This Week in Startups

Jason Calacanis

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

  1. The Self-Driving Startup Nobody Saw Coming | E2289

    9H AGO

    The Self-Driving Startup Nobody Saw Coming | E2289

    This Week In Startups is made possible by: IM8 Health: IM8health.com/TWIST Squarespace: Squarespace.com/TWIST Render - Render.com/TWIST Self-driving just stopped being a science problem and became an engineering challenge instead. That's the through-line of today’s double-header with the CEOs of two of the most important AV companies in the world — Wayve's Alex Kendall and Waabi's Raquel Urtasun. Between them: ~$2B raised in the last six months, Uber as a partner, Nissan and Volvo as OEMs, and a shared bet that end-to-end AI plus world models beats Waymo's city-by-city map-and-pray approach. If you want to understand the state of the self-driving industry beyond recent Waymo announcements, this is the episode for you. Guest Links: Wayve: wayve.ai/ Waabi: http://waabi.ai/ Alex Kendall https://www.linkedin.com/in/alexgkendall/ Raquel Uratsun: https://www.linkedin.com/in/raquel-urtasun-298400139/ Company Links: Wayve’s GAIA-2 world model: https://wayve.ai/thinking/gaia-2/ Wayve’s 500 city roadshow: https://wayve.ai/thinking/ai-500-roadshow-500-cities/ Wavye’s most recent funding round: https://wayve.ai/press/series-d/ Waybe + Uber: https://wayve.ai/press/wayve-nissan-uber-robotaxi-collaboration/ Waabi closed-loop simulator: https://waabi.ai/insights/waabi-world Waabi + Volvo: https://waabi.ai/insights/waabi-and-volvo-autonomous-solutions-partner-to-jointly-develop-and-deploy-autonomous-transportation-solutions Waabi + Uber: https://www.uberfreight.com/en-US/blog/uber-freight-and-waabi-introduce-industry-first-autonomous-truck-deployment-solution Timestamps: 0:00 Alex Kendall (Wayve) joins the show 1:19 The contrarian bet on end-to-end AI and world models in 2017 3:05 What is a world model? GAIA-2 and GAIA-3 explained 7:34 Sensor agnosticism: camera, radar, LiDAR and minimum bar for safety 9:56 $1.5B raised — have we cracked self-driving? 10:09 Render: Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers. 20:38 Squarespace: Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST 25:03 How consumers will actually pay: bundle, subscription, or free trial 30:15 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order. 35:59 Raquel Urtasun (Waabi) joins the show 36:25 World models as controllable simulators for physical AI 43:34 One AI brain across trucks, robotaxis, and beyond 47:35 What changed in AI to make 2026 the deployment year 52:28 Why Waabi raised $1B when they're capital-efficient 58:52 Where Waabi is today: Volvo VNL Autonomous, Dallas-Houston, Uber Freight 1:00:50 Per-mile pricing and the Driver-as-a-Service model 1:07:20 Has Uber tried to buy Waabi? "Not for sale" Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

