The Bioactive Nexus - Elevating Your Supplement Knowledge!

Dr. Bill Clark and Dr. Gene Bruno
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  • HEALTH & FITNESS
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Dive into the world of health and wellness with Dr. Bill and Dr. Gene on The Bioactive Nexus podcast. In each episode, they explore cutting-edge topics in the dietary supplement industry, from formulation and regulatory affairs to product development and market trends to the latest research, they cover it all. Whether you're a seasoned industry expert, a health enthusiast, or someone looking to learn more about the science behind supplements, their podcast has something for everyone. Tune in to gain expert knowledge and stay up to date on the future of dietary supplements.

  1. JAN 21

    S3 EP35 — Regulatory Reckoning: The Future of DSHEA and Product Transparency

    In this episode of Bioactive Nexus, Dr. Bill Clark leads a discussion on the evolving landscape of dietary supplement regulation, focusing on the future of the Dietary Supplement Health and Education Act (DSHEA) and product transparency. Joined by industry experts Asa Waldstein and Ivan Wasserman, the conversation delves into the complexities of regulatory compliance, the challenges faced by the FDA, and the implications of recent enforcement trends. The guests share their insights on the misunderstandings surrounding DSHEA, the importance of substantiation in marketing claims, and the role of technology in enhancing regulatory practices. They also discuss the potential impact of mandatory product listings and the necessity for brands to adapt to a rapidly changing market driven by consumer demand for transparency and science-backed products.

    1h 6m

  2. JAN 9

    S3 EP34 – Stress Less, Sleep Better: Nutraceuticals for Calm and Recovery

    In this episode, Dr. Bill Clark and Dr. Gene Bruno discuss the importance of sleep, stress management, and recovery in relation to bioactive science. They explore the physiological impacts of stress on health, the significance of recovery, and the role of nutraceuticals in promoting calm and recovery. Theconversation emphasizes the need for personalized health approaches and practical strategies for improving sleep quality and overall wellness.

    51 min

  3. 12/17/2025

    S2 EP33 — 2025 Year-End Recap & 2026 Preview

    In this podcast episode, hosts Dr. Gene Bruno and Dr. Bill Clark reflect on the past year, discussing significant growth in their audience and the evolving trends in the nutraceutical industry. They highlight the increasing focus on women's health, longevity, and the demand for educated consumers seekingscientific evidence. The conversation also touches on the impact of AI in the industry, the popularity of GLP-1 drugs, and the innovations from NutriSelect. The hosts express gratitude for their listeners and share insights on the future of bioactive science and the importance of education in health and wellness.

    57 min
  4. S2 EP32 – SupplySide Global Debrief - Hot Takes & Key Takeaways

    11/13/2025

    S2 EP32 – SupplySide Global Debrief - Hot Takes & Key Takeaways

    In this episode, Dr. Bill Clark and Dr. Gene Bruno discuss their experiences at the Supply Side Global 2025 event, highlighting key trends in women's health and longevity. They delve into the significance of NutriSelect.ai, the importance of education sessions, and the dynamics between ingredient companies and product brands. The conversation also touches on recent studies regarding melatonin and its implications, as well as the transformative role of AI in thesupplement industry. The episode concludes with reflections on the event and predictions for the future.Keywords   Supply Side Global, Women's Health, Longevity, NutriSelect.ai, Education Sessions, Ingredient Companies, Melatonin, Consumer Trends, Health Tech, Biohacking   Takeaways   Women's health and longevity are emerging as significant trends in the nutraceutical industry. NutriSelect.ai had a milestone year with over 35 meetings at Supply Side Global. Education sessions focused on science attract larger audiences and enhance credibility. Ingredient companies are eager to differentiate their products through research and branding. The consumer market is increasingly interested in science-based products. Melatonin's association with heart failure requires careful interpretation of studies. AI technology is set to revolutionize the supplement industry and consumer purchasing behavior. The importance of trust and transparency in product claims is paramount. Networking at events like Supply Side Global fosters valuable connections and collaborations. Future trends will likely focus on biohacking and personalized health solutions.   Chapters 00:00 Introduction and Overview of Supply Side Global 02:59 Key Trends: Women's Health and Longevity 05:53 NutriSelect.ai: A Milestone Year 08:55 Education Sessions and GLP-1 Agonists 11:55 Biohacking Longevity: Evidence-Based Nutraceuticals 14:54 Ingredient Companies and Product Brands 17:56 NutriSelect.ai: Consumer-Facing App and Future Vision 21:28 Exciting Developments in NutriSelect 24:40 Trends in Women's Health and Longevity 28:08 Understanding Melatonin and Heart Health 32:18 Trust and Transparency in Nutraceuticals40:56 Key Takeaways from Supply Side 2025

