The DeSci Podcast Molecule
-
- Science
-
Rethinking Science - Let's talk to the leaders of the decentralized science industry about the future of biotech. Brought to you by www.molecule.to
Want to join the stage? Apply as a speaker here: podcast@molecule.to
-
Diagnosing the drug R&D productivity decline with Dr Jack Scannell
In this episode, we discuss the problem of declining R&D efficiency with Dr. Jack Scannell, a scientist and entrepreneur who is well known for coining the term “Eroom’s law,” which highlights the decline in pharmaceutical research and development (R&D) productivity over several decades.
In this episode, Jack sheds light on the root causes of this decline, beginning with a critique of the poor quality of diagnosis surrounding the R&D productivity problem.
He also talks about the challenges in accurately measuring progress in drug research, highlighting the "measurement problem" in the drug industry. Jack suggests adopting a model akin to the "Stern Review” to improve the diagnosis of these challenges.
Jack also addresses topics such as the shift in the frequency of serendipitous drug discoveries, the Eroom’s law article, the entanglement of science, money and drug development and many more.
Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.
___
⭐ Timestamps:
0:00 Intro
01:40 Poor quality of diagnosis of the R&D productivity problem
04:01 The measurement problem
09:21 Chesterton’s fence of R&D
14:38 Science, Drug development, Money.
20:46 The role of Serendipity in drug discovery
26:34 Economics in the drug industry.
34:43 Implicit knowledge within Biotech
41:43 Eroom's Law paper
____
If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.
If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to
Special thanks to
Lea Degen: https://twitter.com/lealeata
Jack Scannell: https://twitter.com/JackScannell13
____
Let's connect:
Website: https://bit.ly/3d6nh2C
X: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao -
How ResearchHub Makes Open Science Rewarding by Reinventing Academic Incentives
Welcome to another episode of the DeSci Podcast. Today, we were joined by Jeffrey Koury, Director & Business Development Lead at ResearchHub, and Jonathan Heppner, Marketing & Social Media Lead.
ResearchHub is a platform designed to accelerate the pace of scientific research by providing a modern mobile and web application where people can collaborate on scientific research more efficiently. It aims to make scientific research accessible, collaborative, and prioritized for everyone.
In this episode, we delved into the shortcomings of the current scientific research model and the need to make science open to everyone.
Our dialogue centered on advocating for a shift from the traditional model towards a more inclusive and transparent system. Central to this shift is the necessity of building better incentive structures, which would drive collaboration among scientists and facilitate accelerated progress in scientific research.
Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.
___
⭐ Timestamps:
0:00 Intro
1:30 What is Research Hub?
03:05 Onboarding process.
05:40 What drove your interest in building Research Hub?
12:16 Past efforts in promoting open science
18:32 The role of Research Hub in scientific literature
26:19 How Research Hub differs from traditional journals
35:14 Public versus Anonymous Peer Review
39:20 Most contentious topics within your field
48:50 Ensuring high quality science
52:35 Why books are important
59:13 How to get involved
59:47 How Research Hub has evolved over the years
1:05:13 Outro
____
If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.
If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to
Special thanks to
Lea Degen: https://twitter.com/lealeata
Jeffrey Koury: https://twitter.com/jeffyfish9
Jonathan Heppner: https://twitter.com/EnactJohnny
____
Let's connect:
Website: https://bit.ly/3d6nh2C
X: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao -
Seemay Chou on Arcadia's Revolutionary Approach to Science and Entrepreneurship
Today we are delighted to host Seemay Chow, Co-founder and CEO of Arcadia Science, a for-profit research institute with a specific focus on novel model organisms that haven't been traditionally studied in the lab and translating discoveries into commercial ventures.
In this episode, we discuss Arcadia’s mission, structure and approach, emphasizing the importance of providing scientists with the context needed to understand the practical applications of their research. Seemay explains how this approach fosters a different kind of creativity among researchers, thus increasing the likelihood of research success.
We also explore the limitations researchers face in the traditional setting while further highlighting the strengths and weaknesses of Academia and industry. Other topics we touched on include notions of diversity in science, strategies for spotting the best talents and ideas to fund, and many more.
Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below.
___
⭐ Timestamps:
0:00 Intro.
0:49 Effects of running a for-profit venture on Arcadia’s structure.
3:05 What is Arcadia?
7:35 Researchers limitations in Academia.
11:45 Academia vs the private sector.
16:21 Insights gained from building Arcadia.
27:54 Arcadia structure.
30:38 Diversity in science.
35:24 Strategies for discovering the best talents.
43:28 Contextualizing science.
49:50 Outro.
____
If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.
If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to
Special thanks to
Lea Degen: https://twitter.com/lealeata
Seemay Chou: https://twitter.com/seemaychou
____
Let's connect:
Website: https://bit.ly/3d6nh2C
X: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao -
The DeSci London Conference 2024: A Preview with Alfred Brown
Welcome to another episode of the DeSci podcast. Today, we were joined by Alfred Brown, co-founder of Desci London, a community dedicated to transforming science through web3 technology.
