The PCOS Podcast

Let's talk about our ovaries and the science of PCOS.

Finding the truth about PCOS. Bringing you the true science of PCOS and women's health with expert guests and a ton of insights. www.thepcosnewsletter.com

  1. The pill, PCOS & the cycle we’re not talking about

    APR 12

    The pill, PCOS & the cycle we’re not talking about

    Hello everyone, Today I bring you a lovely conversation with Registered Dietitian Tara | PCOS Journal on the role of the contraceptive pill in managing PCOS and the importance of the cycle beyond pregnancy. Tara and I share many of the same principles for managing PCOS, and our conversations are always filled with passion, inspiration, and insights. We got so frustrated about the misinformation shared online about PCOS that this will be a 3-part series where we debunk and discuss some of the most common things we see on social media about PCOS. Today, we discuss the pill. We walk through: * The issues we have with the “just take the pill” approach * How the pill works * When it’s appropriate to take it * Why having a natural cycle is important beyond contraception This episode can be listened to on all major platforms, including Spotify, Apple and YouTube. If you prefer reading, I have summarised it below. The pill & the illusion of “fixing” PCOS When most women are diagnosed with PCOS, the first thing they’re offered is the contraceptive pill. At least that was my experience. The main issues I had, and I am seeing, is that it is often done without much explanation. Not because doctors are careless, but because it’s the standard first-line treatment. It regulates periods, reduces androgens, improves acne, and creates predictable cycles. On paper, it looks like it’s solving the problem. However, the pill doesn’t “fix” PCOS. It doesn’t restore ovulation. It doesn’t address insulin resistance. It doesn’t correct the underlying metabolic drivers. What it does is suppress the communication between your brain and your ovaries. Instead of your body producing its own cyclical hormones, you’re given synthetic ones in a steady, controlled dose. Your natural rhythm is paused. For some women, that pause can be relief. If you’re dealing with acne, irregular period, emotional overwhelm, or simply need contraception, the pill can be a helpful tool. There is no shame in using medication. The issue isn’t the pill itself. The issue is when women aren’t told what it’s actually doing, and that is something we have a bit of an issue with. It’s the false illusion that this will fix everything, which is not true. How the pill works In a natural cycle, there’s constant communication between your brain and your ovaries. Hormones rise and fall. Estrogen builds. Ovulation happens. Progesterone rises. Then everything resets and begins again. When we take the combined oral contraceptive pill, that communication is suppressed. Instead of your brain and ovaries leading the process, synthetic hormones take over. They flatten the fluctuations. Ovulation is paused. The “bleed” you get each month isn’t a true menstrual period; it’s a withdrawal bleed triggered by the hormone drop in the pill cycle. So, in PCOS, it gives the illusion of a cycle, and it does help manage some of our most annoying symptoms: * Increases sex hormone binding globulin (SHBG), which binds free testosterone. * Lowers circulating androgens. * Reduces acne and excess hair growth. * Creates predictable cycle patterns. The issue is that the underlying drivers have not been addressed, so once women come off it, PCOS returns. I have a more in-depth article on the mechanism behind the combined oral pill here: What happens when we come off Many women assume that after a few years on the pill, their PCOS will be “sorted”, that the break gave their bodies time to recalibrate. But PCOS is a syndrome. It’s a complex condition influenced by genetics, metabolism, and environment. When you remove the pill, your original physiology returns. Sometimes symptoms come back stronger.Sometimes they look different.Sometimes they were masked for years. And if no one explained that beforehand, it can feel quite a shock. A cycle is important beyond just pregnancy The other issues we have with being on the pill for a very long time are that it assumes that our cycles and hormones produced naturally are not important for other aspects of our lives. That is not true. Estrogen supports: * Bone density * Cardiovascular health * Brain function Progesterone supports: * Mood stability * Sleep quality * Nervous system regulation These functions only touch the tip of the iceberg. Our bodies are highly intelligent machines that have not been designed for any single use. In PCOS, restoring ovulation isn’t just about getting pregnant. It’s a barometer. It tells you insulin resistance is improving. It tells you the hormonal communication loop is functioning better, and it allows your hormones to do their thing in other parts of your body. When you suppress that loop, you lose a piece of feedback. That doesn’t automatically mean it’s wrong, but it does mean something important is different. Tara shared something really powerful - she only truly experienced a natural cycle consistently in her 40s. For much of her life, she was either on hormonal contraception, pregnant, or breastfeeding. When she finally lived with a regular, natural cycle, she started noticing patterns: * Libido rising before ovulation * Cervical mucus shifting. * Mood softening before bleeding. * Energy surges in the follicular phase. She described it as if she'd discovered a hidden rhythm she’d never been taught to listen to. However, we should NOT demonise it Two truths can exist simultaneously. Hormonal contraception has given women enormous autonomy. It has reduced unplanned pregnancies. It has allowed educational and career freedom. And at the same time, it suppresses a complex hormonal system that affects more than reproduction. If you take it, take it consciously. If you need it, use it without shame. But understand: * It manages symptoms. * It does not cure PCOS. * It pauses your natural cycle. * It doesn’t replace lifestyle and metabolic work if those are relevant. And perhaps most importantly, have a plan. Are you using it short-term for symptom relief?For contraception?While you stabilise something else in your life? That’s very different from assuming it has resolved the condition. Our conclusion Women deserve an explanation. Not just prescriptions. PCOS is complex. It requires time, nuance, and often a multidisciplinary approach. So the real message isn’t “Don’t take the pill” but know what you’re choosing, what is does and have a plan on how to come off it once you want to. See you Sunday, Francesca This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thepcosnewsletter.com/subscribe

