The Deep Six

Speakeasy Podcast Network

The Deep Six Podcast is a series of discussions about health, wellness, functional medicine and the journey we all take through life. How his six point model impacts everyone at any age . Each episode, Dr. James Lewerenz invites doctors, scientists, therapists, free thinkers, musicians, entertainers and anyone else to have a chat about living a purposeful, impactful healthy life. Thriving not just surviving!

  1. Near Misses, Second Chances, and the Art of Staying Alive | The Deep Six | Episode 44

    3D AGO

    Near Misses, Second Chances, and the Art of Staying Alive | The Deep Six | Episode 44

    Mike Sullivan is back. The CEO of the Loomis Agency and longtime friend of Dr. Lewerenz returns for a conversation that gets real fast. Between motocross memories and Supercross weekend in Detroit, the two open up about near-death experiences, second chances, and what it actually takes to stay alive long enough to appreciate life. Dr. Lewerenz also breaks down a genetic cholesterol marker most doctors never test for, why carotid screening could be the most important thing you do this year, and why sometimes the best medical decision is getting a second opinion. Don't wait for a near-miss to start paying attention to your health! Timestamps 00:00 Welcome & Introducing Mike Sullivan 03:03 Motocross: Unappreciated Physical Rigor 07:01 Mike’s Near-Death Experience 13:37 Anaphylactic Shock & Life Perspective 19:08 Mike’s Carotid Artery Blockage 27:01 Importance of Early Screening & Blood Pressure 43:49 Lessons Learned & Second Opinions 50:27 Next Chapters & Gratitude About: Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well! Longevity Health Institute 633 E South Blvd. Ste 2200 Rochester Hills, MI 48307  (248) 289-6643 https://www.longevityhealthinstituteinc.com/

    55 min
  2. Ask Me Anything: Build Your Immunity, Beat the Odds | The Deep Six | Episode 43

    MAR 30

    Ask Me Anything: Build Your Immunity, Beat the Odds | The Deep Six | Episode 43

    This week on The Deep Six, Dr. James Lewerenz is back with another Ask Me Anything episode, tackling the questions hitting his inbox on hormones, cancer, microplastics, and dementia. He breaks down why hormone replacement therapy is foundational to brain volume, bone density, and muscle mass, and why fear of it often does more harm than good. He makes a bold case that the future of beating cancer lies in building your own immune system through natural killer cells, a marker hiding in plain sight on every standard blood panel. He then addresses the uncomfortable reality of microplastics and closes with a look at peptide therapy and the blood-brain barrier as a target for dementia prevention. Test, don't guess, treat root causes, and build a body that thrives for decades. Timestamps 00:00 Hormones and Longevity 05:56 Cancer Detection and Immune Response 11:43 The Dangers of Microplastics 15:24 Peptides for Dementia and Brain Health About: Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well! Longevity Health Institute 633 E South Blvd. Ste 2200 Rochester Hills, MI 48307  (248) 289-6643 https://www.longevityhealthinstituteinc.com/

    18 min
  3. Building Strength From the Inside Out | The Deep Six | Episode 42

    MAR 16

    Building Strength From the Inside Out | The Deep Six | Episode 42

    On this episode of The Deep Six Podcast, Dr. James Lewerenz sits down with Sifu Patrick Donahue to explore how discipline, consistency, and purpose shape both physical and mental health. Drawing from decades of martial arts training and teaching, Patrick explains why real confidence is built through daily effort, emotional regulation, and keeping promises to yourself. The conversation connects martial arts to everyday life, showing how movement, structure, and community can help people become calmer under pressure, more resilient in adversity, and more intentional in how they live. This episode is a powerful reminder that motivation comes and goes, but discipline creates lasting change. When the body and mind are trained together, growth reaches far beyond the mat and into every part of life. Timestamps 00:00 Introduction to the Deep Six Podcast 03:34 The Purpose of Life 06:16 Martial Arts: The Ultimate Discipline 09:00 The Power of Purpose and Consistency 12:08 The Lohan Test: Building Confidence 14:46 Mind Over Body: True Confidence 18:09 Daily Discipline and Life’s Challenges 20:00 Journey into Martial Arts and Its Impact 23:55 The Power of Gratitude and Morning Routine 27:18 Purpose, Confidence, and Community 31:02 Discipline Over Motivation 34:39 Addressing the ‘Deep Six’ and Mindset 39:03 Honesty, Action, and Self-Improvement 42:19 Humility, Mentorship, and Forged Willpower 46:42 The Transformative Power of Hardship 49:49 Conclusion: Discipline, Purpose, and Growth About: Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well! Longevity Health Institute 633 E South Blvd. Ste 2200 Rochester Hills, MI 48307  (248) 289-6643 https://www.longevityhealthinstituteinc.com/

