The Conn Job

Ann Conn, MD

5.0 (1)
MENTAL HEALTH

This podcast, The Conn Job, is born from my experience as a physician and mother. It's born from the ashes of loss and fueled by a burning desire to change the landscape of health care, mental health, and neurological care. The first tranche of episodes explores the intersection of neurology and psychiatry.

JAN 26

Episode 5: The Future of Bipolar Disorder: How AI and Brain Science Are Revolutionizing Treatment

Episode 5: The Future of Bipolar Disorder: How AI and Brain Science Are Revolutionizing Treatment Welcome back to The Conn Job with Dr. Ann Conn. In this powerful and forward-looking episode, I sit down with Dr. Cara Altimus, Director at the Milken Institute Center for Strategic Philanthropy, along with leaders from the BD² (Breakthrough Discoveries for Bipolar Disorder) Initiative: Dr. Emily Baxi, Integrated Network Program Director, and Dr. Daniel Pham, Director of the BD² Discovery Research Programs. Together, they share a groundbreaking look into the future of bipolar disorder and psychosis research—one driven by brain omics, AI-powered data integration, and the largest coordinated scientific effort in history aimed at finally understanding what happens in the bipolar brain. For me, this episode is profoundly personal. My sons, Austin and Colin, died by suicide during psychotic episodes more than a decade ago. For the first time since their deaths, the BD² initiative has given me something I thought I lost forever: hope. Hope that the next generation won’t face the same suffering. Hope that psychiatry is finally shifting from guesswork to precision. Hope that we are on the verge of breakthrough change. Episode Overview In this episode, you’ll hear: The BD² Integrative Network What it is and why it's a first-of-its-kind scientific collaboration How brain tissue analysis, clinical history, genetic data, and environmental factors are being combined at unprecedented scale Why this is the first psychiatric project to use technologies not yet applied in any other medical field Understanding “Brain Omics” What omics science means in the context of psychiatric illness How transcriptomics, proteomics, metabolomics, and cellular mapping reveal the biology behind mood episodes Why looking at the brain at single-cell resolution is crucial for understanding bipolar disorder The role of artificial intelligence Why AI and machine learning are essential to analyze the enormous complexity of brain illness How advanced computational modeling is uncovering patterns humans could never detect The ways AI may guide personalized treatment pathways in the near future The promise of precision psychiatry What targeted, individualized treatment could look like How future interventions may be based on biological signatures instead of trial and error When families might begin to see clinically actionable breakthroughs The critical importance of brain donation Why research of this magnitude is impossible without donated brain tissue How the BD² Brain Bank is building one of the world’s most valuable research resources Why I have pledged to donate my own brain to science in honor of my sons Real reasons for optimism Why the last decade produced more progress than the previous seven combined How BD² is reshaping the entire landscape of bipolar disorder research Why this moment represents a true paradigm shift for families and clinicians Why This Episode Matters For 70 years, psychiatric treatment has relied on the same blunt tools—medications discovered by accident, trial-and-error prescribing, and systems that wait until crisis to intervene. That era is ending. The BD² initiative is bringing together neuroscience, genetics, big data, brain tissue research, and artificial intelligence to finally map the biological mechanisms behind bipolar disorder and psychosis. This is not incremental progress—it is transformational. For families who have carried the unbearable weight of these illnesses, this episode offers something rare: clarity, momentum, and genuine hope for the future. Resources Mentioned BD²: Breakthrough Discoveries for Bipolar Disorder Initiative Milken Institute Center for Strategic Philanthropy BD² Integrative Network Brain donation programs supporting psychiatric research Harvard Brain Tissue Resource Center (HBTRC) Connect further with Dr Ann Conn: Website: https://www.annconnmd.com Register for my free webinar: Reversing Chronic Migraine: Your Path to Real Recovery Starts Here: https://annconnmd.mykajabi.com/PreventingandReversingChronicMigraine Learn At Pinnacle & Earn CME: https://learnatpinnacle.com/education Subscribe to newsletter: https://annconnmd.activehosted.com/f/7 Youtube: https://www.youtube.com/@annconnmd Instagram: https://www.instagram.com/annconnmd/ Facebook: https://www.facebook.com/profile.php?id=61574820459419 The Conn Job Podcast: https://podcasts.apple.com/us/podcast/the-conn-job/id1853713314