    26 min
  2. A Behavioural Scientist’s view on your goals - beyond motivation

    JAN 4

    A Behavioural Scientist’s view on your goals - beyond motivation

    Hello everyone, Here we are! 2026 has officially started! You know I like to talk a lot about behaviour change in January, and this year I am bringing you an interview with Dr Rosie Webster, the person who first taught me about behaviour change in 2021.PS: The videos I upload here are available as podcasts on Spotify, Apple Podcasts or on YouTube. If you prefer reading, I have summarised the conversation below. If you have PCOS and feel stuck in cycles of motivation, burnout, and starting over, this episode is for you. We break down why common advice doesn’t work, why weight loss is such a frustrating goal, and how behavioural science can help you build habits that actually support your hormones, health, and long-term life. You’ll leave with a clearer way to think about habits, health, and January resets and a framework you can actually apply to your own life. We answer the following: * Why does motivation fade so quickly when we try to change our habits, especially around weight and lifestyle? * Why doesn’t “just trying harder” work when it comes to weight loss and behaviour change? * How should someone approach lifestyle change in a way that’s realistic and sustainable, rather than all-or-nothing? * What role do our environment and daily context play in why weight-related changes feel so hard to stick to? * Why does focusing on weight loss often backfire, and what should people focus on instead? * How can someone use a fresh start (like January) to actually set up changes that last long term? Rosie has a PhD in Health Psychology and is a behavioural science consultant and health coach, specialising in how people make and sustain health behaviour change. The perfect person to speak to in January, as we are considering making changes to our lifestyle for PCOS. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thepcosnewsletter.com/subscribe

    35 min
  3. Caroline's 10 year PCOS fertility learnings

    11/30/2025

    Caroline's 10 year PCOS fertility learnings

    Hello everyone, Caroline’s 10 years learning regarding her fertility and PCOS were so touching. Listening to her has made me feel angry, hopeful and determined. Sharing these insights will help so many women avoid the pain of having to try for 3 years before conceiving. This episode is also dear to me because it showcases how tools such as ovulation trackers, knowledge and advocating for yourself can help women navigate this challenging time that some of us have to go through. Weather you are just starting your conceiving journey, have been in it for a while or want to know what tools to use once the times comes, this episode is for you. Ultrahuman gifted me their product for review; this interview is part of that collaboration. Caroline goes through her realisation that she had a short luteal phase using the OvuSense vaginal temperature tracker and how she had to fight for ovulation medication due to her weight. A story of resilience, perseverance and love. Caroline is part of the Ultrahuman team, who have recently acquired viO HealthTech company who produces the OvuSense temperature trackers. She left her job at a police department to join this team because of how much she believes in advocating for women with PCOS. The Ultrahuman team has a 30% discount on their ring who has an advanced temperature tracking module. I don’t gain any monetary value from sharing this. Have a good Sunday, Francesca This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thepcosnewsletter.com/subscribe

