CXOTalk

Michael Krigsman

C-Suite Conversations on AI & Strategy. Join industry analyst Michael Krigsman for unfiltered discussions with the leaders shaping the future of business. From AI implementation to digital transformation, hear directly from CIOs, CTOs, CEOs, and more from the world's largest companies. No scripts. No PR fluff. Just real questions from our live audience and honest answers from the C-Suite. Want to participate? Get invited to the next live show: https://www.cxotalk.com/subscribe

  1. The Cardiovascular System, Mapped in Code as a Digital Twin | CXOTalk #901

    HÁ 3 DIAS

    The Cardiovascular System, Mapped in Code as a Digital Twin | CXOTalk #901

    Can a digital replica of your heart save your life? In CXOTalk episode 902, Michael Krigsman talks with Dr. Joe Alexander, Director of the Medical and Health Informatics Lab at NTT Research, to explore the revolutionary world of Bio-Digital Twins.Discover how researchers are using mathematical modeling to build "computational replicas" of the human cardiovascular system. Dr. Alexander explains how these digital twins can predict heart failure, automate critical care in the ICU through closed-loop intervention systems, and pave the way for a future where personalized medicine is accessible to everyone.We dive deep into the science of treating the heart as an electrical circuit, the ethics of AI in medicine, and the "moonshot" goal of eliminating cardiovascular disease..🔷 Show notes: https://www.cxotalk.com/episode/cardiac-digital-twins-inside-the-research-lab🔷 Newsletter: www.cxotalk.com/subscribe🔷 LinkedIn: www.linkedin.com/company/cxotalk🔷 Twitter: twitter.com/cxotalk💡 KEY TOPICS DISCUSSED:Bio-Digital Twins: How digital replicas of organs allow doctors to test treatments virtually before applying them physically.Closed-Loop Systems: The development of autonomous systems that can regulate heart medication beat-by-beat to minimize oxygen consumption and improve recovery.The Physics of the Heart: How Dr. Alexander uses resistors, capacitors, and diodes to model blood flow and pressure.The Future of MedTech: Moving from acute care (ICU) to managing chronic heart failure with wearable technology.👥 ABOUT THE GUEST: Dr. Joe Alexander is the Director of the Medical and Health Informatics Lab at NTT Research. With a unique background as a chemical engineer and a burn survivor who later attended Johns Hopkins for his MD/PhD, Dr. Alexander is leading "moonshot" research into bio-digital twins to transform cardiovascular care.📍 CHAPTERS:0:00 - Introduction: What is a Cardiac Digital Twin? 2:20 - The Aviation Analogy: Predictive Maintenance for the Body 4:54 - The "Electrical Analog" Model: Viewing the Heart as a Circuit 6:42 - Autonomous Closed-Loop Intervention: Automating ICU Care 12:04 - How a Digital Twin is Built (Population vs. Patient Data) 17:09 - Animal Trials & Validating the Technology 22:11 - Ethics & Safety: Can We Trust AI with Life-and-Death Decisions? 29:03 - Causal vs. Black Box AI: Why Physiology Matters 44:58 - The "Bionic" Approach: Interdisciplinary Teams 50:32 - Health Equity & The Quintuple Aims of Healthcare#DigitalTwins #Cardiology #MedTech #AIinHealthcare #NTTResearch #FutureOfMedicine #HeartHealth #CXOTalk

    54min
  2. How AI Changed a 150-Year-Old Industrial Manufacturing Company! | CXOTalk #901

