Welcome to the Hyperexcision podcast. This podcast is a time-efficient alternative to the written content on the website. It supplements the exam preparation material available on the hyperexcision.com website for medical students. You can follow along with the written material on the website while listening to this podcast. If you have any comments or suggestions, email hello@hyperexcision.com. Every case has a script. Clinical approach is a collection of hypothetical case discussions with questions that test the key concepts for a particular disease presentation. A 29-year-old man presents with yellow discolouration of the eyes. For the past week, he has felt unwell with decreased oral intake, a low-grade fever, which he recorded at about 37.7 C, fatigue, anorexia, nausea, and occasional vomiting. He noticed that his eyes became yellow about 4 days ago. Since that time, he has had continuous mild pain in his right upper abdomen. His urine has also gotten darker. There is no change in the colour of his stool. He has no significant past medical history. However, he has been unable to donate blood within the past year for reasons he cannot recall. He has not travelled recently. He works as an accountant. His only medication is Ibuprofen. For his social history, he currently uses marijuana and MDMA (Ecstasy) recreationally and has a prior history of Injection Drug Use (IDU) and cocaine. For his sexual history, he has had 5 sexual partners in the past 6 months. He does not consistently use condoms. On physical exam, he appears ill and has obvious jaundice with scleral icterus. Temperature is 38.0 C, Blood Pressure 110/70 mmHg, Heart Rate 105 beats per minute, Respiratory Rate 16 breaths per minute, and Room air SpO2 of 99%. The lung and heart are normal apart from tachycardia. The upper border of the liver is in the 6ICS MCL. Liver span is 15 cm in percussion and palpable 6 cm below the right costal margin. The liver edge is smooth and tender to palpation. The spleen edge is non-enlarged. There are no stigmata of peripheral liver disease and no peripheral oedema. These are his lab results: AST 1234 U/L, ALT 1560 U/L, ALP 394 U/L, Total Bilirubin 13.4 mg/dL, Direct bilirubin 12.2 mg/dL, INR 2.3, aPTT 52 seconds. These are the results of his hepatitis serology: IgM Anti-HAV Negative, IgG Anti-HAV Negative, IgM Anti-HBc Positive, IgG Anti-HBc Hep B Negative, HBsAg Positive, Anti-HBs Negative, HBeAg Positive, Anti-HBe Negative, Anti-HCV Positive.