Fentanyl is 100 times more potent than morphine. Xylazine — tranq dope — rots flesh and defeats Narcan. Nitazenes are up to 40 times stronger than fentanyl and barely detectable on existing test strips. The street drug supply in 2025 is not the supply you think you know. In this episode of The Loudness McEvil Symposium, host Jason MacLeod — a 30-year opioid addict, former fentanyl user, and now 2+ years sober — breaks down exactly what is in the current North American drug supply, how it got there, and why people are dying who aren't using any more than they always did. This is not an outside perspective. In 2017, heroin disappeared from the supply and got replaced by fentanyl — without warning, without consent, overnight. People he knew died in that transition. This episode is the story of what happened, what's come since, and what's coming next. Covered in this episode: → The history of illicit fentanyl and how it replaced heroin in the supply chain → Counterfeit M30 pills and the hot spot problem killing people who think they know their dose → Carfentanil — 10,000 times stronger than morphine, already in the streets → Xylazine (tranq dope): the veterinary sedative causing flesh-rotting wounds that Narcan cannot reverse → Nitazenes: the next wave of synthetic opioids, already detected across North America → Why overdose deaths are rising not because people are using more, but because the supply is incomparably more dangerous → What this means for harm reduction, naloxone, and fentanyl test strips This is Part 3 of the Loudness McEvil Symposium Opioid Series. Part 1 covers the 5,000-year history of opioids. Part 2 covers the crimes of Purdue Pharma, the Sackler family, and McKinsey. Part 4 covers what actually works in recovery. If you are in active addiction or love someone who is: please carry naloxone. Please use fentanyl test strips. Please do not use alone. Naloxone/Narcan access: findtreatment.gov | SAMHSA helpline: 1-800-662-4357 The Loudness McEvil Symposium is a documentary-style podcast about addiction, recovery, survival, and the systems that shape both. Raw, researched, and told from inside the experience. Keywords: fentanyl, opioid epidemic, xylazine, tranq dope, nitazenes, carfentanil, drug overdose, opioid crisis, harm reduction, naloxone, Narcan, addiction recovery, street drugs, synthetic opioids, opioid addiction, drug supply, fentanyl test strips, opioid overdose, recovery podcast