    24 DE NOV.

    How AI Changed a 150-Year-Old Industrial Manufacturing Company! | CXOTalk #901

    How do you turn a 150-year-old industrial giant into an agile, AI-first organization? ======= Please support our sponsor Emeritus: Explore executive education programs from Emeritus, in collaboration with top universities: https://cxotalk.partner.emeritus.org/ ======= For Hexion CEO Michael Lefenfeld, the answer isn't just about technology, but about culture, safety, and rethinking value. In episode 901 of CXOTalk, Lefenfeld details his strategy for integrating AI across every level of a billion-dollar manufacturing enterprise, from the R&D lab to the factory floor. Michael Krigsman and Michael Lefenfeld discuss the practical realities of moving beyond "pilot purgatory." They dive into how to manage workforce anxiety (the "carrot vs. stick" approach), leverage Private Equity for long-term innovation, and maintain strict safety guardrails while moving fast. If you are a leader navigating the complexities of digital transformation, this interview offers a concrete roadmap for driving growth without sacrificing your company's heritage. 📋 DISCUSSION TOPICS: -- The AI-First Culture: Why Hexion incentivizes AI adoption rather than forcing it. -- Workforce Strategy: How to upskill employees and ensure AI is a "partner," not a "job taker." -- Operational Excellence: Using AI to achieve the "Golden Batch"—reducing waste and energy usage. -- The Private Equity Advantage: How ownership structure impacts long-term tech investment. -- Strategic Partnerships: Using data to deepen customer intimacy and escape the commodity trap. ⏱️ TIMESTAMPS 00:00 🏭 Introduction to Hexion and Its Role in Everyday Life 01:28 🤖 Hexion's Integration of AI Across Operations 03:34 🚀 AI as a Tool for Growth and Empowerment at Hexion 13:47 🤖 Leadership Philosophy and AI Integration at Hexion 16:44 🛡️ AI's Role in Safety and Decision-Making 20:25 ⚙️ AI-Driven Efficiency and Learning in Manufacturing 26:54 💉 Personal Experience with Diabetes and Continuous Glucose Monitoring 28:30 🤖 AI's Role in Customer Service and Business Operations 32:53 🌍 AI Learning, Ecosystem Collaboration, and Organizational Growth 38:32 🤖 Using AI to Enhance Manufacturing and Investment Decisions 40:04 🏢 Hexion's AI-First Strategy and Customer-Centric Approach 46:32 💼 Private Equity's Role in AI Investment and Long-Term Growth 50:20 🧪 Optimizing Products with Data and Batch Chemistry 51:44 🤖 AI's Impact on Business Models and Lessons Learned 53:30 🚀 Advice for AI Implementation and Closing Remarks 🎯 FEATURED GUEST Michael Lefenfeld is the CEO of Hexion Inc. and a serial entrepreneur with a passion for revitalizing legacy industries. -- He holds 100+ patents and was named a World Economic Forum Young Global Leader. -- Michael specializes in bridging the gap between deep science (chemistry/physics) and practical business strategy (AI/profitability). -- Previously served as CEO of Cyanco and SiGNa Chemistry. 📚 RESOURCES 🔷 Show notes:https://www.cxotalk.com/episode/ai-first-rewiring-a-150-year-old-industrial-manufacturer 🔷 Newsletter: www.cxotalk.com/subscribe 🔷 LinkedIn: www.linkedin.com/company/cxotalk 🔷 Twitter: twitter.com/cxotalk Subscribe to CXOTalk newsletter: https://www.cxotalk.com/newsletter 🎙️ ABOUT CXOTALK CXOTalk features unfiltered conversations with C-suite executives from major companies about AI, digital transformation, and business strategy. Hosted by Michael Krigsman. Episode 901 | Recorded November 21, 2025

    56min
  3. Why Your AI Strategy Is Failing: Fortune 500 CEO Advisor Explains | CXOTalk #900

