Girl Doc Survival Guide

Christine J Ko, MD

Young doctors are increasingly in ‘survival’ mode.    Far from flourishing, the relentless pressure of working in medicine means that ‘balance’ is harder than ever to achieve.   On the Girl Doc Survival Guide, Yale professor and dermatologist Dr Christine J Ko sits down with doctors, psychologists and mental health experts to dig into the real challenges and rewards of life in medicine.    From dealing with daily stressors and burnout to designing a career that doesn’t sacrifice your personal life, this podcast is all about giving you the tools to not just survive...    But to be present in the journey.

  1. 3D AGO

    EP209: The Art of Diagnosis: Insights from Dr. Lisa Sanders

    Dr. Lisa Sanders on Diagnosis, Cognitive Bias, and Making Time to Listen Christine interviews Dr. Lisa Sanders, Yale School of Medicine professor and Medical Director of Yale’s Long COVID Multidisciplinary Care Center, known for the New York Times “Diagnosis” column and consulting on House. Sanders describes switching from Emmy-winning CBS News producer to physician after seeing a sports medicine doctor perform CPR and save a drowning woman, and realizing she wanted to save lives. She discusses avoiding diagnostic cognitive bias by staying aware you can be wrong, keeping a differential diagnosis, and “trust but verify,” sharing a case where she accepted a patient’s self-reported POTS diagnosis and later found hyperthyroidism. Sanders argues diagnostic errors often stem from rushed visits and urges physicians to demand more time, noting she secured hour-long new-patient visits and 30-minute follow-ups. She addresses patients not being believed, especially with post-infectious syndromes like long COVID, POTS, MECFS, and fatigue, and advises support for non-linear career paths. 00:00 Welcome and Guest Intro 01:00 From TV News to Medicine 01:31 The CPR Moment That Changed Everything 03:42 Fighting Diagnostic Bias 04:45 Trust but Verify POTS Mix Up 06:49 Reclaiming Time With Patients 10:45 Why Patients Aren't Believed 12:11 Fatigue and Post Infectious Syndromes 13:45 Advice for Nonlinear Careers 14:43 Final Thoughts and Farewell

    15 min
  2. FEB 25

    EP207: Dr. Kevin Ko: New Horizons in Oral and Dermatopathology

    Dr. Kevin Ko on Biomarkers, Oral Dysplasia, and the Limits of H&E Diagnosis Christine interviews Dr. Kevin Ko (DMD, MD), a pathologist at the BC Cancer Agency with training in oral and maxillofacial pathology, anatomic pathology, and dermatopathology. They discuss his ASDP 2025 lecture on using p53 in oral dysplasia as a potential new approach and the broader problem of diagnostic discordance and over-diagnosis when relying on H&E alone. Dr. Ko shares examples from practice, including recognizing oral porokeratosis (previously followed as dysplasia for years) and a chemotherapy-related lip lesion initially suspected to be severe dysplasia but supported by wild-type biomarker results and clinical history, resolving after stopping chemotherapy drugs. He emphasizes the need for reproducible biomarkers and possibly molecular-based classification to improve consistency and patient outcomes, while also describing the pressure to be near-perfect in pathology, the risk of burnout, and efforts to build sustainable systems (QA sessions, colleague consultation, protected time). The conversation closes with his approach to presentations as storytelling, interest in prospective multi-center research, and a final message about balancing perfectionism with rest while remaining open-minded to new diagnostic methods to improve patient care. 00:00 Welcome & Meet Dr. Kevin Ko (DMD/MD, Dermpath at BC Cancer) 01:00 The Controversial Idea: Using p53 Biomarkers in Oral Dysplasia 01:18 Oral vs Skin Pathology: Discovering Porokeratosis in the Mouth 02:07 Diagnostic Error & Overdiagnosis: Why Reproducible Biomarkers Matter 05:19 Case Study: “Severe Dysplasia” vs Toxic Erythema of Chemotherapy —Context Changes Everything 06:36 The Perfectionism Trap in Pathology (and Why 95% Isn’t Good Enough) 08:04 Burnout, QA Systems, and Building Sustainable Workflows 09:14 Work–Life Balance, Kids, and Choosing Priorities (Family vs Research) 11:14 How to Build a Great Talk: Storytelling, Cases, and Future Studies 11:38 Final Takeaways: Balance, Open-Mindedness, and Better Diagnostics