    26 min
  4. 08/24/2025

    Understanding miscarriage risk in PCOS

    Hello everyone, This article was quite hard to write and film emotionally. For anyone who wishes to become a mother, the thought of managing to get pregnant and losing it is terrifying. I have added one more episode to the series. So far we have gone through: * Episode 1: PCOS and fertility - how do I know how much time I have left? * Episode 2: How can I prepare my body for pregnancy? * Episode 3: The other side of the coin -> checking your partner’s fertility and optimising for a family * Episode 4: Finding ovulation when your cycles are irregular * Episode 5: The risk of miscarriage I know numerous women who have gone through miscarriages and then went on to have healthy babies later down the line, or women who needed assistance. The reason why I think it’s important to talk about it is because it normalises it. 90% of miscarriages in the first trimester are down to chromosomal problems - so it’s not your fault if it happens. Many women blame themselves for it, but it’s a natural phenomenon. Of course, we are emotionally intelligent animals, so it’s hard to stay purely in the facts, but understanding the odds is helpful. Approximately 25% of women experience a miscarriage in their lifetime, so that’s 1 in 4 who will have to go through this unpleasant experience. I have been very close to two of my friends’ miscarriages and their experience, which, while painful, normalised it. Here are the numbers for women without PCOS and those with PCOS. ❤️ This content is for our paid subscribers. A lot of work and research goes into writing these articles. Consider becoming a paid subscriber to get the most scientifically-backed PCOS information and learn to control your PCOS. Women without PCOS There is a book that provides in-depth details about the data we have on popular pregnancy myths. It’s called Expecting Better by Emily Oster. I can see that she was a very anxious mom-to-be and found a lot of comfort in understanding risk percentages and delving deeply into the data. If you are seen at week 6, and everything looks good, these are the % of pregnancies that are lost afterwards. Starting at 11% in week 6 and going down to 2% in week 11. A very sharp decrease. Other sources, such as the Tommys, a charity dedicated to pregnancy and babies, report the following numbers: early miscarriages happen to 10-20 in 100 (10 to 20%) of pregnancies. That’s almost 1 in 5. Second-trimester miscarriages happen in 3-4% of pregnancies. The numbers differ according to the source. As you can imagine, it’s pretty hard to estimate, as some of the miscarriages can go unnoticed when they happen. Some studies even put the risk at week 3 at 30%. The risk of losing your pregnancy goes down as time passes and the little cells become a fetus. Women with PCOS It will come as no shock to you that we have a higher chance of miscarriage. With this condition, you can pretty much assume that we have an increased risk of every disease under the sun. It does show the wide range of implications of hormones on our bodies. A paper on pregnancy in women with PCOS puts our first-trimester miscarriage rate between 30 to 50%. It is pretty challenging to determine, so most of these figures come from studies where some form of assistance was provided. For example, treatment with ovulation-inducing agents such as clomiphene or letrozole is associated with a higher incidence of miscarriage compared to the naturally conceiving population. It is not known the rate of miscarriage for those who conceived naturally. I guess that it depends heavily on how well-controlled your PCOS is. Why? 1. Increased LH An increase in LH characterises PCOS. High LH can: * Prematurely trigger oocyte maturation → poorer quality eggs. * Impair corpus luteum function → insufficient progesterone support for early pregnancy - progesterone is needed for the endometrium to develop and be stable where the embryo implants What can I do? Before conceiving, it would be ideal to undergo a test to determine your baseline LH levels. Elevated LH is primarily genetic; however, there is evidence that insulin can increase LH secretion - so taking care of your insulin levels MIGHT*** help. Might*** - with three *** because it’s very hard to prevent miscarriages or be sure of what the issues are - the things that I suggest are in no way saying - if you do this, you won’t have a miscarriage. As we saw at the beginning of this article, most of it’s chromosomal - we are just trying to understand if the percentage increase compared to women without PCOS might be due to PCOS-specific things. I am a control freak - so if there are things that I can try, I will do them even though they might not necessarily have an effect. 