    17 DE NOV.

    Why Your AI Strategy Is Failing: Fortune 500 CEO Advisor Explains | CXOTalk #900

    🚨 STOP treating AI like just another automation tool; you're missing the real transformation.   Most executives are approaching AI completely wrong. They're focused on automating tasks when they should be reimagining their entire business model. In this landmark 900th episode of CXOTalk, Sangeet Paul Choudary, advisor to 40+ Fortune 500 CEOs, reveals why AI is actually COORDINATION INFRASTRUCTURE, not just a productivity tool.   You'll discover: ✅ Why the "automation mindset" guarantees you'll fall behind competitors ✅ The shipping container parable that explains AI's true strategic impact ✅ How to think about AI strategy (hint: it's NOT about "what to do with AI") ✅ The dangerous myth of "AI augmentation" and what actually happens to jobs ✅ Real examples: How TikTok's logic revolutionized manufacturing (Shein) ✅ Above vs. below the algorithm: Where YOU fit in the new economy ✅ The word processor paradox—why complementarity doesn't save jobs ✅ Strategic foresight: The #1 capability leaders must develop NOW   This isn't theoretical. Sangeet breaks down exactly how businesses must reimagine their competitive advantage, how professionals should navigate career decisions, and why yesterday's AI vendors are selling you 1990s solutions.   ⏱️ TIMESTAMPS   00:00 🤖 Rethinking AI Beyond Automation 01:10 📈 AI's Strategic Role in Business Transformation 03:33 🚢 Lessons from the Shipping Container and AI's Potential 08:22 🔮 The Importance of Foresight in Career and Organizational Planning 11:16 🤖 Automation, Augmentation, and the Changing Division of Labor 14:08 📈 Adapting to Shifting Value in the Age of AI 19:04 🤖 The Role of CXOs in the Age of AI 22:50 🏢 Indicators of Organizational Shift with AI 26:00 💡 Lessons Between Startups and Legacy Companies in AI Strategy 31:11 📱 TikTok's Influence on Manufacturing and Shein's Success 33:58 🤖 Challenges in Implementing AI and System Redesign 36:05 🌐 Socio-Technical Systems and Strategic Shifts with AI 38:50 🧪 AI's Impact on the Materials Industry 41:03 🤖 Strategic Application of AI in Industries 42:52 🌐 AI's Role in Ecosystems and Job Dynamics 49:23 ⚙️ The Role of Risk and Constraints in Value Creation 50:51 🤖 AI's Impact on Knowledge Work and Career Advice 55:41 📊 Advice for Companies and Policymakers in the Age of AI   🎯 FEATURED GUEST Sangeet Paul Choudary Advisor to 40+ Fortune 500 CEOsAuthor of "Reshuffle: The New Business Playbook for a World Transformed by AI"Expert on platform business models and digital transformation  📚 RESOURCES 🔷 Show notes: https://www.cxotalk.com/episode/why-ai-works-but-your-strategy-doesnt 🔷 Newsletter: www.cxotalk.com/subscribe 🔷 LinkedIn: www.linkedin.com/company/cxotalk 🔷 Twitter: twitter.com/cxotalk Subscribe to CXOTalk newsletter: https://www.cxotalk.com/newsletter   🎙️ ABOUT CXOTALK CXOTalk features unfiltered conversations with C-suite executives from major companies about AI, digital transformation, and business strategy. Hosted by Michael Krigsman. Episode 900 | Recorded November 14, 2025   #AI #AIStrategy #DigitalTransformation #BusinessStrategy #CEOInsights #FutureOfWork #Leadership #AITransformation #Reshuffle #CXOTalk

