From First Principles

Krishna Choudhary and Lester Nare

From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.

  1. 2 HR AGO

    How Scientists Actually Study Dark Matter (EP 42)

    Hosted by Lester Nare, this episode features astrophysicist Dan Gilman for a deep conversation on one of the biggest open questions in modern physics: what dark matter actually is. Starting from first principles, Lester and Dan walk through why the evidence for dark matter is now so strong, how strong gravitational lensing works, why tiny distortions in lensed light can reveal invisible clumps of matter, and how the next generation of surveys may transform the field. Krishna is out on family leave for this one, but the conversation stays fully in the From First Principles lane: grounded, visual, and science-first. Summary What dark matter is — Dan explains the basic case for dark matter, why it appears to interact only through gravity, and why multiple independent observations now point to the same conclusion.How strong gravitational lensing helps — the episode uses intuitive analogies like tides, fish tanks, and flashlights to explain how astronomers can infer the presence and structure of dark matter without seeing it directly.What Dan actually studies — the core of Dan’s work is building and testing simulations of lensed systems to see which dark matter theories best match reality.Why the next few years matter — Rubin, Roman, Euclid, and AI-assisted lens finding could dramatically increase the number of usable lens systems and sharpen the search for dark matter’s fundamental nature.Show Notes Dan Gilman on strong gravitational lensing and dark matter substructureEuclid mission overviewRubin Observatory overviewRoman Space Telescope mission context

    1hr 7min

  2. 13 MAY

    Dr. John Mulchaey on Carnegie Science and the Future of Astronomy (EP 41)

    Hosted by Lester Nare and Krishna Choudhary, this interview features John Mulchaey, the 12th President of Carnegie Science and former Director of the Carnegie Observatories. The conversation starts with his early work on galaxy groups and dark matter, then expands into how Carnegie works as a scientific institution, what the Giant Magellan Telescope could unlock for exoplanets and astronomy, how science funding actually works, and why eclipse chasing is still one of the most magical experiences in science. Summary Galaxy groups and dark matter — Mulchaey explains why small galaxy groups matter more than most people realize, and how X-ray observations of hot gas helped make their masses measurable. Carnegie’s model — the interview gets into what makes Carnegie unusual: scientific freedom, long time horizons, and room to pursue surprising questions. The Giant Magellan Telescope — a look at why bigger telescopes matter, what GMT changes, and why exoplanet atmospheres are one of the biggest goals ahead. The bigger picture — science funding, philanthropy, how astronomy has changed, and why total solar eclipses still inspire so many astronomers. Support the showDonate: FFPod.com/donateFollow: @FFPod on X / Instagram / TikTok / Facebook Show NotesJohn Mulchaey leadership bio — Carnegie Sciencehttps://carnegiescience.edu/about/leadershipCarnegie Science appoints John Mulchaey as its 12th Presidenthttps://carnegiescience.edu/news/carnegie-science-appoints-john-mulchaey-its-12th-presidentGiant Magellan Telescope — official overviewhttps://giantmagellan.org/about-us/1993 NASA write-up on Mulchaey’s dark matter result in galaxy groupshttps://science.nasa.gov/missions/hubble/dark-matter-found-in-a-typical-cluster-of-galaxies/Carnegie Science Great North American Eclipse outreach recaphttps://carnegiescience.edu/yearbook/2024/science/great-north-american-eclipsePerot Museum eclipse partnership recaphttps://www.perotmuseum.org/events/solar-eclipses/

    37 min

  3. 29 APR

    Ant Scans, Lunar Chickpeas, Hidden Galaxies & Superconductivity (EP 40)

    Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers four new science stories at a high level: a huge new 3D ant imaging database built with synchrotron X-ray microtomography, a lunar agriculture experiment that grew chickpeas in simulated moon soil using fungi and worm waste, AI-assisted discovery of strange objects in the Hubble archive, and a new programmatic roadmap for room-temperature superconductivity. There is also another round of Are You Smarter Than a Scientist? in the middle. Summary Particle accelerators meet biodiversity — researchers built a massive high-resolution ant imaging resource, covering nearly 800 species and thousands of specimens, with AI-assisted 3D reconstruction. Moon farming gets weird — chickpeas were grown in lunar regolith simulant with help from mycorrhizal fungi and worm-derived compost, a first step toward sustainable off-world agriculture. AI found hidden anomalies in Hubble’s archive — AnomalyMatch sifted through roughly 100 million source cutouts in just days and surfaced new candidate lenses, mergers, and other rare objects. The superconductivity long game — a new PNAS perspective argues that room-temperature superconductivity is not ruled out by physics, and calls for a coordinated push to get there. Support the showDonate: FFPod.com/donateFollow: @FFPod on X / Instagram / TikTok / Facebook Show Notes High-throughput phenomics of global ant biodiversity — Nature Methods Bioremediation of lunar regolith simulant through mycorrhizal fungi and plant symbioses enables chickpea to seed — Scientific Reports Identifying astrophysical anomalies in 99.6 million source cutouts from the Hubble legacy archive using AnomalyMatch — Astronomy & Astrophysics The path to room-temperature superconductivity: A programmatic approach — PNAS

    37 min

  4. 21 APR

    The Prometheus Constellation: Dramaturgical and Scientific Analysis of the Physicists in Oppenheimer (EP 39)

