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A podcast focusing on groundbreaking discoveries in cellular and molecular physiology

  1. 28/09/2015

    A well-channeled journey from heart to brain: Dick Tsien

    A conversation with Dick Tsien on moving from cardiac physiology to LTP in a half-dozen years, conformational signaling by channels, and being a physiologist in the UK when Hodgkin, Huxley, and Katz were all doing experiments Download PDF transcript Key words: cardiac physiology, neuroscience, LTP, calcium channels, N-type channels, Denis Noble, Alan Hodgkin

  2. 24/08/2015

    Why we don’t twitch when we smoke: Henry Lester

    A conversation with Henry Lester on nicotinic acetylcholine receptors, inside-out pharmacology, teaching MOOCs, and Richard Feynman’s thoughts about single-channel recording. Download PDF transcript Key words: nicotine, nAChR, nicotinic receptor, inside-out pharmacology, MOOCs

  3. 27/07/2015

    Calcium signaling in the heart: Don Bers

    A conversation with Don Bers on calcium signaling and compartmentation in cardiac myocytes. Download PDF transcript Key words: calcium, cardiomyocytes, cardiac contractility, calcium compartmentation, arrhythmias, CaM kinase

  4. 25/05/2015

    Did Alan Hodgkin dream of calcium sparks? Eduardo Ríos

    A conversation with Eduardo Ríos on post-Hodgkin thought, the voltage sensor in EC coupling, calcium sparks, and the university system in Uruguay. Download PDF transcript Key words: dihydropyridine receptor, ryanodine receptor, calcium sparks, cardiac muscle, skeletal muscle, calcium sparks, excitation-contraction coupling, calsequestrin

  5. 27/04/2015

    Getting from “This can’t be right” to “Of course”: Paul Greengard

    A conversation with Paul Greengard on “hormonal” communication between nerve cells, the biochemical bases by which antidepressants work, and the Pearl Meister Greengard Prize for outstanding women in biomedical research. Download PDF transcript Key words: second messengers, protein phosphorylation, slow synaptic transmission, protein kinases, cGMP, cAMP, synapsin I, serotonin, dopamine, p11, annexin A2, SMARCA3

  6. 30/03/2015

    Fleeing complexity: Chris Miller

    A conversation with Chris Miller on channels, transporters, radical reductionism, and trusting your sense of scientific aesthetics. Download PDF Transcript Key words: ion channels, ion transporters, biophysics, ClC, chloride, fluoride, Fluc, lipid bilayers

  7. 23/02/2015

    Jumping into the unknown: Rich Lewis

    A conversation with Richard Lewis on electrical resonance in hair cells, channels and signals in T cells, papayas in the lab, and following your nose. Download PDF transcript Key words: calcium, T cell, Hair cell, Papain, Orai, STIM, CRAC channels

  8. 26/01/2015

    Molecular hermeneutics and unusual sorbets: Barbara Ehrlich

    A conversation with Barbara Ehrlich on calcium signaling, interpreting Truth, and what’s wrong with green apple-wasabi sorbet. Download PDF transcript Key words: calcium, IP3 receptor, ryanodine receptor, polycystin-2, paramecium, molecular hermeneutics, taxol, lithium, NCS-1, peripheral neuropathy

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A podcast focusing on groundbreaking discoveries in cellular and molecular physiology

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