into modern concepts involving trauma, nervous system regulation, emotional attunement, and relational repair. We also touch on an uncomfortable reality in modern culture: many people are surrounded by communication yet starving for authentic connection. Children especially do not simply need instruction or behavioral management. They need co-regulation, attunement, eye contact, emotional presence, and secure relational anchors. This conversation is not just for therapists. It is for parents, physicians, educators, coaches, and anyone trying to understand why humans behave the way they do under stress, conflict, intimacy, or loss. Duey brings an unusual combination of wisdom, groundedness, tenderness, and clinical depth to this discussion. I have heard him frequently called Yoda, and if you knew him, you would immediately understand and agree with that moniker. You can feel that he has spent a lifetime studying not just psychology, but people. So sit back and enjoy this remarkable conversation with Duey Freeman on attachment, psychology, and the relational foundations of being human. Dr. M