Progress, Potential, and Possibilities Podcast / Show

Ira Pastor

Interviews and Discussions With Fascinating People Who are Creating A Better Tomorrow For All Of Us - Host - Ira S. Pastor

  1. 7H AGO

    Reversing Humanity’s #1 Killer - Arterial Plaque | Dr. Matthew O’Connor, Ph.D. - CEO and Co-Founder - Cyclarity Therapeutics

    Send us Fan Mail In the time it will take you watch this episode, over 2,000 people around the world will die from diseases driven by arterial plaque. But what if we could actually remove the toxic cholesterol already trapped inside arteries? Today we’re diving into one of the biggest unsolved problems in medicine and aging: how do you actually remove arterial plaque instead of merely slowing its progression? Cardiovascular disease remains the world’s leading killer, despite decades of statins, anti-inflammatory drugs, and newer RNA-based therapies. Most existing treatments help manage cholesterol and reduce risk, but very few directly target the toxic debris already embedded inside plaques. But what if we could literally extract some of the most dangerous oxidized cholesterol molecules from the body? My guest today is Dr. Matthew ‘Oki’ O’Connor, Ph.D. - CEO and Co-Founder of Cyclarity Therapeutics ( https://cyclaritytx.com/ ), a biotech company developing engineered cyclodextrin molecules designed to bind and remove 7-ketocholesterol, or 7KC - a toxic oxidized cholesterol strongly implicated in atherosclerosis, inflammation, plaque instability, and even broader age-related diseases. Just recently, the company presented first-in-human clinical data at the American Heart Association Vascular Discovery Scientific Sessions showing dose-dependent urinary excretion of 7KC - potentially the first clinical evidence that this toxic molecule can be safely mobilized and removed from the human body. We’ll discuss what 7KC actually is, why oxidized cholesterol may be a root driver of cardiovascular disease, how engineered cyclodextrins work like molecular “sponges,” what the new human data really shows - and what it would mean if medicine could move from slowing plaque progression to truly reversing it. #HeartDisease #Atherosclerosis #Longevity #CardiovascularDisease #PlaqueReversal #AgingResearch #Biotech #Cholesterol #OxidizedCholesterol #7Ketocholesterol #Cyclarity #Healthspan #PrecisionMedicine #AIinBiotech #DrugDiscovery #PreventiveMedicine #Cardiology #AntiAging #Lifespan #MedicalInnovation #SENS #FoamCells #Plaque #HeartAttack #StrokePrevention Support the show

    47 min
  2. 8H AGO

    Fixing the $100B Fluid Overload Crisis in Heart & Kidney Disease | Ryan Marthaler - Vice President of Product Marketing and Business Development, Nuwellis

    Send us Fan Mail One of the biggest drivers of hospital admissions isn’t what most people think - it’s fluid. Not infection, not surgery…fluid overload. And when the body stops responding to diuretics, medicine runs into a wall. Today we’re exploring one of the most challenging and underappreciated frontiers in hospital medicine: fluid overload and the cardiorenal continuum - where heart failure and kidney dysfunction intersect in ways that dramatically affect outcomes, costs, and quality of life. Our guest is Ryan Marthaler, Vice President of Product Marketing and Business Development at Nuwellis, Inc. ( https://nuwellis.com/ ), a medical technology company focused on integrated fluid management solutions for both adult and pediatric patients. Ryan brings a two-decade career spanning Medtronic, St. Jude Medical, and digital health innovation - working at the intersection of clinical evidence, commercial strategy, and product development. At Nuwellis, he has helped drive a strategic shift toward earlier intervention in fluid management and stronger evidence-based commercialization. We’ll be discussing the company’s core therapy platform, including the Aquadex SmartFlow System, a controlled ultrafiltration system designed to remove excess fluid in patients with fluid overload who are unresponsive to diuretics. Beyond the technology, this conversation is really about a bigger question: How do we better manage fluid balance across the heart-kidney axis - and what happens when we intervene earlier, more precisely, and more consistently? #HeartFailure #CardiorenalSyndrome #FluidOverload #HealthcareInnovation #MedicalDevices #CriticalCare #Nephrology #Cardiology #HospitalMedicine #MedTech #Ultrafiltration #KidneyDisease #ICU #HealthTech #HealthcareEconomics #MedicalInnovation Support the show

    34 min
  3. 2D AGO

    Pharma’s Biggest Blind Spot: Why 99.9% of Chemical Space Was Never Explored | Dr. Olga Nissan, Ph.D. - Vice President of Business Development, Evogene

