UnNatural Selection

Nic Encina

~ Evolution by Design: Synthesizing Cross-Industry Innovation ~ – Curious about what innovation looks like in industries vastly different from yours? The UnNatural Selection Podcast applies ‘Survival of the Fittest’ to the world of business innovation. We explore how organizations adapt, evolve, and outcompete under the ruthless laws of evolution -- directly from the pioneers shaping their frontiers. – * This podcast is a living thesis on innovation strategy. The best place to start are the Synthesis Episodes (eg Episode 25)

  1. Funding the Frontier: Health AI Investing • Scientia Ventures / Harry Glorikian

    5 ngày trước

    Funding the Frontier: Health AI Investing • Scientia Ventures / Harry Glorikian

    Artificial intelligence is beginning to reshape healthcare, drug discovery, diagnostics, and even the structure of business itself. In this episode of UnNatural Selection, Nic Encina sits down with Harry Glorikian — General Partner at Scientia Ventures and Research Affiliate at the MIT Media Lab — to explore the collision between AI, biology, venture capital, and the future of innovation. Together, they discuss how investors distinguish genuine technological breakthroughs from hype, why data infrastructure and inferencing may become the next great competitive battlegrounds, and how startups are increasingly challenging legacy healthcare and pharmaceutical systems. The conversation dives into the evolution from traditional AI to large language models, the future of drug discovery, clinical trials, intelligent agents, digital health ecosystems, and why companies that fail to adapt to accelerating technological change may suddenly find themselves obsolete. From healthcare transformation to societal evolution in the age of AI, this episode explores what happens when innovation itself begins compounding faster than humans can comfortably track.

    51 phút
  2. When Work Evolves: Consumer Productivity • Microsoft / Sam Schillace

    16 thg 6

    When Work Evolves: Consumer Productivity • Microsoft / Sam Schillace

    What allows some companies to survive technological revolutions while others disappear?In this episode of UnNatural Selection, host Nic Encina sits down with Sam Schillace — CVP and Deputy CTO at Microsoft, serial entrepreneur, founder of Writely (which became Google Docs), and one of the leading thinkers shaping the future of AI and software platforms.Together, they explore how major platform shifts — from the internet and cloud computing to artificial intelligence — fundamentally reshape competition, organizations, and society itself.This conversation dives into: why successful companies struggle to adapthow AI is changing the nature of work and softwarethe importance of self-disruptionwhy speed of learning matters more than sizestartup survival and technological evolutionthe future of intelligence, platforms, and human collaborationA fascinating conversation about adaptation, innovation, and what it takes to survive when technology changes faster than institutions can evolve.

    59 phút
  3. Momentum Beats Control: Ground Transportation • NYC Taxi & Limo / Matthew Daus

    9 thg 6

    Momentum Beats Control: Ground Transportation • NYC Taxi & Limo / Matthew Daus

    What really happened when Uber disrupted the taxi industry? In this episode of UnNatural Selection, host Nic Encina sits down with Matthew W. Daus, the longest-serving Chair of the New York City Taxi & Limousine Commission and one of the world’s leading experts on transportation regulation and mobility technology. – This conversation goes far beyond taxis – Together, they unpack how Uber and app-based mobility fundamentally changed transportation, regulation, labor, politics, and consumer expectations — and why the disruption succeeded so rapidly. From immigrant-built taxi fleets and medallion economics to Silicon Valley strategy, generational shifts, lobbying, AI, driverless vehicles, and the future of mobility, this episode reveals the deeper evolutionary forces shaping modern industries. A masterclass on disruption, regulation, innovation, and what happens when technology moves faster than society can adapt.

    1 giờ 44 phút
  4. Those Who Laugh Last: Entertainment Comedy • Veep & Seinfeld / David Mandel

    2 thg 6

    Those Who Laugh Last: Entertainment Comedy • Veep & Seinfeld / David Mandel

    What makes great comedy survive? In Episode 54, Nic speaks with Emmy Award-winning writer, director, and producer David Mandel – the creative force behind Veep, Seinfeld, Curb Your Enthusiasm, Saturday Night Live, and more – about the hidden systems behind some of the most influential comedy ever created. From the legendary Seinfeld writers’ room to running Veep during one of the most politically chaotic periods in modern history, David shares insights into how comedy evolves, how writers compete for originality, and why audiences become harder and harder to surprise over time. The conversation explores the creative arms race inside Hollywood, the pressure of cultural relevance, collaboration under extreme deadlines, and the fine balance between innovation and familiarity in storytelling. They also discuss satire, audience psychology, creative failure, the economics of entertainment, and why the best comedy often emerges from intense structure rather than chaos. This episode is a masterclass in creativity, iteration, and surviving in industries where attention is the ultimate scarce resource.

