The Commons

Wexford Science & Technology

Conversations featuring researchers, innovators, artists, entrepreneurs, community builders, and thought leaders who are improving the human condition in their own backyard and across the globe.

  1. Jun 12

    How Arizona Built a Bioscience Economy at State Scale: A Conversation with Mary O'Reilly

    When people talk about Arizona's emergence as a bioscience leader, the conversation often focuses on Phoenix. But the state's success story is much larger than any single city. In this episode of The Commons, host Thomas Osha welcomes Mary O'Reilly of the Flinn Foundation for a discussion about the Arizona Bioscience Roadmap and the unique role it has played in advancing innovation and economic development across the entire state. For more than two decades, the Roadmap has provided a shared framework for strengthening Arizona's bioscience sector through strategic investments, collaborative partnerships, talent development, research growth, and commercialization. Unlike many economic development initiatives that focus on a single metropolitan area, Arizona's approach has sought to connect assets and opportunities across the state, aligning universities, healthcare systems, research institutions, entrepreneurs, industry leaders, and policymakers around a common vision. In this conversation, O'Reilly explores how the Roadmap was developed, why it has endured through changing economic and political environments, and how it continues to serve as a catalyst for statewide collaboration. She discusses the measurable impact the strategy has had on research capacity, workforce development, startup formation, healthcare innovation, and Arizona's growing reputation as a center for bioscience and technology-driven growth. The discussion also examines a broader question facing regions throughout the world: how can communities sustain a long-term innovation strategy that extends beyond individual projects, leaders, or election cycles? As The Commons prepares to broadcast from the Arizona Pavilion at the BIO International Convention in San Diego, this episode offers an important perspective on the value of statewide thinking and the power of patient, coordinated leadership.

    33 min
  2. Jun 12

    Innovating by Design: Matt Ellsworth on Arizona's Bioscience Roadmap

    What does it take to build a world-class bioscience ecosystem? While many regions aspire to become centers of innovation, few have sustained a coordinated strategy long enough to produce transformative results. Arizona is one of the exceptions. In this episode of The Commons, host Thomas Osha is joined by Matt Ellsworth, Chief Operating Officer of the Flinn Foundation, for a conversation about the Arizona Bioscience Roadmap—one of the nation's most enduring and influential regional innovation strategies. Developed more than two decades ago, the Roadmap was created to help Arizona diversify its economy and strengthen its position in the life sciences. Since then, it has served as a guiding framework for collaboration among universities, healthcare systems, research institutions, entrepreneurs, industry leaders, philanthropies, and government partners across the state. The results have been significant. Arizona has emerged as a growing center for bioscience research, commercialization, healthcare innovation, and talent development, with the Phoenix Bioscience Core becoming one of the most visible manifestations of that progress. In this discussion, Ellsworth reflects on the origins of the Roadmap, the leadership and partnerships that have sustained it through multiple economic cycles, and the lessons learned from more than 20 years of ecosystem building. He also explores how the Roadmap continues to evolve in response to new opportunities in precision medicine, biotechnology, workforce development, and innovation-driven economic growth.

    33 min
  3. Apr 30

    How Breakthroughs Get Built: A Conversation with Steve Potts

    In this episode of The Commons, host Thomas Osha sits down with Steve Potts, CEO of Breakthru Medicine, to explore what it actually takes to turn scientific insight into life-changing therapies. With multiple FDA-approved drugs in his track record and a newly closed $60 million Series A, one of the largest early-stage financings in Phoenix’s bioscience ecosystem, Potts brings a rare perspective on building in a field defined by uncertainty, long timelines, and high stakes. The conversation moves beyond the headlines to unpack the mechanics of innovation. Potts shares how experience, judgment, and data come together to identify which ideas have real potential, and which don’t. He explains Breakthru Medicine’s patient-first, tumor-agnostic approach, and the emerging science behind molecular glues, small molecules, and next-generation antibody-drug conjugates. Osha and Potts also step back to examine the broader system: why so many therapies fail, how startups and large pharma play complementary roles, and why new geographies like Phoenix are becoming credible centers of biotech innovation. At its core, this episode is about decision-making under uncertainty—how leaders place bets when the outcomes matter deeply and the answers aren’t clear. For anyone interested in the future of medicine, innovation, or building at the edge of what’s possible, this conversation offers a clear-eyed look at how breakthroughs actually get built.

    32 min
  4. Jan 11

    A Platform For Discovery and Impact: A Conversation with John Swartley

    What does it take to move ideas out of the laboratory and into the world, at meaningful scale, with purpose, and without losing the soul of academic discovery? In this episode of The Commons, host Thomas Osha sits down with John Swarthy, Chief Innovation Officer of the University of Pennsylvania, to explore how Penn has spent the last two decades intentionally reshaping its approach to innovation, commercialization, and partnership. Penn is widely recognized for breakthrough discoveries—from CAR-T cell therapy to the mRNA platform that enabled COVID-19 vaccines—but those successes did not happen overnight. As John explains, they are the result of sustained leadership, cultural change, and a deliberate shift away from a purely transactional model of “tech transfer” toward a deeply integrated, relationship-driven innovation enterprise. The conversation explores why basic research remains essential even in an era of tightening federal funding and growing industry pressure for near-term results, and why translational research alone is never enough to deliver truly game-changing breakthroughs. John and Tom discuss how universities must balance curiosity-driven discovery with commercialization pathways, and why partnerships with industry, startups, and regional institutions are now central to that mission. Listeners will also hear how Penn has leveraged reinvestment of licensing revenues under the Bayh-Dole framework to strengthen the entire research enterprise, support interdisciplinary institutes, and help catalyze an innovation district in West Philadelphia where academia, healthcare, startups, and global industry converge. From mRNA platforms and interdisciplinary engineering-medicine collaborations to the role of talent, capital, and place, this episode offers a candid look at how one leading research university is navigating the future of innovation and what that future may demand from institutions everywhere. If you’re interested in the evolving role of universities, the economics of innovation, or how ecosystems turn discovery into impact, this conversation offers rare insight from someone who has helped build the system from the inside.

    49 min
  5. 11/09/2025

    Prototyping Place: How Experimentation Shapes University City: A Conversation with Nate Hommel

    In this episode of The Commons, host Thomas Osha talks with Nate Hommel, Director of Planning and Design at University City District (UCD) in Philadelphia — a place where experimentation, partnership, and humility redefine what public space can do. Unlike most business improvement districts, UCD operates as a voluntary collaboration among universities, hospitals, developers, and neighbors within just two and a half square miles of West Philadelphia. It’s a compact but complex ecosystem — home to research towers and historic rowhomes, students and long-time residents, innovation and inequity — and it’s exactly that mix that fuels Nate’s approach to design. Nate and his team see the city as a prototype, not a finished product. Through projects like The Porch at 30th Street Station and The Lawn at UCity Square, they test ideas with temporary materials — moveable furniture, container bleachers, and pop-up decks — to learn what truly works for the community before making anything permanent. Thomas and Nate explore how iteration, listening, and trust can transform a construction site into a commons, a district into a community, and a set of buildings into a place of belonging. It’s a conversation about designing with, not for, and how the most vibrant cities grow not from grand plans, but from the everyday act of trying, learning, and doing better together.

    31 min

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Conversations featuring researchers, innovators, artists, entrepreneurs, community builders, and thought leaders who are improving the human condition in their own backyard and across the globe.

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