Postscripts Rx

PostScripts Rx Team

Conversations Beyond the Prescription. Where pharma, HCPs, life science and digital health solutions meets patients—after the script is written. Conversations on digital health, engagement, and real-world impacts that are re-writing the future of patient engagement.

  1. 15/10/2025

    When MFN Pricing Meets Patient Power: How Digital Support Becomes the Moat

    Prices are leveling, but the real story is where competitive edge is moving: from rebates and discounts to experience, trust, and the moments that keep a patient on therapy. We dig into the MFN pricing model and its ripple effects across U.S. pharma, explaining how reference-based pricing compresses margins and forces brands to compete on loyalty, adherence, and the quality of their support programs. When physicians and patients see real-time costs at the point of prescribing, “comparable” options become a head-to-head test of who delivers better help, clearer guidance, and fewer hurdles. We walk through the new playbook for brand teams: measure what matters (six-to-twelve-month adherence, patient-initiated refills, NPS, and in-app engagement), design push moments that meet patients right when they decide to refill or speak with their doctor, and turn existing content into a living journey. Digital companions are no longer a nice-to-have—they’re loyalty infrastructure. Timely reminders, dose tracking, symptom logs, and doctor discussion guides reduce drop-offs and raise confidence. Layered on top, voice-integrated agents offer scalable, multilingual check-ins that feel personal, follow brand protocols, and escalate to humans when needed, making support available 24/7 without ballooning costs. At the executive table, the strategy becomes both defensive and offensive. Defensively, protect market share by tightening onboarding, reducing abandonment, and integrating digital support from launch. Offensively, differentiate with patient services, bring engagement and adherence lift into payer negotiations, and broaden KPIs beyond price to lifetime value and experience metrics. As MFN pressures grow, the winners will be those who treat loyalty as a system—measured rigorously, designed intentionally, and delivered consistently. Subscribe, share this with a teammate who owns patient experience, and leave a review with the one metric you think should be on every brand dashboard. PostScripts Rx is not intended to constitute medical advice, nor is it intended to influence prescribing decisions or any other medical or clinical decision-making. All medical and clinical judgment and decision-making, prescribing decisions, and all related considerations remain exclusively the responsibility of providers and patients.

    13 phút
  2. 14/10/2025

    PBMs, Transparency, and the D2C Pivot

    Prices that used to hide in the shadows are stepping into the light—and it’s changing how patients get their medicines. We dive deep into the PBM reckoning: why scrutiny is mounting, how California’s new law opens the books on rebates and reimbursements, and what more than 30 states signal for the future of drug access. From there, we chart the path pharma is taking to meet the moment—standing up direct-to-consumer channels, publishing clear cash prices for GLP-1s and insulin, and using digital tools to support patients at the exact moment they need guidance. We unpack the incentives that got us here—spread pricing, formulary gatekeeping, and opaque negotiations—and then show how transparency reshapes behavior across the board. When a payer can see a cash price, the math behind rebates changes. When a patient can tap a support team, dose questions and refills don’t become barriers. And when adherence and symptom data flow securely into connected systems, trial churn falls and real-world evidence grows stronger. It’s not just a commercial pivot; it’s an outcomes strategy that relies on timely education, affordability support, and trust built one interaction at a time. You’ll hear a clear game plan for leaders across pharma: align patient support, access, IT/security, and procurement around HIPAA-compliant, interoperable platforms; embed copay and affordability tools where decisions happen; and design companion experiences early so launches are patient-ready on day one. Over the next two to three years, transparency will be a differentiator, D2C will scale fast, and “digital” will simply be how care is coordinated. If you’re ready to lead in a post-PBM landscape—and prove it with measurable results—hit play, subscribe, and share your take. Your feedback helps us spotlight what’s working and where the industry should go next. PostScripts Rx is not intended to constitute medical advice, nor is it intended to influence prescribing decisions or any other medical or clinical decision-making. All medical and clinical judgment and decision-making, prescribing decisions, and all related considerations remain exclusively the responsibility of providers and patients.

