This Is Why with Dr. Busti

Anthony Busti, MD, PharmD, MSc, FNLA, FAHA
  • 5.0 (4)
  • Education

This Is Why exists to help medical professionals understand the why behind the decisions they make every day in patient care. Our approach is about integrating evidence, clinical relevance and real-world application so that what your learn connects directly with the patients you serve. 

  1. 20h ago ·  Video

    Amiodarone and Digoxin: Drug Interaction Explained

    The amiodarone and digoxin drug interaction is one of the most clinically important cardiovascular drug interactions to understand because it can raise digoxin exposure and increase the risk of digoxin toxicity. In this episode of This Is Why, Dr. Busti explains why amiodarone can increase digoxin concentrations, how P-glycoprotein inhibition changes digoxin handling, and why clinicians should anticipate the need for digoxin dose adjustment and monitoring rather than react after symptoms appear. You’ll learn why this interaction is not just a memorized warning, but a predictable pharmacokinetic and pharmacodynamic issue involving drug transport, renal elimination, cardiac conduction, and patient-specific monitoring. Topics Covered: Why digoxin has a narrow therapeutic window How P-glycoprotein affects digoxin absorption and elimination Why amiodarone increases digoxin exposure Clinical signs of digoxin toxicity Why nausea, fatigue, confusion, and bradycardia matter How to think through dose reduction and monitoring Why renal function and serum concentrations matter Additive electrophysiologic effects on heart rate and conduction How understanding the mechanism improves patient care When we understand the why, we improve the how. 👉 Get more with a free membership at https://www.thisiswhy.health/ Access free downloads from our videos Access deep-dive content from Dr. Busti Organize content via playlists & collections Join live Q&A Receive member newsletters Coupons & discounts for exam prep resources Chapter Table of Contents 00:00 - Introduction 01:49 - Digoxin's Narrow Therapeutic Index 02:31 - P-Glycoprotein: The Key Transporter 04:53 - How Amiodarone Inhibits P-Glycoprotein 06:37 - Clinical Signs of Digoxin Toxicity 08:27 - Managing the Interaction 09:59 - Pharmacodynamic Effects on Cardiac Conduction 11:19 - Key Clinical Takeaways 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more! #Amiodarone #Digoxin #DrugInteraction #DigoxinToxicity #PGlycoprotein Speaker: Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, is a licensed healthcare professional and medical educator with over 30 years of experience in clinical practice and academic teaching. He has trained and practiced as a nurse, pharmacist, and physician, bringing a uniquely comprehensive perspective to patient care and medical education. Dr. Busti is dedicated to advancing evidence-based medicine and helping clinicians understand the underlying “why” behind clinical decisions to improve patient outcomes. About This Channel: This content is created by Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, a board-certified physician with training at Johns Hopkins School of Medicine and University of Oxford and a medical educator for healthcare professionals and students. All material is based on current medical literature and evidence-based guidelines that align with principles of evidence-based medicine (EBM) and Evidence-Based Healthcare (EBHC). Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

