CReATe Podcast

CReATe Consortium
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CReATe Connect podcasts are short recorded interviews on topics we hope will be of interest to patients with ALS and other motor neuron diseases.

  1. 3 Sept

    ALS Untangled Series Ep. 68 - Pyridostigmine

    Pyridostigmine enhances neuromuscular transmission and is commonly used to treat myasthenia gravis. The effect of pyridostigmine in slowing ALS progression is uncertain. Here we discuss the potential mechanisms, cases, clinical trial data, and potential risks.

  2. 7 Aug

    ALS Untangled Series Ep. 67 - Alpha Lipoic Acid

    Alpha-lipoic acid (ALA) is a naturally occurring fatty acid. It has several plausible mechanisms for slowing ALS progression. Preclinical studies showed ALA slowed motor function decline. Some patients reported improvement when taking ALA together with other supplements. Here we discuss the mechanism, clinical studies, and potential risks.

  3. 1 Jul

    CReATe Author Series Ep. 19 - Dr. Paul Lingor on Fasudil as a Potential Therapeutic for ALS

    Paul Lingor, MD, is Professor for Neurology, Group Leader and Head of the Outpatient Clinics for Motoneuron Disorders and Co-head of the Outpatient Clinics for Movement Disorders and at the Department of Neurology of the TUM Klinikum Rechts der Isar in Munich, Germany.  Here he discusses the recent publication "Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial."

  4. 3 Jun

    ALS Untangled Series Ep. 66 - PoNS

    Portable Neuromodulation Stimulator (PoNS) is a type of electrical stimulation that can theoretically increase rewiring in the brain (neuroplasticity).  Small trials suggest that it can improve walking in MS but thus far there are no data in people living with ALS.  Here we further discuss the mechanism, studies in other conditions, and potential risks.

  5. 15 May

    ALS Untangled Series Ep. 65 - ISRIB

    ISRIB stands for “integrated stress response inhibitor).  As we discuss here, it is an oral medication that inhibits an intracellular pathway called the integrative stress response pathway.  It is not FDA approved for any condition but is available in Spain without a prescription.  There are theoretical ways that inhibiting this pathway could help a person with ALS, and there is promising data from preclinical ALS models.  However, it is not clear that ISRIB is soluble enough to get into motor neurons in the brain and spinal cord, and 2 of 3 trials of agents targeting the same pathway failed to show any benefits in people with ALS.  The risks of this product in ALS are not known.

  6. 9 Apr

    CReATe Author Series Ep. 18 - Dr. Michael Benatar on MMI as a prodromal stage of ALS

    Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the University of Miami. Here he discusses the recent publication “Proposed Research Criteria for Mild Motor Impairment as a Prodromal Syndrome in Amyotrophic Lateral Sclerosis."

  7. 8 Jan

    CReATe Author Series Ep. 17 - (AI generated) Podcast on C9orf72 Disease Prevention Trials

    Here we have a podcast produced by artificial intelligence discussing the recent publication “Design considerations for C9orf72 disease prevention trials”.

  8. 10/12/2025

    ALS Untangled Series Ep. 64 - Wahls Protocol

    The Wahls Protocol is a diet that may reduce inflammation, oxidative stress, and mitochondrial dysfunction.  Although these are plausible mechanisms for slowing ALS progression, we discuss the fact that there are no actual data to support this hypothesis, and there are risks which are especially important to consider in people living with ALS.

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About

CReATe Connect podcasts are short recorded interviews on topics we hope will be of interest to patients with ALS and other motor neuron diseases.

Information

  • Creator
    CReATe Consortium
  • Years Active
    2018 - 2026
  • Episodes
    88
  • Rating
    Clean
  • Copyright
    © Copyright CReATe Consortium
  • Show Website
    CReATe Podcast