Uncharted

Uncharted
  • 5.0 (12)
  • BUSINESS
  • UPDATED WEEKLY

Grow your business with advice from the best. Uncharted is a private collective of top-tier founders, funders, and creators — and on this podcast, our members share the unseen tactics and strategies that drive their success. It’s like you’re sitting next to them at an Uncharted event.

  1. 1H AGO

    Do more than Longevity. Generational Health Is the Real Science. with Sanskriti (Sans) Thakur

    Sans Thakur, CEO and Chairman of Tower Capital Group, joins Jason Feifer to explain why the longevity industry is missing the point. The real frontier is generational health: the science of how your DNA, environment, and choices create cascades that shape your descendants' health for up to 16 generations. Sans is one of the named pioneers of generational health. She spent decades helping launch 40+ medicines that reached 6 million patients before becoming an investor. In this conversation, she breaks down what's actually possible right now: dementia prevention infusions that cut risk by 50%, bio-AI that can grow a beating heart from a drop of your blood, and why the food you eat is interacting with your cells in ways science is only beginning to understand. If you've been skeptical of the longevity hype but curious about what real science can do, this episode is for you. Disclaimer: The science descriptions are ultra simplified for general audience consumption. Timestamps: 00:00 Cold open 01:25 Why longevity has become "fluffy" and what it used to mean 02:30 What Tower Capital Group actually does 09:12 Defining generational health and the 16-generation cascade 13:53 From Human Genome Project to today's bio-AI breakthroughs 18:00 The dementia prevention infusion that cuts risk by 50% 21:30 Genetic cascades explained: how your choices imprint on your DNA 24:35 Growing a beating heart from a drop of blood 28:30 Bioethics and why this technology isn't available to everyone yet 29:32 Your mother's mitochondria and why maternal health is underfunded 32:00 Why longevity influencers get it wrong 36:38 Food as medicine and the data gap between groceries and clinics 40:12 How much do we actually know about food and the body? 46:13 How to get involved with Tower Capital Group and Uncharted Pitches 52:48 The "spackle" and why small wins matter too

    43 min

  2. MAY 12

    How AI Startups Actually Land Enterprise Clients

    In the early days of AI products, buyers were willing to experiment and take risks. Now they expect clear ROI. That’s changing the way that AI products are taken to market. Rachel ten Brink, GP and co-founder of Red Bike Capital, breaks down what’s actually working now: founder-led sales, distribution moats, customer adoption, enterprise champions, strategic partnerships, and why the companies that win won’t necessarily have the best models — they’ll have the best go-to-market strategy.

    47 min

  3. APR 28

    How to Win in a Crowded Market

    You don’t win on product alone. You win by recognizing the white space that’s hidden in plain sight In this episode, Jason talks with beverage entrepreneur Michelle Ivey — who built Illegal Mezcal and sold it to Bacardi, helped Megan Thee Stallion launch her tequila, and is now building multiple beverage brands — about what it actually takes to stand out when every shelf is full.

    45 min

  4. APR 14

    How to Lead When Everything Is Changing

    During big technological shifts, leaders face a difficult question: How do you project calm and vision, while everything around you changes? Raynmaker CEO Joe Gagnon has led six companies, and has an answer: You must move as fast as the change itself. He explains how to create confidence in uncertain times, where AI actually helps (not hurts), and why the fundamentals of business matter more than ever.

    39 min

  5. MAR 31

    How the Best Founders Solve Problems Faster

    How do founders stay calm, think clearly, and find answers faster when everything goes wrong?In this episode, host Jason Feifer talks with Gambit Robotics cofounder and former U.S. chess player Nicole Maffeo about the real mechanics of problem solving. They break down how great operators handle ambiguity, why patience is now a competitive advantage, how to “chunk” complex problems into solvable parts, and why losing well may be one of the most valuable entrepreneurial skills.

    38 min

  6. MAR 17

    The Skill That Helps Founders Win in Any Industry

    If you’re thinking about a pivot, a new venture, or a move into unfamiliar territory, this conversation will give you a smarter way to think about starting from scratch. In this episode, Jason Feifer talks with Michael Louis, cofounder and CEO of the AI company Cerebrium, about what it takes to win in spaces you’ve never worked in before. Michael has built companies across blockchain, e-commerce, and AI, and he explains how he approaches every new market: by invalidating ideas fast, solving the next problem instead of obsessing over the long-term plan, building highly autonomous teams, and using relationships to accelerate learning and growth.

    38 min
  7. Achieve More Without Burning Out, with Global Expert Dr. Taryn Marie Stejskal

    MAR 4

    Achieve More Without Burning Out, with Global Expert Dr. Taryn Marie Stejskal

    Burnout is the greatest danger to any ambitious founder. But with the right strategies, you can drive hard, grow fast, and preserve your sanity. Dr. Taryn Marie Stejskal explains how. She’s the founder of the Resilience Leadership Institute, was previously head of executive leadership development & talent strategy at Nike, and a recognized expert on resilience and burnout.

    53 min
  8. Tim Draper, VC Legend

    04/10/2025

    Tim Draper, VC Legend

    Tim Draper graciously joined us while traveling, so we appreciate your patience with any audio variances during the conversation. In this episode of Uncharted, legendary venture capitalist Tim Draper joins for a wide-ranging conversation that’s part masterclass, part manifesto. From backing 20+ unicorns and buying Bitcoin when no one else would, to founding Draper University and creating a global pitch show, Draper unpacks his philosophy, his aversion to bureaucracy, and why trust and freedom are the bedrock of innovation. He shares war stories from early DFJ days, reflects on the rise and fall of China’s entrepreneurial boom, and dishes out advice on where the smart money should go next. Fly-Flat.com/Uncharted for $250 off your eligible long-haul, international, business and first class flight FlyFlat reclaims up to 90% of their customers’ time on booking international premium travel via their 24/7 white-glove concierge service. They average 35% off long-haul, international, business and first-class flights, and offer savings as high as 80% off for one-ways and last-minute flights.

    55 min
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5
out of 5
12 Ratings

About

Grow your business with advice from the best. Uncharted is a private collective of top-tier founders, funders, and creators — and on this podcast, our members share the unseen tactics and strategies that drive their success. It’s like you’re sitting next to them at an Uncharted event.

Information

  • Creator
    Uncharted
  • Years Active
    2023 - 2026
  • Episodes
    29
  • Rating
    Clean
  • Copyright
    © Uncharted
  • Show Website
    Uncharted