Neurotech Pub

Paradromics Inc
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Paradromics Founder and CEO Matt Angle hosts an informal salon with some of the most influential figures in neurotechnology.

  1. 27.08.2024

    Engineering Mental Health

    This episode features Paradromics CEO Matt Angle in a compelling discussion with Amit Etkin, Founder and CEO of Alto Neuroscience; Maryam Shanechi, Dean's Professor in Electrical and Computer Engineering, Neuroscience, Computer Science, and Biomedical Engineering at USC; and Prasad Shirvalkar, Associate Professor of Neurological Surgery, Neurology and Anesthesia at UC San Francisco. They delve into the intersection of neurotechnology and psychiatry, discussing innovative approaches to treating mental health disorders, the potential of machine learning models, and the challenges associated with obtaining and analyzing brain data. The discussion emphasizes the importance of interdisciplinary collaboration and the promising future of personalized therapies for psychiatric conditions. They also address the limitations of current diagnostic tools like the DSM and the need for scalable, real-world solutions.  Guest Quote: “There's artificial intelligence and there's actual intelligence. And that actual intelligence, when it comes to analyzing data, I feel goes a really, really long way. True subject matter expertise.” - Amit Etkin Timestamps: *(00:00) Welcome to Neurotech Pub *(00:45) Icebreaker: Unpopular Beliefs *(05:36) Non-surgical brain activity recording and diagnostics *(13:32) Understanding pain: Subjective reports vs. physical representations *(16:33) Rethinking psychiatry and DSM alignment *(21:07) Determining brain data needs and tool validation *(26:47) The need for explainability in AI algorithms *(35:49) Timescales in mental health interventions *(41:22) Advice for aspiring neurotech researchers *(46:25) Closing Thoughts  Want More? Learn about Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn, and Instagram Follow Matt on LinkedIn and Twitter

    51 мин.

  2. 30.07.2024

    Where There's Blood, There's Signal

    This episode features Paradromics CEO Matt Angle in a compelling discussion with Sumner Norman, Co-founder & CEO at Forest Neurotech; Ryan Field,CEO at Kernel; and Mary Lou Jepsen, Founder and CEO of Openwater. They share their career influences, discuss the challenges of managing interdisciplinary teams, and explore the future of neuroimaging and brain-computer interfaces (BCIs). Delving into ultrasound and optical-based techniques, they highlight the transformative potential of non-invasive methods for diagnosing and treating brain conditions. Furthermore, they addresses regulatory hurdles, the evolution of focused research organizations, and offers valuable advice for early-career researchers on leveraging industry trends and fundamental research to drive technological advancements.   Guest Quote: “And I think what we're trying to work on is the silicon hospital of the future with this capability, like the modern smartphone, that can reach everybody, regardless of income levels or borders.” - Mary Lou Jepsen   Timestamps: *(00:00) Welcome to Neurotech Pub *(00:06) Meet the Guests *(02:48) Balancing Mentorship and Startup Demands *(05:36) Interdisciplinary Challenges in Neurotech *(07:11) Hardware Development and Efficiency *(18:12) Medical Device Development and Regulatory Challenges *(23:37) Technical Deep Dive: Optical and Acoustic Signatures *(24:00) Ultrasound in Brain-Computer Interfaces *(34:57) Near-Infrared Spectroscopy and Mental Health *(55:55) Understanding Stroke and Thrombectomy *(56:51) Innovations in Cancer Treatment and Blood Flow Analysis *(57:39) Challenges and Trials in Medical Technology *(58:42) Open Source Medical Technology and Global Collaboration *(58:59) The Evolution of Brain-Computer Interfaces *(01:02:42) Advancements in Ultrasound Technology *(01:03:39) The Role of MEMS and Silicon in Medical Devices *(01:09:29) The Importance of Fundamental Research *(01:14:48) The Future of Neurotechnology and Industry Trends *(01:17:58) Advice for Aspiring Researchers and Entrepreneurs *(01:29:41) Leadership and Transition in Tech Companies *(01:40:07) Focused Research Organizations and Their Impact *(01:46:08) Final Thoughts and Optimism for Neurotech   Want More? Learn about Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn, and Instagram Follow Matt on LinkedIn and Twitter

    1 ч. 49 мин.