    59min
  4. Big Tech's AI Oligopoly: Lords Reveal the Power Grab | CXOTalk 899

    4 DE NOV.

    Big Tech's AI Oligopoly: Lords Reveal the Power Grab | CXOTalk 899

    Microsoft invested $13 billion in OpenAI. Amazon poured billions into Anthropic. The AI oligopoly is here. Lord Tim Clement-Jones and Lord Chris Holmes, architects of UK AI policy, reveal what business leaders must know about Big Tech's grip on AI - from vendor lock-in risks to circular funding patterns signaling bubble collapse.   🔷 Show notes and resources: https://www.cxotalk.com/episode/house-of-lords-members-on-ai-does-big-tech-own-you 🔷 Newsletter: www.cxotalk.com/subscribe 🔷 LinkedIn: www.linkedin.com/company/cxotalk 🔷 Twitter: twitter.com/cxotalk   🎯 KEY TAKEAWAYS:   -- Why AI concentration mirrors 19th century monopolies -- The regulation vs innovation false choice -- Vendor dependencies creating strategic vulnerabilities -- UK vs EU vs US regulatory approaches -- Copyright battles over training data -- Board-level AI governance essentials   ⏱️ TIMESTAMPS:   00:00 🤖 The AI Oligopoly and Big Tech's Influence 02:27 🌐 Opportunities and Risks of AI Development 09:03 ⚖️ Regulation and the Future of AI 12:43 💻 The Risks of Overdependence on Big Tech 15:33 🧠 The Importance of Media and Digital Literacy 17:55 🌍 Human Values in Technology and Education 21:25 📚 Education and Regulation in the Digital Age 24:36 🌈 Optimism and Diversity in Technology 27:13 ⚠️ Dependency and Vulnerability in Technology 29:58 🤖 Navigating AI's Impact on Employment and Society 34:46 🏛️ The Role of Government and Lifelong Learning in the AI Era 39:16 ⚖️ Challenges of AI Transparency and Regulation 43:07 ⚖️ The Importance of AI Regulation and Transparency 45:00 🌐 Open Source and Diverse AI Models 52:18 ⚙️ Balancing Regulation and Innovation in AI 55:04 💰 Economic Interdependence in AI Development 55:48 📈 Advice for Business Leaders in the AI Era 56:54 ⚖️ Guidance for Regulators and Policymakers on AI   💡 ABOUT CXOTALK:   CXOTalk connects you with the world's most innovative business leaders, senior executives, and experts sharing insights on digital transformation, leadership, and innovation. Every episode brings you actionable strategies from those leading change in their organizations.   #ArtificialIntelligence #AITransformation #monopoly #bigtech #cxotalk #houseoflords #inclusion #aiethics

    59min
  5. CIO Advice on AI: How Chief Information Officers Can Lead in 2025 | CXOTalk #898

    21 DE OUT.

    CIO Advice on AI: How Chief Information Officers Can Lead in 2025 | CXOTalk #898

    Is your organization stuck in AI pilot purgatory? CIO strategic advisor Tim Crawford reveals how enterprise AI is fundamentally transforming the CIO role, and why the decisions you make today will determine which IT leaders succeed tomorrow.   ======= Please support our sponsor Emeritus: Explore executive education programs from Emeritus, in collaboration with top universities: https://cxotalk.partner.emeritus.org/ =======   In CXOTalk episode 898, Tim breaks down the massive multi-dimensional impact AI is having on CIOs: from daily operations and decision-making to board-level relationships and business transformation. You'll discover why efficiency gains are just the beginning, and how strategic CIOs are leveraging AI to drive real business outcomes—not just run technology projects.   🔗 RESOURCES:   🔷 Show notes and resources: https://www.cxotalk.com/episode/the-cios-new-mandate-enterprise-ai 🔷 Newsletter: www.cxotalk.com/subscribe 🔷 LinkedIn: www.linkedin.com/company/cxotalk 🔷 Twitter: twitter.com/cxotalk   🎯 KEY TAKEAWAYS:   - How AI is changing the CIO's day-to-day responsibilities and strategic influence - Why 75% of AI projects fail to prove ROI (and how to avoid this trap) - The critical difference between efficiency plays and transformational innovation - Why change management is now the CIO's #1 responsibility for AI success - The truth about Chief AI Officer roles vs. strategic CIO positioning - How to escape AI pilot purgatory and achieve measurable business outcomes   ⏱️ TIMESTAMPS:   00:00 🤖 The Role of AI in Transforming the CIO's Responsibilities 05:40 🚀 Overcoming AI Pilot Purgatory and Achieving Business Outcomes 11:20 🌐 Navigating the AI Hype and Embracing Innovation 12:21 🤖 Adapting Business Operations for AI Integration 13:20 📊 Measuring AI Value and Business Outcomes 22:35 🔒 Security and Governance in AI Implementation 24:07 🤖 Challenges in AI Governance and Data Management 26:03 💼 AI's Impact on Business Processes and Workforce 28:58 🌍 Sustainability, Partnerships, and AI Proof of Concept Challenges 35:16 ⚖️ Balancing Business Objectives and AI Project Success 38:39 🤝 The Importance of Relationships and Process Understanding 43:56 🤖 AI Ownership, Decision-Making, and Vendor Relationships 46:26 🤝 Strategic Use of External Partners in Organizations 49:33 🤖 The Role of AI in the C-Suite 51:16 📅 Closing Remarks and Upcoming Events   💡 ABOUT CXOTALK:   CXOTalk connects you with the world's most innovative business leaders, senior executives, and experts sharing insights on digital transformation, leadership, and innovation. Every episode brings you actionable strategies from those leading change in their organizations.   #CIO #ArtificialIntelligence #AITransformation #DigitalTransformation #ITLeadership #BusinessStrategy #EnterpriseAI #TechnologyLeadership #CXOTalk #ExecutiveLeadership #AIStrategy #ChangeManagement #Innovation #BusinessOutcomes   👍 If you found this valuable, please LIKE and SHARE with your network.

