This Week in Startups

Jason Calacanis
This Week in Startups

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

  1. 3H AGO

    AI-Powered Coding & Space Tugboats? Inside the Future of Software & Satellites! | E2099

    Today’s show: Alex interviews two incredible founders from the TWIST 500! First, Replit CEO Amjad Masad breaks down how AI-powered coding is changing software development and what the future of agents looks like. Then, Starfish Space co-founder Austin Link explains how they’re building a satellite towing service to extend missions and clean up orbit. Two deep dives into the future of tech and space.Timestamps: (0:00) Alex kicks off the episode!(0:53) Discussing Replit's capabilities and introduction of CEO Amjad Masad(4:17) Replit's evolution and turning down a billion-dollar acquisition offer(9:48) Vapi - Go to https://vapi.ai/twist and get 1000 minutes free per month - for life.(11:42) Impact of LLMs and AI agents(17:13) Choosing Anthropic's Claude for Replit(19:46) LinkedIn Jobs - Post your first job for free at https://www.linkedin.com/twist (21:29) Anthropic success and closed source AI implications(24:37) Replit market response and economics of AI models(28:14) Future of Replit's AI tools and plans(33:41) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit http://northwestregisteredagent.com/twist today!(35:12) Introduction to Starfish Space and its mission(38:50) Core missions and challenges of the Otter satellite(47:29) First official mission with Otter and key partnerships(50:57) Economics and ownership of satellite services(53:11) Key components of the Otter project(57:19) Startups in the space economy and comparison with Orbit Fab(59:08) Starfish Space hiring push and final thoughtsSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpLinks from the show:Check out Starfish Space: https://www.starfishspace.com/Check out Replit: https://replit.com/Follow Amjad:X: https://x.com/amasadLinkedIn: https://www.linkedin.com/in/amjadmasad/Follow Austin Link:X: https://x.com/AustinLinkLinkedIn: https://www.linkedin.com/in/austin-link-space/Follow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmThank you to our partners:(9:48) Vapi - Go to https://vapi.ai/twist and get 1000 minutes free per month - for life.(19:46) LinkedIn Jobs - Post your first job for free at https://www.linkedin.com/twist (33:41) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit http://northwestregisteredagent.com/twist today!All rights for the video shared and linked below belong to the original copyright holder, and we are using the footage under the principle of fair use. * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason’s suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 2m
  2. 1D AGO

    Self-Driving Car Myths, Klarna’s Big IPO & Netflix’s $300M Gamble | E2098

    Today’s show: Jason, Alex, and Lon break down a wild viral test on self-driving cars— will FSD see through fog, or does LiDAR win? Plus, Klarna is finally going public… but is "buy now, pay later" still the future or just a debt trap? And Netflix drops $300M on a Russo Brothers sci-fi blockbuster—critics hate it, but audiences love it. Was it worth it? We also dive into big tech’s crackdown on remote work, the Uber of estate managers, and why content creators might be falling into an algorithmic trap. * Timestamps: (0:00) Teaser: Can you fool a self-driving car? (3:11) The Electric State film discussion (7:35) Netflix's strategy, subscriber growth, and podcast licensing deals (10:06) Disney's content strategy insights (10:55) NetSuite. Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist (14:27) Kids investment club and estate manager service ideas (21:02) Horatio - Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up. (22:44) Estate management expansion and Uber's role in transportation (27:19) Klarna's IPO, financials, and buy now, pay later services concerns (30:25) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist (35:12) E-commerce trends and algorithmic content creation impact (40:21) Remote vs. in-person technical interviews (43:08) Work-life balance, early rising myths, and avoiding burnout (50:45) The importance of mentorship and coaching (52:06) Google autocorrect issues for startup names and future of SEO (56:24) Mark Rober's "Can you fool a self-driving car?" video discussion (1:00:13) Human vs. FSD driving standards and safety (1:03:29) Waymo's strategy and autonomous driving competition concerns (1:06:14) Government regulations and milestones for autonomous vehicles (1:08:18) Global AI competition and safety standards in the automotive industry * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Follow Lon: X: https://x.com/Lons LinkedIn: https://www.linkedin.com/in/lonharris * Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Thank you to our partners: (10:55) NetSuite. Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(21:02) Horatio - Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up.(30:25) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 13m
  3. 4D AGO

