The Joy of Why

“The Joy of Why” is a Quanta Magazine podcast about curiosity and the pursuit of knowledge. The mathematician and author Steven Strogatz and the cosmologist and author Janna Levin take turns interviewing leading researchers about the great scientific and mathematical questions of our time. New episodes are released every other Wednesday. Quanta Magazine is a Pulitzer Prize–winning, editorially independent online publication launched and supported by the Simons Foundation to illuminate big ideas in science and math through public service journalism. Quanta’s reporters and editors focus on developments in mathematics, theoretical physics, theoretical computer science and the basic life sciences, emphasizing timely, accurate, in-depth and well-crafted articles for its broad discerning audience. In 2023, Steven Strogatz received a National Academies Eric and Wendy Schmidt Award for Excellence in Science Communications partly for his work on “The Joy of Why.”

  1. What’s the Future of Gene Editing?

    9h ago

    What’s the Future of Gene Editing?

    One of the most surprising and remarkable discoveries in recent scientific history has been CRISPR. Short for Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR is a form of immune system that evolved in bacteria more than a billion years ago to defend against persistent viral threats. Under attack, bacteria can snip a small fragment of a virus’s DNA, store it in the CRISPR region of their genome, and then use it to recognize and destroy the same virus if it returns. The CRISPR-Cas9 system, to give it its longer name, consists of a short strand of guide RNA that identifies where to cut the DNA and a protein that acts as the molecular scissors. What made this system truly revolutionary was the demonstration in 2012 that it could be reprogrammed with different pieces of guide RNA to edit virtually any genome in any species, and at a level of precision and ease that far surpassed existing gene-editing tools. Since then, the editing capability of CRISPR has been tested on everything from developing disease treatments to engineering drought-resistant crops to resurrecting genes of extinct species. The possibilities have expanded so rapidly that researchers, ethicists, and regulators have found themselves struggling to keep up. One person acutely aware of the power of CRISPR is Jennifer Doudna, co-developer of the technology. Doudna, who received the Nobel Prize in Chemistry in 2020 with Emmanuelle Charpentier for this pioneering work, has been a prominent voice not only for its vast potential but also for its responsible and ethical use. In this episode of The Joy of Why, Doudna tells co-host Janna Levin how her early, “rebellious,” decision to study RNA led her on a serendipitous path to one of biology’s most transformative discoveries. They also discuss the breakthroughs, barriers, and frontiers that will define CRISPR’s true impact.

    51 min

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About

“The Joy of Why” is a Quanta Magazine podcast about curiosity and the pursuit of knowledge. The mathematician and author Steven Strogatz and the cosmologist and author Janna Levin take turns interviewing leading researchers about the great scientific and mathematical questions of our time. New episodes are released every other Wednesday. Quanta Magazine is a Pulitzer Prize–winning, editorially independent online publication launched and supported by the Simons Foundation to illuminate big ideas in science and math through public service journalism. Quanta’s reporters and editors focus on developments in mathematics, theoretical physics, theoretical computer science and the basic life sciences, emphasizing timely, accurate, in-depth and well-crafted articles for its broad discerning audience. In 2023, Steven Strogatz received a National Academies Eric and Wendy Schmidt Award for Excellence in Science Communications partly for his work on “The Joy of Why.”

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