Podcast Description In 2025, the cybersecurity landscape shattered its old paradigm as Artificial Intelligence (AI) moved from a theoretical threat to a force multiplier actively leveraged by adversaries [1-3]. This podcast dives deep into the Adversarial Misuse of Generative AI, analyzing documented activity from government-backed Advanced Persistent Threats (APTs) [4, 5], coordinated Information Operations (IO) actors [6, 7], and financially motivated cybercriminals [8, 9]. We explore how threat actors, including groups linked to Iran, China, and North Korea, are using Large Language Models (LLMs) like Gemini and Claude to augment the entire attack lifecycle [5, 10-14]. These LLMs are providing productivity gains across operations, assisting with research, reconnaissance on target organizations, coding and scripting tasks, payload development, and creating content for social engineering and phishing campaigns [12, 15-22]. The core challenge is the industrialization of the unknown threat [1, 23], where AI accelerates the discovery and weaponization of vulnerabilities, leading to a dramatically compressed timeline from flaw discovery to active deployment [1, 24]. Key topics covered include: Novel AI-Enabled Malware: The emergence of dynamically adaptive threats [2], such as the LLM-orchestrated model, Ransomware 3.0: Self-Composing [25], and new malware families like PROMPTFLUX and PROMPTSTEAL that use LLMs during execution to dynamically generate malicious scripts, obfuscate code, and generate commands for execution [26-30]. Zero-Day Industrialization: How techniques like AI-Powered Vulnerability Research (AIVR) and Automated Exploit Generation (AEG) are transforming exploit crafting from an artisanal craft into a scalable, industrial process [1, 23, 31-33]. AI acts as an indispensable "co-pilot" for human attackers, generating complex boilerplate code in seconds [32, 34]. Lowering the Bar: Instances where AI has lowered the technical barrier to entry for complex crimes [9, 35-37], enabling less-skilled criminals to successfully develop and sell advanced ransomware-as-a-service packages [11, 38] or conduct sophisticated operations that would previously have required years of training [9]. Evasion Tactics: The use of AI-enhanced social engineering [39, 40], including deepfakes for extortion [41, 42] and voice cloning [42, 43], to target victims, as well as the adoption of manipulative pretexts (like posing as "capture-the-flag" students or academic researchers) to bypass AI safety guardrails and elicit malicious code [44-48]. We highlight the urgent need for a proactive, AI-powered defensive strategy to combat this rapidly evolving environment [49-53], recognizing that traditional defenses based on "patching what's known" are no longer sufficient against a deluge of new, AI-accelerated threats [50].