    1h 13m
  2. How Many Startups Will Survive OpenAI? | E2288

    2D AGO

    How Many Startups Will Survive OpenAI? | E2288

    This Week In Startups is made possible by:Pilot -⁠ https://Pilot.com/TWIST⁠Grasshopper Bank -⁠ https://Grasshopper.bank/TWIST⁠Quo -⁠ https://Quo.com/TWiST⁠Plaud - ⁠https://Plaud.ai/twist⁠Anthropic just declared every unauthorized secondary sale of its stock "void" — naming Hiive, Forge, Sydecar, Upmarket, and others in a public hit list. Jason and Alex sit down with Jenny Fielding (Everywhere Ventures), Dave McClure (Practical VC), and Sam Lessin (Slow Ventures) to unpack what the AI lab’s move to limit secondary trades means for SPV operators, brokers, and the founders trying to keep control of their cap tables. Plus: a real story of a founder who returned a $15M Series A six months after closing because Claude was going to eat his startup, SaaS moats, and just what does it mean to be rich?Timestamps:0:00 Guest introductions0:48 Anthropic voids unauthorized SPV trades8:41 Accredited investor reform & the SEC sophisticated investor test8:58 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST11:43 Naval's USVC closed-end fund as a workaround16:41 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!17:48 Pro-rata rights battles: when Series A investors push seed investors out19:36 Grasshopper Bank: Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.29:13 Pilot: Focus on your product, let Pilot handle your bookkeeping. Pilot provides the most reliable accounting, CFO, and tax services for startups and small businesses. Head to https://pilot.com/twist and get $1,200 off your first year.30:23 Storing wealth in stories vs. cash flows34:19 Cerebras and Fervo Energy IPOs — meaningful liquidity?37:54 Will SpaceX, Anthropic, OpenAI IPOs redistribute capital or compound it?45:58 The $15M Series A founder who returned the money because of Claude50:01 Should founders pivot or return capital when the world changes?56:43 OpenAI's $6.6B tender and Shruti Gandhi's viral SF cost-of-living tweet1:00:25 Intercom rebrands to Fin: the AI-first late-stage pivotSubscribe to the TWiST500 newsletter:⁠ https://ticker.thisweekinstartups.com⁠Check out the TWIST500:⁠ https://www.twist500.com⁠Subscribe to This Week in Startups on Apple:⁠ https://rb.gy/v19fcp⁠Follow Lon:X:⁠ https://x.com/lons⁠Follow Alex:X:⁠ https://x.com/alex⁠LinkedIn:⁠ ⁠https://www.linkedin.com/in/alexwilhelm⁠Follow Jason:X:⁠ https://twitter.com/Jason⁠LinkedIn:⁠ https://www.linkedin.com/in/jasoncalacanis⁠Check out all our partner offers:⁠ https://partners.launch.co/⁠Great TWIST interviews:⁠ Will Guidara,⁠⁠ Eoghan McCabe⁠,⁠ Steve Huffman⁠,⁠ Brian Chesky⁠,⁠ Bob Moesta,⁠⁠ Aaron Levie⁠,⁠ Sophia Amoruso⁠,⁠ Reid Hoffman⁠,⁠ Frank Slootman⁠,⁠ Billy McFarland⁠Check out Jason’s suite of newsletters:⁠ https://substack.com/@calacanis⁠Follow TWiST:Twitter:⁠ https://twitter.com/TWiStartups⁠YouTube:⁠ https://www.youtube.com/thisweekin⁠Instagram:⁠ https://www.instagram.com/thisweekinstartups⁠TikTok:⁠ https://www.tiktok.com/@thisweekinstartups⁠Substack:⁠ https://twistartups.substack.com⁠