    53 min
  4. Ask Me Anything: Immune Stress, Viruses, and Aging Well | The Deep Six | Episode 41

    FEB 16

    Ask Me Anything: Immune Stress, Viruses, and Aging Well | The Deep Six | Episode 41

    This week on The Deep Six Podcast, Dr. James Lewerenz answers some of the most common and misunderstood health questions in this Ask Me Anything episode. He breaks down why recurrent herpes outbreaks signal immune stress, how sleep, training load, diet, and arginine balance influence viral flares, and what long-term inflammation may mean for brain health. Dr. Lewerenz also addresses cytomegalovirus and its link to accelerated aging through telomere damage. The episode explores trending topics like methylene blue, outlining potential benefits, real limitations, and why caution is warranted without strong human data. Dr. Lewerenz closes with a clear warning on heavy metals, explaining their role in cardiovascular disease, cognitive decline, and cancer risk. The takeaway is consistent and clear: test, do not guess, and focus on fundamentals that support long-term resilience and longevity. Timestamps 00:00 Welcome & AMA Introduction 02:02 Understanding Herpes and Immune Health 08:17 Cytomegalovirus and Accelerated Aging 10:39 Methylene Blue: Benefits & Cautions 16:47 Heavy Metal Toxicity and Health About: Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well! Longevity Health Institute 633 E South Blvd. Ste 2200 Rochester Hills, MI 48307  (248) 289-6643 https://www.longevityhealthinstituteinc.com/

    22 min
  5. Gut Health Starts in the Kitchen: Practical Nutrition That Works | The Deep Six | Episode 40

    FEB 2

    Gut Health Starts in the Kitchen: Practical Nutrition That Works | The Deep Six | Episode 40

    This week on The Deep Six, Dr. James Lewerenz sits down with Chef Nishan Andonian of Entice Catering LLC to explore the powerful connection between food, flavor, and long-term health. Chef Nishan shares how scratch cooking, fresh herbs, and thoughtful techniques can transform clean eating into something sustainable and deeply satisfying. Together, they discuss gut health, gluten sensitivity, protein intake, and why flavorful meals help prevent overeating and support metabolic health. The conversation also tackles popular weight loss injections, with Dr. Lewerenz explaining when GLP-1 therapies can be helpful and why improper use risks muscle loss and long-term decline. From bone broth and gluten-free alternatives to simple first steps in the kitchen, this episode reinforces a core principle: real health is built through intentional nourishment, not shortcuts. Timestamps 00:00 Welcome to the Deep Six Podcast 02:27 Scratch Cooking 05:50 Culinary Creations and Services 08:40 Personal Health Goals and Cooking 12:17 Gluten-Free Cooking Techniques 18:10 Herbs, Spices, and Protein Sources 22:09 Staying Full and Favorite Meals 26:13 Chef’s Advice for Home Cooks 31:10 GLP-1 Injections and Muscle Loss Guest Links: Entice Catering Website: https://entice-family-meals.square.site About: Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well! Longevity Health Institute 633 E South Blvd. Ste 2200 Rochester Hills, MI 48307  (248) 289-6643 https://www.longevityhealthinstituteinc.com/