    13 min

  2. 5d ago ·  Video

    Likelihood Ratios (LR) Explained for Diagnostic Testing

    Likelihood ratios (LR) are one of the most clinically useful tools in diagnostic testing because they help clinicians determine whether a test meaningfully changes the probability of disease. In this episode of This Is Why with Dr. Busti, Dr. Anthony Busti explains how likelihood ratios integrate sensitivity, specificity, prevalence, and post-test probability into real-world clinical decision-making. This Is Why understanding likelihood ratios (LR) matters for every clinician ordering diagnostic tests. Dr. Busti walks through how positive and negative likelihood ratios influence patient workups, when additional testing is warranted, and how clinicians determine whether a diagnostic test is truly useful. Using practical examples including appendicitis evaluation with the speed bump sign, this episode demonstrates how likelihood ratios help guide evidence-based medicine (EBM) and shared clinical decision-making. Topics Covered: - Likelihood ratios (LR) explained - Positive vs negative likelihood ratios - Pre-test and post-test probability - Disease prevalence and diagnostic testing - Diagnostic decision-making principles - Sensitivity and specificity integration - Fagan nomogram basics - Choosing useful diagnostic tests 👉 Get more with a free membership at https://www.thisiswhy.health/ - Access free downloads from our videos  - Access deep dive content from Dr. Busti - Organize content via playlists & collections - Join live Q&A - Receive member newsletters - Coupons & discounts for exam prep resources 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more! #LikelihoodRatios #DiagnosticTesting #EBM #PostTestProbability #DrBusti Speaker: Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, is a licensed healthcare professional and medical educator with over 30 years of experience in clinical practice and academic teaching. He has trained and practiced as a nurse, pharmacist, and physician, bringing a uniquely comprehensive perspective to patient care and medical education. Dr. Busti is dedicated to advancing evidence-based medicine and helping clinicians understand the underlying “why” behind clinical decisions to improve patient outcomes. About This Channel: This content is created by Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, a board-certified physician with training at Johns Hopkins School of Medicine and University of Oxford and a medical educator for healthcare professionals and students. All material is based on current medical literature and evidence-based guidelines that align with principles of evidence-based medicine (EBM) and Evidence-Based Healthcare (EBHC). Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

    25 min

  3. 6d ago ·  Video

    Positive and Negative Predictive Values Explained Clinically

    Positive and negative predictive values are critical for understanding what diagnostic test results actually mean in clinical practice. In this episode of This Is Why with Dr. Busti, Dr. Busti explains how predictive values help clinicians determine the probability that a patient truly has — or does not have — a disease after diagnostic testing. This Is Why understanding predictive values matters far beyond memorizing formulas. Dr. Busti breaks down how prevalence changes diagnostic interpretation, why false positives and false negatives matter clinically, and how positive and negative predictive values directly impact patient care decisions. Using practical examples including pregnancy testing, appendicitis evaluation, and abdominal pain over speed bumps, this episode demonstrates how clinicians apply predictive values in real-world diagnostic reasoning. Topics Covered: - Positive predictive value explained - Negative predictive value explained - False positives vs false negatives - Disease prevalence and diagnostic testing - Pre-test probability basics - Clinical interpretation of predictive values - Diagnostic reasoning in practice - Sensitivity vs specificity integration - Appendicitis speed bump sign example - Applying predictive values clinically The goal = make medical education easy and clinically relevant. 👉 Get more with a free membership at https://www.thisiswhy.health/ - Access free downloads from our videos  - Access deep dive content from Dr. Busti - Organize content via playlists & collections - Join live Q&A - Receive member newsletters - Coupons & discounts for exam prep resources 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more! #PositivePredictiveValue #NegativePredictiveValue #DiagnosticTesting #EvidenceBasedMedicine #DrBusti Speaker: Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, is a licensed healthcare professional and medical educator with over 30 years of experience in clinical practice and academic teaching. He has trained and practiced as a nurse, pharmacist, and physician, bringing a uniquely comprehensive perspective to patient care and medical education. Dr. Busti is dedicated to advancing evidence-based medicine and helping clinicians understand the underlying “why” behind clinical decisions to improve patient outcomes. About This Channel: This content is created by Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, a board-certified physician with training at Johns Hopkins School of Medicine and University of Oxford and a medical educator for healthcare professionals and students. All material is based on current medical literature and evidence-based guidelines that align with principles of evidence-based medicine (EBM) and Evidence-Based Healthcare (EBHC). Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