50 min
JAN 12

Episode 4: The Neuroscience of Creativity — From Writer’s Block to Breakthrough

EPISODE 4: The Neuroscience of Creativity — From Writer’s Block to Breakthrough Guest: Alice Flaherty, MD — Neurologist, Movement Disorder Specialist, Harvard Medical School & Massachusetts General Hospital Where does creativity live in the brain—and what happens when it suddenly disappears or explodes? In this fascinating conversation, Dr. Ann Conn and renowned Harvard neurologist Dr. Alice Flaherty dive into the neuroscience behind creative drive, writer’s block, and the mysterious link between brain illness and artistic expression. Dr. Flaherty is one of the world’s leading experts on hypergraphia (compulsive writing), creativity, and temporal lobe function—knowledge informed not only by decades of research, but by her own lived experience with postpartum mood changes and dramatic shifts in creative output. Together, they explore why some people experience surges of creative energy during manic or neurologically altered states, how mood and psychosis can shape artistic expression. Most importantly, they discuss how to preserve the gifts of creativity while supporting healthy brain function. In this episode, you’ll discover: The brain circuits that drive creativity—and how illness can modify them Contagious tics syndrome in teenage girls Brain illnesses and blame Mirror neurons, empathy, and compassion. Empathy as a necessity and a potential problem The biological and psychological differences between empathy and compassion How bipolar disorder and psychotic states can influence creativity Why this episode matters:The myth that great art requires suffering has harmed too many brilliant minds. Dr. Flaherty’s work shows a better truth: creativity can thrive alongsidewell-being. This conversation is for anyone who has ever felt their mind was both a gift and a burden—and wondered how to nurture creativity without losing themselves. Connect further with Dr Ann Conn: Website: https://www.annconnmd.com Register for my free webinar: Reversing Chronic Migraine: Your Path to Real Recovery Starts Here: https://annconnmd.mykajabi.com/PreventingandReversingChronicMigraine Learn At Pinnacle & Earn CME: https://learnatpinnacle.com/education Subscribe to newsletter: https://annconnmd.activehosted.com/f/7 Youtube: https://www.youtube.com/@annconnmd Instagram: https://www.instagram.com/annconnmd/ Facebook: https://www.facebook.com/profile.php?id=61574820459419 The Conn Job Podcast: https://podcasts.apple.com/us/podcast/the-conn-job/id1853713314

1h 12m
12/29/2025

Episode 3: The Genetics of Psychosis — What Your DNA Can (and Can’t) Tell You

EPISODE 3: The Genetics of Psychosis — What Your DNA Can (and Can’t) Tell You Guest: Fernando Goes, MD — Johns Hopkins University School of Medicine Is psychosis written in your genes? And if so, how much of the story can science actually read? In this powerful episode, Dr. Ann Conn sits down with Dr. Fernando Goes, one of the world’s leading psychiatric geneticists, to explore the cutting-edge science behind the genetics of psychosis, bipolar disorder, and severe mood disorders. Dr. Goes is at the forefront of massive genome-wide association studies (GWAS) that are identifying hundreds of tiny genetic variations—each one nudging risk in subtle ways—that collectively shape vulnerability to these illnesses. This conversation is both technical and deeply human. After the deaths of her sons, Dr. Conn donated their DNA to Dr. Goes’ research team, hoping that their contribution could help prevent other families from suffering similar losses. Years later, she learned that Dr. Goes regularly shares her New England Journal of Medicine essay with first-year psychiatry residents—a gesture honoring the intersection of grief, purpose, and scientific progress. Dr. Goes breaks down what we now understand from studying hundreds of thousands of genomes, why psychiatric illness is genetically complex, what polygenic risk scores can (and can’t) predict, and why your genes are not your destiny. Understanding genetic risk is about empowerment—early detection, tailored intervention, and ultimately, hope. In this episode, you’ll learn: How GWAS are uncovering genetic risk factors for psychosis and bipolar disorder Why there is no single “schizophrenia gene” What polygenic risk scores actually mean—and whether they’re ready for clinical use How bipolar disorder, schizophrenia, and other brain conditions overlap genetically How environment interacts with inherited vulnerability Whether genetic insights should influence reproductive decisions (a careful, compassionate discussion) The importance of genetic research participation and how families can contribute What the future of precision psychiatry may look like Why this episode matters: The old saying is true: Genetics loads the gun, but the environment pulls the trigger. This episode offers a grounded, science-based answer to the haunting question many families ask: “Will this happen again?” Dedication: This episode is dedicated to Austin and Colin Conn, whose DNA continues to contribute to research that may one day prevent other families from enduring the same loss. Connect further with Dr Ann Conn: Website: https://www.annconnmd.com Register for my free webinar: Reversing Chronic Migraine: Your Path to Real Recovery Starts Here: https://annconnmd.mykajabi.com/PreventingandReversingChronicMigraine Learn At Pinnacle & Earn CME: https://learnatpinnacle.com/education Subscribe to newsletter: https://annconnmd.activehosted.com/f/7 Youtube: https://www.youtube.com/@annconnmd Instagram: https://www.instagram.com/annconnmd/ Facebook: https://www.facebook.com/profile.php?id=61574820459419 The Conn Job Podcast: https://podcasts.apple.com/us/podcast/the-conn-job/id1853713314

