Send us Fan Mail Episode 66 Contact Dermatitis Shoot me any comments or questions @Rotation2ptoh on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Sport Rock by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS Edited by: Todd Fredricks DO MSS Answers for Episode 65 Eczema (Atopic Dermatitis) Question 1 — Systemic Therapy Selection A 32‑year‑old woman with moderate‑to‑severe atopic eczema has failed optimized topical corticosteroids, topical calcineurin inhibitors, and UVB therapy. She has no significant medical history and is not pregnant. She asks about the most evidence‑supported systemic therapy with the best long‑term safety profile and minimal laboratory monitoring. Which of the following is the most appropriate next‑line therapy? C. Dupilumab 600 mg loading dose, then 300 mg every 2 weeks Question 2 — Pediatric Treatment Decision A 10‑year‑old boy (weight 28 kg) has severe atopic eczema poorly controlled with optimized topical therapy and narrow‑band UVB. His parents prefer a systemic option that is FDA/EMA‑approved for his age group and does not require routine blood monitoring. Which treatment is most appropriate? B. Dupilumab 300 mg every 4 weeks Question 3 — Contraindicated Therapy in Pregnancy A 29‑year‑old woman with severe atopic eczema presents for follow‑up. She tells you she is 8 weeks pregnant and her disease is worsening despite appropriate topical corticosteroids and emollient therapy. Which of the following systemic therapies is contraindicated during pregnancy? C. Upadacitinib Paper for Next Week: Bizjak, Mojca, Olivier Aerts, David Pesqué, Melba Muñoz, Riccardo Asero, Margarida Gonçalo, Thomas Rustemeyer, Mitja Košnik, Mark Kačar, An Goossens, Jose Hernán Alfonso, Charlotte G. Mortz, Maryam Ali Al‑Nesf, Joachim W. Fluhr, Howard I. Maibach, and Ana Maria Giménez‑Arnau. “Contact Urticaria and Related Conditions: Clinical Review.” Contact Dermatitis 93 (2025): 87–107. Rotations 2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.