    27 min

  4. Jun 30 ·  Video

    ROC Curves Explained: Understanding Diagnostic Cutoffs

    ROC curves and the AUC (or c-statistic) are some of the most important — and most misunderstood — concepts in diagnostic testing and evidence-based medicine (EBM). In this episode of This Is Why with Dr. Busti, Dr. Busti explains how ROC curves help clinicians determine diagnostic test cutoffs, balance sensitivity and specificity, and improve diagnostic accuracy in real clinical practice. This Is Why understanding ROC curves matters for clinicians interpreting laboratory tests, screening tools, and diagnostic assays. Dr. Busti breaks down area under the curve (AUC), false positives, false negatives, and why changing diagnostic thresholds directly impacts patient care decisions. Using practical examples like diabetes diagnostic cutoffs and D-dimer testing, this episode explains how clinicians choose acceptable tradeoffs between sensitivity and specificity while minimizing diagnostic error. Topics Covered: - Receiver Operating Characteristic (ROC) curves explained - Area under the curve (AUC) - Sensitivity vs specificity tradeoffs - Diagnostic test cutoff values - Diagnostic accuracy principles - Clinical interpretation of ROC curves - Applying ROC curves in practice 👉 Get more with a free membership at https://www.thisiswhy.health/ - Access free downloads from our videos  - Access deep dive content from Dr. Busti - Organize content via playlists & collections - Join live Q&A - Receive member newsletters - Coupons & discounts for exam prep resourcex 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. #ROCCurves #DiagnosticTesting #SensitivityAndSpecificity #EvidenceBasedMedicine #DrBusti Speaker: Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, is a licensed healthcare professional and medical educator with over 30 years of experience in clinical practice and academic teaching. He has trained and practiced as a nurse, pharmacist, and physician, bringing a uniquely comprehensive perspective to patient care and medical education. Dr. Busti is dedicated to advancing evidence-based medicine and helping clinicians understand the underlying “why” behind clinical decisions to improve patient outcomes. About This Channel: This content is created by Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, a board-certified physician with training at Johns Hopkins School of Medicine and University of Oxford and a medical educator for healthcare professionals and students. All material is based on current medical literature and evidence-based guidelines that align with principles of evidence-based medicine (EBM) and Evidence-Based Healthcare (EBHC). Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

    1 min

  5. Jun 27 ·  Video

    Sensitivity & Specificity Explained for Clinical Practice

    Sensitivity and specificity are some of the most misunderstood concepts in evidence-based medicine and diagnostic testing. In this episode of This Is Why with Dr. Busti, Dr. Busti breaks down the clinical meaning behind sensitivity, specificity, true positives, false positives, false negatives, and diagnostic accuracy using practical examples clinicians can immediately apply. This Is Why understanding sensitivity and specificity matters far beyond memorization. Dr. Busti explains how clinicians use highly sensitive tests to rule out disease and highly specific tests to rule in disease while also demonstrating how false positives and false negatives influence patient care decisions. You’ll also learn how to interpret 2x2 diagnostic tables, understand diagnostic accuracy, and apply concepts like SNOUT and SPIN correctly in clinical reasoning and evidence-based medicine. Topics Covered: - Sensitivity vs specificity explained - True positives and false negatives - True negatives and false positives - Diagnostic accuracy basics - Rule in vs rule out testing - SNOUT and SPIN concepts - Clinical interpretation of diagnostic tests - 2x2 diagnostic tables explained - False positive and false negative errors - Applying diagnostic testing clinically The goal = make medical education easy and clinically relevant. 👉 Access bonus materials and downloads from this episode at: https://www.thisiswhy.health/topics/*** [ ADD GPT SLUG HERE ] *** 👉 Get more with a free membership at https://www.thisiswhy.health/ - Access free downloads from our videos  - Access deep dive content from Dr. Busti - Organize content via playlists & collections - Join live Q&A - Receive member newsletters - Coupons & discounts for exam prep resources 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more! #SensitivityAndSpecificity #DiagnosticTesting #EvidenceBasedMedicine #DiagnosticAccuracy #DrBusti Speaker: Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, is a licensed healthcare professional and medical educator with over 30 years of experience in clinical practice and academic teaching. He has trained and practiced as a nurse, pharmacist, and physician, bringing a uniquely comprehensive perspective to patient care and medical education. Dr. Busti is dedicated to advancing evidence-based medicine and helping clinicians understand the underlying “why” behind clinical decisions to improve patient outcomes. About This Channel: This content is created by Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, a board-certified physician with training at Johns Hopkins School of Medicine and University of Oxford and a medical educator for healthcare professionals and students. All material is based on current medical literature and evidence-based guidelines that align with principles of evidence-based medicine (EBM) and Evidence-Based Healthcare (EBHC). Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