    Hosted by Lester Nare and Krishna Choudhary, this special episode ranks the 26 scientists shown in Christopher Nolan’s Oppenheimer by one standard only: their contribution to fundamental science. Starting with the Manhattan Project figures near the bottom and working up through the giants of quantum mechanics, relativity, nuclear physics, and logic, the episode turns a movie cast list into a surprisingly deep walk through the history of modern physics. Summary A ranking framework that actually means something — this list is based on scientific achievement, not movie prominence, clout, or vibes. A tour of 20th-century science — from nuclear chain reactions and black holes to MRI, GPS, quantum mechanics, and information theory. The great debates — several placements are designed to provoke real argument, especially around how Oppenheimer compares to the physicists around him. A top tier full of monsters — the back half of the episode becomes a speedrun through some of the most influential scientific minds of the modern era. Support the showDonate: FFPod.com/donateFollow: @FFPod on X / Instagram / TikTok / Facebook

    1hr 37min

  5. 15 APR

    Harder Than Diamond? The New Hexagonal Diamond Breakthrough (EP 38)

    Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the strangest and most hard-fought materials science stories in decades: the claim that researchers have finally synthesized bulk hexagonal diamond, also known as lonsdaleite. They break down why this material matters, how it differs from ordinary cubic diamond, why scientists argued about its existence for more than 50 years, and what the new Nature paper actually did to convince skeptical reviewers. Summary Why hexagonal diamond matters — if real, it is a long-sought carbon phase that could be slightly harder than conventional diamond and useful in extreme industrial settings. The first-principles chemistry — carbon allotropes, x-ray crystallography, cubic diamond, and the ABAB stacking that makes hexagonal diamond different. The experimental breakthrough — how the new team engineered around the default pathway to ordinary diamond by controlling graphite orientation and pressure direction. The controversy — why the peer review was intense, and how the new paper relates to an earlier 2025 Nature paper with a similar claim. Support the showDonate: FFPod.com/donateFollow: @FFPod on X / Instagram / TikTok / Facebook

    58 min

  6. 9 APR

    Artemis II: Deep Dive on the Moon Flyby, Earthset, and Reentry (EP 37)

    Hosted by Lester Nare and Krishna Choudhary, this episode is a full deep dive on Artemis II as the crew returns from humanity’s first crewed lunar flyby in more than 50 years. Lester and Krishna break down the mission photo by photo, from launch and translunar injection to Earthset, Earthrise, the in-space solar eclipse, the science of lunar observations, and the skip-entry reentry profile bringing Orion home. Summary Why Artemis II is historic, what the crew saw on the far side of the Moon, and why this mission matters for the long-term return to the lunar surface.Why NASA relied on the Nikon D5 for deep-space photography, and what camera physics, low-light performance, and radiation tolerance have to do with getting these images home.The standout observations from the flyby: Earthset, Earthrise, a rare in-space solar eclipse, planetary alignment during eclipse, and the first crewed visual observations of meteoroid impact flashes on the Moon.How Orion’s reentry works, why Artemis II uses skip entry, what happened to Artemis I’s heat shield, and what NASA changed for the crewed return.Support the showDonate: FFPod.com/donateFollow: @FFPod on X / Instagram / TikTok / Facebook

    1hr 26min

  7. 3 APR

    Artemis II, Claude Code Leak, iPhone Spyware & Project Hail Mary (EP 36)

    Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers five new science and tech stories at a high level: NASA’s Artemis 2 moon mission, what actually leaked in the Claude Code incident, a new cancer genomics paper suggesting domesticated cats may be unusually useful real-world models for human cancer, two leaked iPhone spyware toolkits, and a science-focused review of Project Hail Mary. Summary Artemis 2 is finally flying — why this mission matters, why it is not landing yet, and why the moon race is back in geopolitical focus. Claude Code leaked, but not Claude itself — what was exposed, why people got confused, and why the distinction between source code and model weights matters. Cats and cancer — why domesticated cats may offer a more realistic environmental cancer model than traditional lab rodents. iPhone spyware in the wild — what Dark Sword and Coruna are, what they can do, and why this signals a broader shift in cyber risk. Project Hail Mary science review — what the film gets right, what it gets wrong, and which scientific liberties are hardest to buy. Support the showDonate: FFPod.com/donateFollow: @FFPod on X / Instagram / TikTok / Facebook

    1hr 1min

  8. 31 MAR

    Can AI Help Wake Coma Patients? The Science of Consciousness (EP 35)

    Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the hardest questions in neuroscience: what breaks in the brain during a coma, and can we figure out how to turn consciousness back on? We unpack a new paper from Daniel Toker et al. that uses an interpretable AI framework — not a generic black box chatbot model — to reverse engineer the biological mechanisms of prolonged unconsciousness, recover known features of coma, predict new ones, and propose a possible new target for deep brain stimulation. Summary Why diagnosis is so hard — disorders of consciousness are not just about whether a patient is awake, but whether awareness is still present even when motor output is gone. The mesocircuit hypothesis — the episode explains how the cortex, thalamus, and basal ganglia may work together like an electrical grid to support consciousness. Interpretable AI, not black-box hype — Daniel Toker’s team built a biophysically grounded model that rediscovered known coma features and predicted two new biological mechanisms. A possible stimulation target — the subthalamic nucleus emerged as a standout candidate for deep brain stimulation, suggesting a new path toward restoring wakefulness. Support the showDonate: FFPod.com/donateFollow: @FFPod on X / Instagram / TikTok / Facebook Show Notes Daniel Toker et al. — Adversarial AI reveals mechanisms and treatments for disorders of consciousness Nicholas Schiff et al. — deep brain stimulation in a minimally conscious patient Adrian Owen et al. — fMRI evidence of covert awareness in a patient diagnosed as vegetative

    1hr 9min
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About

From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.

Information

  • Creator
    Krishna Choudhary and Lester Nare
  • Years Active
    2025 - 2026
  • Episodes
    42
  • Rating
    Clean
  • Copyright
    © Krishna Choudhary and Lester Nare
  • Show Website
    From First Principles

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