    Europe’s Startup Future with Harry Stebbings | E2097

    This Week in Startups is brought to you by… Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST CLA. Get started with CLA's CPAs, consultants, and wealth advisors now at https://claconnect.com/tech Today’s show: Jason and Alex break down the biggest tech stories of the moment. OpenAI is pushing to rewrite copyright laws to benefit AI companies while suing others for doing the same—hypocrisy or smart strategy? Meanwhile, European startups are fleeing to the U.S. as overregulation and weak IPO markets make scaling harder. Harry Stebbings joins to discuss whether Project Europe can reverse the trend. Plus, with AI-driven startups staying lean, angel investing is evolving—should investors wait for traction or bet on potential? Jason shares his 2024 playbook. Watch the full episode now! Timestamps: (0:00) Episode Teaser(1:15) OpenAI's recommendations, stance on copyright, and ethics(8:30) Sam Altman's political donations and the media's response (9:41) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(15:48) Introduction of guest Harry Stebbings and his venture capital journey(19:51) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(22:05) Discussing the human aspect of investing and handling criticism(27:37) Project Europe and its support for EU founders(30:49) CLA. Get started with CLA's CPAs, consultants, and wealth advisors now at https://www.claconnect.com/tech(32:16) Balancing roles as an investor and public figure(33:04) Analyzing the European startup ecosystem(35:48) Addressing Project Europe's age cap and mentorship(38:09) Global talent competition and Europe's stance(42:29) Economic impacts and the future of Project Europe(45:18) Growth and housing in Austin compared to other tech regions(47:36) Startup funding strategies and angel investment advice(55:27) Evolving startup and content creation landscapes(57:37) Founder University announcement Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Links from the show: Check out Project Europe: https://www.projecteurope.co/ Check out 20VC: https://www.thetwentyminutevc.com/ Check out Stride VC: https://stride.vc/ Follow Harry: X: https://x.com/HarryStebbingsLinkedIn: https://www.linkedin.com/in/harrystebbings Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: (9:41) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(19:51) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(30:49) CLA. Get started with CLA's CPAs, consultants, and wealth advisors now at https://www.claconnect.com/tech Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    59 min
  4. 5D AGO

    Is Project Europe a YC Riff? Nick Denton is Back! And more! | E2096

    Today’s show: Europe wants to keep its founders from fleeing, AI is growing at breakneck speed, and Nick Denton is back with a spicy Twitter storm—so we had to talk about it. Jason, Alex, and Lon break down Project Europe, a new $10M fund aimed at stopping the European startup brain drain. Plus, Anthropic’s revenue just jumped 40% in a single quarter, and we debate what that means for AI’s future. Meanwhile, China’s EV makers are coming for Tesla, Saudi Arabia is building a gaming empire with a $3.5B Pokémon GO buyout, and we ask the big question: Should X and XAI just merge? Since XAI gets real-time data from X, it’s got a major advantage—so what’s stopping them from becoming one? * Timestamps: (0:00) Alex, Jason and Lon kick off the show! (1:29) Recap of Jason's appearance on Glenn Beck's show and advice to MBA students (4:21) The value of an MBA vs. starting a company(8:14) Nick Denton on Musk, Trump, and investment thesis (9:47 Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST (15:16) The rise of Chinese EV manufacturers and Tesla's challenges (19:09) Jason's stance on vandalism, protests, and political affiliations (20:35) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit http://northwestregisteredagent.com/twist today! (23:13) Tesla's brand challenges and future prospects (25:03) Jason's audience and political neutrality(26:35) Inflation data and its implications for startups (28:07) Project Europe and entrepreneurship in the EU and Middle East (29:45) AdQuick. Easily plan, deploy and measure out-of-home campaigns as easily as digital ads. Visit www.AdQuick.com/twist to learn more (38:09) Jason's personal health and productivity protocol (41:18) Anthropic's revenue growth, API credits, and AI developments(45:09) AI competition and consumer trust (46:41) Mainstream adoption of ChatGPT and AI challengers (48:02) Grok AI's integration with X (51:12) Sale of Niantic's games business and global market shifts( 58:06) India's economic rise and TSMC's potential deal with Intel * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Lon: X: https://x.com/Lons LinkedIn: https://www.linkedin.com/in/lonharris Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Thank you to our partners: (9:47 Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST (20:35) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit http://northwestregisteredagent.com/twist today! (29:45) AdQuick. Easily plan, deploy and measure out-of-home campaigns as easily as digital ads. Visit www.AdQuick.com/twist to learn more * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason’s suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 1m
  5. MAR 11