    35 min

  6. Jun 25 ·  Video

    Diagnostic Tests Explained: Precision & Accuracy in Practice

    Diagnostic tests used in research and clinical practice are essential to evidence-based medicine because they shape how clinicians diagnose disease, interpret tests, and make patient care decisions. In this episode of This Is Why with Dr. Busti, Dr. Busti explains how the precision and accuracy of diagnostic studies are designed, validated, and critically appraised using clinically relevant examples and practical reasoning. This Is Why understanding sensitivity, specificity, predictive values, and likelihood ratios matters far beyond memorization. Dr. Busti walks through how clinicians determine whether a diagnostic test is useful, how bias affects study validity, and why gold-standard reference testing is critical in medical research. Topics Covered: - Diagnostic tests in clinical medicine - Precision and accuracy of diagnostic tests explained - Bias and error in diagnostic studies - Considerations about the Gold Standard or Reference Tests The goal = make medical education easy and clinically relevant. 👉 Get more with a free membership at https://www.thisiswhy.health/ - Access free downloads from our videos  - Access deep dive content from Dr. Busti - Organize content via playlists & collections - Join live Q&A - Receive member newsletters - Coupons & discounts for exam prep resources 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more! #DiagnosticStudies #Diagnostictests #EvidenceBasedMedicine #EBM #DrBusti Speaker: Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, is a licensed healthcare professional and medical educator with over 30 years of experience in clinical practice and academic teaching. He has trained and practiced as a nurse, pharmacist, and physician, bringing a uniquely comprehensive perspective to patient care and medical education. Dr. Busti is dedicated to advancing evidence-based medicine and helping clinicians understand the underlying “why” behind clinical decisions to improve patient outcomes. About This Channel: This content is created by Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, a board-certified physician with training at Johns Hopkins School of Medicine and University of Oxford and a medical educator for healthcare professionals and students. All material is based on current medical literature and evidence-based guidelines that align with principles of evidence-based medicine (EBM) and Evidence-Based Healthcare (EBHC). Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

    14 min

  7. Jun 22 ·  Video

    Diagnostic Tests & Studies: How to Use & Evaluate in Practice

    Diagnostic studies are foundational to evidence-based medicine because they help clinicians determine disease presence, severity, progression, and treatment response. In this episode of This Is Why with Dr. Busti, Dr. Busti explains the essential framework behind diagnostic studies, including sensitivity, specificity, predictive values, likelihood ratios, and critical appraisal tools used to evaluate study validity. This Is Why understanding diagnostic studies matters for every clinician. Dr. Busti breaks down how diagnostic assays are developed, validated, and interpreted using practical clinical examples, including troponins, HIV viral load monitoring, BNP in heart failure, and lactate clearance in sepsis. You’ll also learn how evidence-based medicine frameworks differ for diagnostic research, including PER, PIRT, and PIRO formats, along with the importance of gold standard reference tests, observer agreement, bias reduction, and diagnostic study reporting standards. Topics Covered: - Diagnostic studies in clinical medicine - Sensitivity vs specificity explained - Positive and negative predictive values - Pre-test and post-test probability - Likelihood ratios and diagnostic accuracy - Gold standard reference testing - Evidence-based medicine diagnostic frameworks - Bias and validity in diagnostic studies - QUADAS-2 critical appraisal overview - Applying diagnostic evidence clinically 👉 High-Yield EBM Practice Questions: https://www.highyieldmedreviews.com/ebm-biostatistics-literature-evaluation-online-review-course 👉 Get more with a free membership at https://www.thisiswhy.health/ - Access free downloads from our videos  - Access deep dive content from Dr. Busti - Organize content via playlists & collections - Join live Q&A - Receive member newsletters - Coupons & discounts for exam prep resources 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more! #DiagnosticStudies #SensitivityAndSpecificity #EvidenceBasedMedicine #ClinicalReasoning #MedicalDiagnostics #DrBusti Speaker: Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, is a licensed healthcare professional and medical educator with over 30 years of experience in clinical practice and academic teaching. He has trained and practiced as a nurse, pharmacist, and physician, bringing a uniquely comprehensive perspective to patient care and medical education. Dr. Busti is dedicated to advancing evidence-based medicine and helping clinicians understand the underlying “why” behind clinical decisions to improve patient outcomes. About This Channel: This content is created by Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, a board-certified physician with training at Johns Hopkins School of Medicine and University of Oxford and a medical educator for healthcare professionals and students. All material is based on current medical literature and evidence-based guidelines that align with principles of evidence-based medicine (EBM) and Evidence-Based Healthcare (EBHC). Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