In this episode, we talked about the DeSci London conference (scheduled for Saturday, 23 Mar 2024, 09:30 - Sunday, 24 Mar 2024, 16:30 GMT).
This two-day event aims to spotlight the transformative potential of blockchain technology in the field of science, covering agendas such as Longevity research, Rare diseases, DeSci Tooling and Infrastructure, Climate tech innovations, Women’s health, and more.
Alfred shares insights into the event's objectives, potential speakers, and details on how to livestream for those unable to attend in person.
In addition to the main discussion, we explored the intersection between web3 and science, the importance of community in Desci, and several other topics.
Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below.
___
⭐ Timestamps:
0:00 intro
1:16 Alfred’s journey into DeSci.
04:57 What was your experience diving into blockchain as a beginner?
07:12 Recommendations for scientists venturing into DeSci.
11:34 DeSci London event.
16:55 How to apply for the travel grant.
22:38 The role of art and creativity in science.
28:33 Community-building in DeSci.
29:54 How to find the DeSci London monthly meetups.
30:46 Insights for aspiring Desci community builders.
37:22 Potential speakers for the event.
45:36 How to live stream the DeSci London event.
49:29 Other notable DeSci events.
52:23 Impact of younger generations in DeSci.
56:00 Molecule and Nucleate partnership.
58:48 The necessity of community in Desci.
1:08:09 Outro
____
If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.
If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to
Special thanks to
Ella McCarthy-Page: https://twitter.com/EMcCarthyPage
Alfred Brown: https://twitter.com/AlfredJBrown99
____
Let's connect:
Website: https://bit.ly/3d6nh2C
X: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao -
Challenging the Status Quo: Stuart Buck on Science Funding & Research
Welcome to another episode of the DeSci Podcast! Today, we are delighted to host Stuart Buck. Stuart serves as a Senior Advisor at the Social Science Research Council and is the Executive Director of the Good Science Project—an organization dedicated to enhancing the funding and practice of science.
In this episode, Stuart addresses key challenges in the scientific landscape, such as bureaucratic obstacles to funding and the distinction between basic and applied science.
He emphasizes the interconnected nature of basic and applied research, highlighting how discoveries from basic research lay the foundation for applied innovations and challenges addressed through applied science inspire new questions in basic research.
Moving further, Stuart shares his view on the metaphor of failure in science. According to him, failure is not synonymous with defeat; instead, encountering failures in scientific endeavors indicates that one is posing pertinent questions and pushing the boundaries of knowledge.
Other topics covered in the podcast include scientific reproducibility, the measurement problem in science, enforcing data accessibility, and many more.
Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below.
___
⭐ Timestamps:
0:00 Intro
01:27 Good science project main focus.
03:37 Stuart’s theory of social change
10:04 Areas that need improvement
13:00 Recommendation for young researchers
17:35 Why grantmakers tend to be conservative in funding basic science
21:45 Basic vs Applied research
24:15 The notion of failure in science
30:59 Revisiting anti-portfolio
37:37 The value of funding replication in research
43:45 The problem with metrics
46:49 Outro
____
If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.
If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to
Special thanks to
Lea Degen: https://twitter.com/lealeata
Stuart Buck: https://twitter.com/stuartbuck1
____
Let's connect:
Website: https://bit.ly/3d6nh2C
X: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao -
Advancing Research in Brain Health and Longevity through Decentralized Science | Brian Magierski
Welcome to another episode of the DeSci Podcast!
Today we were joined by Brian Margierski, Brian is the CEO and Founder of Cerebrum DAO, an open, global community that seeks to reimagine impact funding to advance brain longevity and accelerate solutions and cures to Alzheimer’s disease and other neurological disorders.
In this episode, Brian delves into Cerebrum DAO, outlining its mission and commitment to advancing brain health research. He sheds light on the motivating factors behind his interest in this field and elaborates on why he opted for the DAO model as the most fitting framework to achieve these objectives.
We also discuss how the DAO model enables entrepreneurship by creating an environment for innovation and empowering individuals to propose and pursue unconventional projects without the constraints typically associated with centralized funding models.
Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.
___
⭐ Timestamps:
0:00 Intro
01:04 Cerebrum DAO’s mission
02:54 What drove your interest in brain health research?
07:05 What made you choose the DAO model?
13:37 Cerebrum DAO structure.
18:14 Collaborating with biotech companies
20:37 Maintaining scientific quality in decentralized funding
24:50 How DAOs enables entrepreneurship
30:12 Contentious topics in your workplace.
32:05 How to get involved.
35:05 Outro
____
If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.
If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to
Special thanks to
Lea Degen: https://twitter.com/lealeata
Brian Magierski: https://twitter.com/bmagierski
____
Let's connect:
Website: https://bit.ly/3d6nh2C
X: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao