Radio EBM

Oleg Karaduta
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This is Radio EBM. The only channel you need for your free dive in Evidence Based Medicine.

Episodes

  1. Proteogenomics in Nephrology

    15h ago

    Proteogenomics in Nephrology

    What happens when we combine the power of genomics, transcriptomics, and proteomics to study kidney disease? In this episode, we dive into the emerging field of proteogenomics - a cutting-edge approach that integrates multiple layers of biological information to reveal how genes, RNA, and proteins work together in health and disease. By connecting these molecular pieces, researchers are gaining unprecedented insight into the mechanisms driving kidney disorders and uncovering opportunities for more precise diagnosis and treatment. We explore the proteogenomic workflow, discuss how massive datasets are transformed into meaningful biological discoveries, and examine real-world applications in conditions such as clear cell renal cell carcinoma (ccRCC) and Autosomal Recessive Polycystic Kidney Disease (ARPKD). Along the way, we highlight the promise of novel biomarkers, personalized therapies, and a deeper understanding of kidney pathology. Join us as we explore one of the most exciting frontiers in nephrology and discover how proteogenomics is helping to bridge the gap between molecular biology and precision medicine.

    27 min
  2. Metaproteomics, Resistant Starch and CKD

    Jun 22

    Metaproteomics, Resistant Starch and CKD

    Can a type of fibre change the course of chronic kidney disease? In this episode, we explore how resistant starch - a prebiotic fermented by gut bacteria—can reshape the microbiome and potentially protect kidney function. Using advanced metaproteomics, we move beyond simply identifying which microbes are present to uncover what they are actually doing inside the gut. We discuss how resistant starch supplementation shifts the microbial ecosystem toward beneficial butyrate-producing bacteria while reducing microbes that degrade the protective mucus layer of the intestine. Along the way, we examine how these changes influence host biology, affect proteins linked to kidney injury, and reveal a fascinating connection between diet, microbes, and chronic disease. Most importantly, this study demonstrates how metaproteomics can provide an unprecedented view of host–microbiome interactions, delivering both functional and taxonomic insights that traditional sequencing methods often miss. Join us as we uncover how a simple dietary intervention can transform the gut ecosystem and what that transformation may mean for the future of chronic kidney disease management.

    21 min
  3. Metaproteomics of host-microbiome interactions

    Jun 15

    Metaproteomics of host-microbiome interactions

    The microbiome revolution has generated an explosion of new technologies, new datasets, and new promises — but how do we actually understand the conversation between microbes and their host? In this episode, we take a deep dive into the rapidly evolving world of multi-omics and explore why studying the microbiome requires much more than simply identifying which bacteria are present. We discuss the strengths and limitations of genomics, transcriptomics, metabolomics, and proteomics, and examine how these approaches can be combined to reveal the complex biological interactions occurring inside the human body. At the centre of the discussion is metaproteomics — a powerful technique that moves beyond microbial identity to uncover what microbes are actually doing. By measuring proteins directly, metaproteomics provides a unique window into microbial function, host responses, and the dynamic processes that shape health and disease. Join us as we explore the future of microbiome research, the promise of precision interventions ranging from probiotics to fecal microbiota transplantation, and why metaproteomics may become one of the most important tools for decoding host–microbiome interactions.

    22 min
  4. RS modulates host-microbiome interactions

    Jun 8

    RS modulates host-microbiome interactions

    For decades, chronic kidney disease was viewed primarily as a disorder of the kidneys. Today, researchers are discovering that some of the most important changes may be happening much farther downstream—in the gut. In this episode, we explore how resistant starch, a special type of dietary fibre, can reshape the gut microbiome and potentially slow the progression of chronic kidney disease. Using cutting-edge metaproteomics, we examine how resistant starch alters both bacterial communities and their biological activity, revealing a shift toward beneficial butyrate-producing microbes and a reduction in bacteria associated with harmful metabolites. We discuss the fascinating interplay between diet, microbes, and kidney health, the power of mass spectrometry to uncover hidden biological networks, and the evidence showing reduced kidney injury in animals receiving resistant starch supplementation. Join us as we follow the journey from the dinner plate to the microbiome and ultimately to the kidneys, uncovering how a simple dietary intervention may influence one of the most complex host–microbe interactions in medicine.

    22 min
  5. CKD and Gut Microbiotme

    Jun 1

    CKD and Gut Microbiotme

    What if kidney disease isn't just a kidney problem? In this episode, we explore the fascinating connection between the gut microbiome and chronic kidney disease (CKD). As kidney function declines, rising levels of urea can reshape the microbial communities living in our intestines, weakening the gut barrier and promoting the production of harmful toxins. These changes may create a vicious cycle that accelerates kidney damage and contributes to disease progression. We discuss the emerging concept of the gut-kidney axis, the tools researchers use to study the microbiome, and the growing interest in therapies designed to restore microbial balance. From probiotics and prebiotics to novel microbiome-targeted interventions, could the key to slowing kidney disease lie within the trillions of microbes living in our gut? Join us as we examine one of the most intriguing frontiers in nephrology and discover how the gut microbiome is reshaping our understanding of chronic kidney disease.

    6 min
  6. Pulmonary Microbiota

    May 29

    Pulmonary Microbiota

    For decades, medical textbooks taught us that the lungs were sterile. It turns out they were wrong. In this episode, we explore the fascinating world of the pulmonary microbiome—the diverse community of microorganisms living within our airways—and its surprising role in asthma. We discuss how specific bacterial groups, including Haemophilus and Moraxella, may contribute to airway inflammation, disease severity, and immune dysregulation. We also examine an intriguing question: could probiotics become part of future asthma treatment? Drawing from current evidence, we review how manipulating microbial communities might help restore balance, reduce inflammation, and potentially improve clinical outcomes. Join us as we challenge old assumptions about lung biology, uncover the hidden ecosystem inside our airways, and explore whether tiny microbes could hold the key to a new generation of asthma therapies.

    6 min
  • 6 Episodes

About

This is Radio EBM. The only channel you need for your free dive in Evidence Based Medicine.

Information

  • Creator
    Oleg Karaduta
  • Years Active
    2K
  • Episodes
    6
  • Rating
    Clean
  • Copyright
    © Oleg Karaduta
  • Show Website
    Radio EBM