    53min
  6. What is Google's Agentic AI Strategy? (Explained by Google Cloud's CTO) | CXOTalk #897

    17 DE OUT.

    What is Google's Agentic AI Strategy? (Explained by Google Cloud's CTO) | CXOTalk #897

    Please support our sponsor Emeritus: Explore executive education programs from Emeritus, in collaboration with top universities: https://cxotalk.partner.emeritus.org/ ======= Will Grannis, Chief Technology Officer of Google Cloud, explains Google's vision for agentic AI and multimodel LLMs, including these key topics on CXOTalk #897: -- The latest AI news from Google -- Why "AI as judge" determines whether your agent deployment scales or stalls -- How regulated industries have an unexpected advantage in agent adoption -- The hidden organizational rules that break agent workflows -- Why generic AI models alone provide zero competitive differentiation -- How multimodal AI changes customer support from chat to visual problem-solving -- The evaluation architecture behind successful agent deployments -- Why CEOs must participate directly in AI experimentation 🔷 Show notes and resources: https://www.cxotalk.com/episode/google-clouds-cto-inside-the-ai-strategy 🔷 Newsletter: www.cxotalk.com/subscribe 🔷 LinkedIn: www.linkedin.com/company/cxotalk 🔷 Twitter: twitter.com/cxotalk #agenticai #cxotalk #googlecloud Chapters: 00:00 🤖 Google's AI Strategy and Agent Development 04:07 🌐 Gemini Enterprise: Google's Unified AI Platform 08:21 📈 Best Practices for Agent Deployment and Future Trends 11:25 📡 Modernizing Customer Support with Multimodal Experiences 13:24 🤖 AI as a Judge: Evaluating and Automating Decision Processes 16:55 🔧 Continuous Improvement Through Small Adjustments 17:15 🤖 The Evolution and Challenges of AI Agents 18:57 🛠️ Task-Specific vs. Role-Based AI Agents 25:00 🏢 Organizational Challenges in AI Agent Implementation 28:58 🤖 Customizing AI for Industry-Specific Applications 31:20 🌐 Practical AI Integration for Businesses and Public Services 38:24 🚀 Challenges and Success Factors in AI Deployment 41:27 🤝 The Role of Leaders in AI Adoption 43:25 🌌 Multimodal AI and NanoBanana 45:17 🔮 Practical AI Development and Future Trends

    50min
  7. Top Data Scientists Explain Bad Data, Poisoned Datasets, and Other AI Killers | CXOTalk #896

    9 DE OUT.

    Top Data Scientists Explain Bad Data, Poisoned Datasets, and Other AI Killers | CXOTalk #896

