The Future Conceived

SSR Podcast

The Future Conceived podcast is the official podcast for the Society for the Study of Reproduction. In this podcast, you'll hear about emerging scientists, new techniques, investigators from around the world, untold stories about our annual conference, and so much more! For more information about the Society for the Study of Reproduction and all things reproductive biology related please visit: https://www.ssr.org. Enjoy!

  1. -2 J

    EP 58: Early Embryo Development: The Material Physics of Cell Division with Dr. Colm Kelleher

    In today’s episode, we have the pleasure of chatting with Dr. Colm Kelleher, a physicist in the Bioinspired Institute at Syracuse University.  During cell division, the chromosomes that contain the genetic material must be copied and segregated. Failure to segregate correctly has dire consequences for cell viability and is a common problem during IVF and pre-implantation embryo culture.  The spindle apparatus that segregates the chromosomes is comprised of ~1000 distinct types of proteins with many thousands of copies of each type. With that in mind, we can imagine the spindle as an extremely complicated molecular machine with millions of parts that each need to be in the right place at the right time for the spindle to carry out its essential functions. This kind of description raises some serious questions.  For example, how can we know which parts are the most consequential when there are so many, and the relative importance of different parts changes over time or depends on the molecular details of the cellular environment?  Dr. Kelleher argues that there is another way to think about it. He is working to apply intermediate scale models from materials physics to describe spindle formation in a way that minimizes that number of things that need to be measured in the lab. In other words, how should we describe spindle formation, if we can’t rely on knowing everything about the molecules that make it up? As it turns out, the spindle apparatus has more in common with a handful of dried spaghetti than you might think.  Check out our website: https://ssr.org/ Link to Dr. Kelleher's faculty page: https://artsandsciences.syracuse.edu/people/faculty/colm-kelleher/#Biography

    1 h 34 min
  2. 13 FÉVR.

    EP 53: 2024 Repro BioArt Awards with Ingrid Carvacho, and Martin Estermann

    What happens when you look at a scientific failure from a different angle? In this episode, we celebrate the intersection of aesthetic beauty and rigorous research as we sit down with the inaugural winners of the SSR ReproBioArt Contest. Join us as Dr. Ingrid Carvacho (Universidad Católica del Maule, Chile) and Dr. Martin Estermann (NIH) reveal the stories behind their award-winning images. From a "rejected" chicken embryo that transformed into a vibrant butterfly to a two-cell embryo that looks like a distant solar system, our guests discuss how high-resolution imaging is changing the way we understand the beginnings of life. In this episode, we explore: The Serendipity of Discovery: How a 180-degree flip turned Martin’s "urogenital butterfly" from a rejected journal cover into a prize-winning masterpiece.Science Beyond the Capital: Ingrid’s powerful story of building a research program in regional Chile and the "infrastructure gap" that required a three-hour drive just to access a microscope. The Power of Metaphor: Why describing early embryo development as a "complex universe" helps bridge the gap between the lab and the general public. The Future of Imaging: A look at cutting-edge techniques like Expansion Microscopy and how researchers are "stretching" cells to see life in higher resolution than ever before. Featured Guests:Dr. Ingrid Carvacho: Associate Professor and PI of the Lab of Ion Channels and Reproduction. Winner of the People’s Choice Award. Dr. Martin Estermann: Postdoctoral Fellow in Dr. Humphrey Yao’s lab at NIEHS. Winner of the SSR Members' Choice Award.About the ReproBioArt Contest: Organized by the SSR Public Affairs Committee, this contest celebrates the visual representation of scientific research related to the study of reproduction. To view the winning images discussed in this episode, follow SSR on social media or visit [SSR.org].

    28 min

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À propos

The Future Conceived podcast is the official podcast for the Society for the Study of Reproduction. In this podcast, you'll hear about emerging scientists, new techniques, investigators from around the world, untold stories about our annual conference, and so much more! For more information about the Society for the Study of Reproduction and all things reproductive biology related please visit: https://www.ssr.org. Enjoy!

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