The Vitals

Mount Sinai Podcast Network

Gain insights about health, science, and wellness with this groundbreaking video podcast from the acclaimed Mount Sinai Health System. Showcasing Mount Sinai's most renowned doctors, researchers, medical experts, and patients, The Vitals explores what happens when the most respected minds in medicine meet at the same table.

  1. 1d ago

    Healthspan Explained: A Miniseries | Episode 3: How Clinical Trials Work

    How do scientists know if a new treatment actually works?  In Episode 3 of our HealthSpan Explained miniseries, host Dr. Shruti Naik is joined by physician-scientists Dr. Tom Marron and Dr. Fanny Elahi to explore the science behind clinical trials—and why they're the foundation of modern medicine.  As excitement grows around longevity research and anti-aging interventions, separating evidence from hype has never been more important. The team explains how randomized clinical trials, placebo controls, biomarkers, and precision medicine help researchers determine whether treatments are truly safe and effective—and why anecdotes and supplements alone aren't enough.  In this episode, you'll learn:  Why randomized clinical trials remain the gold standard in medicineThe difference between FDA-approved drugs and dietary supplementsHow placebo and nocebo effects influence medical researchWhy biomarkers are transforming the future of clinical trialsWhat "precision clinical trials" could mean for personalized medicineHow the XPRIZE Healthspan Challenge aims to redefine healthy aging Medicine doesn't move on hype—it moves on evidence. Discover how today's clinical trials are laying the groundwork for tomorrow's breakthroughs in longevity and healthspan.  Learn more about XPrize Healthspan: https://www.mountsinai.org/about/newsroom/2025/mount-sinai-researchers-in-semifinals-of-101-million-xprize-healthspan-a-competition-seeking-innovative-approaches-to-aging-well  🎧 Subscribe to The Vitals and explore more podcast programming from Mount Sinai for expert conversations on the biggest issues in medicine, research, and patient care: https://www.youtube.com/playlist?list=PLCT7BA-HcHliU8QIXyuk_74L_uH0gyKGt

  2. May 20

    Pioneering Ketamine Treatment for Depression

    How did ketamine evolve from an anesthetic to one of the most important mental health treatment breakthroughs in decades?  In this episode of The Vitals, guest host Dennis Charney, MD sits down with specialists James Murrough , MD, PhD, and Adriana Feder, MD, to explore the science behind ketamine treatment for depression and PTSD—and why it may offer hope for patients who have not responded to traditional therapies.  The conversation traces the origins of ketamine research to the pioneering clinical work conducted at Mount Sinai. The doctors explain how ketamine differs from standard antidepressants, why it can work within hours instead of weeks, and how it is helping patients with treatment-resistant depression and suicidal thinking.   The panel also discusses:   How ketamine became the FDA-approved treatment Spravato Why researchers believe ketamine increases neuroplasticity in the brain The growing evidence for ketamine in treating PTSD How psychotherapy may enhance ketamine’s long-term effects Why patients should not lose hope, even after years of severe symptoms To learn more about Mount Sinai’s Depression and Anxiety Center or to book an appointment with a Mount Sinai expert, visit the Mount Sinai Health System’s website: https://icahn.mssm.edu/research/depression-anxiety-center  🎧 Subscribe to The Vitals and explore more podcast programming from Mount Sinai for expert conversations on the biggest issues in medicine, research, and patient care: https://www.youtube.com/playlist?list=PLCT7BA-HcHliU8QIXyuk_74L_uH0gyKGt

  3. May 6

    Rises and Advancements in Colorectal Cancer

    Colorectal cancer is no longer just a disease of older adults—and the data is raising alarm bells.  On this episode of The Vitals, host Leslie Schlachter sits down with the Mount Sinai Health System’s leading experts   To unpack why rates are rising, especially among younger populations, and what you need to know right now.   Joining the conversation are gastroenterologists Dr. David Greenwald and Dr. Pascale White, along with medical oncologist Dr. Deirdre Cohen. Together, they explore the latest research, evolving screening guidelines, and breakthrough treatments that are changing outcomes for patients.  From early warning signts to cutting-edge therapies, this episode delivers practical, evidence-based insights that could change lives:   The likely reasons why colorectal cancer is increasing in adults under 50;  Common symptoms you should never ignore; Screening options—from stool tests to colonoscopy—and when to start; The role of lifestyle, diet, and the microbiome;  Advances in treatment, including immunotherapy and personalized medicine; How early detection dramatically improves survival. Colorectal cancer is one of the most preventable—and treatable—cancers when caught early. Whether you’re approaching screening age or simply want to stay informed, this conversation is essential listening.  📞For more information on Mount Sinai’s colorectal cancer treatments or to schedule an appointment with a Mount Sinai physician, click here: https://www.mountsinai.org/care/gastroenterology/services/endoscopy-colonoscopy/colonoscopy/colorectal-screening  🎧 Subscribe to The Vitals and explore more podcast programming from Mount Sinai for expert conversations on the biggest issues in medicine, research, and patient care: https://www.youtube.com/playlist?list=PLCT7BA-HcHliU8QIXyuk_74L_uH0gyKGt

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About

Gain insights about health, science, and wellness with this groundbreaking video podcast from the acclaimed Mount Sinai Health System. Showcasing Mount Sinai's most renowned doctors, researchers, medical experts, and patients, The Vitals explores what happens when the most respected minds in medicine meet at the same table.