    48 min

  5. 10/24/2025

    S2 EP31 - Demystifying AI – Trust, Transparency, and Transformation in Personalized Nutrition

    In this conversation, experts discuss the integration of AI in health technology, focusing on building trust among consumers, understanding the differences between generative and predictive AI, and the future of personalized nutrition. They emphasize the importance of evidence-based nutraceuticals and the need for transparency to enhance consumer confidence in AI applications. In this conversation, experts discuss the transformative role of AI in health andnutrition, emphasizing the importance of transparency, trust, and data integrity. They explore consumer perspectives on AI-driven supplement recommendations, the challenges of algorithmic bias, and the future potential of AI in personalizing health care. The discussion highlights the need for clear communication of scientific data to consumers and the evolving landscape of health technology.  Keywords AI, health technology, personalized nutrition, trust in AI, predictive algorithms, consumer sentiment, nutraceuticals, evidence-based science, machine learning, biohacking, AI, health, nutrition, supplements, trust, transparency, algorithmic bias, consumer perspectives, future of health, NutriSelect   Takeaways ·      AI is becoming integral in health technology. ·      Public perception of AI is often rooted in mistrust. ·      Generative AI is different from predictive AI. ·      Trust in AI can be built through transparency and evidence. ·      Personalized nutrition is the future of health supplements. ·      AI can analyze vast amounts of data quickly and efficiently. ·      Consumer sentiment is crucial for AI product acceptance. ·      Evidence-based nutraceuticals are essential for credibility. ·      AI can help in pattern recognition and optimization. ·      The future of AI in health is about collaboration with experts. ·      AI can help improve health marketing by providing real tools for consumers. ·      Transparency in AI is essential for building consumer trust. ·      Consumers need objective information about supplements, not just influencer hype. ·      AI can analyze individual health data to provide personalized recommendations. ·     The future of health care will involve more predictive medicine through AI. ·      Algorithmic bias can lead to inaccurate AI outputs if data is not balanced. ·      Consumers should be educated on the science behind health products in an understandable way. ·      Wearable technology will play a significant role in health monitoring. ·      AI can help bridge the gap between consumers and health professionals. ·      The integration of AI in health will lead to more efficient and effective care.   Chapters 00:00 Introduction and Overview of AI in Health 02:57 Panelist Introductions and Backgrounds 06:02 Trust Issues and Public Perception of AI 09:14 Consumer Perspectives on AI in Health 12:01 AI 101: Understanding AI and Its Applications 14:50 Distinguishing Between Predictive and Generative AI 18:10 The Future of AI in Health and Nutrition 20:56 Challenges and Opportunities in AI Implementation 24:01 The Importance of Validation in Health Products 26:59 Conclusion and Future Directions 32:12 Building Trust in Science 35:04 The Role of AI in Personalized Nutrition 39:10 The Evolution of AI in Health Research 46:05 Trust, Transparency, and Ethics in AI 58:02 Understanding Science for the Everyday Consumer 58:37 Bridging the Gap: Science and Consumer Understanding 01:00:24 The Role of AI in Personal Health 01:02:47 Complexity of Natural Products and Personalization 01:06:01 The Future of AI in Health and Nutrition 01:11:47 Transforming Healthcare with Technology 01:18:10 Key Takeaways and Future Perspectives

    1h 25m

  6. 10/22/2025

    S2 EP30 - Timepie Wellness Summit & NutriSelect.ai Science Accelerator 2.0

    In this episode of the Bioactive Nexus podcast, Dr. Bill Clark and Dr. Gene Bruno discuss Gene's recent trip to China for the Timepie Longevity Summit, exploring key insights on health,wellness, and the role of inflammation. They delve into traditional Chinese medicine, the cultural differences in dietary practices, and the future of NutriSelect's data-driven wellness platform. The conversation highlights the importance of bridging Eastern and Western health practices and the potential for collaboration in the nutraceutical industry. Keywords bioactive, longevity, inflammation, nutraceuticals, traditional Chinese medicine, health tech, NutriSelect, wellness, biohacking, dietary supplements Takeaways - Gene's trip to China included a fascinating experience at the Longevity Summit. - The summit highlighted the importance of inflammation in health and longevity. - Traditional Chinese medicine offers valuable insights into health practices. - Dietary choices play a crucial role in managinginflammation. - The use of nutraceuticals can help reduce chronic inflammation. - AI and biohacking are more prevalent in China than in the U.S. - NutriSelect aims to bridge the gap between consumers and ingredient suppliers. - Cultural differences in food impact health and wellness practices. - The supplement market in China is rapidly growing and innovative. - Collaboration between East and West can enhance health and wellness solutions. Chapters 00:00 Technical Difficulties and Podcast Introduction 02:10 Gene's Trip to China and the Longevity Summit 05:03 Key Insights on Inflammation and Health 07:57 Exploring Traditional Chinese Medicine 11:00 Cultural Differences in Food and Health Practices 16:19 The Future of NutriSelect and Data-Driven Wellness30:11 East Meets West: Bridging Knowledge in Health