    1h 25m
  3. Cerebras's IPO goes vertical, and the death of OpenClaw? | E2287

    4D AGO

    Cerebras's IPO goes vertical, and the death of OpenClaw? | E2287

    Today’s show: Cerebras just jacked its IPO range to $150–$160 a share, OpenAI bought a consulting firm to seed its $4 billion private-equity joint venture, and a startup in Oakland is electrolyzing magnesium out of seawater for one-third the going price. Alex Wilhelm and Jason Calacanis go deep with AI21 co-CEO Ori Goshen on why model orchestration, not bigger LLMs, will decide who wins enterprise AI. The crew also covered the decline of OpenClaw, TikTok's new £3.99 ad-free tier, more entries in the live-show sidebar bounty, and had time for a little Off Duty before signing off. Guest Links: Ori Goshen on LinkedIn AI21 Alex Grant on LinkedIn Magrathea Metals Timestamps: 0:00 Ori Goshen, CEO of AI21 joins the show 1:20 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 5:14 Why enterprises care about token cost optimization 6:01 Jamba as open-weight; Maestro as proprietary orchestration 10:08 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist 12:56 AI21 customer roster: FNAC, US tech giants, Israeli companies 19:01 Alex Grant, CEO of Magrathea Metals joins to discuss pulling magnesium from seawater 20:03 Live video of the Oakland pilot electrolyzer 20:10 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more. 22:01 Magnesium as a "gateway metal" for aluminum, defense, aerospace 23:20 TETRA joint venture & the Evergreen Project in Arkansas 23:38 Series A close, JV economics: $3,000/ton vs. $7,000/ton market 29:10 Sidebar bounty update: Glass Sidebar (Oliver Choy) demo 30:47 Netsuite - Get the free business guide Demystifying AI at https://netsuite.com/twist 31:47 Sidebar bounty update: Sidecast (Patrick Hughes) demo 36:09 Reducing scope to "real-time fact checker only" for final round 37:24 Ro.co: Ro's insurance checker will let you know if your coverage includes GLP-1s for FREE. Go to https://Ro.co/Twist for your free insurance check. 39:07 Cerebras IPO: $115–$125 → $150–$160 per share 44:19 Will OpenAI's compute commitments to Cerebras actually get funded? 49:19 Fervo Energy IPO — venture-backed geothermal company going public 49:40 OpenAI Deployment Company + Tomoro acquisition explained 53:51 Anthropic's parallel $1.5B PE joint venture with Blackstone & Goldman 56:05 Why Jason thinks these PE spinouts are convoluted financial engineering 56:40 OpenClaw's decline + competition from Cowork, Perplexity, Grok 1:04:22 TikTok's £3.99 ad-free subscription launches in the UK 1:09:09 Knicks sweep 76ers — Jason's playoff predictions 1:11:24 Off-duty: "There Is No Antimemetics Division" by qntm 1:13:25 Off-duty: Fall of Civilizations podcast by Paul Cooper 1:16:37 States' rights, federalism, housing supply & closing thoughts Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

    1h 23m
  4. 5,000+ Tech Workers Laid Off This Week. It's Just The Beginning. | E2286

    MAY 9

    5,000+ Tech Workers Laid Off This Week. It's Just The Beginning. | E2286

    This Week In Startups is made possible by: IM8 Health - https://IM8health.com/TWIST Every - Every.io Sentry - https://Sentry.io/TWIST Banks don’t want to hand over their data to AI labs. So David Moscatelli built a $250,000 box that runs AI on-prem. He already has 1,600 pre-orders. On today’s episode of TWiST, Jason and Alex sit down with the Go Abacus founder and Yanez's Jose Caldera to unpack how regulated industries are getting AI without the cloud, why Bittensor subnet 54 is incentivizing miners to attack identity systems, and why Cloudflare just laid off 20% of its workforce in the same week it raised guidance. The show closes with Jason explaining what it means to build an AI-first startup, and how workers can derisk their future employment! Guest Links: Go Abacus Go1 direct link David Moscatelli on LinkedIn Yanez Bittensor Subnet 54 on TAOstats Jose Caldera on LinkedIn LAUNCH Links: Founder University Founder University Japan application portal News Links: Cloudflare lays off 20% of its staff Coinbase cuts 14% of its staff Block post on how it is rebuilding its company Block’s earnings, including its raised guidance Anthropic’s massive upcoming funding round WHOOP’s new on-demand clinicians Stripe Atlas’s growth Timestamps: 0:00 Introduction: Jason in Brooklyn, Knicks playoffs 2:30 Go Abacus joins: AI infrastructure for regulated industries 3:25 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 4:00 The Go1: 2,000-user on-prem AI appliance 7:04 Pricing the Go1: How far does $250,000 go? 7:24 1,600 orders and the hardware delivery challenge 10:14 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST 20:23 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io 27:22 Chicago tech scene and in-office culture 30:09 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order. 35:11 Yanez joins: How to prove personhood and uniqueness 38:32 How biometric capture and bio-keys work 40:05 Agent delegation: proving humans authorized AI agents 44:19 Bittensor Subnet 54 and incentivizing adversarial miners 47:11 Founder University Japan Cohort 2 applications open 49:15 Tech layoffs: Cloudflare cuts 20%, Coinbase cuts 14%, Block raises guidance 1:02:14 Anthropic's $50B round at $900B pre-money 1:04:22 WHOOP adds on-demand clinicians 1:06:42 Federalism, state-level regulation, and AI policy Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