    1 giờ 9 phút
  5. Winning by Milliseconds: Formula One • Aston Martin / Shergul Arshad

    26 thg 5

    Winning by Milliseconds: Formula One • Aston Martin / Shergul Arshad

    Formula One is one of the most technologically advanced and hyper-competitive industries on Earth. In Episode 53, Nic speaks with Shergul Arshad, Head of North America for Aston Martin Formula One, about what it takes to compete in a world where races – and championships – can be decided by hundredths of a second. Shergul takes us behind the scenes of modern Formula One: AI-driven engineering, real-time analytics, wind tunnel testing, logistics operations resembling NASA mission control, and the relentless pursuit of microscopic advantages across thousands of moving parts. The conversation explores how regulation shapes innovation, how elite organizations sustain competitive advantage, why Formula One exploded in popularity in the United States, and what every industry can learn from a sport obsessed with precision, iteration, and performance under pressure. From sponsorship strategy and global brand building to telemetry, aerodynamics, and the future of Formula One, this episode is a masterclass in modern competition at 200 miles per hour.

    53 phút
  6. At First, There Was Light: Candle Manufacturing • Alene Candles / Rodney Harl

    19 thg 5

    At First, There Was Light: Candle Manufacturing • Alene Candles / Rodney Harl

    Candles are one of the oldest technologies in human history. They lit our homes, guided our nights, and shaped civilization – until the light bulb nearly made them obsolete. So how does a 3,000-year-old industry reinvent itself and grow in a world flooded with artificial light? In Episode 52 of UnNatural Selection, Nic speaks with Rodney Harl, Chairman of Alene Candles, about innovation, safety, supply chains, and the surprising science behind a product millions of people light in their homes every day. Rodney shares how candles evolved from survival technology into lifestyle and identity products—and why modern candle manufacturing looks more like a biotech lab than a craft workshop. From chemical formulation and safety testing to rapid supply chains and global competition, this episode reveals how even the oldest industries must constantly reinvent themselves to stay relevant. If you think candle making is simple, this conversation will change your mind.

    59 phút
  7. Infrastructure Wins: Research & Diagnostics • Danaher / JC Gutierrez-Ramos

    12 thg 5

    Infrastructure Wins: Research & Diagnostics • Danaher / JC Gutierrez-Ramos

    Breakthroughs don’t fail because of bad science – they fail because the systems needed to deliver them don’t exist yet. In this episode of UnNatural Selection, Nic speaks with Jose-Carlos Gutierrez-Ramos, Senior Vice President and Chief Science Officer at Danaher, about the hidden bottlenecks slowing progress in life sciences – and what they reveal about innovation in every industry. JC shares how his journey from patient to immunologist shaped his mission to improve human health, and why the biggest barriers today aren’t discovering new therapies – they’re selecting the right patients, generating real-world evidence, and building the manufacturing and diagnostic infrastructure needed to scale breakthroughs. The conversation explores why innovation increasingly happens between industries, why incentives across ecosystems often don’t align, and why the next decade will reshape who leads discovery, development, and delivery. This episode is about the uncomfortable truth behind progress: discovery is only the beginning.

    54 phút
  8. Brand Beats Commodity: Casual Hospitality • bartaco / Anthony Valletta

    5 thg 5

    Brand Beats Commodity: Casual Hospitality • bartaco / Anthony Valletta

    Tacos might be one of the most commoditized products on the planet. You can find them everywhere, at every price point, in nearly every city. So how do you build a truly distinctive brand around something so common? In this Season 2 premiere of UnNatural Selection, we explore how bartaco has done exactly that. CEO Anthony Valletta shares how the company escaped the commodity trap by focusing on something deeper than the menu: experience, community, and the feeling of belonging. This conversation dives into why the real competitor in hospitality isn’t another restaurant—it’s isolation, convenience, and digital overload. You’ll hear how bartaco designs environments that encourage connection, why simplicity can be the ultimate form of innovation, and how a brand can scale emotional experiences without losing authenticity. If you care about differentiation, brand strategy, hospitality, or building meaningful experiences in crowded markets, this episode is a masterclass in turning the ordinary into the unforgettable. Season 2 starts here.

    59 phút
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Giới Thiệu

~ Evolution by Design: Synthesizing Cross-Industry Innovation ~ – Curious about what innovation looks like in industries vastly different from yours? The UnNatural Selection Podcast applies ‘Survival of the Fittest’ to the world of business innovation. We explore how organizations adapt, evolve, and outcompete under the ruthless laws of evolution -- directly from the pioneers shaping their frontiers. – * This podcast is a living thesis on innovation strategy. The best place to start are the Synthesis Episodes (eg Episode 25)

Thông Tin

  • Nhà sáng tạo
    Nic Encina
  • Năm hoạt động
    2025 - 2026
  • Tập
    57
  • Xếp hạng
    Thô tục
  • Bản quyền
    © Nic Encina
  • Trang web chương trình
    UnNatural Selection