    35 min

  7. 09/14/2025

    S2 EP29 – Inflammation - Calming the Fire Within with Nutraceutical Science

    In this episode, Dr. Bill Clark and Dr. Gene Bruno delve into the complexities of inflammation, particularly its role in aging and chronic diseases. They discuss the differences between acute and chronic inflammation, the molecular players involved, and how chronic inflammation accelerates age-related decline. The conversation also highlights the importance of nutraceuticals in managing inflammation and the best practices for formulating effective supplements. The episode emphasizes a proactive approach to health and the significance of evidence-based practices in the nutraceutical industry. Keywords inflammation, aging, nutraceuticals, chronic inflammation,health span, supplements, anti-inflammatory, wellness, longevity, immune system Takeaways - Inflammation can be both beneficial and harmfuldepending on its type. - Acute inflammation is necessary for healing,while chronic inflammation is detrimental. - NFKB is a key regulator in the inflammatoryprocess. - Oxidative stress and inflammation areinterconnected in a vicious cycle. - Chronic inflammation is linked to variousage-related diseases. - Nutraceuticals can help manage inflammationeffectively. - Using clinically relevant doses in formulationsis crucial. - Avoid the kitchen sink approach in supplementformulation. - Proactive health measures can mitigate theeffects of aging. - Evidence-based practices are essential foreffective nutraceuticals. Chapters 00:00 Introduction to Inflammation and Aging 07:21 Understanding Acute vs. Chronic Inflammation 14:10 Molecular Players in Inflammation 19:49 Impact of Chronic Inflammation on Aging 20:42 Understanding Chronic Inflammation 21:06 Exploring Anti-Inflammatory Botanicals 22:15 Nutrients and Lipids in Inflammation Management 24:35 The Role of Probiotics in Inflammation 26:25 Innovative Compounds for Inflammation Relief 28:13 The Power of Quercetin 30:00 Best Practices for Formulating Anti-Inflammatory Products 35:07 Proactive Approaches to Health and Inflammation 38:56 Looking Ahead: Future Innovations in Nutraceuticals

    43 min

  8. 08/25/2025

    S2 EP28 – Personalized Nutrition – From One-Size-Fits-All to True Precision

    In this conversation, Dr. Bill Clark and Dr. Gene Brunoexplore the evolving landscape of personalized nutrition, discussing its definition, the spectrum of personalization, and the implications of emerging technologies. They emphasize the importance of scientific rigor and consumer trust in the industry, while also addressing the potential of biohacking and true precision nutrition. The discussion highlights the need for innovation and evidence-based approaches to meet the growing demand for personalized wellness solutions. Keywords personalized nutrition, precision nutrition, biohacking,nutraceuticals, health optimization, genomics, biomarkers, wellness, dietary supplements, health technology Takeaways ·      Personalized nutrition is about unique dietaryneeds for optimal health. ·      The spectrum of personalized nutrition rangesfrom generalized to true precision. ·      Most current personalized nutrition offeringsare not scientifically rigorous. ·      Wearable technology is enhancing thepersonalization of nutrition. ·      Biomarker-driven approaches are becoming moreaccessible and sophisticated. ·      Biohacking allows individuals to take control oftheir health but lacks regulation. ·      True precision nutrition combines various datainputs for tailored solutions. ·      Consumer demand is shifting towardsevidence-based personalized wellness. ·      The supplement industry must evolve to meetconsumer expectations for personalization. ·      Innovation and consumer trust are key to thefuture of personalized nutrition. Chapters 00:00 Introduction to Personalized Nutrition 02:55 Defining Personalized Nutrition 06:07 The Spectrum of Personalized Nutrition 08:53 Generalized Programs vs. Category-Based Personalization 11:57 Lifestyle and Symptom-Based Personalization 14:53 Biomarker Driven Personalization 17:45 Biohacking and DIY Personalization 18:52 Understanding Nutrigenomics and Biohacking 21:13 The Future of Precision Nutrition 26:13 Market Implications of Personalized Nutrition 33:32 The Evolution of Evidence-BasedSupplementation

    38 min
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About

Dive into the world of health and wellness with Dr. Bill and Dr. Gene on The Bioactive Nexus podcast. In each episode, they explore cutting-edge topics in the dietary supplement industry, from formulation and regulatory affairs to product development and market trends to the latest research, they cover it all. Whether you're a seasoned industry expert, a health enthusiast, or someone looking to learn more about the science behind supplements, their podcast has something for everyone. Tune in to gain expert knowledge and stay up to date on the future of dietary supplements.

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