    1h 12m
  5. The end of Venture Capital? (VC Roundtable) | E2285

    MAY 6

    The end of Venture Capital? (VC Roundtable) | E2285

    This Week In Startups is made possible by: Grasshopper Bank - https://grasshopper.bank/twist PaperOS - https://paperos.com/twist LinkedIn Jobs - https://linkedIn.com/twistPlaud - https://Plaud.ai/twist The top 5 U.S. venture firms captured 73% of all LP commits in Q1, and three veteran VCs say the math may have officially broken. Aleph's Michael Eisenberg argues we may be witnessing the end of a 60-year run for venture capital as a craft business. Maniv's Mike Granoff and Oxcart's Larry Covert push back, arguing it's merely splitting into two asset classes: "Consensus VC" and traditional VC. Either way, the implications for founders, LPs, and the next decade of innovation are enormous. TWiST is back on the beat with a venture round table discussing investment concentration, the IPO drought, "b******t ARR" in the AI era, AI gross margins, the U.S.-China chip war, the Iran conflict's impact on defense tech, the death of NATO and the rise of allied supply chains, why Tel Aviv's stock exchange could become the next NASDAQ, and a lightning round on each VC's favorite portfolio company. Let’s go! Timestamps: 0:00 Intro + sponsor reads (Grasshopper Bank, PaperOS, LinkedIn Jobs) 0:58 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 2:13 Introductions: Eisenberg (Aleph), Granoff (Maniv), Covert (Oxcart) 3:57 The impact of rising venture capital concentration 6:43 "We may be witnessing the end of venture capital" 9:17 Consensus VC vs. Traditional VC 10:01 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist 11:48 Why mid-size firms beat the behemoths on founder access 19:35 Coining "Consensus Colossal Collaborative Capital" (CCCC) 20:03 AngelList's USVC retail VC fund — does it help mid-size funds? 20:18 PaperOS - Whether you're raising a round, launching a fund, or managing a venture portfolio, PaperOS can unlock simplicity and scale across your empire of capital, contracts, and companies. Claim your $10,000 credit at https://paperos.com/twist 23:27 Are there more breakout startups today than 5 years ago? 28:36 The "b******t ARR" problem and AI gross margins 30:03 Grasshopper Bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account. 32:08 Cursor's negative gross margins and the hyperscaler funding flywheel 33:06 Are we all electron constrained? 35:35 Are we headed for surge pricing on compute? 40:22 Will anything replace NVIDIA? NextSilicon, Hailo & Israel's chip stack 43:33 Distillation, small models, and Apple's edge advantage 46:38 Public trust in AI: should government mandate Waymo & FSD? 1:02:58 Defense tech: Saronic, Anduril & the coming defense M&A wave 1:06:35 The Iran war timeline & supply chain impact 1:18:52 Lightning round: Jiga, Divergent, Volaback, Firehawk, Harbinger Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