    Send us Fan Mail Pharma has only explored a tiny fraction - less than one-tenth of one percent - of all possible drug-like molecules. So the question is: what happens when AI suddenly opens up the other 99.9%? Dr. Olga Nissan, Ph.D. is Vice President of Business Development at Evogene ( https://evogene.com/ ) where she leads pharmaceutical partnerships for the company’s ChemPass AI generative chemistry platform - an advanced system designed to dramatically expand the searchable universe of drug-like molecules. With over 15 years of experience spanning biotech, pharma, and computational biology, Dr. Nissan operates at the intersection of science, strategy, and commercialization. Prior to Evogene, she was Co-Founder and CEO of Protica Bio, a precision oncology company focused on translating novel biological insights into therapeutic opportunities. Earlier in her career, she held scientific and operational roles at Teva Pharmaceutical Industries, as well as EcoPhage and BiomX, building expertise across microbiology, molecular biology, and translational R&D. Dr. Nissan has a strong track record of advancing technologies from early discovery through clinical and commercial partnerships, and of aligning cutting-edge innovation with the practical needs of pharmaceutical companies. She earned her Ph.D. and completed her postdoctoral training at the Weizmann Institute of Science. #DrugDiscovery #AIinPharma #GenerativeAI #Biotech #PharmaInnovation #ChemistryAI #MachineLearning #DrugDevelopment #PharmaceuticalIndustry #Bioinformatics #AIResearch #ChemPass #Evogene #ComputationalChemistry #FutureOfMedicine #DrugDesign #DeepLearning #HealthcareInnovation #BiotechNews #SciencePodcast Support the show

    44 min
  4. 3D AGO

    Programming Biology: Inside the DNA Supply Chain Powering Modern Drug Discovery - Dr. Patrick Finn, Ph.D. - President & COO -Twist Bioscience

    Send us Fan Mail We used to think of DNA as something we read. Now we’re starting to treat it like something we write - and that changes everything about how medicine gets made. Dr. Patrick Finn, Ph.D. is President and COO of Twist Bioscience ( https://www.twistbioscience.com/ ), a company that’s helping turn biology into something you can engineer, iterate, and even industrialize.  Dr. Finn has spent his entire career building the infrastructure layer of modern biotech - from sequencing and sample prep at Beckman Coulter and Invitrogen, to scaling commercial platforms at Agilent Technologies and now Twist. Dr. Finn also served as Vice President of Sales and Marketing for Enzymatics (recently acquired by QIAGEN), leading commercial activities for North America and Europe, delivering significant top line growth and expanding the base of business to business customers. So this isn’t just a conversation about the future - it’s about how the tools that make the future possible are actually built and deployed. On this episode we go beyond the buzzwords and dig into what it really means to “program biology”, and how close we actually are to designing medicines the way we design software. In addition to his role at Twist, Dr. Finn currently serves on the Scientific Advisory Board of Lasergen and previously served on the Scientific Advisory Board of Enzymatics. He holds a PhD in Nucleic Acid Chemistry from Southampton University and a BSc Hons in Chemistry from Heriot-Watt University. #SyntheticBiology #Biotech #DrugDiscovery #AIinHealthcare #ArtificialIntelligence #DNA #Genomics #Bioengineering #ProgrammableBiology #CRISPR #GeneTherapy #Biotechnology #LifeSciences #MachineLearning #AIResearch #PharmaInnovation #Biology #SciencePodcast #FutureOfMedicine #Biodesign #SyntheticDNA #GenomeSequencing #Bioeconomy #DeepTech #HealthTech Support the show

    51 min
  5. 3D AGO

    The Future of Aging: From Healthspan to Joyspan | Dr. Sanjay Shetty, MD - President, CenterWell/Humana & Dr. Kerry Burnight, Ph.D. - Author, Joyspan