    15 phút
  3. 01/10/2025

    Inside Pfizer’s Bold Bet on Direct-to-Consumer Drug Sales—and What It Means for Access, Pricing, and Power

    A pharmaceutical giant just pressed the D2C button—and the ripple effects could reset how Americans find, pay for, and receive their medications. We unpack Pfizer’s move to list discounted drugs on TrumpRX, why visible pricing matters to patients skipping doses due to cost, and how a retail-like experience collides with the realities of safety, compliance, and payer rules. The story isn’t just about cheaper price tags; it’s about whether pharma can deliver trust, guidance, and continuity when the product page becomes the front door to care. We walk through the e‑commerce playbook for medicine: SEO that respects fair balance, conversion paths that embed indication boundaries, and omnichannel journeys that connect telehealth, fulfillment, and ongoing support. On the access side, we explore how Medicaid‑like pricing without prior auth might ease friction—while raising new questions about regimen stability, monitoring, and the role of nurse educators and pharmacists. Think “pizza tracker,” but for prescriptions: status visibility, document checks, counseling prompts, and time‑to‑therapy metrics that actually predict outcomes. For leaders, the tradeoffs are real. Cutting out PBMs promises transparency and faster feedback, yet risks channel conflict and insurer steering toward network pharmacies with lower copays. We dig into governance, logistics, and security: HIPAA controls, phishing and spoofing defenses, serialization and cold‑chain integrity, and the optics of “Made in America” as a quality signal. The early verdict will hinge on data—fill speed, adherence, and safety. If results improve, smaller manufacturers and select generics may follow, accelerating a digital-first shift across the sector. Ready to see where pharma e‑commerce goes next? Tune in, share your take, and help us chart a smarter path from intent to appropriate use. If this conversation helped, follow or subscribe, leave a review, and pass it along to someone rethinking access, pricing, or digital patient support. PostScripts Rx is not intended to constitute medical advice, nor is it intended to influence prescribing decisions or any other medical or clinical decision-making. All medical and clinical judgment and decision-making, prescribing decisions, and all related considerations remain exclusively the responsibility of providers and patients.

    12 phút
  4. 01/10/2025

    Why Pharma Is Investing Back in the U.S.—And What It Means for Your Medicine

    Policy sparks the shift, but patients feel the impact—faster access, steadier supply, and smarter support. We dig into why major pharma players are pouring billions into U.S. manufacturing, how most favored nation pricing is reshaping reimbursement strategy, and where digital medication tools close the gap between a written script and a successful outcome. With examples like Eli Lilly’s Texas investment and Pfizer’s recent pricing moves, we map the real-world changes that determine whether your therapy is affordable, on time, and easier to manage. We walk through the trade‑offs behind reshoring: tighter quality control, shorter lead times, and greater resilience against geopolitical shocks versus the historic lure of lower-cost offshore production. Then we connect the dots to patient experience—what happens when factories are closer to demand, distribution is more predictable, and cybersecurity protects data as digital companions guide dosing, side effects, and adherence. For complex regimens like GLP‑1 therapies and oncology protocols, the combination of reliable supply and tailored digital support reduces stress, prevents missed doses, and improves outcomes that value‑based care models increasingly reward. Throughout, we share how leaders across market access, IT, and the C‑suite are aligning strategy so affordability and reliability reinforce each other. Domestic capacity, policy adaptation, and data‑driven patient support aren’t parallel tracks—they’re a single system designed to deliver safer, more reliable therapies with fewer surprises. If you care about the future of drug pricing, supply chains, and real patient results, this conversation offers a clear, practical roadmap you can use to benchmark your own strategy or ask smarter questions at your next appointment. Subscribe, share with a colleague, and leave a review to help more people find these insights. PostScripts Rx is not intended to constitute medical advice, nor is it intended to influence prescribing decisions or any other medical or clinical decision-making. All medical and clinical judgment and decision-making, prescribing decisions, and all related considerations remain exclusively the responsibility of providers and patients.