    The Future of AI Customer Support with LiveX AI’s Jia Li | AI Basics with Google Cloud

    In this episode of AI Basics, Jason sits down with Jia Li from LiveX AI to explore how human-like AI agents are changing the game for businesses. Instead of clunky bots, these AI agents engage customers in real-time, helping with onboarding, support, and even stopping them from leaving before they churn. We’ll break down how they work, why they feel more natural than traditional chatbots, and how companies can train them to eliminate costly mistakes. Plus, we’ll talk about whether AI-powered support might actually be better than human agents. * Timestamps: (0:00) Introduction to startup and AI basics(1:00) Collaboration with Google and insights from industry experts(1:44) Introduction of Jia Li and LiveX AI's innovative customer retention(4:32) LiveX AI's AI agent demonstration and training methodologies(9:38) Personalizing user experience with LiveX AI * Uncover more valuable insights from AI leaders in Google Cloud's 'Future of AI: Perspectives for Startups' report. Discover what 23 AI industry leaders think about the future of AI—and how it impacts your business. Read their perspectives here: https://goo.gle/futureofai * Check out all of the Startup Basics episodes here: https://thisweekinstartups.com/basics Check out Google Cloud: https://cloud.google.com/ Check out LiveX AI: https://www.livex.ai/ * Follow Jia Li: LinkedIn: https://www.linkedin.com/in/lijiali/ X: https://x.com/lijiali_vision * Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

    14 min
  6. MAR 11

    Student Roy Lee Hacks Amazon, SBF's Jailhouse Chat + more! | E2095

    Timestamps: (0:00) Roy Lee's hack and Amazon's reaction (3:03) MicroStrategy's Bitcoin strategy(4:29) Market reactions to Trump's policies(6:33) Creating value in current market conditions(8:00) South by Southwest highlights (10:19) Coda. Empower your startup with Coda’s Team plan for free—get 6 months at https://www.Coda.io/twist (12:03) The $20,000 electric car concept(16:18) Electric unicycles as a startup category (19:12) Vanta. TWiST listeners automate your SOC2 and get $1,000 off at http://www.vanta.com/twist (20:31) Electric unicycles trend discussion(21:31) Guest introduction: Roy Lee(23:32) Roy Lee's background and startup idea(25:41) Technical coding tests and InterviewCoder (30:14) LinkedIn Jobs. Post your first job for free at https://www.linkedin.com/twist (32:01) Amazon's reaction to InterviewCoder and Columbia's actions(37:03) Roy Lee's future and startup funding discussion(41:19) Hiring, revenue, and fundraising strategies(44:37) Venture capital dynamics and maintaining company control(47:52) Capturing audience before investment and SBF's legal issues(57:57) ServiceNow acquires Moveworks(1:00:00) Impact of Tiger's peak valuations on LPs and IRR calculations* Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Follow Roy: X: https://x.com/im_roy_lee LinkedIn: https://www.linkedin.com/in/roy-lee-goat/ * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Thank you to our partners: (10:19) Coda. Empower your startup with Coda’s Team plan for free—get 6 months at https://www.Coda.io/twist (19:12) Vanta. TWiST listeners automate your SOC2 and get $1,000 off at http://www.vanta.com/twist (30:14) LinkedIn Jobs. Post your first job for free at https://www.linkedin.com/twist * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason’s suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 1m
  7. MAR 7

