Society of Hematologic Oncology Insider news

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SOHO Insider delivers on the latest news in hematologic oncology and updates from the Society of Hematologic Oncology

  1. 3D AGO

    Dr. DiPersio: Cross-sector partnerships needed to sustain innovation in blood cancer treatment

    John DiPersio, MD, PhD, current president of SOHO and director of the Center for Gene and Cellular Immunotherapy at Washington University School of Medicine in St. Louis, Missouri, discusses the need for public-private partnerships to move novel therapies forward in the treatment of blood cancers. He also speaks about how cross-sector collaboration can create better research paths for the future. For SOHO 2026, Dr. DiPersio chose the theme “Advancing care through collaborative science,” a timely topic as NIH funding continues to decline. “SOHO 2026 will explore how public-private partnerships can sustain discovery, preserve basic research, and ensure access to innovation for patients around the world,” Dr. DiPersio said in a recent interview with SOHO Insider. Register for SOHO 2026 today Register today for SOHO 2026 at soho.click/2026. SOHO members receive a 40% discount. Join SOHO for free at http://soho.click/join.

    4 min

  2. JAN 30

    Drs. Melody, Phillips talk glofitamab in MCL

    In this podcast episode recorded at the Thirteenth Annual Meeting of the Society of Hematologic Oncology (SOHO 2025), Megan Melody, MD, from Tampa General Hospital, spoke with Tycel J. Phillips, MD, from the City of Hope Cancer Center, on the latest advancements in mantle cell lymphoma (MCL), including the phase 1/2 trial in relapsed or refractory MCL recently published in the Journal of Clinical Oncology. In the trial led by Dr. Phillips, the investigators evaluated glofitamab monotherapy in patients with relapsed or refractory B-cell lymphomas, with obinutuzumab pretreatment to mitigate the risk of cytokine release syndrome with glofitamab. Dr. Phillips also spoke about treating patients with relapsed or refractory non-Hodgkin lymphoma with venetoclax. Listen to other podcast episodes of SOHO Insider.

    8 min

  3. JAN 16

    Advances in essential thrombocythemia with Drs. Kuykendall, Tremblay

    In this episode of the SOHO Insider podcast, Andrew Kuykendall, MD, assistant member at Moffitt Cancer Center, and Douglas Tremblay, MD, assistant professor of medicine at Icahn School of Medicine at Mount Sinai, discuss how to approach the treatment of essential thrombocythemia. “The first thing I do whenever a patient walks into the clinic with ET is think about their risk status,” Dr. Tremblay said. “When we speak about risk status, what we’re really speaking about is risk of thrombosis. There’s several different risk stratification methods, but they all rely on three clinical factors in general, which is age of prior thrombosis, which is probably the most potent risk factor.” This episode also includes a discussion on the SURPASS-ET trial, which showed ropeginterferon alfa-2b outperformed anagrelide for disease control. Plus, a look into how new CALR-targeted antibodies improve bone marrow in early studies.   Dr. Masarova discusses SURPASS-ET study at EHA 2025

    17 min

  4. JAN 10

    Dr. Thomas Martin interviews 1st US patient treated with cilta-cel

    In this episode of the SOHO Insider podcast, Thomas Martin, MD, professor of medicine at University of California, San Francisco, talks with patient Craig Chase, an American father of two who was diagnosed with myeloma in 2014; Chase was the only American to travel to Nanjing, China, in 2017 to receive ciltacabtagene autoleucel (cilta-cel; then LCAR-B38M). Chase shares his experience traveling to China for the therapy as a heavily-treated patient with limited treatment options. Chase talked about his treatment journey, his experience being treated in a foreign country with an experiment therapy, and what it was like achieving long-term remission. Dr. Martin also discussed the five-year CARTITUDE-1 follow-up date presented at both ASCO(R) and EHA 2025. Those date showed that one-third of myeloma patients were in remission more than five years after cilta-cel treatment. The results of these trials and other trial data on therapies other than cilta-cel, prompted Sundar Jagannath, MD, during SOHO 2025 to address the potential of using the word cure when speaking with patients.