    6 phút
  5. 01/10/2025

    Why Your Medicine May Soon Say "Made in America"

    The pharmaceutical landscape is undergoing a seismic shift as the Trump administration drops a bombshell 100% tariff on imported branded and patented drugs, effective October 1st. This game-changing policy mandates that pharmaceutical companies build manufacturing plants on American soil or face potentially devastating market consequences. We dive deep into the multifaceted implications of this dramatic policy shift that has already prompted nearly $20 billion in promised pharmaceutical manufacturing investments across the United States. The tariff represents a fundamental pivot toward economic nationalism in healthcare, framed around dual imperatives of national security and domestic job creation following the supply chain vulnerabilities exposed during the COVID pandemic. For pharmaceutical brand marketers, this creates unprecedented communication challenges as companies navigate how to maintain brand value when prices may potentially double overnight. Patient access teams must rapidly scale copay assistance programs and develop new financial navigation resources to prevent affordability barriers. Meanwhile, innovation teams face profound questions about where research and development should physically occur, potentially fragmenting the collaborative global research model that has accelerated breakthrough therapies. The operational dimensions cannot be understated—building FDA-compliant facilities requires substantial time and expertise, with procurement teams facing the complex task of securing U.S.-based contract manufacturers and redefining supply chains when 79% of active pharmaceutical ingredients are currently imported. This transition creates new cybersecurity concerns as domestic facilities handling sensitive biologic intellectual property become targets for industrial espionage. Digital patient engagement platforms will become increasingly critical during this transition, offering pharmaceutical companies their most direct pathway to maintaining patient relationships while navigating affordability challenges. The administration has promised expedited regulatory approvals for new manufacturing facilities, potentially creating a new American era of biopharmaceutical independence—if executed thoughtfully and inclusively. Subscribe to Postscripts for ongoing analysis at the intersection of pharmaceutical policy, technology and patient impact as this watershed moment continues to reshape the healthcare landscape. PostScripts Rx is not intended to constitute medical advice, nor is it intended to influence prescribing decisions or any other medical or clinical decision-making. All medical and clinical judgment and decision-making, prescribing decisions, and all related considerations remain exclusively the responsibility of providers and patients.

    14 phút
  6. 24/09/2025

    Made in America: Eli Lilly's $6.5B Texas Spend

    Pharmaceutical giants are bringing manufacturing back to American soil in a massive strategic pivot. Eli Lilly's recent $6.5 billion investment in a Texas facility for its obesity medications signals a transformative shift that's rapidly spreading throughout the industry, with Pfizer, Amgen, and Novo Nordisk collectively announcing over $20 billion in domestic manufacturing projects. This reshoring revolution isn't happening by chance. The Biden administration's Most Favored Nation pricing framework aims to align U.S. drug prices with those in other developed countries, fundamentally disrupting the traditional premium pricing model that has made America the profit center for global pharmaceutical sales. With the U.S. representing 41% of the global pharma market value but just 4% of world population, companies are scrambling to maintain profitability as pricing power diminishes. Manufacturing domestically offers multiple strategic advantages beyond mere publicity. It provides greater control over production costs, accelerates speed to market, reduces regulatory delays, and addresses the supply chain vulnerabilities painfully exposed during the COVID-19 pandemic. The administration has sweetened the deal by promising expedited FDA and EPA approvals for new pharmaceutical facilities and potentially offering flexibility on MFN enforcement for companies making significant U.S. investments. Digital health platforms are emerging as crucial components in this new landscape. Solutions that improve medication adherence, provide real-world data, and demonstrate measurable outcomes offer pharmaceutical companies powerful tools for negotiating with payers and justifying their pricing strategies. With improvements in adherence reaching up to 34%, these technologies directly support better patient outcomes while potentially reducing overall healthcare costs. This manufacturing migration affects every department within pharmaceutical organizations. Brand teams must rethink product roadmaps to prioritize therapies with U.S.-aligned supply chains. Patient access groups need to integrate digital companions into their support programs. Procurement must accelerate domestic partner vetting, while IT departments ensure compliance with U.S. regulatory frameworks like HIPAA. What's your organization doing to adapt to this new reality where domestic manufacturing and digital innovation are becoming critical to pharma success? Subscribe to Postscripts for more insights at the intersection of pharmaceutical strategy, technology, and patient impact. Sources: CNBC: “Eli Lilly plans $6.5 billion Texas manufacturing plant for obesity pill” (2025-09-23)IQVIA Institute for Human Data Science: “The Global Use of Medicine in 2023 and Outlook to 2027”Medisafe internal outcomes data, 2023Health Affairs: "Implications of Most Favored Nation Drug Pricing Proposal" (2022) PostScripts Rx is not intended to constitute medical advice, nor is it intended to influence prescribing decisions or any other medical or clinical decision-making. All medical and clinical judgment and decision-making, prescribing decisions, and all related considerations remain exclusively the responsibility of providers and patients.