    40 min
  6. The Rhythm of Recovery and Performance | The Deep Six | Episode 39

    JAN 19

    The Rhythm of Recovery and Performance | The Deep Six | Episode 39

    On this episode of The Deep Six, Dr. James Lewerenz sits down with Nik Hughes, drummer for the rock band Bush, to explore the physical, mental, and emotional demands of life on tour. Nik shares how drumming at a high level requires intentional training, long warmups, hydration, and recovery, especially as he ages and manages past injuries. The conversation connects performance with longevity, highlighting how fitness, nutrition, sleep, and mindset support both musicians and everyday professionals. Nik also opens up about balancing touring with family life and caring for a child with type 1 diabetes. This episode reinforces how sustainable health habits, consistency, and purpose allow people to perform at their best while protecting long-term well-being. Chapters 00:00 Introduction to Nik Hughes, Drummer for Bush 05:15 Drumming Inspirations and Influences 07:30 Rock Doc to Rocker: Health on Tour 11:04 Balancing Family and a Musician’s Life 16:19 Travel Experiences and Cultural Connections 21:00 Fitness Routine and Injury Recovery 29:34 Dietary Habits and On-Tour Nutrition 34:08 Evolution of Musician Lifestyles 39:04 Bush’s Future and Band Culture 42:44 Future of Type 1 Diabetes Treatment Guest Links: Personal Website: https://www.nikhughesdrum.com/ Band Website: https://www.bushofficial.com/ About: Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well! Longevity Health Institute 633 E South Blvd. Ste 2200 Rochester Hills, MI 48307  (248) 289-6643 https://www.longevityhealthinstituteinc.com/

    51 min
  7. Inside the Six-Point Model: An AMA on Prevention and Longevity | The Deep Six | Episode 38

    12/22/2025

    Inside the Six-Point Model: An AMA on Prevention and Longevity | The Deep Six | Episode 38

    In this AMA episode of The Deep Six Podcast, Dr. James Lewerenz answers listener questions that span daily habits, emerging diagnostics, and long-term brain and heart health. He walks through his personal non-negotiables, including gratitude, movement, heat and cold exposure, and intentional community, explaining how small daily practices shape physiology over time. Dr. Lewerenz also highlights newer biomarkers for cognitive decline, advances in genetic cancer screening, and why cardiac imaging plays a growing role in proactive care. Throughout the conversation, he reinforces the importance of viewing health through the Six Point Model and thinking beyond short-term goals. This episode emphasizes prevention, clarity, and playing the long game so listeners can protect their brains, hearts, and overall vitality for decades to come. Chapters 00:00 Introduction to the Deep Six 02:56 Daily Routine and Non-Negotiables 06:50 New Biomarkers and Genetic Screening 12:12 Deeper Dive into Heart Health 14:47 Toxins and Cognitive Decline 19:27 Long Game for Lifelong Health About: Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well! Longevity Health Institute 633 E South Blvd. Ste 2200 Rochester Hills, MI 48307  (248) 289-6643 https://www.longevityhealthinstituteinc.com/

    21 min
  8. East Meets West: Where Chinese Medicine and Modern Longevity Align | The Deep Six | Episode 37

    12/08/2025

    East Meets West: Where Chinese Medicine and Modern Longevity Align | The Deep Six | Episode 37

    On this episode of The Deep Six Podcast, Dr. James Lewerenz sits down with Dr. Samantha Buchanan, DACM, owner of Pointe Acupuncture & Integrative Medicine, to explore how Chinese medicine and Western functional medicine can work together in modern longevity care. Dr. Buchanan shares how a serious running injury led her from a pre-med path into acupuncture, herbs, and integrative practice, along with what comprehensive intake and pattern-based assessment look like in real life. They break down how acupuncture may support the autonomic nervous system and vagus nerve, helping with stress, sleep, chronic pain, and recovery, and why practitioner training and licensure matter when symptoms could signal something more serious. The conversation also touches on fertility and IVF support, plus the “five pillars” fundamentals, including the often-overlooked impact of social connection on long-term health. Chapters 00:00 Introduction to Dr. Sam’s Practice 04:07 Journey to Chinese Medicine 08:39 Acupuncture Experience and Diagnosis 14:24 Acupuncture Approaches and Specialties 19:16 The Importance of Licensed Practitioners 23:56 Acupuncture for Stress and Infertility 33:49 Social Life and Generational Wisdom 43:20 Acupuncture for Pets and Powerful Results Guest Links: Point Acupuncture: https://www.pointeacupuncture.com/ About: Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well! Longevity Health Institute 633 E South Blvd. Ste 2200 Rochester Hills, MI 48307  (248) 289-6643 https://www.longevityhealthinstituteinc.com/

    47 min
5
out of 5
20 Ratings

About

The Deep Six Podcast is a series of discussions about health, wellness, functional medicine and the journey we all take through life. How his six point model impacts everyone at any age . Each episode, Dr. James Lewerenz invites doctors, scientists, therapists, free thinkers, musicians, entertainers and anyone else to have a chat about living a purposeful, impactful healthy life. Thriving not just surviving!

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