  3. 02.07.2024

    Now That’s a Lot of Power

    This episode features Paradromics CEO Matt Angle in a compelling discussion with Grayson Zulauf, CEO of Resonant Link; Alex Yeh, CTO and VP of R&D at Neuspera Medical; and Jacob Robinson, Founder and CEO of Motif Neurotech. They explore the latest advancements in neurotechnology, focusing on wireless power transfer, implantable devices, and brain-computer interfaces (BCIs). The conversation highlights transformative innovations in treating mental health conditions like major depressive disorder, OCD, and ADHD with less invasive wireless devices, enhancing patient care and acceptance. Personal stories and insights on market expansion and patient-friendly treatments are shared, along with valuable advice for investors on the potential of neurotechnology in improving overall mental health and medical care. Guest Quote: “The message that I would want to send is, there is a future in which we look at neurotechnologies no differently than we look at cardiac pacemakers. These are life saving devices, in many cases less invasive than a device that goes in your heart. There's no reason why  anybody wouldn't want to feel better. To be healthier mentally and just live a better quality of life. So that's what we're trying to enable” - Jacob Robinson Show Notes: *(00:00) Welcome to Neurotech Pub *(00:46) Meet the Guests *(02:45) Discussing Industry Competitors *(09:54) Wireless Power Transfer in Medical Devices *(16:38) Exploring Inductive and Magnetoelectric Power *(27:35) Ultrasound in real-world devices *(33:31) Patient Experience and Device Miniaturization *(36:24) Designing for Patient Comfort and Practicality *(38:20) Innovations in Power and Data Transmission *(39:32) Miniaturization and Its Impact *(41:12) Battery Technology in Medical Devices *(43:19) Future of Implantable Batteries *(45:16) Implanted Battery Companies Integer and Resonetics *(46:31) Intermittent Stimulation and Therapy *(49:28) Power Consumption in Future Implants *(59:52) Data Transmission and Compression *(01:05:42) Reflections on the Journey of Medical Innovation *(01:08:36) Final Thoughts and Messages to Investors Want More? Follow Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn, and Instagram Follow Matt on LinkedIn and Twitter

    1 ч. 14 мин.

  4. 22.03.2023

    Your Future Self Will Thank You | Connectomics Part II

    We’re back with Part II of our two-part series on Connectomics!  In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome.  Our guests are:  Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) Robert McIntyre, CEO at Nectome Jeremy Maitin-Shepard, PhD, Software Engineer–Connectomics at Google In this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy’s recent paper on BioRxiv, as well as his published work at Google.  If you missed part one, you can listen and explore the show notes here. Cheers! Show Notes:  0:00 | Intro 1:03 | Kenneth Hayworth, PhD 1:12 | Robert McKintyre, CEO, Nectome 1:17 | Jeremy Maitin-Shepard, PhD 1:51 | Setting the record straight  3:09 | The nucleotide sequence of bacteriophage φX174 4:22 | Frozen Zoo at San Diego Zoo 12:01| Glutaraldehyde and reduction techniques for immunolabeling  17:39 | SWITCH Framework 19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude  Enhanced mirror neuron network activity and effective connectivity during live interaction among female subjects  Permeabilization-free en bloc immunohistochemistry for correlative microscopy  19:57 | Synaptic Signaling in Learning and Memory  Structure and function of a neocortical synapse  Engineering a memory with LTD and LTP  Synapse-specific representation of the identity of overlapping memory engrams  20:28 | Ultrastructure of Dendritic Spines Structure–stability–function relationships of dendritic spines  24:25 | Reconstructing the connectome  24:32 | Connectomics Research Team at Google  24:55 | Google x HHMI: Releasing the Drosophila Hemibrain Connectome  28:38 | Serial Block-Face Scanning Electron Microscopy  29:22 | Automated Serial Sections to Tape 29:45 | Mapping connections in mouse neocortex 30:59 | A connectome and analysis of the adult Drosophila central brain  32:14 | Expansion Microscopy 34:37 | The future of connectomics  45:13 | Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons 49:49 | Mice and rats achieve similar levels of performance in an adaptive decision-making task  Want More? Follow Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn, and Instagram Follow Matt on LinkedIn and Twitter

    1 ч. 1 мин.