    AI’s Next Leap: Hyper-Realistic Agents & Unlimited Power | E2094

    Today’s show: AI is evolving at lightning speed—smarter assistants, faster models, and now, the massive energy demands that come with it. In this episode, Alex dives into two cutting-edge companies from the TWIST 500 that are shaping AI’s future in very different ways. First, Alex interviews Zap Energy, where CEO Benj Conway explains how their breakthrough fusion power technology could provide unlimited, clean energy to fuel AI and beyond. Then, we talk to PolyAI, where CEO Nikola Mrkšić shares how their conversational AI is revolutionizing customer service with ultra-realistic, human-like voice assistants. If you're excited about where AI is headed—from hyper-realistic agents to a future powered by fusion—this is an episode you don’t want to miss! * Timestamps: (0:00) AI's impact on business and technology; Fusion technology; AI powered voice assistants(1:51) Power demands of AI; Fusion energy's potential and commercialization(6:50) Zap Energy's approach to scaling and efficiency in fusion(9:58) Oracle. Try OCI and save up to 50% on your cloud bill at https://w⁠⁠⁠⁠ww.oracle.com/twist(12:11) Zap Energy's Sentry project and the future of fusion power(18:02) Competition in fusion development and importance of liquid metal walls(20:10) Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(21:38) Thermal management in fusion energy and Zap Energy's milestones(24:19) PolyAI's CEO on conversational AI and generative AI(28:39) Founding PolyAI and advancements in AI technology(30:30) Atlassian. Head to https://www.atlassian.com/software/startups to see if you qualify for 50 free seats for 12 months.(32:30) PolyAI's technology stack and deep learning advancements(39:13) Growth, competitive landscape, and AI's impact on employment(46:16) Startups M&A in applied AI and conclusion with Nikola Mrkšić* Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Links from the show: Check out Zap Energy: https://www.zapenergy.com/ Check out Poly AI: https://poly.ai/ * Follow Benj Conway: X: https://x.com/Energy_Zap * Follow Nikola Mrkšić: X: https://x.com/nikola_mrksic LinkedIn: https://www.linkedin.com/in/nikola-mrksic * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Thank you to our partners: (9:58) Oracle. Try OCI and save up to 50% on your cloud bill at https://w⁠⁠⁠⁠ww.oracle.com/twist(20:10) Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(30:30) Atlassian. Head to https://www.atlassian.com/software/startups to see if you qualify for 50 free seats for 12 months. * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason’s suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    49 min
  8. MAR 5

    Coreweave IPO, AVRide & Digg is Back! | E2093

    This Week in Startups is brought to you by… Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today! Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up. Today’s show: Jason and Alex cover CoreWeave’s filing for a $35 billion IPO after explosive revenue growth. But with 77% of its revenue coming from just two customers, is it built to last? Meanwhile, AVRide is bringing autonomous Hyundai robotaxis to Uber in Dallas, pushing the self-driving revolution forward as Waymo scales to 200,000 weekly rides. And finally, Digg is back! Kevin Rose and Alexis Ohanian are reviving the iconic social news platform, using AI-powered moderation to tackle Reddit’s biggest challenge. Tune in as Jason and Alex break it all down! Timestamps: (0:00) Episode teaser(1:34) Jason's South by Southwest appearances & All In fan meetups(4:17) Digg relaunch, history, and Kevin Rose's AI strategy(10:05) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(11:43) Jason’s involvement with Digg’s revival and lessons learned(15:02) Using Reddit for startup communities(20:00) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(22:07) Kevin Rose's journey and ketamine therapy(24:18) CoreWeave's public filing, clients, and revenue growth(29:52) Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up.(34:22) CoreWeave's potential acquisition and investor IRR(40:45) Using LLMs for financial analysis and political funding discussion(46:19) CoreWeave data centers and AV Ride partnership with Uber(50:18) Challenges in electric bikes and healthcare startups(53:10) Novo Nordisk's direct-to-consumer strategy with Wegovy(57:28) Future of healthcare and Brian Johnson's health regimen(1:05:52) Challenges and excitement in the autonomous vehicle industry Links from episode: Check out digg: https://digg.com/ Check out AVRide: https://www.avride.ai/robot Check out the Mozi app: https://www.mozi.app/ Check out Nerd Crawler: https://www.nerdcrawler.com/ Check out article about Novo Nordisk and Wegovy: https://www.cnbc.com/2025/03/05/novo-nordisk-goes-direct-to-consumer-with-wegovy-what-it-means-for-obesity-rival-eli-lilly.html Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: (10:05) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(20:00) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(29:52) Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up. Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1h 9m
4.2
out of 5
1,237 Ratings

About

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

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