    41 min

  8. Jun 18 ·  Video

    Regression Analysis Explained: Confounders & Clinical Meaning

    Regression analysis explained — understanding how variables influence outcomes is essential for interpreting clinical research in this episode of This Is Why with Dr. Busti. Dr. Busti breaks down regression analysis and how it helps identify relationships between variables while controlling for confounders. This Is Why mastering regression allows you to determine whether an intervention truly drives outcomes—or if other factors are influencing the results. You’ll learn the difference between linear and multivariate regression, how independent and dependent variables interact, and why controlling for confounders is critical for internal validity. Dr. Busti also connects regression analysis to the bigger picture of evidence-based medicine, helping you integrate statistical tools into real clinical decision-making. Topics Covered: - What regression analysis actually measures - Independent vs dependent variables - Linear regression and line of best fit - Multivariate (multilinear) regression explained - Logistic regression and outcome prediction - Identifying and controlling confounders - Reasons variables may not show significance - Role of sample size and statistical power - Internal vs external validity connection - Applying regression to clinical research interpretation The goal = make medical education easy and clinically relevant. 👉 Get more with a free membership at https://www.thisiswhy.health/ - Access free downloads from our videos  - Access deep dive content from Dr. Busti - Organize content via playlists & collections - Join live Q&A - Receive member newsletters - Coupons & discounts for exam prep resources 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more! #regressionanalysis #confounders #biostatistics #clinicalresearch #Dr Busti Speaker: Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, is a licensed healthcare professional and medical educator with over 30 years of experience in clinical practice and academic teaching. He has trained and practiced as a nurse, pharmacist, and physician, bringing a uniquely comprehensive perspective to patient care and medical education. Dr. Busti is dedicated to advancing evidence-based medicine and helping clinicians understand the underlying “why” behind clinical decisions to improve patient outcomes. About This Channel: This content is created by Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, a board-certified physician with training at Johns Hopkins School of Medicine and University of Oxford and a medical educator for healthcare professionals and students. All material is based on current medical literature and evidence-based guidelines that align with principles of evidence-based medicine (EBM) and Evidence-Based Healthcare (EBHC). Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

    26 min
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Ratings & Reviews

5
out of 5
4 Ratings

About

This Is Why exists to help medical professionals understand the why behind the decisions they make every day in patient care. Our approach is about integrating evidence, clinical relevance and real-world application so that what your learn connects directly with the patients you serve. 

Information

  • Creator
    Anthony Busti, MD, PharmD, MSc, FNLA, FAHA
  • Years Active
    2025 - 2026
  • Episodes
    113
  • Rating
    Clean
  • Copyright
    © 2026 This Is Why with Dr. Busti
  • Show Website
    This Is Why with Dr. Busti

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