  5. 14.03.2023

    We're in Heated Agreement Over Here | Connectomics Part I

    Welcome back to Neurotech Pub!  In this first installment of two episodes on Connectomics, host and Paradromics CEO Matt Angle kicks off a lively discussion on the rapidly accelerating research in the mapping, preservation, and reconstruction of the human connectome. We explore the ethical and legal ramifications of disruptive technology, and some of the unique challenges faced when driving innovation in emerging industries.  Our guests are:  Nita Faraheny, JD, PhD, Everett Distinguished Professor of Law & Philosophy at Duke Law School, the Founding Director of Duke Science & Society, the Faculty Chair of the Duke MA in Bioethics & Science Policy, and principal investigator of SLAP Lab.  Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) Robert McIntyre, CEO at Nectome As an exciting new development since the recording of this episode, Nita recently published a book, The Battle for Your Brain, which examines many topics in neuroethics, from Connectomics to Brain-Computer Interfaces. It is currently available on Amazon. Keep an eye out for part two in this series, which will take a deep dive into the latest technical and engineering innovations in the connectomics ecosystem. Coming soon! Please be advised that this episode contains a brief discussion of assisted suicide in a medical setting. Show Notes:  0:00 | Episode Intro  1:16 | Nita A. Farahany, JD, PhD 1:21 | Kenneth Hayworth, PhD 1:27 | Robert McKintyre, CEO, Nectome 1:56 | Meeting of the minds  2:53 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize 3:56 | The Brain Preservation Foundation 4:09 | Documentary series on the Brain Preservation Foundation 5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps’ caveats) 5:51 | Nita's 2018 Neuroethics Ted Talk  5:54 | International Neuroethics Society 6:25 | Connectomics & new paths in neuroscience  8:10 | Allen Institute for Brain Science 8:47 | A connectome and analysis of the adult Drosophila central brain 9:33 | A visual intro to synaptic imaging in connectomics 10:28 | The structure of the nervous system of the nematode Caenorhabditis elegans  11:16 | Mouse Connectome Project at CIC 14:59 | Cryonics controversy  19:00 | Death, taxes, and synapses  20:51 | Uniform Law Commission 21:08 | The Uniform Determination of Death Act 24:25 | Watch Altered Carbon on Netflix 25:49 | Understanding the “Loss of Chance” Doctrine  37:13 | Understanding Physician-Assisted Death, or ‘Death with Dignity’  40:21 | Euthanasia in the Netherlands 46:01 | Autonomy, Dignity, and Consent to Harm, Rutgers Law Review  Want More? Follow Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn, and Instagram Follow Matt on LinkedIn and Twitter

    49 мин.

  6. 25.08.2022

    Neuro Mapping & Napping

    Welcome back to Neurotech Pub! In this episode we’re talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity.  Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine. This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you’re unfamiliar with the stages of sleep and want to follow along later in the episode. Cheers! Show Notes:  00:00 | Episode intro with Matt Angle and Amy Kruse 1:07 | StimScience in Fast Company 5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep 6:43 | Connect with Prime Movers Lab 7:01 | PML on Medium 7:45 | Introduction to Sleep Stages References:  Stages of Sleep Overview  REM vs Non-REM Sleep Sleep Walking Benefits of REM Sleep Consequences of low REM sleep Importance of Deep Sleep Check out Zoe’s nonprofit organization, ALS Heroes, and her Ted Talk 12:24 | Pulling all-nighters 12:50 | Amy Kruse, PhD 13:00 | Ram Gurumoorthy, PhD 13:07 | Stimscience, now Somnee 13:30 | Luis de Lecea, PhD 18:26 | Gordon Rule, PhD 18:40 | Knights of the Old Republic II: The Sith Lords (2004) 19:50 | Why do we sleep? 20:26 | Sleep drives metabolite clearance from the adult brain 20:35 | Sleep & DNA Repair 22:13 | Neural Activity can cause DNA damage 23:22 | Jerry Seigal 24:26 | DARPA Sleep Research 24:55 | Fur seals and sleep 25:08 | How do Whales and Dolphins Sleep Without Drowning? 25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars 27:36 | Sleep and Mortality 28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices 28:27 | Giulio Tononi, MD, PhD 28:45 | Sleep, Memory, and Plasticity 28:52 | Sleep Cognition and Memory 29:00 | Sleeping up and down the phylogenetic tree 29:05 | Actually...worms do sleep 29:20 | Decoding sleep 29:36 | Fruit flies and their mini sleeps 29:44 | Mapping sleep in the brain 30:35 | Hypocretin-positive neurons 31:17 | Clearly Matt slept through his midterm... again 31:57 | The hypocretins/orexins: integrators of multiple physiological functions 32:05 | Stress-sleep interactions 33:30 | The Science of Narcolepsy 35:08 | Equivalence of sleep deprivation and intoxication | Additional reference 36:21 | Sleep Pressure: Homeostatic Sleep Drive  40:38 | EEG Visualization of electrodermal activity during sleep 44:08 | Circuitry of Sleep Stages 45:00 | Regional slow waves and spindles in human sleep | Local sleep in awake rats 48:00 | Emerging Sleep Technologies 1:00:56 | Hypothalamus and Sleep Want More? Follow Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn, and Instagram Follow Matt on LinkedIn and Twitter

    1 ч. 6 мин.