    12 min
  3. FEB 18

    EP206: The Art and Science of Diagnosing: Dr. Raymond Barnhill on Melanocytic Lesions

    Dr. Raymond Barnhill on Diagnostic Drift, Uncertainty, and the MPATH-Dx V2.0 Approach to Melanocytic Lesions In this episode of The Girl Doc Survival Guide, Christine interviews Dr. Raymond Barnhill, a world-recognized dermatopathology expert known for work on diagnostically challenging melanocytic lesions, melanoma pathology references, and contributions to WHO skin tumor classification and AJCC melanoma staging. Dr. Barnhill shares career anecdotes and key communities at Yale and in Boston, collaborations with numerous melanoma leaders, and the founding of the North American Melanoma Pathology Study Group and the International Melanoma Pathology Study Group, as well as participation in the NIH-funded MPATH Study Group. The discussion focuses on overdiagnosis, underdiagnosis, and diagnostic discordance in melanocytic lesions, including evidence of diagnostic drift toward calling more lesions melanoma over time and the overlap between melanoma criteria and atypical/dysplastic nevi. He describes MPATH research, explains the revised MPATH-Dx V2.0 schema, explicitly recognizing uncertainty along a continuum rather than a strict benign/malignant threshold. He emphasizes practical diagnostic approaches including measuring lesion size (noting a 4 mm threshold associated with conventional dysplastic nevi and increasing concern at larger sizes), focusing on key architectural features (junctional nest variation/disarray and lentiginous proliferation), using nuclear size relative to keratinocyte nuclei (including a 1.5× threshold and counting atypical cells per high-power field) while accounting for site-specific pitfalls such as scalp nevi. The conversation also covers “gestalt” versus systematic review, the importance of due diligence using full clinical and morphologic information before ancillary testing, and cautions against overreliance on immunohistochemistry or molecular tests. Dr. Barnhill closes with career advice ends with a message that setbacks can be opportunities for growth. 00:00 Welcome + Meet Dr. Raymond Barnhill (Dermatopathology Legend) 01:51 Career Origins & Melanoma Pathology Mentors (Yale → Boston) 03:59 Building Melanoma Pathology Study Groups (North American & International) 05:57 Overdiagnosis, Diagnostic Drift & Why Discordance Happens 09:43 Inside the MPATH Study: Measuring Interobserver & Intraobserver Agreement 11:39 MPATH-Dx V2.0 Explained: Standardized Classes & Treatment Guidance 13:59 Redefining “Low-Risk” Melanoma: Stringent pT1a Criteria + Embracing Uncertainty 18:47 Practical Grading Tips: Lesion Size, Architecture & Nuclear Atypia Thresholds 22:42 Gestalt vs Due Diligence: Avoiding Traps + Using IHC/Molecular Wisely (PRAME) 28:39 Career Advice: Passion, Mentors, Community + Final Reflections

    31 min
4.8
out of 5
12 Ratings

About

Young doctors are increasingly in ‘survival’ mode.    Far from flourishing, the relentless pressure of working in medicine means that ‘balance’ is harder than ever to achieve.   On the Girl Doc Survival Guide, Yale professor and dermatologist Dr Christine J Ko sits down with doctors, psychologists and mental health experts to dig into the real challenges and rewards of life in medicine.    From dealing with daily stressors and burnout to designing a career that doesn’t sacrifice your personal life, this podcast is all about giving you the tools to not just survive...    But to be present in the journey.

You Might Also Like