1h 5m
12/15/2025

Episode 2: Brain Donation-The Most Powerful Gift You'll Never See

A Conversation with Dr. Sabina Berretta In this extraordinary episode of The Conn Job, Dr. Ann Conn sits down with Dr. Sabina Berretta, MD, PhD—Director of the Harvard Brain Tissue Resource Center (HBTRC) at McLean Hospital, part of the NIH Neurobiobank. Dr. Berretta is a globally recognized leader in human brain research whose work has transformed our understanding of psychiatric and neurological illness. This conversation explores one of the most profound contributions any person can make to science: brain donation. It is the cornerstone of progress in Alzheimer’s, schizophrenia, bipolar disorder, depression, addiction, PTSD, Parkinson’s disease, and more—yet it remains widely misunderstood. This episode is deeply personal for Dr. Conn, who has pledged to donate her own brain to the HBTRC in honor of her sons, Austin and Colin, whose deaths during psychotic episodes propel her mission forward. Through this act, she hopes their suffering will become part of the knowledge that saves others. Episode Overview Dr. Berretta’s path from Italy to Harvard How studying medicine in Catania sparked her passion for neuroscience Her early research in clinical neuroscience Receiving a national fellowship that brought her to the U.S. Postdoctoral work at MIT studying foundational mechanisms of brain disorders Why she joined McLean Hospital to study the human brain directly How access to donated human brain tissue changed the trajectory of her career Why brain donation is essential Why no imaging, genetics, or animal models can replace the human brain How studying real tissue reveals the molecular and cellular changes behind psychiatric symptoms Why we cannot understand—or treat—mental illness without donated brains How every donated brain contains unique and irreplaceable scientific information Breakthrough research made possible by brain tissue Technological leaps: single-cell transcriptomics, proteomics, spatial mapping Understanding how neurons, glia, and circuits communicate Using AI, machine learning, and big-data tools to decode complex psychiatric illness How tissue research has fueled treatment breakthroughs in neurodegenerative disease Why psychiatry is entering its most hopeful scientific era Psychiatric illness is a brain illness Why the absence of visible neurodegeneration has long misled the public Evidence that psychiatric disorders show clear molecular and cellular brain differences How new technologies are overturning old myths and stigma What actually happens during brain donation How the HBTRC responds immediately after death Why donation does not interfere with funeral arrangements or open-casket services The difference between autopsy and research donation The importance of discussing wishes with family ahead of time Why families often report healing, purpose, and meaning through donation How to register as a brain donor Why registration is not consent—but a critical conversation starter How the process takes less than 10 minutes What families should know and prepare for Why we urgently need more brain donors Especially from people with psychiatric illness Why scientific progress slows without adequate tissue samples How every brain—affected or not—tells part of the story The global shortage of tissue for research How donors accelerate discoveries that could prevent suffering for generations Why This Episode Matters Your brain is the most complex organ in the universe. After death, it can become the key to unlocking treatments that save lives, transform care, and end decades of suffering in silence. Brain donation is: an act of courage an act of love an act of scientific importance a legacy that continues long after life ends Whether you are a clinician, caregiver, family member, scientist, or someone seeking meaning, this conversation will change how you understand mental illness, scientific progress, and the profound gift of donation. Resources Mentioned Harvard Brain Tissue Resource Center (HBTRC) – McLean Hospital NIH Neurobiobank Registration resources for brain donation Information on brain tissue research for psychiatric illness Connect further with Dr Ann Conn: Website: https://www.annconnmd.com Register for my free webinar: Reversing Chronic Migraine: Your Path to Real Recovery Starts Here: https://annconnmd.mykajabi.com/PreventingandReversingChronicMigraine Learn At Pinnacle & Earn CME: https://learnatpinnacle.com/education Subscribe to newsletter: https://annconnmd.activehosted.com/f/7 Youtube: https://www.youtube.com/@annconnmd Instagram: https://www.instagram.com/annconnmd/ Facebook: https://www.facebook.com/profile.php?id=61574820459419 The Conn Job Podcast: https://podcasts.apple.com/us/podcast/the-conn-job/id1853713314