    10 min

  5. 11/27/2025

    Tara Graff, DO, talks community care and the CAR-T vs bispecific debate

    SOHO Insider lymphoma podcast host Megan Melody, MD, assistant professor at the University of South Florida, interviews Tara Graff, DO, director of clinical trials and lymphoma specialist at Mission Cancer and Blood, part of University of Iowa Health Care, on treating patients with blood cancers in community settings, and whether the future belongs to bispecific antibodies or CAR-T therapies. “To be able to give your patients these novel therapies is amazing,” Dr. Graff said on the podcast. “I think it’s going to be a bispecific-versus-CAR-T world in all the different disease states of lymphoma. But I don’t think I would choose one or the other across the board.” They also discussed how hematologist-oncologists can support colleagues who have not managed toxicities associated with cell therapies. “I think we’re just going to have to be patient and really help, because if we don’t help them, all the specialists are going to wind up seeing all the other specialties’ patients,” Dr. Graff said. “And there’s no way we can do that. It’s just being patient and helping each other.” Listen to more SOHO Insider podcasts. Read more about Dr. Melody here.

    24 min

  6. 11/20/2025 · VIDEO

    A 2025 lymphoma snapshot from Julie Vose, MD, MBA

    Ahead of SOHO Breakthroughs in Blood Cancers—and in the spirit of end-of-year lists—SOHO Insider asked Dr. Vose for her take on the biggest lymphoma developments of 2025. Her answer: bispecific antibodies continue to dominate the field. She noted that the biggest shift in the field is moving away from chemotherapy alone and toward immunotherapy and bispecific-based approaches. Dr. Vose will be speaking at 12:30 pm Central time on November 20, 2025, during SBBC. At 12:55 pm Central time, attendees can ask questions via the virtual platform. Major shift toward integrating bispecifcs Dr. Vose points to a major shift toward integrating bispecifics in combination regimens with chemotherapy to help patients reach CAR-T or transplant, and now increasingly in frontline therapy for diffuse large B-cell lymphoma and follicular lymphoma. She highlighted both the STARGLO study, a randomized, global, phase 3 study that is evaluating glofitamab plus gemcitabine and oxaliplatin in the relapsed or refractory setting in DLBCL, and the SUNMO phase 3 trial that is evaluating mosunetuzumab plus polatuzumab vedotin to R-GemOx in transplant-ineligible patients with relapsed or refractory LBCL. There is still time to register at soho.click/SBBC. Registration is free for SOHO members and $50 for non-SOHO members. Join SOHO for free today.

    2 min

  7. 11/19/2025

    Does the future of myeloma treatment belong to trispecific antibodies?

    In this SOHO Insider podcast, Saad Usmani, MD, chief of the myeloma service at Memorial Sloan Kettering Cancer Center, and Niels W C J van de Donk, MD, professor of hematology at Amsterdam UMC, provide an overview of immunotherapies. They discuss bispecific and trispecific antibodies, including early data from the trispecifics and the therapies moving into the frontline setting in multiple myeloma treatment. The pair spoke about the novel trispecific antibody JNJ-5322 that targets BCMA and GPRC5D via T-cell redirection and ISB 2001, an investigational trispecific antibody that received FDA fast track designation earlier in 2025. “The future looks bright for the trispecifics,” Dr. van de Donk said. “We are also looking at combination strategies now in that patients with earlier, lines of therapy, less prior lines of therapy, we are even testing the trispecific now in combination with dara in newly diagnosed patients and the future hopefully again challenging transplant which is still a key component in Europe for the newly diagnosed myeloma patient. Listen to more SOHO Insider podcasts.

    10 min

  8. 10/30/2025

    Drs. O’Brien, Jain discuss FLAIR trial, BTK degraders in CLL

    In this episode of the SOHO Insider podcast, Susan O’Brien, MD, a professor of medicine from the Chao Family Comprehensive Cancer Center at the University of California, Irvine Medical Center, and Nitin Jain, MD, professor of medicine in the Department of Leukemia at the University of Texas MD Anderson Cancer Center, discuss updated results from the phase 3 FLAIR trial; the pair also speak about Bruton’s tyrosine kinase degraders in treating CLL.

    12 min
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SOHO Insider delivers on the latest news in hematologic oncology and updates from the Society of Hematologic Oncology

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