    1h 24m
  6. Naval's GP, Ankur Nagpal, Breaks Down The Viral “USVC” Fund | E2284

    MAY 5

    Naval's GP, Ankur Nagpal, Breaks Down The Viral “USVC” Fund | E2284

    This Week In Startups is made possible by: Render - render.com/twist Vanta - vanta.com/twist Northwest Registered Agent - northwestregisteredagent.com/twist Have you wanted to invest in venture capital alongside your 401k contributions, but struggled to find a way to place a bet? Search no more, for the AngelList team has created USVC, a new fund that will accept investments of as little as $500 from folks who lack accreditation. USVC’s Ankur Napgal swung by the show to chat about investment strategies, access, fees, and just how illiquid the venture-like vehicle will prove to be. Jason and Alex were then joined by Jon Durbin, core contributor at Chutes, and Yash Goenka, co-founder and CEO of Humwork. Chutes is the most valuable Bittensor subnet, focused on aggregating GPUs to offer trustless AI compute. Humwork wants to help bring a human into your agentic workflow to unstick your agent when it runs into a hitch. The show closes with a news lightning round — enjoy! Timestamps: 0:00 Intro + Plaud AI sponsor read (Jason demos the NotePin S) 2:06 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 3:50 Episode overview: USVC, Chutes, Humwork 7:41 USVC structure: $500 min, no accreditation, quarterly redemptions 10:28 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist 11:39 Fee structure breakdown: 1% mgmt fee, ~2.5% net expense ratio 15:41 USVC portfolio: xAI, Anthropic, OpenAI, Crusoe, Vercel 16:17 Strategy: 1/3 emerging managers, 1/3 growth, 1/3 secondaries 19:00 $1B cap and path to expanding the fund 20:33 Vanta - Compliance and security shouldn't be a deal-breaker for startups to win new business. Vanta makes it easy for companies to get a SOC 2 reports fast. Get $1,000 off for a limited time at https://www.vanta.com/twist 28:00 What is sovereign compute? Permissionless GPU networks explained 30:10 Render - Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers. 44:53 Usage history: 160B tokens/day peak, free-to-paid transition 46:41 GPU pricing: from $0.77/hr to $3.50/hr as shortage bites 49:13 DeepSeek censorship demo: Taiwan test on DeepSeek chat 57:27 Permissionless supply curves: Uber/Airbnb analogy for induced demand 59:20 Yash Goenka, co-founder of Humwork (YC S26) 1:00:49 Lightning Round: Ryan Cohen wants to buy eBay — Jason's hot take 1:12:36 Lightning Round: Cerebras IPO update ($27–36B valuation range) 1:14:05 Lightning Round: Spirit Airlines / JetBlue / M&A regulation debate 1:19:10 OFF-DUTY: Star Wars: Maul - Shadow Lord 1:32:57 Alex's OFF-DUTY: Captain of Industry Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

    1h 38m
  7. Can an AI Agent Legally Own a Company? Christian van der Henst's Wild Experiment| E2283

    MAY 1

    Can an AI Agent Legally Own a Company? Christian van der Henst's Wild Experiment| E2283

    This Week In Startups is made possible by: Pilot - https://pilot.com/twist Shopify - https://shopify.com/twist Grasshopper Bank - https://grasshopper.bank/twist Today’s show: An AI agent named Valerie is running a real vending machine in San Francisco — setting prices, ordering inventory, managing a bank account, and posting to Instagram. And it's not just a stunt. We’re getting an early look at the future of one-agent companies. There’s still work to do to help agents ease into the economy, potentially opening up new startup opportunities. Jason Calacanis and Alex Wilhelm cover a stacked docket: Christian van der Henst demos the Valerie AI vending machine powered by OpenClaw; Robert Myers, CEO of Manifold Labs, breaks down Targon, a confidential GPU compute marketplace running on Bittensor Subnet 4; Jason calls Bitcoin "played out;" Alex is impressed by Anthropic's stunning $900 billion upcoming valuation; and the guys discuss Big Tech's accelerating CapEx spend, Chinese AI models in Congress crosshairs, and the NBA Playoffs. Timestamps: 0:00 Intro & sponsor reads (Pilot, Shopify, Grasshopper Bank) 1:06 Christian van der Henst: Valerie the AI vending machine demo 4:28 Legal structure: Giving an AI agent business ownership via trust 7:23 Where agents can and can't operate today 10:10 Grasshopper Bank: Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account. 11:48 AI café in Stockholm running on agents 18:21 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 19:05 Robert Myers, Manifold Labs: Targon & Bittensor Subnet 4 interview 20:21 What is Bittensor? An "incubator with 128 subnets" 21:08 Shopify: Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist 25:21 Pricing, utilization caps, and why GPUs are sold out 26:38 Who's using Targon? Customers, use cases, and the mom-and-pop data center argument 30:06 Pilot: Focus on your product, let Pilot handle your bookkeeping. Pilot provides the most reliable accounting, CFO, and tax services for startups and small businesses. Head to https://pilot.com/twist and get $1,200 off your first year. 35:07 Jason explains the annotated.com vision — 15 years in the making 39:11 Polymarket: Will Anthropic flip Bitcoin by Dec 31? 40:29 Jason's Bitcoin bear case: "It's played out. No incremental buyers." 46:05 MicroStrategy / Strategy updates 52:37 AI compute demand vs. the fiber overbuild analogy 55:55 Congress pressuring startups over Chinese AI models (DeepSeek, Moonshot) 57:11 A16z on the geopolitical risk of Chinese AI models 1:00:08 Reflection AI — America's open source AI champion (or lack thereof) 1:01:26 Off Duty: Knicks blow out Atlanta Hawks 140–89, Jason goes road-tripping Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

