Rotations 2.0

Todd Fredricks DO MSS

A weekly discussion of medicine and science trends between people far too old to be trying something this new.

  1. 1D AGO

    Rotations 2.0 Episode 64 Psoriasis

    Send us Fan Mail Episode 64 Psorasis Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Ambient Tension by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 63 AcneQuestion 1 A 17‑year‑old adolescent presents with moderate inflammatory acne on the face and back. Microbiome analysis of her lesions shows decreased alpha diversity and an overrepresentation of Enterococcaceae on both the face and back. Which of the following best explains these findings? D. Dysbiosis characterized by decreased microbial diversity and overgrowth of specific taxa Question 2 A 19‑year‑old woman with moderate acne begins treatment with 2% supramolecular salicylic acid (SSA) for 8 weeks. At follow‑up, she reports clinical improvement. Microbiome analysis shows increased alpha and beta diversity and reductions in Staphylococcus, Ralstonia, and Streptococcus species. Which mechanism best explains these findings? B. Anti‑inflammatory effects with stabilization of microbial communities Question 3 A researcher evaluates the impact of different acne treatments on the cutaneous microbiome. She notes that only one standard therapy consistently produced a statistically significant change in alpha diversity across multiple studies included in a meta‑analysis. Which treatment is she referring to? D. Topical benzoyl peroxide (BPO) Paper for Next Week: Wollenberg, A., M. Kinberger, B. Arents, N. Aszodi, S. Barbarot, T. Bieber, H. A. Brough, et al. 2025. “European Guideline (EuroGuiDerm) on Atopic Eczema: Living Update.” Journal of the European Academy of Dermatology and Venereology 39: 1537–1566. https://doi.org/10.1111/jdv.20639. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

    41 min
  2. APR 20

    Rotations 2.0 Episode 63 Acne

    Send us Fan Mail Episode 63 Acne Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Epic Industrial Future by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 62 Pharyngitis Question 1: Adolescent with red flags after “sore throat” A 17-year-old previously healthy male presents with 5 days of worsening sore throat, high fevers, and new right-sided neck pain with swelling. A rapid antigen detection test (RADT) for group A Streptococcus done 2 days ago at an urgent care was negative. Today he appears toxic, and there is tenderness along the anterior border of the sternocleidomastoid. Which of the following is the most likely pathogen–complication pairing explaining this presentation? B. Fusobacterium necrophorum — Lemierre syndrome (internal jugular vein thrombophlebitis with anaerobic septicemia) Question 2: Testing strategy in a child with suspected GAS An 8-year-old girl presents with fever (39.3 °C), throat pain, and tonsillar exudates without cough. Her McIsaac score is 3. A point‑of‑care RADT for GAS is negative. Which of the following is the best next step? B. Send a throat culture (or molecular test if available) to confirm the negative RADT Question 3: Reemerging pathogen and optimal diagnostic confirmation A 32-year-old recent immigrant with unknown vaccination status presents with fever, malaise, and severe sore throat. Examination reveals a gray‑white adherent membrane over the pharynx and tender anterior cervical lymphadenopathy. Which diagnostic approach most rapidly and accurately confirms the suspected diagnosis? B. Duplex real‑time PCR on a throat swab to simultaneously detect Corynebacterium diphtheriae and the toxin‑encoding gene Paper for Next Week: Chan, Jonathan J. “Psoriasis: An Update on Topical and Systemic Therapies.” Australian Prescriber 48, no. 3 (June 2025): 87–92.  Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

    41 min
  3. APR 13

    Rotations 2.0 Episode 62 Pharyngitis

    Send us Fan Mail Episode 62 Pharyngitis Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Childhood Memories by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 61 Otitis Media Question 1 — Initial management (observation vs antibiotics) A 28‑month‑old boy is brought in for 1 day of ear pain and fussiness. His temperature in clinic is 38.3 °C (100.9 °F). He is otherwise healthy, immunizations are up to date, and there has been no antibiotic use in the past month. Otoscopy shows a mildly bulging, erythematous tympanic membrane on the right with preserved landmarks; the left ear is normal. He is drinking adequately and has mild, controllable pain. What is the most appropriate next step in management? B. Watchful waiting for 48–72 hours with scheduled oral analgesics and clear return precautions Question 2 — First‑line antibiotic and dosing A 3‑year‑old girl presents with 2 days of bilateral ear pain and poor sleep. She is well‑appearing, has no conjunctivitis, and has not taken antibiotics in the last 30 days. Otoscopy reveals moderate bulging of both tympanic membranes with middle‑ear effusions. What is the most appropriate initial antibiotic regimen? D. Amoxicillin 80–90 mg/kg/day PO divided twice daily Question 3 — Duration of therapy A 6‑year‑old boy with non‑severe unilateral AOM is started on high‑dose amoxicillin. He has no tympanic membrane perforation, and symptoms are improving after 48 hours. What is the most appropriate total duration of antibiotic therapy for this patient? C. 5–7 days Paper for Next Week: Podwojniak, A., Tan, I. J., Sauer, J., Neubauer, Z., Rothenberg, H., Ghani, H., Parikh, A. K., & Cohen, B. (2025). Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatments. Journal of the European Academy of Dermatology and Venereology, 39, 793–805. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