18 min
11/14/2025

Episode 1: Early Psychosis - Why Catching It Early Changes Everything

Early Psychosis - Why Catching It Early Changes Everything Changing the Trajectory of Psychosis: A Conversation with Dr. Ashley Weiss Welcome to the very first episode of The Conn Job with Dr. Ann Conn. In this powerful debut, I sit down with Dr. Ashley Weiss, a child and adolescent psychiatrist, Program Director for Child Psychiatry at Tulane University, and a nationally recognized leader in early psychosis intervention. Dr. Weiss is the founder of EPIC New Orleans, an early intervention program for psychosis, and CALM New Orleans, a community mental health advocacy organization. Her work has reshaped the landscape of mental health care in Louisiana and brought hope to countless families. This episode is deeply personal for me, my own sons, Austin and Colin, suffered from psychotic illness. Their experiences, and the gaps in care that ultimately contributed to their loss fuel her mission to illuminate the realities of psychosis, challenge stigma, and advocate for better systems of care. Episode Overview In this episode, you’ll hear: Dr. Weiss’s path into child and adolescent psychiatry How early curiosity shaped her training Navigating stigma within the medical field How she found her calling working with teens and young adults in psychiatric crisis Understanding psychosis What psychosis actually is How it manifests Why psychosis is a symptom, not a diagnosis What the internal experience of disconnection from reality feels like Why early intervention matters and how it can change lives The origin story of EPIC New Orleans How Dr. Weiss became fascinated with early psychosis care The cold-call to Yale’s STEP program director who became her mentor Starting EPIC with just a few borrowed clinical hours How the program grew into a comprehensive, long-term care model serving young people across Louisiana CALM New Orleans: Reducing stigma and increasing awareness How CALM (Clear Answers to Louisiana Mental Health) educates the public Tools for families to recognize early signs of psychosis How CALM encourages earlier self-referral Their work to shift community attitudes about serious mental illness Why the U.S. is behind on early psychosis care and what’s changing Why young people are often psychotic for more than a year before receiving care The role of stigma across patients, families, and clinicians Systemic failures in early detection How early intervention programs prevent decades of suffering Changing the trajectory of serious mental illness What outcomes data from Europe and abroad shows Why early intervention works Why continuity of care past the 2–3 year mark is crucial for long-term success Success stories from Dr. Weiss’s clinic Insight into her research as a principal investigator for the NIH Early Psychosis Intervention Network (EPINET) The urgent need for community mental health care We discuss: Why psychiatric illnesses require the same seriousness as ICU-level medical events The need for a mental health “medical home” How multidisciplinary teams (therapy, medication, family support, peer groups) create stability and hope Why This Episode Matters Psychosis is stigmatized, misunderstood, and often missed until crisis emerges. Families frequently navigate trauma, confusion, fear, and isolation on their own. This episode brings light to a subject often met with silence. Whether you’re a clinician, caregiver, family member, student, or someone seeking understanding, this conversation offers: clarity compassion scientific grounding hope It is a call to action for early recognition, early intervention, and community-based support. Resources Mentioned EPIC New Orleans – Early Psychosis Intervention Clinic CALM New Orleans – Clear Answers to Louisiana Mental Health National Institute of Mental Health (NIMH) Early Psychosis Intervention Network (EPINET) Connect further with Dr Ann Conn: Website: https://www.annconnmd.com Register for my free webinar: Reversing Chronic Migraine: Your Path to Real Recovery Starts Here: https://annconnmd.mykajabi.com/PreventingandReversingChronicMigraine Learn At Pinnacle & Earn CME: https://learnatpinnacle.com/education Subscribe to newsletter: https://annconnmd.activehosted.com/f/7 Youtube: https://www.youtube.com/@annconnmd Instagram: https://www.instagram.com/annconnmd/ Facebook: https://www.facebook.com/profile.php?id=61574820459419

45 min

5 Episodes

This podcast, The Conn Job, is born from my experience as a physician and mother. It's born from the ashes of loss and fueled by a burning desire to change the landscape of health care, mental health, and neurological care. The first tranche of episodes explores the intersection of neurology and psychiatry.

Creator

Ann Conn, MD
Years Active

2025 - 2026
Episodes

5
Rating

Clean
Copyright

© 2026 Ann Conn
Show Website

The Conn Job