    11 phút
  7. 19/09/2025

    From Hype to Impact: Pharma's 2025-26 Marketing Trends

    Curious about where healthcare marketing is heading in the age of AI? Kait Tuson, Founder and CEO of Hello Helio, shares invaluable insights on navigating the complex intersection of technology, regulation, and patient care with Ryan Janvion of Medisafe. The conversation begins with a candid look at AI adoption in healthcare—not just the hype, but the practical realities. While AI has become "table stakes" in the tech world, pharmaceutical companies face unique regulatory challenges that require a more measured approach. Kate offers a refreshing perspective on how tech innovators and Medical, Legal, and Regulatory (MLR) teams can collaborate rather than clash, suggesting that successful AI implementation will happen through "bite-sized moments" of testing and piloting in safe spaces. We dive deep into the overcrowded messaging landscape where seemingly every healthcare company claims to offer "AI-powered patient engagement solutions." Kate cuts through the noise with practical advice on authentic differentiation: "Product has to be different actually." She emphasizes the importance of specificity—understanding exactly which part of the healthcare journey you're addressing and how your solution uniquely solves real problems. Her warning against the temptation to oversell capabilities resonates strongly: "Don't try to be something that you can't live up to." What makes this conversation particularly valuable is Kate's perspective on healthcare transformation as a collaborative journey. She frames the current moment as a rare opportunity to participate in industry-wide change, encouraging tech innovators to approach regulatory teams with patience and understanding. For anyone working at the intersection of healthcare and technology, this discussion offers both strategic insights and practical wisdom for making a meaningful impact on patient care. Ready to rethink your approach to healthcare marketing? Listen now and discover how to align your messaging with your unique contribution to healthcare transformation. PostScripts Rx is not intended to constitute medical advice, nor is it intended to influence prescribing decisions or any other medical or clinical decision-making. All medical and clinical judgment and decision-making, prescribing decisions, and all related considerations remain exclusively the responsibility of providers and patients.

    8 phút
  8. 18/09/2025

    How FDA's 2025 DTC Ad Enforcement Reshapes Patient Communication

    Pharmaceutical marketing stands at a critical turning point following the FDA and HHS's September 2025 coordinated crackdown on direct-to-consumer prescription drug advertising. This watershed moment marks an unprecedented shift in enforcement, with regulators issuing approximately  enforcement actions—including warning letters to industry giants like Eli Lilly, Novo Nordisk, and telehealth providers. The heart of this regulatory action targets what the FDA calls the "adequate provision loophole" that has long allowed marketers to shift detailed safety information away from prime advertising space. The new enforcement environment demands a fundamental recalibration: consumers must receive clear, balanced safety information at the exact moment they encounter benefit claims, not buried in fine print or on separate websites. This raises significant challenges for traditional advertising channels like television, where limited time has historically pushed risk information to the margins. However, this regulatory shift creates a compelling opportunity for digital health platforms and patient support technologies. Unlike time-constrained TV spots, these channels can deliver step-by-step information tailored to individual patient journeys, embedding precautions alongside benefits in formats that ensure comprehension. For pharmaceutical marketers navigating this new landscape, success requires immediate campaign audits, earlier collaboration with Medical Legal Review teams, and a strategic pivot toward channels that naturally facilitate balanced information delivery. The FDA's message is clear: put patients first while telling the complete truth about both benefits and risks. Those who embrace this challenge will not only achieve compliance but build stronger, more transparent relationships with the patients they serve. Follow or subscribe to Postscripts for more insights at the intersection of pharmaceutical innovation and patient impact. Share your thoughts on how these regulatory changes are reshaping your marketing approach. PostScripts Rx is not intended to constitute medical advice, nor is it intended to influence prescribing decisions or any other medical or clinical decision-making. All medical and clinical judgment and decision-making, prescribing decisions, and all related considerations remain exclusively the responsibility of providers and patients.

    7 phút

Giới Thiệu

Conversations Beyond the Prescription. Where pharma, HCPs, life science and digital health solutions meets patients—after the script is written. Conversations on digital health, engagement, and real-world impacts that are re-writing the future of patient engagement.