  7. 12.07.2022

    BCI Pioneers Part II

    The Panel:  Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn.  Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram.  Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin.  00:00 | Intro 0:14 | Neurotech Pub Episode 13: BCI Pioneers Part I 0:47 | Neurotech Pub Episode 10: Business Models in Neurotech 1:30 | BCI & Identity 1:30 | New Yorker - Do Brain Implants Change Your Identity? 2:09 | The Utah Array (Blackrock Neurotech) 16:05 | Learn more about Hector in Part 1 17:14 | Talking Form Factors 18:36 | CerePlex System 22:36 | Support Systems in BCI Adoption 38:35 | Get in Touch 38:54 | The Ian Burkhart Foundation 39:13 | Book Ian as a speaker 39:25 | North American Spinal Cord Injury Consortium (NASCIC) 40:04 | Where to find Ian 40:19 | Contact Nathan 40:25 | Nathan on Instagram, LinkedIn, and Twitter 40:32 | Nathan's NFTs on OpenSea Links to Jan’s lab photos and how to get in touch can be found here Want More? Follow Paradromics on Twitter, LinkedIn, and Instagram Follow Blackrock Neurotech on Twitter, LinkedIn, and Instagram Follow Taryn on LinkedIn, Instagram, and Twitter Follow Matt on LinkedIn and Twitter

    44 мин.

  8. 16.06.2022

    BCI Pioneers Part I

    In this very special two part series in collaboration with Blackrock Neurotech, Paradromics CEO Matt Angle and Blackrock Creative Director Taryn Southern co-host a discussion with BCI research pioneers Jan Scheuermann, Ian Burkhart, and Nathan Copeland. In part one, we discuss their personal journeys to becoming BCI pioneers, implant experiences with the Utah Array,  their time in the lab, and some of their current projects. Learn more about Jan, Ian, and Nathan below and stay tuned for part two, coming in July 2022!  The Panel:  Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn.  Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram.  Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin.  00:00 | Intro 6:10 | Who came first? 7:07 | Jan Scheuermann 7:18 | Tim Hemmes & the UPitt/UPMC Team 8:05 | New Yorker profile of Jan and the UPitt team 8:55 | View Jan’s photos from the lab 10:10 | Nathan Copeland 13:00 | Parietal Cortex 13:22 | Saccade Movements 14:12 | The Pioneer Experience 16:04 | Neuro Life Study | Additional Reference | Interview with Ian | Archives of PMR 18:15 | Mirror Therapy 23:50 | Jan in the Pilot Seat 25:07 | Ian's Experience in the Car Simulator 25:53| Thinking About Thinking 31:24 | Jan's novel, Sharp as a Cucumber 37:37 | View Jan’s photos from the lab 38:04 | Andy Schwartz 38:45 | Nathan's NFTs 43:22 | Nathan's Instagram 45:03 | 15 Minutes of Fame 45:12 | A Presidential Greeting 45:45 | Jan on 60 Minutes 45:54 | Jan in SciAM 46:00 | Book Jan as a keynote speaker 46:32 | SfN 47:05 | Investment in BCI 47:17 | The Ian Burkhart Foundation Want More? Follow Paradromics on Twitter, LinkedIn, and Instagram Follow Blackrock Neurotech on Twitter, LinkedIn, and Instagram Follow Taryn on LinkedIn, Instagram, and Twitter Follow Matt on LinkedIn and Twitter

    49 мин.
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Paradromics Founder and CEO Matt Angle hosts an informal salon with some of the most influential figures in neurotechnology.

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  • Автор
    Paradromics Inc
  • Годы выхода
    2021 - 2024
  • Выпуски
    20
  • Ограничения
    Без ненормативной лексики
  • Авторские права
    © Copyright 2020 Paradromics Inc
  • Сайт подкаста
    Neurotech Pub