2. Elevated androgens Elevated free/total testosterone ratios were found to be predictive of early pregnancy loss in two different studies. The authors speculated that high androgen levels antagonise estrogen, which may affect endometrial development and implantation. The endometrium is incredibly important for the embryo to implant and find its cosy home for the next 9 months. What can I do? Similarly, testing your testosterone levels beforehand is probably a good idea. It’s all about understanding your baseline and giving yourself 3-12 months prep time. We discuss how to prepare for pregnancy at length in our second episode. 4. Plasminogen activator inhibitor-1 (PAI-1) High plasminogen activator inhibitor-1(PAI-1) activity is associated with recurrent pregnancy loss in women with unexplained recurrent miscarriages. It has also been found to be significantly higher in women with PCOS. PAI-1 inhibits fibrinolysis - the body’s ability to dissolve clots. Tiny clots can form in the blood vessels that feed the placenta (the organ that supplies the baby with oxygen and nutrients). These clots block the blood flow, so the placenta doesn’t get enough circulation. Without proper blood supply, the placenta can’t support the baby → leading to pregnancy loss. What can I do? There is a study which documented improved pregnancy outcomes with metformin in overweight women with PCOS and correlated it to significantly reduced PAI-1 activity levels resulting from treatment. This is an option. Metformin will come up later in the article. 5. Insulin Resistance You knew this one was coming. This one has multiple implications: * Alters oocyte quality and maturation. * Interferes with glucose uptake in the endometrium → poor energy support for implantation. * Exposure to excess glucose can turn on a “self-destruct switch” ( apoptosis) * Suppresses GLUT4 expression in endometrial cells, reducing glucose transport. * Reduces glycodelin & IGFBP-1 (proteins crucial for implantation and maternal immune tolerance). What can I do? Allowing yourself time to adjust your diet before trying to conceive is important. Metformin can also be your friend in these instances, together with Inositol, a low-GI diet and muscle building. 6. Endometrial Dysfunction Even beyond hormones and insulin resistance, women with PCOS may show: * Reduced β3 integrins → cell adhesion molecules needed for embryo attachment. * Reduced glycodelin → supports placental development and immune modulation * Reduced IGFBP-1 - regulates fetal growth and implantation Can I do anything to prevent a miscarriage? There is a retrospective review where 65 women with PCOS who continued metformin during pregnancy had a much lower rate of first-trimester loss (8.8%) compared to 31 women who did not take it (41.9%). Among those with a history of miscarriage, the protective effect was even more substantial (11.1% vs. 58.3%). These findings suggest that metformin use in pregnancy may significantly reduce early pregnancy loss in women with PCOS. There is a current research study ongoing, called the LOCIS Trial, which is due to be published later this year. The LOCI trial will generate robust evidence on whether continuing metformin treatment throughout the 1st trimester can reduce the risk of miscarriage for approximately 1,800 women with PCOS. I would discuss this with your doctor and consider taking Metformin for a while before you start conceiving and throughout your first trimester. Lifestyle and weight management are universally recommended and provide broader health and fertility benefits. Looking after our PCOS markers is essential. Supplementation with Vitamin D, Omega-3, and Folate is also very important. A good prenatal multivitamin can help. If you need specialised support, don’t hesitate to contact me at francesca.abalasei@gmail.com This concludes our fertility series. I will create a lot more pregnancy content later on. I hope this has offered you a window into what you need to know about this chapter in our lives. See you next Sunday, Francesca This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thepcosnewsletter.com/subscribe

    19 min

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Finding the truth about PCOS. Bringing you the true science of PCOS and women's health with expert guests and a ton of insights. www.thepcosnewsletter.com