    44 min
  4. APR 6

    Rotations 2.0 Episode 61 Otitis Media

    Send us Fan Mail Episode 61 Otitis Media Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Innovation by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 60 Mononucleosis  Question 1 — Diagnostic strategy early in illness A 19‑year‑old college student presents on day 3 of fever, severe sore throat, fatigue, and posterior cervical lymphadenopathy. A rapid heterophile (Monospot) test obtained today is negative. Her CBC shows 52% lymphocytes with 12% atypical lymphocytes. She does not take regular medications. Which of the following is the most appropriate next step? C. Order Epstein–Barr virus (EBV) viral capsid antigen (VCA) IgM/IgG serology Question 2 — Therapeutics and special situations A 17‑year‑old with confirmed infectious mononucleosis has progressive tonsillar hypertrophy, drooling, and muffled voice but maintains oxygen saturation at 97% on room air. Which of the following is the best next step? A. Administer a short course of systemic corticosteroids Question 3 — Return‑to‑play and splenic complications A 20‑year‑old linebacker is diagnosed with infectious mononucleosis after 5 days of symptoms. He is afebrile today and wants to play in next week’s game. Which statement is most accurate for counseling? C. Most splenic ruptures occur within the first 21 days of symptom onset, and ~90% occur by day 31; therefore, no athletic activity should occur for the first 3 weeks Paper for Next Week: Caldwell, Jane M., Nathan A. Ledeboer, and Bobby L. Boyanton Jr. 2024. “Review: Known, Emerging, and Remerging Pharyngitis Pathogens.” The Journal of Infectious Diseases 230, Supplement 3: S173–S181. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

    45 min
  5. APR 1

    Rotations 2.0 Point Episode 59.2 Protecting Medical Part II

    Send us Fan Mail Episode 59.2 Protecting Medical Part II Shoot me any comments or questions @Rotations2ptoh  on X Intro/Outro: Night Detective by Amaksi Courtesy of Pixabay under Creative Commons for non-Commercial Educational use only. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Papers referenced: Erickson, Jon V. “Operating in a Multidomain Environment: Combat Support Training Exercise 86‑24‑02.” Military Review (January–February 2025): 96–102. Crowley, Julie, and John S. G. Wells. “Assaulting Medical Neutrality: Reflections on Attacks on Healthcare and Clinicians in the Two World Wars and Implications for Contemporary Conflicts.” Nursing Inquiry 32 (2025): e70052. https://doi.org/10.1111/nin.70052. If you are interested in this topic I have assembled quite a resource set, please contact me at fredrick@ohio.edu and I can provide you with them. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

    47 min
  6. MAR 30

    Rotations 2.0 Episode 60 Mononucleosis

    Send us Fan Mail Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Cloud Atlas by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 58 Abcesses Question 1 – Diagnosis of Early Lyme Disease A 42‑year‑old woman from Pennsylvania presents with 5 days of fever, fatigue, headaches, and diffuse myalgias. She denies noticing a tick bite. Physical examination reveals no rash. Initial two‑tier Lyme serology (ELISA + Western blot) is negative. Which of the following is the most accurate interpretation of this test result? C. Serologic testing is often insensitive in early Lyme disease, and a negative early test does not exclude infection Question 2 – Persistent Symptoms After Treatment A 33‑year‑old man was treated for early Lyme disease 9 months ago with a standard course of doxycycline. He now reports debilitating fatigue, impaired concentration, unrefreshing sleep, and intermittent musculoskeletal pain that have persisted for 6 months and interfere with daily life. Which of the following features best supports the diagnosis of Post‑Treatment Lyme Disease Syndrome (PTLD)? B. Prolonged symptoms affecting functional ability ≥6 months after standard treatment Question 3 – Antibiotic‑Refractory Lyme Arthritis A 55‑year‑old woman presents with persistent right‑knee swelling 3 months after completing two courses of oral doxycycline for Lyme arthritis. Synovial fluid analysis shows an inflammatory profile but no bacterial growth. Which mechanism best explains her persistent joint inflammation? C. Persistence of Borrelia peptidoglycan antigenic debris that promotes ongoing inflammation Paper for Next Week: El Feghaly, R. E., Nedved, A., Katz, S. E., & Frost, H. M. (2023). New insights into the treatment of acute otitis media. Expert Review of Anti-infective Therapy, 21(5), 523–534.  Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.  Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

    40 min
  7. MAR 25

    Rotations 2.0 Point Episode 59.1 Protecting Medicine Part I

    Send us Fan Mail Episode 59.1  Intro to Protecting Providers Part 1 Shoot me any comments or questions @Rotations2ptoh  on X  Intro/Outro: Night Detective by Amaksi  Courtesy of Pixabay under Creative Commons for non-Commercial Educational use only  Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS References  Full episode references available upon request just email me at fredrick@ohio.edu  Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

    39 min
  8. MAR 23

    Rotations 2.0 Episode 59 Lyme Disease

    Send us Fan Mail Episode 59 Lyme Disease Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Touch by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 58 Abcesses A 26‑year‑old woman reports recurrent painful deep nodules in both axillae that have persisted for 4 months despite topical care. Which feature from the Lancet review most directly supports a clinical diagnosis of hidradenitis suppurativa in this patient? C. Persistence of one or more active lesions for at least 3 months. According to the review, which comorbidity is most commonly associated with hidradenitis suppurativa and is reported in up to half of affected patients, warranting routine screening? C. Metabolic syndrome Which of the following systemic therapies approved for moderate‑to‑severe hidradenitis suppurativa acts primarily by inhibiting tumor necrosis factor (TNF)? D. Adalimumab Paper for Next Week: Sylvester, J. E., Buchanan, B. K., & Silva, T. W. (2023). Infectious mononucleosis: Rapid evidence review. American Family Physician, 107(1), 71–78.  Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

    36 min

About

A weekly discussion of medicine and science trends between people far too old to be trying something this new.