    1h 10m
  8. Mastering AI Video Marketing w/ Magnific CEO Joaquín Cuenca Abela | AI Basics

    APR 30

    Mastering AI Video Marketing w/ Magnific CEO Joaquín Cuenca Abela | AI Basics

    The TWiST AI Basics series is made possible by Google Cloud!Check out Google Cloud’s new report, “Future of AI: Perspectives on generative media for startups,” Featuring thoughts from today’s guest, Joaquín Cuenca AbelaVisit: goo.gle/futureofgenmedia to check it out!Today’s show:In today’s edition of TWiST AI Basics, J-Cal is joined by Joaquin Cuenca Abela, co-founder and CEO of Magnific (formerly known as Freepik). We’re discussing how generative AI is transforming the creative landscape for startups.In watching today’s show you’ll have-consider your expectations of what AI video can actually do for you and your business. What used to take a high end production team months and tens of thousands of dollars now takes 24 hours and one person with patience to learn the right tools. This conversation explores how founders can use these tools to scale their creative output better, cheaper, and faster.Timestamps:0:00 Google Cloud - Check out Google Cloud's new report, "Future of AI: Perspectives on generative media for startups," Featuring thoughts from today's guest, Joaquín Cuenca Abela at https://goo.gle/futureofgenmedia1:10 Welcome to AI Basics, presented by Google Cloud!2:11 Meet Joaquín Cuenca Abela, CEO of Magnific (formerly Freepik)3:12 Building a post-apocalyptic SF ad for TWiST in 24 hours4:25 Storyboarding characters, blending images, and text-prompting scenes6:39 The finished product: post-apocalyptic Jason!7:56 How much cheaper is this than traditional advertising?9:34 The tech stack: Magnific's upscaler and 3rd party frontier models11:02 Which Hollywood productions are actually using AI?13:14 Hollywood's 180 from "F these tools" to enthusiastic adoption14:38 One director's 600-person AI-enabled production15:23 Why Magnific built in Málaga, Spain and how they recruit AI talent16:40 Can AI ever match human creative vision?18:43 The future: 100 versions of the same ad, hyper-localized by city21:35 Where to find Magnific + Google Cloud's Future of AI reportConnect with Joaquín and Magnific!Magnific (formerly Freepik) — Joaquín's AI creative platform, 150M+ MAU, $230M ARR → https://magnific.comJoaquín Cuenca Abela on X → https://x.com/cuencaJoaquín Cuenca Abela on LinkedIn → https://www.linkedin.com/in/joaquin-cuenca-abela-905717a/Magnific on X → https://x.com/magnificPanoramio — Joaquín's prior startup, acquired by Google in 2007 → https://en.wikipedia.org/wiki/PanoramioFortune feature on Magnific's $230M ARR rebrand (April 2026) → https://fortune.com/2026/04/28/freepik-magnific-joaquin-cuenca-abela-230-million-arr-video-generation-ai-pivot/Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partner!Google Cloud - Check out Google Cloud’s new report, “Future of AI: Perspectives on generative media for startups,” Featuring thoughts from today’s guest, Joaquín Cuenca Abela at goo.gle/futureofgenmediaCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason’s suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

    23 min
4.2
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1,282 Ratings

About

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

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