    Is your AI built on quicksand? Learn how bad data, poisoned datasets, and deep fakes threaten your AI systems, and what to do about it. In this episode of CXOTalk (#896), AI luminaries Dr. David Bray and Dr. Anthony Scriffignano reveal the hidden dangers lurking in your AI foundations. They share practical strategies for building trustworthy AI systems and escaping the "AI quicksand" that traps countless organizations. 🎯 KEY TAKEAWAYS: The Five Ms framework for identifying AI failures before they scaleWhy red teams are essential for AI risk managementHow nation-states are actively poisoning AI training dataCritical questions every leader must ask about their AI initiativesThe future of specialized AI models vs. mega LLMs 🔷 Show notes and resources: https://www.cxotalk.com/episode/escape-ai-quicksand-data-misuse-misadventures-and-mal-intent 🔷 Newsletter: www.cxotalk.com/subscribe 🔷 LinkedIn: www.linkedin.com/company/cxotalk 🔷 Twitter: twitter.com/cxotalk 00:00 🤖 Understanding AI Quicksand and the Challenges of Data 02:16 ⚠️ The Five Ms of AI Risks and Practical Examples 07:12 💡 The Disconnect in AI Adoption and the Importance of Purpose 09:46 🤖 The Challenges and Risks of Generative AI 14:28 ⚖️ Ethical and Intellectual Property Concerns in AI 16:30 🛡️ Responsibility and Oversight in Ethical AI 20:22 ⚖️ Liability and Critical Thinking in AI Services 22:12 📜 AI Regulation and Consumer Advocacy 25:55 🤖 Future Directions in AI Development 30:59 🤖 Exploring AI's Potential and Limitations 33:03 🧪 Data Poisoning and Its Implications 40:07 ⚠️ Addressing AI Risks and Perception of Reality 41:38 📊 The Evolution of Data Analysis and Critical Thinking 44:36 🧠 Teaching Critical Thinking and AI Critique 46:36 🤖 Embodied AI, Data Misuse, and Global AI Perspectives 50:57 🤖 The Evolution of Work and AI's Role 52:59 🌟 AI's Positive Impact on Healthcare and Society 56:23 🌈 Hope and Resilience in the Age of AI #AI #ArtificialIntelligence #DataScience #AIEthics #MachineLearning #DataPoisoning #GenerativeAI #EnterpriseAI #AIStrategy #DigitalTransformation #CyberSecurity #AIRegulation #FutureOfWork #TechLeadership #CXOTalk

    1h
  8. Former Accenture Tech CEO Reveals Top AI Mistakes to Avoid | CXOTalk #895

    26 DE SET.

    Former Accenture Tech CEO Reveals Top AI Mistakes to Avoid | CXOTalk #895

    AI luminary and former Group CEO of Technology at Accenture, author Paul Daugherty, offers a hard-hitting take on enterprise AI and consumer-grade artificial intelligence on CXOTalk episode 895. He examines what's working, where companies stall with their AI transformation, and what new technology trends leaders should monitor. Peer into the future of AI and see the importance of responsible AI development. 🔷 Show notes and resources: https://www.cxotalk.com/episode/ai-reality-check-what-works-and-whats-new 🔷 Newsletter: www.cxotalk.com/subscribe 🔷 LinkedIn: www.linkedin.com/company/cxotalk 🔷 Twitter: twitter.com/cxotalk #AITransformation #ArtificialIntelligence #BusinessStrategy #ResponsibleAI #Innovation #EnterpriseAI #Leadership #DigitalTransformation #AIStrategy #ExecutiveLeadership #cxotalk 00:00 🌟 Paul Daugherty's Career and Current Roles 01:52 🤖 AI Reality Check: Hype vs. Reality 05:51 📈 Generative AI's Impact on Work and Organizations 07:11 🌱 Challenges and Early Adoption of AI in Organizations 08:46 🔄 Invasiveness and Organizational Transformation with AI 13:40 📊 AI Applications and Measuring Business Value 18:14 🎯 Focusing on Impactful Use Cases in AI 19:48 🤖 AI Deployment Challenges and Talent Transformation 24:23 🚀 Prerequisites and Challenges in AI Adoption 25:56 🤔 Defining Failure in AI Projects 29:43 💼 AI's Role in Private Equity and Investment Analysis 33:55 🚀 Future Trends Beyond AI and AGI 35:07 🤖 AI's Impact on Data Management and EMR Systems 36:56 📊 AI's Influence on Jobs and Responsible AI Practices 40:15 🌟 Future Technologies and Personal Reflections

    43min
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Sobre

C-Suite Conversations on AI & Strategy. Join industry analyst Michael Krigsman for unfiltered discussions with the leaders shaping the future of business. From AI implementation to digital transformation, hear directly from CIOs, CTOs, CEOs, and more from the world's largest companies. No scripts. No PR fluff. Just real questions from our live audience and honest answers from the C-Suite. Want to participate? Get invited to the next live show: https://www.cxotalk.com/subscribe

Informações

  • Criado por
    Michael Krigsman
  • Anos de atividade
    2015 - 2025
  • Episódios
    530
  • Classificação
    Livre
  • Copyright
    © Michael Krigsman
  • Site do podcast
    CXOTalk

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