    Send us Fan Mail For decades, medicine focused on helping us live longer. Then came healthspan - helping us stay healthier longer. But what if the next frontier is something even deeper: joyspan… the quality, meaning, and fulfillment of the years we actually live? Today’s conversation sits at the intersection of healthcare delivery, aging science, and one of the most important - and perhaps least discussed - questions in modern medicine: How do we help people not simply live longer… but live fulfilled lives? For decades, healthcare systems have largely measured success through clinical outcomes - lowering blood pressure, reducing hospitalizations, extending survival curves. But as populations age and chronic disease becomes increasingly intertwined with loneliness, purpose, financial security, cognition, and emotional well-being, a much broader picture of health is emerging. And that broader picture is exactly what we explore on this episode. Joining us is Dr. Sanjay Shetty, MD, President of CenterWell ( https://www.centerwell.com/ ) and a senior leader at Humana ( https://www.humana.com/ ).  Dr. Shetty has one of the most fascinating and diverse backgrounds in modern healthcare - physician, radiologist, Harvard Medical School faculty member, Bain healthcare strategist, hospital system operator, value-based care leader, and now the executive overseeing one of America’s largest senior-focused healthcare platforms spanning primary care, home health, pharmacy, and military health services. Under Dr. Shetty's leadership, CenterWell has increasingly focused on the idea that healthcare for older adults must move beyond episodic medicine and toward deeply integrated, personalized, and human-centered care. We’re also joined by Dr. Kerry Burnight, Ph.D. ( https://drkerryburnight.com/ ) - gerontologist, educator, elder justice advocate, and author of the bestselling book Joyspan ( https://www.amazon.com/Joyspan-Science-Thriving-Lifes-Second/dp/1546007350 ).  Dr. Burnight has spent decades studying aging not as decline, but as a stage of life that can be rich with purpose, connection, growth, and meaning. Her work challenges the fear-driven “anti-aging” narrative and introduces the concept of “joyspan” - the quality, vitality, and emotional richness of the years we live. Together, our guests bring two critically important perspectives: one from the operational front lines of transforming healthcare delivery for millions of seniors…and the other from the psychological, emotional, and social science of what actually makes later life meaningful. Part of today’s discussion will center around a fascinating new CenterWell/Humana report titled Understanding Fulfillment for Older Adults: Definition and Impact ( https://assets.humana.com/is/content/humana/CenterWell%20Understanding%20Fulfillment%20in%20Older%20Adultspdf ), which examined more than 5,500 Americans over age 62 and attempted to quantify something medicine rarely measures directly: fulfillment. The findings are remarkable: that fulfillment in later life is influenced less by traditional clinical variables alone and more by factors like self-contentment, purpose, optimism, gratitude, emotional connection, and feeling appreciated by others. So on this episode, we ask: - Can healthcare systems measure fulfillment? - Should fulfillment become a clinical endpoint? - What happens when longevity medicine evolves from merely extending lifespan… to supporting joyspan? - And how do we redesign healthcare, communities, technologies, and even culture itself around what older adults actually value most? #Aging #Longevity #Healthspan #Joyspan #Fulfillment #CenterWell #Humana #SanjayShetty #KerryBurnight #HealthyAging #SeniorCare #FutureOfHealthcare #Gerontology #Loneliness #ValueBasedCare #HealthcareInnovation #PrecisionHealth #AgingWell #HealthcareTransformation #OlderAdults #LongevityScience #Purpose #Wellbeing #HomeHealthcare #PPPShow Support the show

    57 min
  6. 3D AGO

    The Hidden Ripple Effect of Saving a Life | Brad & Kiera Newbury - National Medical Education & Training Center Inc.

    Send us Fan Mail What if saving a life isn’t a single moment…but the beginning of thousands of future moments that only exist because someone chose to act? Today’s guests are father-daughter duo Brad Newbury ( https://bradnewbury.com/ ) and Kiera Newbury ( https://kieranewbury.com/ ) - two voices at the intersection of emergency medicine, leadership, resilience, and human impact. Brad is a veteran Fire Captain and paramedic with nearly four decades on the front lines of emergency response.  Over the course of his career, Brad has trained thousands of EMTs and paramedics around the world and built one of the pioneering online EMS education platforms through National Medical Education & Training Center Inc. ( NMETC -  https://nmetc.com/ ). Drawing from years of responding to crises, leading under pressure, and building businesses while serving in the firehouse, Brad recently authored the Amazon #1 bestseller The First Responder Advantage ( https://www.amazon.com/First-Responder-Advantage-Thriving-Business/dp/1967424837 ), a guide showing how the mindset and skills developed in emergency services can translate into entrepreneurship, leadership, and long-term impact. Joining Brad is his daughter Kiera, an EMT and emerging voice in emergency preparedness and public health advocacy.  Together, Brad and Kiera co-authored The Saved Effect ( https://www.amazon.com/Saved-Effect-Stories-Reclaimed-Willing/dp/1637635923 ), a deeply human exploration of what happens after a life is saved - the ripple effects that extend into families, futures, communities, and generations. Through true stories of cardiac arrests, rescues, bystander CPR, and ordinary people stepping forward in extraordinary moments, the book asks a powerful question: What if the most important part of saving a life is everything that comes afterward? Together, Brad and Kiera bring a rare blend of frontline experience, leadership under pressure, entrepreneurship, public service, and deeply personal storytelling - all centered around one core belief: preparedness, courage, and the willingness to act can change the trajectory of countless lives. #FirstResponders #Paramedic #EMT #EmergencyMedicine #CPR #TheSavedEffect #BradNewbury #KieraNewbury #Firefighter #EMS #Healthcare #Preparedness #CardiacArrest #Leadership #Resilience #PublicHealth #MedicalStories #BystanderCPR #EmergencyResponse #LifeSaving #Podcast #HealthcareInnovation #MentalHealth #Trauma #EMSLeadership Support the show

