RNA Insights

Eclipsebio
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  • Medicine
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From mRNA vaccines to RNA-editing therapies, RNA and RNA-based therapeutics are the future of health and medicine — and new insights are made every day. In each episode of RNA Insights by Eclipsebio, host Grace Gudwien chats with a different RNA expert about their career and how their work has impacted RNA therapeutics and RNA research. We also review the latest RNA industry news and look forward to what's next in the world of RNA medicine.

Episodes

  1. 4d ago

    Episode 2: RNA helicases and the rise of mRNA therapeutics with Dr. Eckhard Jankowsky

    On this episode of RNA Insights, we chat with Dr. Eckhard Jankowsky about his work with RNA helicases and their impact on health, his transition from academia to Big Pharma, and how the past three decades of RNA therapeutic research will influence the future of RNA medicine.    Resources referenced in the episode:  The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes: https://pubmed.ncbi.nlm.nih.gov/9582286/   The DExH protein NPH-II is a processive and directional motor for unwinding RNA: https://pubmed.ncbi.nlm.nih.gov/10667799/   Jankowsky’s publications: https://scholar.google.com/citations?hl=en&user=z6F2cuoAAAAJ   More information on DDX3X: https://www.ncbi.nlm.nih.gov/gene/1654   More information on DDX3X syndrome: https://www.ucsf.edu/news/2020/03/416816/scientists-unravel-mystery-rare-genetic-disorder-causes-intellectual-disability  The Viral Protein K7 Inhibits Biochemical Activities and Condensate Formation by the DEAD-box Helicase DDX3X: https://www.sciencedirect.com/science/article/abs/pii/S0022283623003169   Hidden specificity in an apparently non-specific RNA-binding protein: https://pmc.ncbi.nlm.nih.gov/articles/PMC3800043/#S1    International mRNA Health Conference: https://mrna-conference.com/  AIRNA Presents New Preclinical Data on AATD Therapeutic Candidate AIR-001 and Cardiometabolic RNA-Editing Programs at ASGCT: https://airna.com/news/airna-presents-new-preclinical-data-on-aatd-therapeutic-candidate-air-001-and-cardiometabolic-rna-editing-programs-at-asgct/   Therorna to Showcase Clinical-Ready Circular RNA in vivo CAR-T and CircRNA Pipeline at the 2026 American Society of Gene & Cell Therapy (ASGCT) Annual Meeting: https://www.businesswire.com/news/home/20260511897230/en/Therorna-to-Showcase-Clinical-Ready-Circular-RNA-in-vivo-CAR-T-and-CircRNA-Pipeline-at-the-2026-American-Society-of-Gene-Cell-Therapy-ASGCT-Annual-Meeting   AviadoBio Presents Positive Preclinical Data for AVB-406 Program in Alzheimer’s Disease and Other Tauopathies at ASGCT 2026: https://aviadobio.com/aviadobio-presents-positive-preclinical-data-for-avb-406-program-in-alzheimers-disease-and-other-tauopathies-at-asgct-2026/   Music by Ievgen Poltavskyi from Pixabay  Sound Effect by Ribhav Agrawal from Pixabay  Eclipsebio host: Grace Finnell-Gudwien

    35 min

  2. Apr 30

    How eCLIP revolutionized RNA-based therapeutic research with Dr. Gene Yeo   

    Welcome to RNA Insights, an RNA therapeutics podcast hosted by Eclipsebio. Each month, we interview a different expert in the field of RNA and RNA-based medicine about their career and thoughts on the ever-evolving RNA therapeutic space.  On this inaugural episode, we talk with Dr. Gene Yeo, co-developer of the eCLIP protocol and co-founder of Eclipsebio, about his journey identifying the need for and developing a more efficient method of crosslinking immunoprecipitation that changed the ways scientists perform RNA research.  Resources referenced in the episode:  Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals: https://pubmed.ncbi.nlm.nih.gov/15285897/  Identification and analysis of alternative splicing events conserved in human and mouse: https://pubmed.ncbi.nlm.nih.gov/15708978/  Yeo Lab Publications: https://yeolab.com/publications   ENCODE Overview: https://www.encodeproject.org/help/project-overview/   Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP): https://www.nature.com/articles/nmeth.3810  Circio enters in vivo cell therapy evaluation agreement with Acuitas Therapeutics: https://www.circio.com/en/circio-enters-in-vivo-cell-therapy-evaluation-agreement-with-acuitas-therapeutics/  Afrigen Biologics Announces RSV mRNA Vaccine Collaboration: https://www.afrigen.co.za/news-press-release-events/  Immorna Announces First Evidence of Tissue B Cell Depletion with In Vivo CAR T JCXH 213 in Systemic Sclerosis Patient, Underscoring Platform’s Potential to Address Autoimmune Diseases: https://www.immornabio.com/News-details/41.html  Music by Ievgen Poltavskyi from Pixabay  Sound Effect by Ribhav Agrawal from Pixabay  Hosted by Grace Finnell-Gudwien

    37 min
  • 2 Episodes

About

From mRNA vaccines to RNA-editing therapies, RNA and RNA-based therapeutics are the future of health and medicine — and new insights are made every day. In each episode of RNA Insights by Eclipsebio, host Grace Gudwien chats with a different RNA expert about their career and how their work has impacted RNA therapeutics and RNA research. We also review the latest RNA industry news and look forward to what's next in the world of RNA medicine.

Information

  • Creator
    Eclipsebio
  • Years Active
    2K
  • Episodes
    2
  • Rating
    Clean
  • Copyright
    © Eclipsebio
  • Show Website
    RNA Insights

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