    1h 32m
  7. 6D AGO

    Induced Proximity Meets Oncology: A New Era In Cancer Therapy | Dr. Angela Coxon, Ph.D., Vice President of Research and Development, Amgen

    Send us Fan Mail For more than 30 years, small cell lung cancer has remained one of the most aggressive and difficult-to-treat cancers - marked by rapid progression, high relapse rates, and very few meaningful advances. But that may finally be starting to change. Today, we’re joined by Dr. Angela Coxon, Ph.D., Vice President of Research and Development at Amgen ( https://www.amgen.com/ ), where she helps lead the development of next-generation therapies aimed at tackling exactly these kinds of challenges. Her work spans discovery research, translational medicine, and molecular oncology - bridging the gap between early scientific insight and real-world impact for patients. If you’ve been following the show, you may remember our conversation with Amgen's Dr. Ryan Potts, where we explored the emerging concept of Induced Proximity - the idea that instead of simply blocking biology, we can design drugs that bring components together to create entirely new functions. That idea is now playing out in the clinic through approaches like bispecific T-cell engagers, which physically link immune cells to cancer cells and force a targeted immune response - offering a new way to go after tumors that have historically been very hard to treat. Dr. Coxon earned her D. Phil in Molecular Biology from the University of Oxford and completed postdoctoral training in vascular biology at Harvard Medical School and Brigham and Women’s Hospital. She has built her career at the intersection of cutting-edge biology and strategic drug development, contributing to Amgen’s pipeline in areas of significant unmet need, including lung cancer. #SmallCellLungCancer #SCLC #CancerBreakthrough #Immunotherapy #CancerResearch #Biotech #Amgen #DrugDevelopment #Oncology #CancerTreatment #BiTE #BispecificAntibodies #InducedProximity #PrecisionMedicine #ClinicalTrials #MedicalInnovation #FutureOfMedicine #LungCancerAwareness #TranslationalMedicine #Biology #SciencePodcast #HealthcareInnovation #CancerTherapy #Pharma #NextGenMedicine Support the show

    25 min
  8. 6D AGO

    Why Longevity Medicine Is Shifting From Optimization to Disease Interception | Dr. Julie Chen, MD - Chief Medical Officer - Radence and Sidestep Health AI

    Send us Fan Mail What if the future of medicine isn’t about treating disease…but detecting it 20 years before symptoms ever appear? Dr. Julie Chen, MD is helping lead one of the newest precision-health companies trying to build that future. Dr. Julie Chen, MD is a physician operating at one of the most interesting intersections in modern medicine: rigorous clinical research, precision longevity medicine, integrative care, and the rapidly evolving world of AI-driven health optimization. Dr. Chen graduated Summa Cum Laude and Phi Beta Kappa from the University of Rochester before earning her M.D. with Distinction in Research and Alpha Omega Alpha honors from the university’s School of Medicine. She went on to complete her internal medicine residency and later trained in integrative medicine under Andrew Weil at the University of Arizona Center for Integrative Medicine. Over the course of her career, Dr. Chen has conducted research and published work through institutions including the U.S. Food and Drug Administration, National Institutes of Health, National Cancer Institute, Mount Sinai School of Medicine, and University of Southern California. Dr. Chen has also become a prominent operational leader in the longevity industry, serving in executive medical roles at companies including Human Longevity, Inc., Vitagene, and now as Chief Medical Officer of Radence ( https://radence.com/ ) and Sidestep Health AI. She additionally serves as a Leadership Circle Advisor for the Buck Institute for Research on Aging. What makes Dr. Chen particularly compelling is that she has seen the longevity ecosystem from nearly every angle: academic medicine, FDA-level research, integrative clinical care, Silicon Valley health-tech, and AI-enabled prevention. In today’s conversation, we’ll explore where the science around longevity is genuinely promising, where the hype may be outrunning the evidence, how precision medicine is shifting toward early disease interception, and what responsible longevity medicine should actually look like in an era increasingly driven by consumer demand and social-media-driven health trends. #Longevity #Peptides #PrecisionMedicine #Healthspan #DrJulieChen #PreventiveMedicine #Biohacking #Aging #DiseaseInterception #GLP1 #LongevityMedicine #AIHealthcare #IntegrativeMedicine #HealthOptimization #HumanLongevity #FutureOfMedicine #MetabolicHealth #PreventiveHealth #Biotech #CraigVenter #Wearables #Biomarkers #Genomics #Radence Support the show

    46 min

Ratings & Reviews

5
out of 5
6 Ratings

About

Interviews and Discussions With Fascinating People Who are Creating A Better Tomorrow For All Of Us - Host - Ira S. Pastor

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